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CH547785A - PROCESS FOR THE PRODUCTION OF 2 ', 3' (ALPHA) -TETRAHYDROFURAN-2'SPIRO-17 (6.7 (ALPHA) -DIHALOGENMETHYLENE-1,2 (ALPHA) -METHYLENE-4-ANDROSTENE-3-ON) DERIVATIVES. - Google Patents

PROCESS FOR THE PRODUCTION OF 2 ', 3' (ALPHA) -TETRAHYDROFURAN-2'SPIRO-17 (6.7 (ALPHA) -DIHALOGENMETHYLENE-1,2 (ALPHA) -METHYLENE-4-ANDROSTENE-3-ON) DERIVATIVES.

Info

Publication number
CH547785A
CH547785A CH327973A CH327973A CH547785A CH 547785 A CH547785 A CH 547785A CH 327973 A CH327973 A CH 327973A CH 327973 A CH327973 A CH 327973A CH 547785 A CH547785 A CH 547785A
Authority
CH
Switzerland
Prior art keywords
alpha
dihalogenmethylene
androstene
spiro
tetrahydrofuran
Prior art date
Application number
CH327973A
Other languages
German (de)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CH547785A publication Critical patent/CH547785A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH327973A 1969-05-14 1970-05-06 PROCESS FOR THE PRODUCTION OF 2 ', 3' (ALPHA) -TETRAHYDROFURAN-2'SPIRO-17 (6.7 (ALPHA) -DIHALOGENMETHYLENE-1,2 (ALPHA) -METHYLENE-4-ANDROSTENE-3-ON) DERIVATIVES. CH547785A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467269A 1969-05-14 1969-05-14
US2118370A 1970-03-19 1970-03-19

Publications (1)

Publication Number Publication Date
CH547785A true CH547785A (en) 1974-04-11

Family

ID=26694377

Family Applications (2)

Application Number Title Priority Date Filing Date
CH683870A CH547792A (en) 1969-05-14 1970-05-06 METHOD FOR MANUFACTURING SPIRO-STEROIDS.
CH327973A CH547785A (en) 1969-05-14 1970-05-06 PROCESS FOR THE PRODUCTION OF 2 ', 3' (ALPHA) -TETRAHYDROFURAN-2'SPIRO-17 (6.7 (ALPHA) -DIHALOGENMETHYLENE-1,2 (ALPHA) -METHYLENE-4-ANDROSTENE-3-ON) DERIVATIVES.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH683870A CH547792A (en) 1969-05-14 1970-05-06 METHOD FOR MANUFACTURING SPIRO-STEROIDS.

Country Status (17)

Country Link
JP (1) JPS532865B1 (en)
AR (1) AR192305A1 (en)
BE (1) BE750330A (en)
CA (1) CA926385A (en)
CH (2) CH547792A (en)
CS (2) CS151552B2 (en)
DE (1) DE2023450C3 (en)
DK (3) DK126992B (en)
FI (2) FI47355C (en)
FR (1) FR2051526B1 (en)
GB (1) GB1265444A (en)
IE (1) IE34194B1 (en)
IL (1) IL34431A (en)
NL (1) NL168844C (en)
NO (1) NO131131C (en)
SE (2) SE386904B (en)
YU (1) YU34052B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3356677A (en) * 1966-04-05 1967-12-05 Syntex Corp 1alpha, 2alpha-and 6alpha, 7alpha-dihalomethylene androstenes

Also Published As

Publication number Publication date
DE2023450B2 (en) 1978-10-05
SE386904B (en) 1976-08-23
NL168844C (en) 1982-05-17
CH547792A (en) 1974-04-11
SE366305B (en) 1974-04-22
IL34431A (en) 1974-03-14
FI47355C (en) 1973-11-12
YU117670A (en) 1978-05-15
FI47355B (en) 1973-07-31
YU34052B (en) 1978-10-31
GB1265444A (en) 1972-03-01
JPS532865B1 (en) 1978-02-01
AR192305A1 (en) 1973-02-14
BE750330A (en) 1970-11-13
DK127880C (en) 1974-06-10
FR2051526A1 (en) 1971-04-09
CA926385A (en) 1973-05-15
FI47885B (en) 1974-01-02
NO131131C (en) 1975-04-09
DK127880B (en) 1974-01-28
NL168844B (en) 1981-12-16
DE2023450C3 (en) 1979-05-31
FR2051526B1 (en) 1974-04-12
CS151552B2 (en) 1973-10-19
IE34194B1 (en) 1975-03-05
DE2023450A1 (en) 1971-01-14
NO131131B (en) 1974-12-30
IE34194L (en) 1970-11-14
IL34431A0 (en) 1970-07-19
DK127505B (en) 1973-11-19
FI47885C (en) 1974-04-10
CS151551B2 (en) 1973-10-19
DK126992B (en) 1973-09-10
NL7006474A (en) 1970-11-17

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Legal Events

Date Code Title Description
PL Patent ceased