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CH318362A - Process for the preparation of a hydrazone of a heterocyclic aldehyde - Google Patents

Process for the preparation of a hydrazone of a heterocyclic aldehyde

Info

Publication number
CH318362A
CH318362A CH318362DA CH318362A CH 318362 A CH318362 A CH 318362A CH 318362D A CH318362D A CH 318362DA CH 318362 A CH318362 A CH 318362A
Authority
CH
Switzerland
Prior art keywords
hydrazone
preparation
heterocyclic aldehyde
piperonal
nicotinic acid
Prior art date
Application number
Other languages
German (de)
Inventor
Hans-Albert Dr Offe
Werner Dr Siefken
Domagk Gerhard Prof Dr Dr H C
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CH318362A publication Critical patent/CH318362A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/88—Nicotinoylhydrazones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Herstellung eines     Hydrazons    eines     heterocyclischen        Aldehyds       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Herstellung eines neuen       Hydrazons    eines     heterocyclischen        Aldehyds,     Glas dadurch gekennzeichnet ist, dass man     Pi-          peronal    mit     Nikotinsäurehydrazid        umsetzt.     Das so erhaltene     Piperonal-nikotinsäurehydra-          zon    schmilzt bei 199-200  C. Es soll als Arz  neimittel verwendet werden.  



  <I>Beispiel</I>  69 Gewichtsteile     Nikotinsäurehydrazid    wer  den in 1000     Volumteilen    Methanol warm ge  löst und diese Lösung mit 75 Gewichtsteilen         Piperonal    etwa drei     Stunden    am     Rückfluss     gekocht. Das nach dem Erkalten abgeschie  dene     Piperonal-nikotinsäurehydrazon,    das in  einer Menge von 127     Gewichtsteilen    entstan  den ist, schmilzt bei 199-200  C.



  Process for the preparation of a hydrazone of a heterocyclic aldehyde The present invention relates to a process for the preparation of a new hydrazone of a heterocyclic aldehyde, glass is characterized in that piperonal is reacted with nicotinic acid hydrazide. The piperonal nicotinic acid hydrazone thus obtained melts at 199-200 C. It is intended to be used as a medicinal product.



  <I> Example </I> 69 parts by weight of nicotinic acid hydrazide are dissolved in 1000 parts by volume of methanol and this solution is refluxed with 75 parts by weight of piperonal for about three hours. The piperonal nicotinic acid hydrazone deposited after cooling, which was produced in an amount of 127 parts by weight, melts at 199-200 C.

Claims (1)

PATENTANSPRUCH Verfahren zur Herstellung eines Hydra- zons eines heter ocyclischen Aldehyds, dadurch gekennzeichnet, dass man Piperonal mit Niko- tinsäurehydrazid umsetzt. Das so erhaltene Piperonal-nikotinsäurehydrazon schmilzt bei 199-200 C. PATENT CLAIM Process for the production of a hydrazone of a heterocyclic aldehyde, characterized in that piperonal is reacted with nicotinic acid hydrazide. The piperonal nicotinic acid hydrazone thus obtained melts at 199-200 C.
CH318362D 1951-12-22 1952-11-12 Process for the preparation of a hydrazone of a heterocyclic aldehyde CH318362A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE318362X 1951-12-22
CH313876T 1952-11-12

Publications (1)

Publication Number Publication Date
CH318362A true CH318362A (en) 1956-12-31

Family

ID=25735984

Family Applications (1)

Application Number Title Priority Date Filing Date
CH318362D CH318362A (en) 1951-12-22 1952-11-12 Process for the preparation of a hydrazone of a heterocyclic aldehyde

Country Status (1)

Country Link
CH (1) CH318362A (en)

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