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CH258756A - Process for the production of a new therapeutically useful product. - Google Patents

Process for the production of a new therapeutically useful product.

Info

Publication number
CH258756A
CH258756A CH258756DA CH258756A CH 258756 A CH258756 A CH 258756A CH 258756D A CH258756D A CH 258756DA CH 258756 A CH258756 A CH 258756A
Authority
CH
Switzerland
Prior art keywords
production
therapeutically useful
useful product
new therapeutically
ethyl
Prior art date
Application number
Other languages
German (de)
Inventor
Ag Galactina Biomalz
Original Assignee
Galactina & Biomalz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galactina & Biomalz Ag filed Critical Galactina & Biomalz Ag
Publication of CH258756A publication Critical patent/CH258756A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  <B>Zusatzpatent</B> zum Hauptpatent Nr.     2150375.       Verfahren zur Herstellung eines neuen therapeutisch verwendbaren Produktes.    Im Hauptpatent ist ein Verfahren zur       Iieratellung        eines,    neuen therapeutisch ver  wendbaren Produktes beschrieben, gemäss       welehem    man.     5-Me@thyl-5-s,tyryl-hydantoin     mit Brom behandelt.  



  Es wurde     nun,        gefunden"dass,    man ein wei  teres     neues,        therapeutisch        verwendbares        Pro-          dukt    erhält, wenn man     5-Äthyl-5-styryl-          hydantoin    der     Formel     
EMI0001.0016     
    mit.

   Brom     behandelt.    Man erhält     :däs        5-Äthyl-          5    -     (1',2'-:dibrom    -2'-     phenyl    -     ät:hyl)    -     hyd:antoin          der    Formel  
EMI0001.0026     
    <I>Beispiel:

  </I>       5-Äthyl-5-styryl-hydantoin    wird in was  lerfreiem Eisessig unter Erwärmen gelöst  und nach dem Erkalten bei     2i0     C mit einem       Mol    Brom (in Eisessig gelöst) langsam     bro-          riiiert.    Der Eisessig     -wird        unter        vermindertem          Druck        abdest.lliert    und der Rückstand aus       3thylalkohol        uml@riGtallis:

  iert.    Das.     5-Äthyl-          5    -     (1',2'-dibrom    -     2'-phenyl    -     äthyl)        -hydantoln     der Formel  
EMI0001.0045     
    scheidet sieh in feinen     Nadeln    vom Schmelz  punkt     2,116\2117     C ab.  



  Die neue     Verbindung    kann entweder -di  rekt als     solche    oder in Form ihrer Salze the  rapeutisch verwendet werden. Wasserlösliche  Salze     werden    durch Umsetzung mit     Alkali-          oder        Magnesiumhy        droxyd    erhalten.



  <B> Additional patent </B> to main patent no. 2150375. Process for the production of a new therapeutically useful product. In the main patent, a method for Iieratell a new therapeutically ver usable product is described, according to which one. 5-methyl-5-s, tyryl-hydantoin treated with bromine.



  It has now been found "that another new, therapeutically useful product is obtained if 5-ethyl-5-styrylhydantoin of the formula
EMI0001.0016
    With.

   Bromine treated. The following is obtained: the 5-ethyl- 5 - (1 ', 2' -: dibromo -2'-phenyl - ät: hyl) - hyd: antoin of the formula
EMI0001.0026
    <I> example:

  </I> 5-Ethyl-5-styryl-hydantoin is dissolved in what is free glacial acetic acid with warming and after cooling at 20 ° C. with one mole of bromine (dissolved in glacial acetic acid) is slowly burnt. The glacial acetic acid is distilled off under reduced pressure and the residue is converted from ethyl alcohol by means of riGtallis:

  iert. The. 5-ethyl-5 - (1 ', 2'-dibromo-2'-phenyl-ethyl) -hydantoln of the formula
EMI0001.0045
    It separates out in fine needles with a melting point of 2.116 \ 2117 C.



  The new compound can either be used directly as such or in the form of its salts. Water-soluble salts are obtained by reacting with alkali or magnesium hydroxide.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines neuen therapeutisch verwendbaren Produktes, da durch gekennzeiehnet, dass man 5-Äthyl-5- styryl-hy dantain der Formel EMI0001.0061 mit Brom behandelt. PATENT CLAIM: Process for the production of a new therapeutically usable product, because it is marked by the fact that one has 5-ethyl-5-styryl-hy dantain of the formula EMI0001.0061 treated with bromine. Das erhaltene Produkt bildet feine Na- @d,eln vom Schmelzpunkt 216-217 C. Diel -durch Umsetzung mit Alkali- oder Magne- siumhydToxyd erhältlichen Salze sind wass er- löslich. The product obtained forms fine Na- @ d, eln with a melting point of 216-217 C. Diel - salts obtainable by reaction with alkali or magnesium hydroxide are soluble in water.
CH258756D 1946-08-24 1946-12-17 Process for the production of a new therapeutically useful product. CH258756A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH250375T 1946-08-24
CH258756T 1946-12-17

Publications (1)

Publication Number Publication Date
CH258756A true CH258756A (en) 1948-12-15

Family

ID=25729449

Family Applications (1)

Application Number Title Priority Date Filing Date
CH258756D CH258756A (en) 1946-08-24 1946-12-17 Process for the production of a new therapeutically useful product.

Country Status (1)

Country Link
CH (1) CH258756A (en)

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