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CH134865A - Process for the preparation of a therapeutically valuable dye preparation. - Google Patents

Process for the preparation of a therapeutically valuable dye preparation.

Info

Publication number
CH134865A
CH134865A CH134865DA CH134865A CH 134865 A CH134865 A CH 134865A CH 134865D A CH134865D A CH 134865DA CH 134865 A CH134865 A CH 134865A
Authority
CH
Switzerland
Prior art keywords
preparation
therapeutically valuable
dye
valuable dye
blue
Prior art date
Application number
Other languages
German (de)
Inventor
Sandoz Chemische Fabri Vormals
Original Assignee
Chem Fab Vormals Sandoz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem Fab Vormals Sandoz filed Critical Chem Fab Vormals Sandoz
Publication of CH134865A publication Critical patent/CH134865A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/02—Dyestuff salts, e.g. salts of acid dyes with basic dyes
    • C09B69/04—Dyestuff salts, e.g. salts of acid dyes with basic dyes of anionic dyes with nitrogen containing compounds
    • C09B69/045—Dyestuff salts, e.g. salts of acid dyes with basic dyes of anionic dyes with nitrogen containing compounds of anionic azo dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

  Verfahren zur Darstellung eines     therapeutisch    wertvollen     Farbstoffpräparates.       Es wurde gefunden, dass man zu einem  wertvollen     Farbstoffpräparat    gelangen kann,  wenn man auf den     Farbstoff,    der durch al  kalische Kupplung von     tetrazotiertem        Tolidin     mit     1,8-Amidonaphtol-3,6-disulfosäure    erhal  ten wird,     Natriumdesogycholat    einwirken lässt.  Es ist nach Wieland (Zeitschrift für physio  logische Chemie, Band 97, Seite 1) bekannt,  dass sowohl Gallensäuren, wie auch ihre Al  kalisalze mit organischen Substanzen Ad  ditionsverbindungen eingehen.  



       Beispiel:     300 Teile des     Farbstoffes,    der durch al  kalische Kupplung von     tetrazotiertem        Tolidin     mit     1,8-Amidonaphtol-3,6-disulfosäure    erhal  ten wird, werden mit 700 Teilen Natrium  desosycholat gemischt, die Mischung in 10000  Teile Wasser eingetragen und nach erfolgter  Lösung zur Trockne eingedampft. Die neue  Substanz bildet ein graublaues Pulver, das    sich in Wasser mit blauvioletter Farbe. löst  und das sich     vor    dem reinen     Farbstoff    durch  eine stärkere Wirkung auf Blutparasiten,  sowie durch eine geringere     Toaicität    aus  zeichnet.



  Process for the preparation of a therapeutically valuable dye preparation. It has been found that a valuable dye preparation can be obtained if sodium desogycholate is allowed to act on the dye which is obtained by alkaline coupling of tetrazotized tolidine with 1,8-amidonaphthol-3,6-disulfonic acid. According to Wieland (Journal of Physiological Chemistry, Volume 97, Page 1) it is known that both bile acids and their alkali metal salts enter into addition compounds with organic substances.



       Example: 300 parts of the dye obtained by alkaline coupling of tetrazotized tolidine with 1,8-amidonaphthol-3,6-disulfonic acid are mixed with 700 parts of sodium desosycholate, the mixture is added to 10,000 parts of water and, after dissolution is complete evaporated to dryness. The new substance forms a gray-blue powder that turns blue-violet in color in water. dissolves and is characterized by a stronger effect on blood parasites, as well as by a lower toxicity from the pure dye.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines therapeu tisch wertvollen Farbstoffpräparates, dadurch gekennzeichnet, dass man auf den Farbstoff, der durch alkalische Kupplung von tetrazo- tiertem Tolidin mit 1,8-Amidonaphtol-3,6-di- sulfosäure erhalten wird, Natriumdesogycholat einwirken lässt. PATENT CLAIM: Process for the preparation of a therapeutically valuable dye preparation, characterized in that sodium desogycholate is allowed to act on the dye obtained by the alkaline coupling of tetrazo- tated tolidine with 1,8-amidonaphthol-3,6-disulfonic acid. Die neue Substanz bildet ein graublaues Pulver, das sich<B>-</B>in Wasser mit blauvioletter Farbe löst und das sich vor dem reinen Farb stoff durch eine stärkere Wirkung auf Blut parasiten, sowie durch eine geringere Togici- tät auszeichnet. The new substance forms a gray-blue powder that <B> - </B> dissolves in water with a blue-violet color and which, compared to the pure color, has a stronger effect on blood parasites and is less effective.
CH134865D 1928-02-15 1928-02-15 Process for the preparation of a therapeutically valuable dye preparation. CH134865A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH126504T 1928-02-15
CH134865T 1928-02-15

Publications (1)

Publication Number Publication Date
CH134865A true CH134865A (en) 1929-08-15

Family

ID=25710682

Family Applications (5)

Application Number Title Priority Date Filing Date
CH126504D CH126504A (en) 1928-02-15 1927-01-15 Process for the preparation of a therapeutically valuable dye preparation.
CH134865D CH134865A (en) 1928-02-15 1928-02-15 Process for the preparation of a therapeutically valuable dye preparation.
CH134864D CH134864A (en) 1928-02-15 1928-02-15 Process for the preparation of a therapeutically valuable dye preparation.
CH134862D CH134862A (en) 1928-02-15 1928-02-15 Process for the preparation of a therapeutically valuable dye preparation.
CH134863D CH134863A (en) 1928-02-15 1928-02-15 Process for the preparation of a therapeutically valuable dye preparation.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH126504D CH126504A (en) 1928-02-15 1927-01-15 Process for the preparation of a therapeutically valuable dye preparation.

Family Applications After (3)

Application Number Title Priority Date Filing Date
CH134864D CH134864A (en) 1928-02-15 1928-02-15 Process for the preparation of a therapeutically valuable dye preparation.
CH134862D CH134862A (en) 1928-02-15 1928-02-15 Process for the preparation of a therapeutically valuable dye preparation.
CH134863D CH134863A (en) 1928-02-15 1928-02-15 Process for the preparation of a therapeutically valuable dye preparation.

Country Status (1)

Country Link
CH (5) CH126504A (en)

Also Published As

Publication number Publication date
CH134862A (en) 1929-08-15
CH134863A (en) 1929-08-15
CH126504A (en) 1928-06-16
CH134864A (en) 1929-08-15

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