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CA2710929A1 - Imidazopyrazines comme inhibiteurs de proteines kinases - Google Patents

Imidazopyrazines comme inhibiteurs de proteines kinases Download PDF

Info

Publication number
CA2710929A1
CA2710929A1 CA2710929A CA2710929A CA2710929A1 CA 2710929 A1 CA2710929 A1 CA 2710929A1 CA 2710929 A CA2710929 A CA 2710929A CA 2710929 A CA2710929 A CA 2710929A CA 2710929 A1 CA2710929 A1 CA 2710929A1
Authority
CA
Canada
Prior art keywords
compound
alkyl
heteroaryl
group
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2710929A
Other languages
English (en)
Inventor
Matthew Paul Rainka
Matthew Ernst Voss
Lisa Helen Peterson
Mike Fleming
David B. Belanger
Patrick J. Curran
Bheemashankar A. Kulkarni
Tao Yu
Yonglian Zhang
Yushi Xiao
Angela D. Kerekes
Jayaram R. Tagat
Ronald J. Doll
M. Arshad Siddiqui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Albany Molecular Research Inc
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albany Molecular Research Inc, Schering Corp filed Critical Albany Molecular Research Inc
Publication of CA2710929A1 publication Critical patent/CA2710929A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2710929A 2008-01-28 2009-01-26 Imidazopyrazines comme inhibiteurs de proteines kinases Abandoned CA2710929A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2401008P 2008-01-28 2008-01-28
US61/024,010 2008-01-28
PCT/US2009/031972 WO2009097233A1 (fr) 2008-01-28 2009-01-26 Imidazopyrazines comme inhibiteurs de protéines kinases

Publications (1)

Publication Number Publication Date
CA2710929A1 true CA2710929A1 (fr) 2009-08-06

Family

ID=40456241

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2710929A Abandoned CA2710929A1 (fr) 2008-01-28 2009-01-26 Imidazopyrazines comme inhibiteurs de proteines kinases

Country Status (2)

Country Link
CA (1) CA2710929A1 (fr)
WO (1) WO2009097233A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010311511B2 (en) 2009-10-30 2014-07-17 Janssen Pharmaceutica Nv Imidazo[1,2-b]pyridazine derivatives and their use as PDE10 inhibitors
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
US9468642B2 (en) 2010-03-18 2016-10-18 Bayer Intellectual Property Gmbh Imidazopyrazines
EP2576560B1 (fr) 2010-06-01 2015-09-30 Bayer Intellectual Property GmbH Imidazopyrazines substituées
CA2838645C (fr) 2011-06-27 2020-03-10 Janssen Pharmaceutica Nv Derives de 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline
CN102363618A (zh) * 2011-07-04 2012-02-29 华东理工大学 一种表皮生长因子受体的新型抑制剂及其应用
JP5792128B2 (ja) 2011-07-29 2015-10-07 富士フイルム株式会社 １，５−ナフチリジン誘導体又はその塩
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2014001314A1 (fr) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinaisons comprenant des inhibiteurs de la pde 2 tels que des composés 1-aryl-4-méthyl-[1, 2, 4] triazolo [4, 3-a]-quinoxaline et des inhibiteurs de la pde 10 pour utilisation dans le traitement de troubles neurologiques ou métaboliques
CA2875057C (fr) 2012-07-09 2021-07-13 Janssen Pharmaceutica Nv Composes d'imidazo (1,2-b) pyridazine et d'imidazo (1,2-a) pyrazine et leur utilisation en tant qu'inhibiteurs de la phosphodiesterase 10
EP3964507A1 (fr) 2013-10-04 2022-03-09 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
WO2015051241A1 (fr) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
JP6701088B2 (ja) 2014-03-19 2020-05-27 インフィニティー ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物
WO2016054491A1 (fr) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
EP3350183B1 (fr) 2015-09-14 2025-04-02 Twelve Therapeutics, Inc. Formes solides de dérivés d'isoquinolinone, leur procédé de fabrication, compositions les comprenant et méthodes d'utilisation de celles-ci
WO2017161116A1 (fr) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues de composés isoquinolinone et quinazolinone et leurs utilisations comme inhibiteurs de la kinase pi3k
WO2017214269A1 (fr) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005023333D1 (de) * 2004-10-15 2010-10-14 Takeda Pharmaceutical Kinaseinhibitoren
AU2006315718B2 (en) * 2005-11-10 2012-10-04 Merck Sharp & Dohme Corp. Imidazopyrazines as protein kinase inhibitors
CA2628534A1 (fr) * 2005-11-10 2007-05-18 Schering Corporation Methodes d'inhibition de proteine kinases
JP2009539840A (ja) * 2006-06-06 2009-11-19 シェーリング コーポレイション プロテインキナーゼ阻害剤としてのイミダゾピラジン
MX2010001340A (es) * 2007-07-31 2010-06-02 Schering Corp Combianacion de agente antimitotico e inhibidor de aurora quinasa como tratamiento anticancerigeno.

Also Published As

Publication number Publication date
WO2009097233A9 (fr) 2009-09-24
WO2009097233A1 (fr) 2009-08-06

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