CA2320798C - Advanced active devices and methods for molecular biological analysis and diagnostics - Google Patents

Advanced active devices and methods for molecular biological analysis and diagnostics Download PDF

Info

Publication number: CA2320798C
Authority: CA; Canada
Prior art keywords: substrate; array; chip; sealant; electronic device
Prior art date: 1998-02-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA002320798A

Other languages

English (en)

French (fr)

Other versions

CA2320798A1 (en

Inventor

Donald E. Ackley

Paul D. Swanson

Scott O. Graham

Elizabeth L. Mather

Timothy L. Leclair

William F. Butler

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nanogen Inc

Original Assignee

Nanogen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-20

Filing date

1999-02-11

Publication date

2008-01-15

1998-02-20 Priority claimed from US09/026,618 external-priority patent/US6099803A/en

1999-01-29 Priority claimed from US09/239,569 external-priority patent/US6068818A/en

1999-01-29 Priority claimed from US09/240,920 external-priority patent/US6254827B1/en

1999-01-29 Priority claimed from US09/239,598 external-priority patent/US6331274B1/en

1999-01-29 Priority claimed from US09/240,489 external-priority patent/US6225059B1/en

1999-01-29 Priority claimed from US09/240,931 external-priority patent/US6315953B1/en

1999-02-11 Application filed by Nanogen Inc filed Critical Nanogen Inc

1999-08-26 Publication of CA2320798A1 publication Critical patent/CA2320798A1/en

2008-01-15 Application granted granted Critical

2008-01-15 Publication of CA2320798C publication Critical patent/CA2320798C/en

2019-02-11 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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Classifications

- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
- G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
- G11C13/0009—RRAM elements whose operation depends upon chemical change
- G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
- G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
- G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
- G11C13/0009—RRAM elements whose operation depends upon chemical change
- G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C19/00—Digital stores in which the information is moved stepwise, e.g. shift registers
- H—ELECTRICITY
- H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
- H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
- H10D64/00—Electrodes of devices having potential barriers
- H10D64/01—Manufacture or treatment
- H10D64/021—Manufacture or treatment using multiple gate spacer layers, e.g. bilayered sidewall spacers
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
- H01L2924/0001—Technical content checked by a classifier
- H01L2924/0002—Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Dispersion Chemistry (AREA)
Analytical Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Clinical Laboratory Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Spectroscopy & Molecular Physics (AREA)
Fluid Mechanics (AREA)
Nanotechnology (AREA)
Mathematical Physics (AREA)
Theoretical Computer Science (AREA)
Crystallography & Structural Chemistry (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

CA002320798A 1998-02-20 1999-02-11 Advanced active devices and methods for molecular biological analysis and diagnostics Expired - Fee Related CA2320798C (en)

Applications Claiming Priority (13)

Application Number	Priority Date	Filing Date	Title
US09/026,618 US6099803A (en)	1994-07-07	1998-02-20	Advanced active electronic devices for molecular biological analysis and diagnostics
US09/026,618		1998-02-20
US09/239,569 US6068818A (en)	1993-11-01	1999-01-29	Multicomponent devices for molecular biological analysis and diagnostics
US09/240,920 US6254827B1 (en)	1993-11-01	1999-01-29	Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US09/239,598 US6331274B1 (en)	1993-11-01	1999-01-29	Advanced active circuits and devices for molecular biological analysis and diagnostics
US09/240,489 US6225059B1 (en)	1993-11-01	1999-01-29	Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US09/239,569		1999-01-29
US09/240,489		1999-01-29
US09/240,920		1999-01-29
US09/239,598		1999-01-29
US09/240,931 US6315953B1 (en)	1993-11-01	1999-01-29	Devices for molecular biological analysis and diagnostics including waveguides
US09/240,931		1999-01-29
PCT/US1999/003080 WO1999042558A1 (en)	1998-02-20	1999-02-11	Advanced active devices and methods for molecular biological analysis and diagnostics

Publications (2)

Publication Number	Publication Date
CA2320798A1 CA2320798A1 (en)	1999-08-26
CA2320798C true CA2320798C (en)	2008-01-15

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Application Number	Title	Priority Date	Filing Date
CA002320798A Expired - Fee Related CA2320798C (en)	1998-02-20	1999-02-11	Advanced active devices and methods for molecular biological analysis and diagnostics

Country Status (9)

Country	Link
EP (1)	EP1054949A4 (zh)
JP (1)	JP2003524750A (zh)
KR (1)	KR20010041147A (zh)
CN (1)	CN1237165C (zh)
AU (1)	AU742960B2 (zh)
BR (1)	BR9909207A (zh)
CA (1)	CA2320798C (zh)
NZ (1)	NZ506204A (zh)
WO (1)	WO1999042558A1 (zh)

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CN111867729B (zh)	2018-01-08	2022-06-10	宽腾矽公司	用于亚微米级反应室的电气动力装载的系统及方法
CN111229342B (zh) *	2020-01-17	2022-02-11	上海新微技术研发中心有限公司	基于cmos图像传感的光栅波导多微流道芯片的制造方法
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1999
- 1999-02-11 EP EP99908135A patent/EP1054949A4/en not_active Withdrawn
- 1999-02-11 NZ NZ506204A patent/NZ506204A/xx unknown
- 1999-02-11 CA CA002320798A patent/CA2320798C/en not_active Expired - Fee Related
- 1999-02-11 AU AU27638/99A patent/AU742960B2/en not_active Ceased
- 1999-02-11 CN CNB998050032A patent/CN1237165C/zh not_active Expired - Fee Related
- 1999-02-11 KR KR1020007009196A patent/KR20010041147A/ko not_active Application Discontinuation
- 1999-02-11 WO PCT/US1999/003080 patent/WO1999042558A1/en not_active Application Discontinuation
- 1999-02-11 BR BR9909207-7A patent/BR9909207A/pt not_active IP Right Cessation
- 1999-02-11 JP JP2000532499A patent/JP2003524750A/ja active Pending

Also Published As

Publication number	Publication date
AU742960B2 (en)	2002-01-17
BR9909207A (pt)	2001-11-06
CA2320798A1 (en)	1999-08-26
CN1296525A (zh)	2001-05-23
CN1237165C (zh)	2006-01-18
JP2003524750A (ja)	2003-08-19
EP1054949A4 (en)	2006-09-27
WO1999042558A1 (en)	1999-08-26
AU2763899A (en)	1999-09-06
NZ506204A (en)	2003-06-30
EP1054949A1 (en)	2000-11-29
KR20010041147A (ko)	2001-05-15

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US6068818A (en)	2000-05-30	Multicomponent devices for molecular biological analysis and diagnostics
US7858034B2 (en)	2010-12-28	Circuits for the control of output current in an electronic device for performing active biological operations
US6225059B1 (en)	2001-05-01	Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6254827B1 (en)	2001-07-03	Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US6821729B2 (en)	2004-11-23	Devices for molecular biological analysis and diagnostics including waveguides
CA2320798C (en)	2008-01-15	Advanced active devices and methods for molecular biological analysis and diagnostics
US6099803A (en)	2000-08-08	Advanced active electronic devices for molecular biological analysis and diagnostics
US6245508B1 (en)	2001-06-12	Method for fingerprinting utilizing an electronically addressable array
CA2169852C (en)	2008-09-23	Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics
US7172864B1 (en)	2007-02-06	Methods for electronically-controlled enzymatic reactions
US6638482B1 (en)	2003-10-28	Reconfigurable detection and analysis apparatus and method
US7704726B2 (en)	2010-04-27	Active programmable matrix devices
US6726880B1 (en)	2004-04-27	Electronic device for performing active biological operations and method of using same
AU746974B2 (en)	2002-05-09	Method for electronically controlled enzymatic reaction at an addressable location
AU752151B2 (en)	2002-09-05	Methods for fingerprinting utilizing an electronically addressable array

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2000-12-07	EEER	Examination request
2009-02-11	MKLA	Lapsed