[go: up one dir, main page]

NZ506204A - Advanced active devices and methods for molecular biological analysis and diagnostics - Google Patents

Advanced active devices and methods for molecular biological analysis and diagnostics

Info

Publication number
NZ506204A
NZ506204A NZ506204A NZ50620499A NZ506204A NZ 506204 A NZ506204 A NZ 506204A NZ 506204 A NZ506204 A NZ 506204A NZ 50620499 A NZ50620499 A NZ 50620499A NZ 506204 A NZ506204 A NZ 506204A
Authority
NZ
New Zealand
Prior art keywords
array
diagnostics
methods
materials
active devices
Prior art date
Application number
NZ506204A
Inventor
Donald E Ackley
Paul D Swanson
Scott O Graham
Elizabeth L Mather
Timothy L Leclair
William F Butler
Original Assignee
Nanogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/026,618 external-priority patent/US6099803A/en
Priority claimed from US09/239,598 external-priority patent/US6331274B1/en
Priority claimed from US09/240,920 external-priority patent/US6254827B1/en
Priority claimed from US09/240,489 external-priority patent/US6225059B1/en
Priority claimed from US09/239,569 external-priority patent/US6068818A/en
Priority claimed from US09/240,931 external-priority patent/US6315953B1/en
Application filed by Nanogen Inc filed Critical Nanogen Inc
Publication of NZ506204A publication Critical patent/NZ506204A/en

Links

Classifications

    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C19/00—Digital stores in which the information is moved stepwise, e.g. shift registers
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D64/00—Electrodes of devices having potential barriers
    • H10D64/01—Manufacture or treatment
    • H10D64/021—Manufacture or treatment using multiple gate spacer layers, e.g. bilayered sidewall spacers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/0001—Technical content checked by a classifier
    • H01L2924/0002—Not covered by any one of groups H01L24/00, H01L24/00 and H01L2224/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Fluid Mechanics (AREA)
  • Nanotechnology (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

An electronic device for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. The device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to an array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. In yet another embodiment, a concentric ring design is provided.
NZ506204A 1998-02-20 1999-02-11 Advanced active devices and methods for molecular biological analysis and diagnostics NZ506204A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US09/026,618 US6099803A (en) 1994-07-07 1998-02-20 Advanced active electronic devices for molecular biological analysis and diagnostics
US09/239,598 US6331274B1 (en) 1993-11-01 1999-01-29 Advanced active circuits and devices for molecular biological analysis and diagnostics
US09/240,920 US6254827B1 (en) 1993-11-01 1999-01-29 Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
US09/240,489 US6225059B1 (en) 1993-11-01 1999-01-29 Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US09/239,569 US6068818A (en) 1993-11-01 1999-01-29 Multicomponent devices for molecular biological analysis and diagnostics
US09/240,931 US6315953B1 (en) 1993-11-01 1999-01-29 Devices for molecular biological analysis and diagnostics including waveguides
PCT/US1999/003080 WO1999042558A1 (en) 1998-02-20 1999-02-11 Advanced active devices and methods for molecular biological analysis and diagnostics

Publications (1)

Publication Number Publication Date
NZ506204A true NZ506204A (en) 2003-06-30

Family

ID=27556084

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ506204A NZ506204A (en) 1998-02-20 1999-02-11 Advanced active devices and methods for molecular biological analysis and diagnostics

Country Status (9)

Country Link
EP (1) EP1054949A4 (en)
JP (1) JP2003524750A (en)
KR (1) KR20010041147A (en)
CN (1) CN1237165C (en)
AU (1) AU742960B2 (en)
BR (1) BR9909207A (en)
CA (1) CA2320798C (en)
NZ (1) NZ506204A (en)
WO (1) WO1999042558A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582421B2 (en) 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
JP2003507714A (en) * 1999-08-13 2003-02-25 ナノゲン・インコーポレイテッド Microelectronic molecular descriptor array device, method, operation and format for combinatorial selection of intermolecular ligand binding structures and drug screening
WO2001016859A2 (en) * 1999-08-27 2001-03-08 Pljvita Corporation System and method for genomic and proteomic animal disease assessment via expression profile comparison
US6589778B1 (en) 1999-12-15 2003-07-08 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6569674B1 (en) 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
JP2003517156A (en) * 1999-12-15 2003-05-20 モトローラ・インコーポレイテッド Compositions and methods for performing biological reactions
DE10015818A1 (en) * 2000-03-30 2001-10-18 Infineon Technologies Ag Biosensor and method for determining macromolecular biopolymers using a biosensor
DE10049901C2 (en) * 2000-10-10 2003-01-02 Aventis Res & Tech Gmbh & Co Apparatus and method for electrically accelerated immobilization and for detection of molecules
WO2002071980A2 (en) 2001-03-09 2002-09-19 Georgia Tech Research Corporation Intravascular device and method for axially stretching blood vessels
DE10122659A1 (en) * 2001-05-10 2002-12-05 Infineon Technologies Ag Biochip arrangement
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
JP3848226B2 (en) * 2001-08-31 2006-11-22 株式会社東芝 Biological substance detection device and biological substance detection element
US7198754B2 (en) 2001-08-31 2007-04-03 Kabushiki Kaisha Toshiba Biological material detection element, biological material detection method and apparatus, charged material moving apparatus
WO2003029830A1 (en) * 2001-10-03 2003-04-10 Genomic Solutions Acquisitions Limited Cleaning method
GB0200705D0 (en) * 2002-01-14 2002-02-27 Univ Cambridge Tech Fluid movement
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
CN1429917A (en) * 2002-10-11 2003-07-16 薛永新 AIDS virus in-situ nucleic acid chip and its preparation method
DE102004010635B4 (en) * 2004-03-02 2006-10-05 Micronas Gmbh Device for carrying out measurements on biocomponents
NL1031465C2 (en) * 2006-03-30 2007-10-03 C2V B V Method for constructing a device with fluidic and electrical functions.
WO2008020364A2 (en) * 2006-08-14 2008-02-21 Koninklijke Philips Electronics N. V. Biochemical sensor device
GB2457851B (en) * 2006-12-14 2011-01-05 Ion Torrent Systems Inc Methods and apparatus for measuring analytes using large scale fet arrays
CH701701A2 (en) * 2009-08-28 2011-02-28 Kgmed Gmbh Method for calibration of a diagnostic measuring device.
CN111867729B (en) 2018-01-08 2022-06-10 宽腾矽公司 System and method for electrokinetic loading of sub-micron reaction chambers
CN111229342B (en) * 2020-01-17 2022-02-11 上海新微技术研发中心有限公司 Method for manufacturing grating waveguide multi-micro-channel chip based on CMOS image sensing
CN112517093A (en) * 2020-11-17 2021-03-19 四川大学 Fish saliva automatic sample separation detection disc and detection method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0213825A3 (en) * 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
EP0376611A3 (en) * 1988-12-30 1992-07-22 The Board Of Trustees Of The Leland Stanford Junior University Electrophoretic system
US5527681A (en) * 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
DE69233087T2 (en) * 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Process for the production of polymer arrays
JPH05236997A (en) * 1992-02-28 1993-09-17 Hitachi Ltd Polynucleotide capture chip
US5728532A (en) * 1996-05-31 1998-03-17 Ackley; Donald E. Electrode configuration for matrix addressing of a molecular detection device

Also Published As

Publication number Publication date
AU742960B2 (en) 2002-01-17
BR9909207A (en) 2001-11-06
CA2320798A1 (en) 1999-08-26
CN1296525A (en) 2001-05-23
CN1237165C (en) 2006-01-18
JP2003524750A (en) 2003-08-19
EP1054949A4 (en) 2006-09-27
WO1999042558A1 (en) 1999-08-26
AU2763899A (en) 1999-09-06
CA2320798C (en) 2008-01-15
EP1054949A1 (en) 2000-11-29
KR20010041147A (en) 2001-05-15

Similar Documents

Publication Publication Date Title
NZ506204A (en) Advanced active devices and methods for molecular biological analysis and diagnostics
WO2003061037A3 (en) Electrochemical cells comprising laminar flow induced dynamic conducting interfaces, electronic devices and methods using such cells
DK0945910T3 (en) Membrane Electrode Unit for Polymer Electrolyte Fuel Cells and Method for its Preparation
NO802635L (en) THIN CARBON TISSUE-BASED ELECTROCATALYTIC GAS DIFFUSION ELECTRODES, PROCEDURES FOR PRODUCING THEREOF, AND ELECTROCHEMICAL CELLS CONTAINING THESE
DE60040631D1 (en) Negative electrode material and non-aqueous electrolyte containing battery
DE69906860D1 (en) Separator plate for fuel cells, process for their production and fuel cell containing them
DE69900256D1 (en) Supported Pt-Ru electrocatalyst, as well as the electrode containing it, MEA and solid electrolyte fuel cell
DE69302827D1 (en) Bifunctional air electrode
DE69836593D1 (en) METHOD AND DEVICE FOR OPERATING AN ELECTROCHEMICAL FUEL CELL WITH PERIODIC FUEL INTERRUPTION AT THE ANODE
DE60235058D1 (en) Thin-film polymer electrolyte fuel cell and its operating method
IT7924431A0 (en) ELECTRODE FOR AN ELECTROCHEMICAL CELL AND ELECTROCHEMICAL CELL.
DE69729469D1 (en) CELL-BASED SOLID PHASE TEST
NO883153D0 (en) SEPARATOR FOR ELECTROCHEMICAL BATTERY CELLS.
ES2103197A1 (en) Conducting paste, electrodes, sensors and electrochemical reactors containing said paste, and their manufacturing method
GB2029578B (en) Apparatus for gas analysis with galvanic solid electrolyte cells
EP1381099A4 (en) Negative electrode for non-aqueous electrolyte secondary cell and non-aqueous electrolyte secondary cell using the negative electrode
ATE226264T1 (en) ELECTROCHEMICAL HALF CELL
EP0653797A4 (en) Lithium secondary cell containing organic electrolyte, active material for positive electrode of lithium secondary cell, and method for manufacturing the active material.
EP4109602A4 (en) POSITIVE ELECTRODE CURRENT COLLECTOR AND POSITIVE ELECTRODE PLATE, BATTERY, BATTERY MODULE, BATTERY PACK AND APPARATUS INCLUDING SAME
EP1069423A3 (en) Flow cell for particle analyser using electrical sensing zone method
EP1092789A4 (en) Electrolytic cell using gas diffusion electrode and power distribution method for the electrolytic cell
ATE38861T1 (en) ELECTROLYTIC CELL WITH GAS ELECTRODE AND SMALL ELECTRODE DISTANCE.
DE2964807D1 (en) Bipolar separator for electrochemical cells, a method for its preparation and an electrochemical cell comprising said separator
DE69012310D1 (en) Electrochemical cell containing getter electrode.
IL136194A0 (en) Method and device for disintegrating biological cells for the purpose of extracting and analyzing cell contents

Legal Events

Date Code Title Description
RENW Renewal (renewal fees accepted)
PSEA Patent sealed