CA2270057A1 - Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes - Google Patents

Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes Download PDF

Info

Publication number: CA2270057A1
Authority: CA; Canada
Prior art keywords: phenyl; cis; hydroxy; formula; compound
Prior art date: 1996-10-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002270057A

Other languages

English (en)

French (fr)

Inventor

Svend Treppendahl

Poul Jacobsen

Paul Stanley Bury

Anders Kanstrup

Lise Brown Christiansen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-28

Filing date

1997-10-28

Publication date

1998-05-07

1997-10-28 Application filed by Individual filed Critical Individual

1998-05-07 Publication of CA2270057A1 publication Critical patent/CA2270057A1/en

Status Abandoned legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Gynecology & Obstetrics (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pregnancy & Childbirth (AREA)
Psychiatry (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CA002270057A 1996-10-28 1997-10-28 Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes Abandoned CA2270057A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK119696		1996-10-28
DK1196/96		1996-10-28
PCT/DK1997/000479 WO1998018772A1 (en)	1996-10-28	1997-10-28	NOVEL cis-3,4-CHROMAN DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES

Publications (1)

Publication Number	Publication Date
CA2270057A1 true CA2270057A1 (en)	1998-05-07

Family

ID=8102057

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002270057A Abandoned CA2270057A1 (en)	1996-10-28	1997-10-28	Novel cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes

Country Status (8)

Country	Link
EP (1)	EP0934297A1 (no)
JP (1)	JP2002503213A (no)
AU (1)	AU4699997A (no)
CA (1)	CA2270057A1 (no)
IL (1)	IL129626A0 (no)
NO (1)	NO992002L (no)
WO (1)	WO1998018772A1 (no)
ZA (1)	ZA979646B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1794141B1 (en)	2004-09-21	2011-11-09	Marshall Edwards, Inc.	Substituted chroman derivatives, medicaments and use in therapy
US8080675B2 (en)	2004-09-21	2011-12-20	Marshall Edwards, Inc.	Chroman derivatives, medicaments and use in therapy
WO2012061413A2 (en)	2010-11-01	2012-05-10	Marshall Edwards, Inc.	Isoflavonoid compositions and methods for the treatment of cancer
EP3253208B1 (en)	2015-02-02	2021-05-05	MEI Pharma, Inc.	Combination therapies for use in the treatment of breast cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3340276A (en) *	1964-04-01	1967-09-05	Ciba Geigy Corp	3, 4-diphenyl-chromans
DE1543749A1 (de) *	1966-02-16	1969-12-11	Merck Ag E	Verfahren zur Herstellung von 3,4-cis-4-Aryl-isoflavanen
US5280040A (en) *	1993-03-11	1994-01-18	Zymogenetics, Inc.	Methods for reducing bone loss using centchroman derivatives
HUP9702244A3 (en) *	1995-01-13	1999-12-28	Novo Nordisk As	Use of 3,4-diphenyl chromans for manufacture of a pharmaceutical composition for treatment or prophylaxis of gynaecological disorders

1997
- 1997-10-28 IL IL12962697A patent/IL129626A0/xx unknown
- 1997-10-28 WO PCT/DK1997/000479 patent/WO1998018772A1/en not_active Application Discontinuation
- 1997-10-28 EP EP97909216A patent/EP0934297A1/en not_active Withdrawn
- 1997-10-28 CA CA002270057A patent/CA2270057A1/en not_active Abandoned
- 1997-10-28 AU AU46999/97A patent/AU4699997A/en not_active Abandoned
- 1997-10-28 JP JP51993898A patent/JP2002503213A/ja active Pending
- 1997-10-28 ZA ZA9709646A patent/ZA979646B/xx unknown
1999
- 1999-04-27 NO NO992002A patent/NO992002L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1998018772A1 (en)	1998-05-07
EP0934297A1 (en)	1999-08-11
JP2002503213A (ja)	2002-01-29
NO992002D0 (no)	1999-04-27
AU4699997A (en)	1998-05-22
NO992002L (no)	1999-06-25
IL129626A0 (en)	2000-02-29
ZA979646B (en)	1998-04-28

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Legal Events

Date	Code	Title	Description
2003-10-28	FZDE	Discontinued