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CA2218083A1 - Identification de enantiomeres - Google Patents

Identification de enantiomeres Download PDF

Info

Publication number
CA2218083A1
CA2218083A1 CA 2218083 CA2218083A CA2218083A1 CA 2218083 A1 CA2218083 A1 CA 2218083A1 CA 2218083 CA2218083 CA 2218083 CA 2218083 A CA2218083 A CA 2218083A CA 2218083 A1 CA2218083 A1 CA 2218083A1
Authority
CA
Canada
Prior art keywords
amino acid
macromolecule
domain
binds
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2218083
Other languages
English (en)
Inventor
Antonius Nicolaas Maria Schumacher
Peter S. Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/627,497 external-priority patent/US5780221A/en
Application filed by Whitehead Institute for Biomedical Research filed Critical Whitehead Institute for Biomedical Research
Publication of CA2218083A1 publication Critical patent/CA2218083A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur un procédé d'identification de macromolécules (peptides, oligonucléotides, sucres et complexes macromoléculaires, tels que des complexes protéine/ARN et des complexes lipide/protéine), n'étant pas naturellement chirales (dépourvues de la chiralité d'origine naturelle ou rencontrée dans des molécules de type sauvage) et qui sont des ligands pour d'autres macromolécules chirales.
CA 2218083 1995-05-03 1996-05-02 Identification de enantiomeres Abandoned CA2218083A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US43357295A 1995-05-03 1995-05-03
US08/433,572 1995-05-03
US48230995A 1995-06-07 1995-06-07
US08/482,309 1995-06-07
US106795P 1995-07-11 1995-07-11
US60/001,067 1995-07-11
US08/627,497 1996-03-28
US08/627,497 US5780221A (en) 1995-05-03 1996-03-28 Identification of enantiomeric ligands

Publications (1)

Publication Number Publication Date
CA2218083A1 true CA2218083A1 (fr) 1996-11-07

Family

ID=27485054

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2218083 Abandoned CA2218083A1 (fr) 1995-05-03 1996-05-02 Identification de enantiomeres

Country Status (4)

Country Link
EP (1) EP0825997A1 (fr)
JP (1) JPH11505527A (fr)
CA (1) CA2218083A1 (fr)
WO (1) WO1996034879A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682886B1 (en) 1994-04-28 2004-01-27 Gilead Sciences, Inc. Bivalent binding molecules of 7 transmembrane G protein-coupled receptors
WO1997035194A2 (fr) * 1996-03-21 1997-09-25 President And Fellows Of Harvard College Procede de criblage enantiomere et compositions pour ce procede
GB9609722D0 (en) * 1996-05-09 1996-07-10 Smithkline Beecham Corp Novel method
ATE228529T1 (de) * 1996-08-30 2002-12-15 Jens Peter Fuerste Spiegelselektion und spiegelevolution von nucleinsäuren
US6251666B1 (en) 1997-03-31 2001-06-26 Ribozyme Pharmaceuticals, Inc. Nucleic acid catalysts comprising L-nucleotide analogs
ATE452655T1 (de) * 2001-06-10 2010-01-15 Noxxon Pharma Ag Verwendung von l-polynukleotiden zur diagnostischen bilderzeugung
US7750140B2 (en) 2002-08-01 2010-07-06 Noxxon Pharma Ag Ghrelin binding nucleic acids
CA2544805A1 (fr) * 2003-11-10 2005-06-02 Noxxon Pharma Ag Acides nucleiques se liant specifiquement a une ghreline bioactive
ATE474046T1 (de) 2004-11-29 2010-07-15 Noxxon Pharma Ag Vasopressin bindende l-nukleinsäure
AR052741A1 (es) 2005-04-08 2007-03-28 Noxxon Pharma Ag Acidos nucleicos de union a ghrelin
EP2850095B1 (fr) 2012-05-17 2019-10-09 RA Pharmaceuticals, Inc. Inhibiteurs peptidiques et peptidomimétiques

Also Published As

Publication number Publication date
JPH11505527A (ja) 1999-05-21
WO1996034879A1 (fr) 1996-11-07
EP0825997A1 (fr) 1998-03-04

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Legal Events

Date Code Title Description
FZDE Dead