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CA2166988A1 - Novel dialkoxy-pyridinyl-benzimidazole derivatives - Google Patents

Novel dialkoxy-pyridinyl-benzimidazole derivatives

Info

Publication number
CA2166988A1
CA2166988A1 CA002166988A CA2166988A CA2166988A1 CA 2166988 A1 CA2166988 A1 CA 2166988A1 CA 002166988 A CA002166988 A CA 002166988A CA 2166988 A CA2166988 A CA 2166988A CA 2166988 A1 CA2166988 A1 CA 2166988A1
Authority
CA
Canada
Prior art keywords
methyl
pyridinyl
carbomethoxy
benzimidazole
sulfinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002166988A
Other languages
English (en)
French (fr)
Inventor
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Per Oskar Sverker Von Unge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2166988A1 publication Critical patent/CA2166988A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002166988A 1994-05-27 1995-05-11 Novel dialkoxy-pyridinyl-benzimidazole derivatives Abandoned CA2166988A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9400511 1994-05-27
WOPCT/SE94/00511 1994-05-27
PCT/SE1995/000519 WO1995032959A1 (en) 1994-05-27 1995-05-11 Novel dialkoxy-pyridinyl-benzimidazole derivatives

Publications (1)

Publication Number Publication Date
CA2166988A1 true CA2166988A1 (en) 1995-12-07

Family

ID=20392945

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002166988A Abandoned CA2166988A1 (en) 1994-05-27 1995-05-11 Novel dialkoxy-pyridinyl-benzimidazole derivatives

Country Status (18)

Country Link
EP (1) EP0712401A1 (sv)
JP (1) JPH09504557A (sv)
CN (1) CN1128997A (sv)
AU (1) AU2633095A (sv)
BR (1) BR9506235A (sv)
CA (1) CA2166988A1 (sv)
CZ (1) CZ24396A3 (sv)
EE (1) EE9600011A (sv)
FI (1) FI960367A0 (sv)
HU (1) HU9600005D0 (sv)
IL (1) IL113604A0 (sv)
IS (1) IS4321A (sv)
MA (1) MA23563A1 (sv)
NO (1) NO960268L (sv)
PL (1) PL312692A1 (sv)
TN (1) TNSN95062A1 (sv)
WO (1) WO1995032959A1 (sv)
ZA (1) ZA954125B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
JP4610086B2 (ja) 1998-11-18 2011-01-12 アストラゼネカ・アクチエボラーグ 改善された化学的方法および医薬処方物
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2008057802A2 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
CN101980700A (zh) 2008-02-20 2011-02-23 密苏里大学董事会 包含奥美拉唑和兰索拉唑以及缓冲剂的组合的组合物及其使用方法
CN102209529A (zh) 2008-09-09 2011-10-05 阿斯利康(瑞典)有限公司 将药物组合物递送至有需要的患者的方法
SG176724A1 (en) 2009-06-25 2012-01-30 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
US9539214B2 (en) 2011-12-28 2017-01-10 Pozen Inc. Compositions and methods for delivery of omeprazole plus acetylsalicylic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0593463B1 (en) * 1990-06-20 1999-09-15 Astra Aktiebolag Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
DE4035455A1 (de) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung

Also Published As

Publication number Publication date
IL113604A0 (en) 1995-08-31
CZ24396A3 (en) 1996-06-12
EP0712401A1 (en) 1996-05-22
MA23563A1 (fr) 1995-12-31
NO960268D0 (no) 1996-01-23
BR9506235A (pt) 1997-08-12
WO1995032959A1 (en) 1995-12-07
IS4321A (is) 1996-01-17
ZA954125B (en) 1995-11-27
AU2633095A (en) 1995-12-21
PL312692A1 (en) 1996-05-13
JPH09504557A (ja) 1997-05-06
FI960367L (sv) 1996-01-26
NO960268L (no) 1996-01-23
HU9600005D0 (en) 1996-03-28
TNSN95062A1 (fr) 1996-02-06
FI960367A0 (sv) 1996-01-26
EE9600011A (et) 1996-04-15
CN1128997A (zh) 1996-08-14

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Legal Events

Date Code Title Description
FZDE Discontinued