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CA2096969A1 - Derives 6-o-methylerythromycine a - Google Patents

Derives 6-o-methylerythromycine a

Info

Publication number
CA2096969A1
CA2096969A1 CA2096969A CA2096969A CA2096969A1 CA 2096969 A1 CA2096969 A1 CA 2096969A1 CA 2096969 A CA2096969 A CA 2096969A CA 2096969 A CA2096969 A CA 2096969A CA 2096969 A1 CA2096969 A1 CA 2096969A1
Authority
CA
Canada
Prior art keywords
derivatives
methylerythromycin
against gram
group
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2096969A
Other languages
English (en)
Other versions
CA2096969C (fr
Inventor
Masato Kashimura
Toshifumi Asaka
Shigeo Morimoto
Katsuo Hatayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taisho Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2096969A1 publication Critical patent/CA2096969A1/fr
Application granted granted Critical
Publication of CA2096969C publication Critical patent/CA2096969C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002096969A 1990-11-28 1991-11-22 Derives 6-o-methylerythromycine a Expired - Fee Related CA2096969C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP32652990 1990-11-28
JP326529/90 1990-11-28
PCT/JP1991/001608 WO1992009614A1 (fr) 1990-11-28 1991-11-22 Derive de 6-o-methylerythromycine a

Publications (2)

Publication Number Publication Date
CA2096969A1 true CA2096969A1 (fr) 1992-05-29
CA2096969C CA2096969C (fr) 2000-11-21

Family

ID=18188854

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002096969A Expired - Fee Related CA2096969C (fr) 1990-11-28 1991-11-22 Derives 6-o-methylerythromycine a

Country Status (8)

Country Link
US (1) US5403923A (fr)
EP (1) EP0559896B1 (fr)
KR (1) KR0166096B1 (fr)
AT (1) ATE157368T1 (fr)
CA (1) CA2096969C (fr)
DE (1) DE69127457T2 (fr)
ES (1) ES2104889T3 (fr)
WO (1) WO1992009614A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309613B2 (en) 2003-08-28 2012-11-13 Abbvie Inc. Solid pharmaceutical dosage form

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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WO1993021200A1 (fr) * 1992-04-22 1993-10-28 Taisho Pharmaceutical Co., Ltd. Derive de 5-o-desosaminylerythronolide a
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697523B1 (fr) * 1992-11-05 1994-12-02 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2707088B1 (fr) * 1993-07-02 1995-08-25 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5747466A (en) * 1995-11-08 1998-05-05 Abbott Laboratories 3-deoxy-3-descladinose derivatives of erythromycins A and B
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
EP0876388B1 (fr) * 1995-11-08 2004-02-18 Abbott Laboratories Derives tricycliques d'erythromycine
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
ES2244716T3 (es) * 1996-09-04 2005-12-16 Abbott Laboratories Cetolidos 6-o-sustituidos que tienen actividad antibacteriana.
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
US5804565A (en) * 1996-09-24 1998-09-08 Taisho Pharmaceutical Co., Ltd. Erythromycin A derivatives
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
US6034069A (en) * 1997-09-30 2000-03-07 Abbott Laboratories 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity
US6046171A (en) * 1997-10-29 2000-04-04 Abbott Laboratories 6,11-bridged erythromycin derivatives
US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
US5972898A (en) * 1998-03-27 1999-10-26 Abbott Laboratories 3',3-N-bis-substituted macrolide LHRH antagonists
US5955440A (en) * 1998-03-27 1999-09-21 Abbott Laboratories Macrolide LHRH antagonists
PT952157E (pt) 1998-04-24 2003-11-28 Pfizer Prod Inc Derivados 9a, 11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina
US6387885B1 (en) 1998-08-26 2002-05-14 Abbott Laboratories 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
US6020521A (en) * 1998-08-26 2000-02-01 Abbott Laboratories Macrolide LHRH antagonists
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6355620B1 (en) 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
US6420535B1 (en) 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
US6627743B1 (en) 1999-12-03 2003-09-30 Abbott Laboratories 6-O-methylerythromycin A crystal form III
BR0109544A (pt) * 2000-03-28 2003-06-10 Biochemie Gmbh Partìculas granuladas com sabor ocultado
EP1146051A3 (fr) * 2000-04-10 2001-10-31 Pfizer Products Inc. Dérivées de l' érythromycine A
US20030069332A1 (en) * 2001-09-14 2003-04-10 Giorgio Agostini Prepared elastomer/reinforcing filler composite and tire having component thereof
US6878760B2 (en) * 2001-09-14 2005-04-12 The Goodyear Tire & Rubber Company Preparation of starch reinforced rubber and use thereof in tires
US6838511B2 (en) * 2001-10-11 2005-01-04 The Goodyear Tire & Rubber Company Tire with configured rubber sidewall designed to be ground-contacting reinforced with carbon black, starch and silica
US20030092801A1 (en) * 2001-11-15 2003-05-15 Giorgio Agostini Rubber composition comprised of functionalized elastomer and starch composite with coupling agent and tire having at least one component thereof
US20030096900A1 (en) * 2001-11-16 2003-05-22 Holden Brian David Organic plant derived precipitated silica aggregates, elastomers reinforced therewith and articles such as tires with component thereof
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US6753318B1 (en) * 2002-07-25 2004-06-22 Enanta Pharmaceuticals, Inc. 6,11-4-carbon bridged erythromycin derivatives
US6841664B2 (en) 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
WO2005070918A1 (fr) * 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Procede de preparation de derives bicycliques 6-11 d'erythromycine
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7064110B2 (en) * 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
US7129221B2 (en) * 2002-05-13 2006-10-31 Enanta Pharmaceuticals, Inc. 6,11-bicyclic erythromycin derivatives
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6812216B2 (en) 2002-06-25 2004-11-02 Enanta Pharmaceuticals, Inc. 11-C-substituted derivatives of clarithromycin
US6750204B2 (en) 2002-06-25 2004-06-15 Enanta Pharmaceuticals, Inc. 11-C-substituted ketolides
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US7276487B2 (en) * 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US20050145312A1 (en) * 2003-12-18 2005-07-07 Herberger James R.Sr. Tire component, and tire with such component, of rubber composition which contains combination of soybean oil and starch/plasticizer composite
WO2005067919A1 (fr) * 2003-12-24 2005-07-28 Enanta Pharmaceuticals, Inc. Derives d'erythromycine 11-c substitues
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (fr) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. Derives d'erythromycine bicycliques 9-n substitues en c6-c11
US7229972B2 (en) 2004-12-07 2007-06-12 Enanta Pharmaceuticals, Inc. 3,6-Bicyclolides
JP2008522978A (ja) 2004-12-07 2008-07-03 エナンタ ファーマシューティカルズ インコーポレイテッド ３，６−ビシクロライド
US7291602B2 (en) 2004-12-13 2007-11-06 Enanta Pharmaceuticals, Inc. 11,12-lactone bicyclolides
TW200635600A (en) 2004-12-13 2006-10-16 Enanta Pharm Inc Tetracyclic bicyclolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
ES2691252T3 (es) * 2007-09-17 2018-11-26 Enanta Pharmaceuticals, Inc. Macrólidos de biarilo con puente en 6,11
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
EP0184921A3 (fr) * 1984-12-08 1986-10-29 Beecham Group Plc Dérivés d'érythromycine
US4640910A (en) * 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
GB8729369D0 (en) * 1987-12-16 1988-01-27 Beecham Group Plc Chemical compounds
JP2782793B2 (ja) * 1988-06-15 1998-08-06 大正製薬株式会社 エリスロマイシンａ誘導体およびその製造方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309613B2 (en) 2003-08-28 2012-11-13 Abbvie Inc. Solid pharmaceutical dosage form
US8333990B2 (en) 2003-08-28 2012-12-18 Abbott Laboratories Solid pharmaceutical dosage form
US8399015B2 (en) 2003-08-28 2013-03-19 Abbvie Inc. Solid pharmaceutical dosage form
US8691878B2 (en) 2003-08-28 2014-04-08 Abbvie Inc. Solid pharmaceutical dosage form

Also Published As

Publication number Publication date
CA2096969C (fr) 2000-11-21
KR0166096B1 (ko) 1999-01-15
ATE157368T1 (de) 1997-09-15
EP0559896A1 (fr) 1993-09-15
EP0559896A4 (en) 1993-10-27
ES2104889T3 (es) 1997-10-16
DE69127457T2 (de) 1998-01-22
WO1992009614A1 (fr) 1992-06-11
DE69127457D1 (en) 1997-10-02
US5403923A (en) 1995-04-04
EP0559896B1 (fr) 1997-08-27

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Effective date: 20021122