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CA2064878A1 - Proteine specifique des os - Google Patents

Proteine specifique des os

Info

Publication number
CA2064878A1
CA2064878A1 CA 2064878 CA2064878A CA2064878A1 CA 2064878 A1 CA2064878 A1 CA 2064878A1 CA 2064878 CA2064878 CA 2064878 CA 2064878 A CA2064878 A CA 2064878A CA 2064878 A1 CA2064878 A1 CA 2064878A1
Authority
CA
Canada
Prior art keywords
protein
ile
sequence
polypeptide
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2064878
Other languages
English (en)
Inventor
Hanne Bentz
Ranga Nathan
David M. Rosen
James R. Dasch
Saeid M. Seyedin
Karl A. Piez
Yasushi Ogawa
William H. Andrews
Frank H. Stephenson
Joel Hedgpeth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celtrix Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2064878A1 publication Critical patent/CA2064878A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA 2064878 1989-08-21 1990-08-21 Proteine specifique des os Abandoned CA2064878A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39777989A 1989-08-21 1989-08-21
US397,779 1989-08-21

Publications (1)

Publication Number Publication Date
CA2064878A1 true CA2064878A1 (fr) 1991-02-22

Family

ID=23572594

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2064878 Abandoned CA2064878A1 (fr) 1989-08-21 1990-08-21 Proteine specifique des os

Country Status (5)

Country Link
EP (1) EP0489062A4 (fr)
JP (1) JPH05500503A (fr)
AU (1) AU632160B2 (fr)
CA (1) CA2064878A1 (fr)
WO (1) WO1991002744A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5939388A (en) * 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US5366875A (en) * 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
EP0723013B1 (fr) 1988-04-08 2003-06-18 Stryker Corporation Protéines biosynthétiques ostéogènes, et dispositifs contenant les-dites
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US7378392B1 (en) 1990-05-16 2008-05-27 Genetics Institute, Llc Bone and cartilage inductive proteins
US5650276A (en) * 1991-03-11 1997-07-22 Creative Biomolecules, Inc. Morphogenic protein screening method
US5707810A (en) * 1991-03-11 1998-01-13 Creative Biomolecules, Inc. Method of diagnosing renal tissue damage or disease
US6287816B1 (en) * 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
AU652472B2 (en) * 1991-06-25 1994-08-25 Genetics Institute, Llc BMP-9 compositions
DE69231567T2 (de) * 1991-08-30 2001-06-28 Creative Biomolecules, Inc. Screeningverfahren von morphogenischen Proteinen
AU674500B2 (en) * 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
EP0733109B9 (fr) 1993-12-07 2006-07-05 Genetics Institute, LLC Bmp-12, bmp-13 et compositions de celles-ci pour l'induction de tendons
US6492508B1 (en) 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
CA2386408A1 (fr) 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations a base d'acide hyaluronique aux fins de l'administration de proteines osteogenes
DE60226321T2 (de) 2001-06-01 2009-07-09 Wyeth Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
EP0128041A3 (fr) * 1983-06-06 1986-12-03 David Jeston Baylink Polypeptides ayant une activité de facteur de croissance du squelette
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
DE3588058T3 (de) * 1984-07-16 2005-04-07 Celtrix Pharmaceuticals, Inc., Palo Alto Knorpel-induzierende Polypeptid-Faktoren aus Knochen
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US4816442A (en) * 1986-11-07 1989-03-28 Collagen Corporation Method of inhibiting tumor growth sensitive to CIF-βtreatment
PT90216A (pt) * 1988-04-06 1989-11-10 Processo para a preparacao de polipeptidos com actividade osteogenica

Also Published As

Publication number Publication date
AU632160B2 (en) 1992-12-17
EP0489062A4 (en) 1992-08-12
EP0489062A1 (fr) 1992-06-10
AU6187090A (en) 1991-04-03
JPH05500503A (ja) 1993-02-04
WO1991002744A1 (fr) 1991-03-07

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead