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CA2035967A1 - Oxetanones - Google Patents

Oxetanones

Info

Publication number
CA2035967A1
CA2035967A1 CA002035967A CA2035967A CA2035967A1 CA 2035967 A1 CA2035967 A1 CA 2035967A1 CA 002035967 A CA002035967 A CA 002035967A CA 2035967 A CA2035967 A CA 2035967A CA 2035967 A1 CA2035967 A1 CA 2035967A1
Authority
CA
Canada
Prior art keywords
oxetanones
formula
beta
inhibiting
description
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002035967A
Other languages
French (fr)
Other versions
CA2035967C (en
Inventor
Romano Derungs
Hans Peter Marki
Henri Stalder
Andre Szente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2035967A1 publication Critical patent/CA2035967A1/en
Application granted granted Critical
Publication of CA2035967C publication Critical patent/CA2035967C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

Novel pancreas lipase-inhibiting oxetanones of the formula (see formula I) wherein Q, R1 and R2 have the significance given in the description, are manufactured starting from corresponding .beta.-hydroxycarboxylic acids.
CA002035967A 1990-02-26 1991-02-07 Oxetanones Expired - Fee Related CA2035967C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH60490 1990-02-26
CH604/90 1990-02-26
CH400590 1990-12-17
CH4005/90 1990-12-17

Publications (2)

Publication Number Publication Date
CA2035967A1 true CA2035967A1 (en) 1991-08-27
CA2035967C CA2035967C (en) 2001-10-16

Family

ID=25685091

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002035967A Expired - Fee Related CA2035967C (en) 1990-02-26 1991-02-07 Oxetanones

Country Status (18)

Country Link
EP (1) EP0444482B1 (en)
JP (1) JP2753403B2 (en)
KR (1) KR0183036B1 (en)
AT (1) ATE133167T1 (en)
AU (1) AU645291B2 (en)
CA (1) CA2035967C (en)
DE (1) DE59107262D1 (en)
DK (1) DK0444482T3 (en)
ES (1) ES2082869T3 (en)
FI (1) FI115054B (en)
GR (1) GR3019618T3 (en)
HU (1) HU218272B (en)
IE (1) IE72196B1 (en)
IL (1) IL97148A (en)
MC (1) MC2226A1 (en)
NO (1) NO177055C (en)
NZ (1) NZ237170A (en)
PT (1) PT96887B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2035972C (en) * 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor
NL1004559C2 (en) * 1996-11-18 1998-05-19 Unilife Butter.
MXPA01006755A (en) * 1999-10-29 2003-05-15 Jason Gentry Mullins John Oxetanone derivatives.
US6342519B2 (en) * 1999-10-29 2002-01-29 2 Pro Chemical Oxetanone derivatives
US6348492B1 (en) * 1999-10-29 2002-02-19 2Pro Chemical Oxetanone derivatives
DE102004009076A1 (en) * 2004-02-23 2005-10-27 Solvay Pharmaceuticals Gmbh Alkylcarbamate-substituted β-lactones, processes and intermediates for their preparation, and medicaments containing these compounds
US7074822B2 (en) 2004-02-23 2006-07-11 Solvay Pharmaceuticals Gmbh Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
JP2011502167A (en) 2007-10-31 2011-01-20 バーンハム インスティテュート フォー メディカル リサーチ β-lactone compounds
JP7224331B2 (en) * 2017-07-12 2023-02-17 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ Compounds for reduction of lipotoxic damage

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608117B2 (en) * 1977-02-08 1985-02-28 財団法人微生物化学研究会 New physiologically active substance esterastin and its production method
GB2023604B (en) * 1978-05-25 1982-07-28 Microbial Chem Res Found Physiologically active derivatives of esterastin and production thereof
JPH0669130B2 (en) * 1984-08-09 1994-08-31 三菱電機株式会社 Delay line

Also Published As

Publication number Publication date
EP0444482A2 (en) 1991-09-04
ATE133167T1 (en) 1996-02-15
JP2753403B2 (en) 1998-05-20
EP0444482A3 (en) 1991-12-04
KR910021391A (en) 1991-12-20
AU7122891A (en) 1991-08-29
KR0183036B1 (en) 1999-05-01
IE910631A1 (en) 1991-08-28
GR3019618T3 (en) 1996-07-31
FI910925A (en) 1991-08-27
ES2082869T3 (en) 1996-04-01
HUT56557A (en) 1991-09-30
MC2226A1 (en) 1993-02-02
CA2035967C (en) 2001-10-16
IL97148A0 (en) 1992-05-25
FI910925A0 (en) 1991-02-26
NO910729L (en) 1991-08-27
JPH0770099A (en) 1995-03-14
IE72196B1 (en) 1997-03-26
FI115054B (en) 2005-02-28
PT96887B (en) 1998-09-30
PT96887A (en) 1991-10-31
HU218272B (en) 2000-07-28
NO910729D0 (en) 1991-02-25
NZ237170A (en) 1993-12-23
EP0444482B1 (en) 1996-01-17
DK0444482T3 (en) 1996-05-06
NO177055C (en) 1995-07-12
IL97148A (en) 1996-11-14
AU645291B2 (en) 1994-01-13
DE59107262D1 (en) 1996-02-29
NO177055B (en) 1995-04-03

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