CA2007200A1 - Derives de 2-aminopyrimidinone - Google Patents

Derives de 2-aminopyrimidinone

Info

Publication number: CA2007200A1
Authority: CA; Canada
Prior art keywords: piperidinyl; subjects suffering; treating subjects; aminopyrimidinone; disorders
Prior art date: 1989-01-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2007200A

Other languages

English (en)

Other versions

CA2007200C (fr

Inventor

Ludo E. J. Kennis

Jan Vandenberk

Jozef M. Boey

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-09

Filing date

1990-01-05

Publication date

1990-07-09

1990-01-05 Application filed by Individual filed Critical Individual

1990-07-09 Publication of CA2007200A1 publication Critical patent/CA2007200A1/fr

1999-07-20 Application granted granted Critical

1999-07-20 Publication of CA2007200C publication Critical patent/CA2007200C/fr

2010-01-05 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CA002007200A 1989-01-09 1990-01-05 Derives de 2-aminopyrimidinone Expired - Fee Related CA2007200C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB89.00.382.6		1989-01-09
GB898900382A GB8900382D0 (en)	1989-01-09	1989-01-09	2-aminopyrimidinone derivatives

Publications (2)

Publication Number	Publication Date
CA2007200A1 true CA2007200A1 (fr)	1990-07-09
CA2007200C CA2007200C (fr)	1999-07-20

Family

ID=10649779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002007200A Expired - Fee Related CA2007200C (fr)	1989-01-09	1990-01-05	Derives de 2-aminopyrimidinone

Country Status (25)

Country	Link
EP (1)	EP0378255B1 (fr)
JP (1)	JP2938492B2 (fr)
KR (1)	KR0159099B1 (fr)
CN (1)	CN1034865C (fr)
AT (1)	ATE104971T1 (fr)
AU (1)	AU617918B2 (fr)
CA (1)	CA2007200C (fr)
DE (1)	DE69008366T2 (fr)
DK (1)	DK0378255T3 (fr)
ES (1)	ES2055860T3 (fr)
FI (1)	FI94525C (fr)
GB (1)	GB8900382D0 (fr)
HU (1)	HU203747B (fr)
IE (1)	IE62874B1 (fr)
IL (1)	IL92730A (fr)
JO (1)	JO1605B1 (fr)
MA (1)	MA21722A1 (fr)
MY (1)	MY106259A (fr)
NO (1)	NO173139C (fr)
NZ (1)	NZ231788A (fr)
PT (1)	PT92806B (fr)
RU (1)	RU2028297C1 (fr)
TN (1)	TNSN90003A1 (fr)
ZA (1)	ZA90123B (fr)
ZW (1)	ZW290A1 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2058527T3 (es) *	1988-06-16	1994-11-01	Smith Kline French Lab	Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen.
GB9008850D0 (en) *	1990-04-19	1990-06-13	Janssen Pharmaceutica Nv	Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
US5075315A (en) *	1990-05-17	1991-12-24	Mcneilab, Inc.	Antipsychotic hexahydro-2H-indeno[1,2-c]pyridine derivatives
US5143923B1 (en) *	1991-04-29	1993-11-02	Hoechst-Roussel Pharmaceuticals Incorporated	Benzoisothiazole-and benzisoxazole-3-carboxamides
PT672043E (pt) *	1992-07-13	2001-11-30	Janssen Pharmaceutica Nv	Novos derivados de 4-(3-benzofuranil)piperidinilo e 4-(3-benzotienil)piperidinilo e composicoes farmaceuticas que os contem
WO1994018197A1 (fr) *	1993-02-04	1994-08-18	Meiji Seika Kabushiki Kaisha	Compose a effet neuroleptique
GB9305623D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
US5521196A (en) *	1994-10-05	1996-05-28	Eli Lilly And Company	5-HT1F agonists for the treatment of migraine
US5521197A (en) *	1994-12-01	1996-05-28	Eli Lilly And Company	3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
TW421649B (en) *	1995-01-31	2001-02-11	Janssen Pharmaceutica Nv	4-(1H-indol-1yl)-1-piperidinyl derivatives
NZ305166A (en) *	1995-03-20	1998-12-23	Lilly Co Eli	5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments
IL122072A (en)	1996-11-14	2001-03-19	Akzo Nobel Nv	Piperidine derivatives their preparation and pharmaceutical compositions containing them
ES2165274B1 (es) *	1999-06-04	2003-04-01	Almirall Prodesfarma Sa	Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
US6995144B2 (en)	2002-03-14	2006-02-07	Eisai Co., Ltd.	Nitrogen containing heterocyclic compounds and medicines containing the same
ES2201907B1 (es)	2002-05-29	2005-06-01	Almirall Prodesfarma, S.A.	Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
US20040242566A1 (en)	2003-03-25	2004-12-02	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
ZA200602051B (en) *	2003-08-13	2007-10-31	Takeda Pharmaceutical	4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
EP1911754B1 (fr) *	2003-08-13	2013-10-09	Takeda Pharmaceutical Company Limited	Inhibiteurs de peptidase dipeptidyl
EP1699777B1 (fr) *	2003-09-08	2012-12-12	Takeda Pharmaceutical Company Limited	Inhibiteurs de la dipeptidylpeptidase
UA85871C2 (uk)	2004-03-15	2009-03-10	Такеда Фармасьютікал Компані Лімітед	Інгібітори дипептидилпептидази
US7371769B2 (en)	2004-12-07	2008-05-13	Solvay Pharmaceuticals B.V.	Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
KR20070091009A (ko) *	2004-12-07	2007-09-06	솔베이 파마슈티칼스 비. 브이	도파민-ｄ2 수용체 및 세로토닌 재흡수 부위에 대한친화성이 조합된 테트라하이드로피리딘-4-일 인돌
US8101619B2 (en)	2004-12-08	2012-01-24	Solvay Pharmaceuticals B.V.	Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
JP2008524331A (ja)	2004-12-21	2008-07-10	武田薬品工業株式会社	ジペプチジルペプチダーゼ阻害剤
PE20070522A1 (es)	2005-09-14	2007-07-11	Takeda Pharmaceutical	2-[6-(3-amino-piperidin-1-il)-3-metil-2,4-dioxo-3,4-dihidro-2h-pirimidin-1-ilmetil]-4-fluoro-benzonitrilo como inhibidor de dipeptidil peptidasa y composiciones farmaceuticas que lo contienen
CA2622642C (fr)	2005-09-16	2013-12-31	Takeda Pharmaceutical Company Limited	Inhibiteurs de dipeptidylpeptidase
TW200813015A (en)	2006-03-15	2008-03-16	Mitsubishi Pharma Corp	2-(cyclic amino)-pyrimidone derivatives
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
PE20091236A1 (es) *	2007-11-22	2009-09-16	Astrazeneca Ab	Derivados de pirimidina como immunomoduladores de tlr7
BR102012024778A2 (pt) *	2012-09-28	2014-08-19	Cristalia Prod Quimicos Farm	Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica
WO2015064714A1 (fr) *	2013-10-31	2015-05-07	国立大学法人東京大学	Dérivé substitué en position 1 d'imidazopyrimidinone ayant une activité inhibitrice sur l'autotaxine
EP3448859B1 (fr)	2017-03-20	2019-07-10	Forma Therapeutics, Inc.	Compositions de pyrrolopyrrole en tant qu'activateurs de la pyruvate kinase (pkr)
CA3056501A1 (fr) *	2017-04-11	2018-10-18	Sunshine Lake Pharma Co., Ltd.	Composes indazole substitues par fluor et leurs utilisations
JP7450610B2 (ja)	2018-09-19	2024-03-15	ノヴォ・ノルディスク・ヘルス・ケア・アーゲー	ピルビン酸キナーゼｒの活性化
EP3853206B1 (fr)	2018-09-19	2024-04-10	Novo Nordisk Health Care AG	Traitement de la drépanocytose avec un composé activant la pyruvate kinase r
CN114615977B (zh)	2019-09-19	2025-01-14	诺沃挪第克健康护理股份公司	丙酮酸激酶r(pkr)活化组合物
US12128035B2 (en)	2021-03-19	2024-10-29	Novo Nordisk Health Care Ag	Activating pyruvate kinase R

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4443451A (en) *	1981-07-15	1984-04-17	Janssen Pharmaceutica N.V.	Bicyclic pyrimidin-5-one derivatives
US4485107A (en) *	1982-11-01	1984-11-27	Janssen Pharmaceutica N.V.	[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
FR2537764A1 (fr) *	1982-12-08	1984-06-15	Framatome Sa	Dispositif de commande de deux grappes de crayons de reglage deplacables verticalement dans un meme assemblage combustible du coeur d'un reacteur nucleaire
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB8900380D0 (en) *	1989-01-09	1989-03-08	Janssen Pharmaceutica Nv	2-aminopyrimidinone derivatives

1989
- 1989-01-09 GB GB898900382A patent/GB8900382D0/en active Pending
- 1989-12-14 NZ NZ231788A patent/NZ231788A/en unknown
- 1989-12-15 IL IL92730A patent/IL92730A/xx not_active IP Right Cessation
1990
- 1990-01-02 JO JO19901605A patent/JO1605B1/en active
- 1990-01-03 ES ES90200005T patent/ES2055860T3/es not_active Expired - Lifetime
- 1990-01-03 DE DE69008366T patent/DE69008366T2/de not_active Expired - Fee Related
- 1990-01-03 EP EP90200005A patent/EP0378255B1/fr not_active Expired - Lifetime
- 1990-01-03 DK DK90200005.8T patent/DK0378255T3/da active
- 1990-01-03 AT AT9090200005T patent/ATE104971T1/de not_active IP Right Cessation
- 1990-01-05 CA CA002007200A patent/CA2007200C/fr not_active Expired - Fee Related
- 1990-01-06 MY MYPI90000016A patent/MY106259A/en unknown
- 1990-01-08 NO NO900071A patent/NO173139C/no not_active IP Right Cessation
- 1990-01-08 FI FI900085A patent/FI94525C/fi not_active IP Right Cessation
- 1990-01-08 ZA ZA90123A patent/ZA90123B/xx unknown
- 1990-01-08 RU SU904742788A patent/RU2028297C1/ru not_active IP Right Cessation
- 1990-01-08 MA MA21982A patent/MA21722A1/fr unknown
- 1990-01-08 HU HU9064A patent/HU203747B/hu not_active IP Right Cessation
- 1990-01-08 AU AU47779/90A patent/AU617918B2/en not_active Ceased
- 1990-01-08 PT PT92806A patent/PT92806B/pt not_active IP Right Cessation
- 1990-01-08 IE IE6990A patent/IE62874B1/en not_active IP Right Cessation
- 1990-01-08 ZW ZW2/90A patent/ZW290A1/xx unknown
- 1990-01-09 TN TNTNSN90003A patent/TNSN90003A1/fr unknown
- 1990-01-09 KR KR1019900000188A patent/KR0159099B1/ko not_active Expired - Fee Related
- 1990-01-09 JP JP2002415A patent/JP2938492B2/ja not_active Expired - Fee Related
- 1990-01-09 CN CN90100075A patent/CN1034865C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2007200C (fr)	1999-07-20
NZ231788A (en)	1990-12-21
ZW290A1 (en)	1991-09-11
EP0378255A2 (fr)	1990-07-18
JPH02225482A (ja)	1990-09-07
HU203747B (en)	1991-09-30
MY106259A (en)	1995-04-29
PT92806B (pt)	1995-11-30
PT92806A (pt)	1990-07-31
IE62874B1 (en)	1995-03-08
IE900069L (en)	1990-07-09
FI900085A0 (fi)	1990-01-08
DK0378255T3 (da)	1994-05-24
GB8900382D0 (en)	1989-03-08
EP0378255A3 (fr)	1991-01-09
KR900011755A (ko)	1990-08-02
NO173139B (no)	1993-07-26
ATE104971T1 (de)	1994-05-15
TNSN90003A1 (fr)	1991-03-05
MA21722A1 (fr)	1990-10-01
DE69008366D1 (de)	1994-06-01
CN1044094A (zh)	1990-07-25
RU2028297C1 (ru)	1995-02-09
NO173139C (no)	1993-11-03
AU617918B2 (en)	1991-12-05
IL92730A (en)	1993-06-10
FI94525C (fi)	1995-09-25
JO1605B1 (en)	1990-07-01
ES2055860T3 (es)	1994-09-01
AU4777990A (en)	1990-07-12
CN1034865C (zh)	1997-05-14
EP0378255B1 (fr)	1994-04-27
ZA90123B (en)	1991-09-25
HU900064D0 (en)	1990-03-28
DE69008366T2 (de)	1994-08-25
KR0159099B1 (ko)	1998-12-01
NO900071D0 (no)	1990-01-08
JP2938492B2 (ja)	1999-08-23
IL92730A0 (en)	1990-09-17
FI900085L (fi)	1990-07-10
NO900071L (no)	1990-07-10
FI94525B (fi)	1995-06-15
HUT52770A (en)	1990-08-28

Publication	Publication Date	Title
CA2007200A1 (fr)	1990-07-09	Derives de 2-aminopyrimidinone
US5151423B1 (en)	1994-08-30	Heterocyclic n-oxide derivatives of substituted benzo(5,6)cycloheptapyridines, compositions and methods of use
IE851918L (en)	1986-02-01	An indole derivative.
AU6194694A (en)	1994-11-10	Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
CA2216796A1 (fr)	1996-10-03	Derives de quinazoline
BG103268A (en)	2000-12-29	Propionic acid derivatives and their application
AU658619B2 (en)	1995-04-27	Benzopyranones, methods of manufacture and use thereof
CA2201785A1 (fr)	1996-04-25	Nouveaux derives d'acide carboxylique, leur preparation et leur utilisation
CA2263561A1 (fr)	1998-02-19	Thienopyrimidines
HUT62290A (en)	1993-04-28	Process for producing imidazole derivatives substituted with aromatic group, as well as pharmaceutical compositions comprising same as active ingredient
UA48946C2 (uk)	2002-09-16	Арилалкілдіазинони, спосіб їх одержання (варіанти), фармацевтичний склад, спосіб його одержання та спосіб лікування
AU633754B2 (en)	1993-02-04	Composition for eye drops
CA2122911A1 (fr)	1993-05-27	Cycloalcenes et cycloalcanes substitues en 1,3, utilises comme agents du systeme nerveux central
CA2094702A1 (fr)	1992-05-06	Derives de substitution de tetrahydropyridines et d'hydroxypiperidines, agents therapeutiques pour le systeme nerveux central
WO1992007832A3 (fr)	1992-06-11	Piperazines substituees utilisees comme agents de traitement du systeme nerveux central
CA2138289A1 (fr)	1994-01-06	Derives azabicycloheptane substitues en n, leur preparation et leur utilisation
CA2041417A1 (fr)	1991-11-02	Traitement d'une maladie du pancreas a l'aide de composes de 15-ceto-prostaglandine
CA2046069A1 (fr)	1992-01-11	Traitement des maladies inflammatoires au moyen de composes de 15-cetoprostaglandine
HUT46508A (en)	1988-11-28	Insecticidal compositions comprising 6-member heterocyclic derivatives of n'-substituted-n,n'-diacylhydrazine and process for producing the active ingredients
AU5116590A (en)	1990-11-15	N-containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same
HUT54358A (en)	1991-02-28	Process for producing substituted 1,3,5-triazinetrione derivatives and medical compositions comprising such compounds as active ingredient
IL125002A0 (en)	1999-01-26	Novel substituted 4-(1H-benzimidazol-2-yl) [1,4] diazepanes useful for the treatment of allergic diseases
CA2195747A1 (fr)	1996-02-15	Nouveaux derives substitues en position 3 de 3h-2,3-benzodiazepine, leur preparation et leur utilisation comme medicaments
EP1121932A4 (fr)	2001-12-19	Medicaments pour maladies oculaires
AU5992990A (en)	1991-01-31	14,17alpha-etheno- and -ethanoestratrienes, processes for the preparation of these compounds, as well as their use for the production of medicinal agents

Legal Events

Date	Code	Title	Description
1996-12-30	EEER	Examination request
2008-01-07	MKLA	Lapsed