CA2004261A1 - Synthetic interleukin-6 - Google Patents
Synthetic interleukin-6Info
- Publication number
- CA2004261A1 CA2004261A1 CA002004261A CA2004261A CA2004261A1 CA 2004261 A1 CA2004261 A1 CA 2004261A1 CA 002004261 A CA002004261 A CA 002004261A CA 2004261 A CA2004261 A CA 2004261A CA 2004261 A1 CA2004261 A1 CA 2004261A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- protein
- recombinant
- gene
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27869088A | 1988-12-01 | 1988-12-01 | |
| US07/278,690 | 1988-12-01 | ||
| US44062489A | 1989-11-22 | 1989-11-22 | |
| US07/440,624 | 1989-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2004261A1 true CA2004261A1 (en) | 1990-06-01 |
Family
ID=26959230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002004261A Abandoned CA2004261A1 (en) | 1988-12-01 | 1989-11-30 | Synthetic interleukin-6 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0446283A4 (pt) |
| JP (1) | JPH04503301A (pt) |
| AU (1) | AU639428B2 (pt) |
| CA (1) | CA2004261A1 (pt) |
| GR (1) | GR890100799A (pt) |
| IL (1) | IL92525A0 (pt) |
| PT (1) | PT92479A (pt) |
| WO (1) | WO1990006370A1 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ236819A (en) * | 1990-02-03 | 1993-07-27 | Max Planck Gesellschaft | Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions |
| JPH04218000A (ja) * | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| US5210075A (en) * | 1990-02-16 | 1993-05-11 | Tanabe Seiyaku Co., Ltd. | Interleukin 6 antagonist peptides |
| ZA924674B (en) * | 1991-07-02 | 1993-04-28 | Imclone Systems Inc | Cysteine depleted il-6 mutein |
| IL99803A (en) * | 1991-10-20 | 1997-02-18 | Yeda Res & Dev | Pharmaceutical compositions comprising interleukin-6 for the treatment of chronic lymphocytic leukemia and B-cell lymphomas |
| US5338833A (en) * | 1992-07-23 | 1994-08-16 | The University Of North Carolina At Chapel Hill | Carboxy terminal IL-6 muteins |
| WO1994003492A1 (en) * | 1992-08-06 | 1994-02-17 | The University Of Melbourne | Interleukin-6 variants and uses therefor |
| US5338834A (en) * | 1993-01-26 | 1994-08-16 | Allelix Biopharmaceuticals Inc. | Ultrapure human interleukin-6 |
| DK0814154T3 (da) | 1993-09-15 | 2009-08-31 | Novartis Vaccines & Diagnostic | Rekombinante alfavirusvektorer |
| JPH093099A (ja) * | 1995-06-20 | 1997-01-07 | Toyobo Co Ltd | マクロファージ刺激蛋白質改変体およびその製造法 |
| AU2800797A (en) | 1996-04-05 | 1997-10-29 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
| WO1998012332A1 (en) | 1996-09-17 | 1998-03-26 | Chiron Corporation | Compositions and methods for treating intracellular diseases |
| US6265204B1 (en) | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
| US6602705B1 (en) | 1998-12-31 | 2003-08-05 | Chiron Corporation | Expression of HIV polypeptides and production of virus-like particles |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| WO2003004657A1 (en) | 2001-07-05 | 2003-01-16 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b and/or type c polypeptides, polypeptides and uses thereof |
| US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
| WO2003093417A2 (en) | 2002-05-01 | 2003-11-13 | Cell Genesys, Inc. | Lentiviral vector particles resistant to complement inactivation |
| US20100015211A1 (en) | 2004-11-01 | 2010-01-21 | Barnett Susan W | Combination Approaches For Generating Immune Responses |
| KR100692389B1 (ko) * | 2005-04-21 | 2007-03-09 | 주식회사수산중공업 | 차압스위치 |
| US20100196336A1 (en) | 2006-05-23 | 2010-08-05 | Dongsu Park | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
| EP3608401A1 (en) | 2012-07-05 | 2020-02-12 | Ohio State Innovation Foundation | Compositions and methods related to viral vaccines |
| EP3344290A4 (en) | 2015-08-31 | 2019-02-27 | Technovax, Inc. | VACCINE BASED ON VIRUS-LIKE PARTICLES OF HUMAN RESPIRATORY SYNZYTIAL VIRUS (HRSV) |
| MX2018012376A (es) | 2016-04-13 | 2019-08-01 | Synthetic Genomics Inc | Sistemas de replicón de arterivirus recombinantes y usos de estos. |
| US11364310B2 (en) | 2016-10-17 | 2022-06-21 | Janssen Pharmaceuticals, Inc. | Recombinant virus replicon systems and uses thereof |
| JP2020500536A (ja) | 2016-12-05 | 2020-01-16 | シンセティック ジェノミクス インコーポレーテッド | 遺伝子発現増強のための組成物および方法 |
| US11389531B2 (en) | 2017-12-19 | 2022-07-19 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines |
| EA202091516A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv) |
| US11021692B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Hepatitis B virus (HBV) vaccines and uses thereof |
| US11083786B2 (en) | 2018-01-19 | 2021-08-10 | Janssen Pharmaceuticals, Inc. | Induce and enhance immune responses using recombinant replicon systems |
| CN114805537A (zh) * | 2022-04-26 | 2022-07-29 | 华南农业大学 | 一种表达犬白介素6的重组质粒、稳定表达犬白介素6蛋白的细胞株及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62102157A (ja) * | 1985-10-30 | 1987-05-12 | Chuzo Kishimoto | 抗体 |
| DE3750106T3 (de) * | 1986-08-06 | 1999-04-22 | Ajinomoto Co., Inc., Tokio/Tokyo | Rekombinanter B-Zell-Differenzierungsfaktor. |
| IL85204A0 (en) * | 1988-01-26 | 1988-07-31 | Yeda Res & Dev | Recombinant human interferon beta2,its preparation and pharmaceutical compositions comprising it |
| CA1341588C (en) * | 1988-01-26 | 2009-01-06 | Michel Revel | Human ifn-beta2/i1-6, its purification and use |
| JPH04218000A (ja) * | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
-
1989
- 1989-11-30 PT PT92479A patent/PT92479A/pt not_active Application Discontinuation
- 1989-11-30 AU AU48014/90A patent/AU639428B2/en not_active Ceased
- 1989-11-30 JP JP2501355A patent/JPH04503301A/ja active Pending
- 1989-11-30 CA CA002004261A patent/CA2004261A1/en not_active Abandoned
- 1989-11-30 WO PCT/US1989/005421 patent/WO1990006370A1/en not_active Application Discontinuation
- 1989-11-30 EP EP19900900700 patent/EP0446283A4/en not_active Withdrawn
- 1989-12-01 GR GR890100799A patent/GR890100799A/el unknown
- 1989-12-01 IL IL92525A patent/IL92525A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990006370A1 (en) | 1990-06-14 |
| EP0446283A1 (en) | 1991-09-18 |
| GR890100799A (el) | 1991-03-15 |
| JPH04503301A (ja) | 1992-06-18 |
| IL92525A0 (en) | 1990-08-31 |
| EP0446283A4 (en) | 1992-01-08 |
| PT92479A (pt) | 1990-06-29 |
| AU4801490A (en) | 1990-06-26 |
| AU639428B2 (en) | 1993-07-29 |
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Effective date: 19950531 |