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CA1341503C - Clonage moleculaire et expression d'interleukine-3 humaine - Google Patents

Clonage moleculaire et expression d'interleukine-3 humaine Download PDF

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Publication number
CA1341503C
CA1341503C CA000554561A CA554561A CA1341503C CA 1341503 C CA1341503 C CA 1341503C CA 000554561 A CA000554561 A CA 000554561A CA 554561 A CA554561 A CA 554561A CA 1341503 C CA1341503 C CA 1341503C
Authority
CA
Canada
Prior art keywords
leu
asn
thr
ala
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000554561A
Other languages
English (en)
Inventor
Lambertus Christiaan Johannes Dorssers
Gerard Wagemaker
Yvonne Johanna Vos
Robert Willem Van Leen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of CA1341503C publication Critical patent/CA1341503C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA000554561A 1986-12-16 1997-12-16 Clonage moleculaire et expression d'interleukine-3 humaine Expired - Fee Related CA1341503C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP86202285.2 1986-12-16
EP86202285 1986-12-16
EP87201322 1987-07-13
EP87201322.2 1987-07-13

Publications (1)

Publication Number Publication Date
CA1341503C true CA1341503C (fr) 2006-04-04

Family

ID=26103432

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000554561A Expired - Fee Related CA1341503C (fr) 1986-12-16 1997-12-16 Clonage moleculaire et expression d'interleukine-3 humaine

Country Status (14)

Country Link
JP (2) JPH01502157A (fr)
AT (1) ATE161882T1 (fr)
AU (1) AU617095B2 (fr)
CA (1) CA1341503C (fr)
DE (1) DE3752158T2 (fr)
ES (1) ES2113338T3 (fr)
FI (1) FI102293B1 (fr)
GR (1) GR3025857T3 (fr)
IE (1) IE81129B1 (fr)
IL (1) IL84852A (fr)
NO (1) NO180544C (fr)
NZ (1) NZ222939A (fr)
PT (1) PT86381B (fr)
WO (1) WO1988004691A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US6238889B1 (en) 1986-12-16 2001-05-29 Dsm N.V. Molecular cloning and expression of the Pro8 isoform of human IL-3
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
US5304637A (en) * 1987-07-13 1994-04-19 Gist-Brocades N.V. Expression and purification of human interleukin-3 and muteins thereof
GB2210883B (en) * 1987-10-08 1992-01-02 British Bio Technology Synthetic interleukin-3 gene
US6384194B1 (en) 1987-12-16 2002-05-07 Dsm N.V. Expression and purification of human interleukin-3 and muteins thereof
AU3864089A (en) * 1988-07-20 1990-02-19 Immunex Corporation Nonglycosylated human interleukin-3 compositions
NZ232913A (en) * 1989-03-15 1992-08-26 Gist Brocades Nv Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations
US5128450A (en) * 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
DK0413383T3 (da) 1989-08-14 1997-07-07 Gist Brocades Nv Mutanter af humant interleukin-3.
US5516512A (en) 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
DK0596881T3 (da) * 1991-08-01 1997-10-13 Fond Nat Transfusion Sanguine Ekspression i ikke-tumurale humane lymofoblastoider med en integrativ vektor
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
ATE251669T1 (de) * 1992-11-24 2003-10-15 Searle & Co Mutierte polypeptide des interleukin-3(il-3)
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
WO1999041382A2 (fr) * 1998-02-17 1999-08-19 Hyseq, Inc. Nouvelle interleukine 3 et ses utilisations
WO2006079169A1 (fr) * 2005-01-25 2006-08-03 Apollo Life Sciences Limited Gm-csf, il-3, il-4, il-5 choisis en fonction de parametres et leurs chimeres dans des applications therapeutiques et diagnostiques
JP2009532061A (ja) * 2006-04-03 2009-09-10 ニユー・イングランド・バイオレイブス・インコーポレイテツド 組換えウシ血清アルブミン（ｒＢＳＡ）の発現、分泌及び精製、並びにその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695542A (en) * 1983-10-04 1987-09-22 Dnax Research Institute Of Molecular And Cellular Biology, Inc. cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
AU570762B2 (en) * 1983-12-23 1988-03-24 Australian National University, The Cloning of cdna for il-3
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors

Also Published As

Publication number Publication date
ATE161882T1 (de) 1998-01-15
IL84852A0 (en) 1988-06-30
GR3025857T3 (en) 1998-04-30
NO180544C (no) 1997-05-07
AU617095B2 (en) 1991-11-21
DE3752158T2 (de) 1998-05-20
FI102293B (fi) 1998-11-13
ES2113338T3 (es) 1998-05-01
FI883688A0 (fi) 1988-08-08
NO180544B (no) 1997-01-27
FI102293B1 (fi) 1998-11-13
NO883614D0 (no) 1988-08-12
PT86381B (pt) 1990-11-20
NO883614L (no) 1988-08-12
WO1988004691A1 (fr) 1988-06-30
NZ222939A (en) 1991-03-26
AU1057788A (en) 1988-07-15
JPH1080286A (ja) 1998-03-31
IE81129B1 (en) 2000-03-22
PT86381A (en) 1988-01-01
DE3752158D1 (de) 1998-02-12
JPH01502157A (ja) 1989-08-03
FI883688A (fi) 1988-08-08
IE873409L (en) 1988-06-12
IL84852A (en) 1994-06-24

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MKLA Lapsed
MKLA Lapsed

Effective date: 20090406