FI102293B1 - Ihmisen interleukiini-3:n molekulaarinen kloonaus ja ilmentäminen - Google Patents

Ihmisen interleukiini-3:n molekulaarinen kloonaus ja ilmentäminen

Info

Publication number: FI102293B1
Authority: FI; Finland
Prior art keywords: human interleukin; hil; expression; molecular cloning; produced
Prior art date: 1986-12-16

Application number

FI883688A

Other languages

English (en)

Swedish (sv)

Other versions

FI102293B (fi

FI883688A0 (fi

FI883688A (fi

Inventor

Lambertus Christiaan Dorssers

Gerard Wagemaker

Yvonne Johanna Vos

Leen Robert Willem Van

Original Assignee

Gist Brocades Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-16

Filing date

1988-08-08

Publication date

1998-11-13

1988-08-08 Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv

1988-08-08 Publication of FI883688A0 publication Critical patent/FI883688A0/fi

1988-08-08 Publication of FI883688A publication Critical patent/FI883688A/fi

1998-11-13 Application granted granted Critical

1998-11-13 Publication of FI102293B publication Critical patent/FI102293B/fi

1998-11-13 Publication of FI102293B1 publication Critical patent/FI102293B1/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI883688A 1986-12-16 1988-08-08 Ihmisen interleukiini-3:n molekulaarinen kloonaus ja ilmentäminen FI102293B1 (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
EP86202285		1986-12-16
EP86202285		1986-12-16
NL8700037		1987-01-09
EP87201322		1987-07-13
EP87201322		1987-07-13
PCT/NL1987/000037 WO1988004691A1 (en)	1986-12-16	1987-12-16	Molecular cloning and expression of human il-3

Publications (4)

Publication Number	Publication Date
FI883688A0 FI883688A0 (fi)	1988-08-08
FI883688A FI883688A (fi)	1988-08-08
FI102293B FI102293B (fi)	1998-11-13
FI102293B1 true FI102293B1 (fi)	1998-11-13

Family

ID=26103432

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI883688A FI102293B1 (fi)	1986-12-16	1988-08-08	Ihmisen interleukiini-3:n molekulaarinen kloonaus ja ilmentäminen

Country Status (14)

Country	Link
JP (2)	JPH01502157A (fi)
AT (1)	ATE161882T1 (fi)
AU (1)	AU617095B2 (fi)
CA (1)	CA1341503C (fi)
DE (1)	DE3752158T2 (fi)
ES (1)	ES2113338T3 (fi)
FI (1)	FI102293B1 (fi)
GR (1)	GR3025857T3 (fi)
IE (1)	IE81129B1 (fi)
IL (1)	IL84852A (fi)
NO (1)	NO180544C (fi)
NZ (1)	NZ222939A (fi)
PT (1)	PT86381B (fi)
WO (1)	WO1988004691A1 (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR871029B (en) *	1986-07-14	1987-11-02	Genetics Inst	Novel osteoinductive factors
US6238889B1 (en)	1986-12-16	2001-05-29	Dsm N.V.	Molecular cloning and expression of the Pro8 isoform of human IL-3
OA09736A (en) *	1987-02-18	1993-11-30	Schering Biotech Corp	"Human interleukin-3 and muteins thereof".
US5304637A (en) *	1987-07-13	1994-04-19	Gist-Brocades N.V.	Expression and purification of human interleukin-3 and muteins thereof
GB2210883B (en) *	1987-10-08	1992-01-02	British Bio Technology	Synthetic interleukin-3 gene
US6384194B1 (en)	1987-12-16	2002-05-07	Dsm N.V.	Expression and purification of human interleukin-3 and muteins thereof
AU3864089A (en) *	1988-07-20	1990-02-19	Immunex Corporation	Nonglycosylated human interleukin-3 compositions
NZ232913A (en) *	1989-03-15	1992-08-26	Gist Brocades Nv	Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations
US5128450A (en) *	1989-06-30	1992-07-07	Urdal David L	Nonglycosylated human interleukin-3 analog proteins
DK0413383T3 (da)	1989-08-14	1997-07-07	Gist Brocades Nv	Mutanter af humant interleukin-3.
US5516512A (en)	1989-08-14	1996-05-14	Gist-Brocades, N.V.	N- and C-terminal truncation and deletion mutants of human interleukin-3
DK0596881T3 (da) *	1991-08-01	1997-10-13	Fond Nat Transfusion Sanguine	Ekspression i ikke-tumurale humane lymofoblastoider med en integrativ vektor
US5738849A (en) *	1992-11-24	1998-04-14	G. D. Searle & Co.	Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
ATE251669T1 (de) *	1992-11-24	2003-10-15	Searle & Co	Mutierte polypeptide des interleukin-3(il-3)
US5501962A (en) *	1993-06-21	1996-03-26	G. D. Searle & Co.	Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US6017523A (en) *	1995-06-06	2000-01-25	G.D. Searle & Co.	Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
WO1999041382A2 (en) *	1998-02-17	1999-08-19	Hyseq, Inc.	A novel interleukin-3 and uses thereof
WO2006079169A1 (en) *	2005-01-25	2006-08-03	Apollo Life Sciences Limited	Parameter selected gm-csf, il-3, il-4, il-5 and chimeras thereof for therapeutic and diagnostic purposes
JP2009532061A (ja) *	2006-04-03	2009-09-10	ニユー・イングランド・バイオレイブス・インコーポレイテツド	組換えウシ血清アルブミン（ｒＢＳＡ）の発現、分泌及び精製、並びにその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4695542A (en) *	1983-10-04	1987-09-22	Dnax Research Institute Of Molecular And Cellular Biology, Inc.	cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
AU570762B2 (en) *	1983-12-23	1988-03-24	Australian National University, The	Cloning of cdna for il-3
GR871029B (en) *	1986-07-14	1987-11-02	Genetics Inst	Novel osteoinductive factors

1987
- 1987-12-16 IL IL8485287A patent/IL84852A/en not_active IP Right Cessation
- 1987-12-16 PT PT86381A patent/PT86381B/pt not_active IP Right Cessation
- 1987-12-16 WO PCT/NL1987/000037 patent/WO1988004691A1/en active IP Right Grant
- 1987-12-16 JP JP63500606A patent/JPH01502157A/ja active Pending
- 1987-12-16 DE DE3752158T patent/DE3752158T2/de not_active Expired - Fee Related
- 1987-12-16 ES ES87202566T patent/ES2113338T3/es not_active Expired - Lifetime
- 1987-12-16 AU AU10577/88A patent/AU617095B2/en not_active Ceased
- 1987-12-16 IE IE340987A patent/IE81129B1/en not_active IP Right Cessation
- 1987-12-16 AT AT87202566T patent/ATE161882T1/de not_active IP Right Cessation
- 1987-12-16 NZ NZ222939A patent/NZ222939A/en unknown
1988
- 1988-08-08 FI FI883688A patent/FI102293B1/fi not_active IP Right Cessation
- 1988-08-12 NO NO883614A patent/NO180544C/no not_active IP Right Cessation
1997
- 1997-05-28 JP JP9154513A patent/JPH1080286A/ja active Pending
- 1997-12-16 CA CA000554561A patent/CA1341503C/en not_active Expired - Fee Related
1998
- 1998-01-08 GR GR980400027T patent/GR3025857T3/el unknown

Also Published As

Publication number	Publication date
ATE161882T1 (de)	1998-01-15
IL84852A0 (en)	1988-06-30
GR3025857T3 (en)	1998-04-30
NO180544C (no)	1997-05-07
AU617095B2 (en)	1991-11-21
DE3752158T2 (de)	1998-05-20
FI102293B (fi)	1998-11-13
ES2113338T3 (es)	1998-05-01
FI883688A0 (fi)	1988-08-08
CA1341503C (en)	2006-04-04
NO180544B (no)	1997-01-27
NO883614D0 (no)	1988-08-12
PT86381B (pt)	1990-11-20
NO883614L (no)	1988-08-12
WO1988004691A1 (en)	1988-06-30
NZ222939A (en)	1991-03-26
AU1057788A (en)	1988-07-15
JPH1080286A (ja)	1998-03-31
IE81129B1 (en)	2000-03-22
PT86381A (en)	1988-01-01
DE3752158D1 (de)	1998-02-12
JPH01502157A (ja)	1989-08-03
FI883688A (fi)	1988-08-08
IE873409L (en)	1988-06-12
IL84852A (en)	1994-06-24

Publication	Publication Date	Title
FI102293B1 (fi)	1998-11-13	Ihmisen interleukiini-3:n molekulaarinen kloonaus ja ilmentäminen
BG60253B1 (bg)	1994-03-24	Човешки тъканен плазминогенен активатор
ATE152172T1 (de)	1997-05-15	Herstellung eines rekombinanten menschlichen interleukin-1-hemmers
ATE66614T1 (de)	1991-09-15	Insulinzubereitung fuer nicht-parenterale verabreichung.
DK193887A (da)	1987-10-18	Peptid med bronchodilartorisk og hypotensiv aktivitet
MY102806A (en)	1992-11-30	Human interleukin-3 and muteins thereof
NZ230155A (en)	1991-08-27	N-2,3-butadienyl-n"-substituted-triamindalkanes and alkenes, and pharmaceutical compositions
IT8521468A0 (it)	1985-07-08	Procedimento per ottenere interferon leucocitario alfa-2dell'uomo.
FR2610633B1 (fr)	1992-09-18	Procede d'obtention d'un concentre d'a 1-antitrypsine a partir de plasma humain et son utilisation a titre de medicament
ATE164882T1 (de)	1998-04-15	Verfahren zur herstellung von aktivierten killer- monozyten und verfahren zur überprüfung ihrer tumoriziden aktivität
DE59704194D1 (de)	2001-09-06	Verwendung von multipotenten paramunitätsinducern aus attenuierten, nicht-immunogenen pockenviren oder parapockenviren zur herstellung von arzneimitteln
DK708488D0 (da)	1988-12-20	Faktor i praeparat
DK0609242T3 (da)	1997-01-06	Nyt thrombininhibitorisk protein fra blodmider
BG44874A3 (bg)	1989-02-15	Метод за получаване на кондензирани аs-триазини
BG44873A3 (bg)	1989-02-15	Метод за получаване на кондензирани аs-триазини
JPS52148487A (en)	1977-12-09	Filter membrane of hollow fiber
IT1216188B (it)	1990-02-22	Strumento indicatore del grado di abbronzatura dell'epidermide.
DK563886A (da)	1987-05-27	Terapeutisk komposition
UA19417A (uk)	1997-12-25	Спосіб діагhостики кліhічhих варіаhтів циркулярhої депресії
ATE99692T1 (de)	1994-01-15	Optisch aktive rhodiumkomplexe von 3,4bis(diarylphosphino)-pyrrolidinen und ihre verwendung zur herstellung von phosphinothricin durch asymmetrische hydrierung.
IT8659810V0 (it)	1986-05-28	Posata da tovala a denti sfaltati per facilitare la raccolta e l'arrotolamento di pasta lunga (spaghetti, bucatini, tagliatelle, ecc.).
BE888324A (fr)	1981-07-31	Medicament pour favoriser la guerison du diabete.

Legal Events

Date	Code	Title	Description
1998-12-30	PC	Transfer of assignment of patent	Owner name: DSM N.V.
2004-08-31	MM	Patent lapsed	Owner name: DSM N.V.