CA1276084C - Composition and method for improving the efficiency of ruminant feed utilization - Google Patents

Composition and method for improving the efficiency of ruminant feed utilization

Info

Publication number: CA1276084C
Authority: CA; Canada
Prior art keywords: rumen; composition; feedstuff; strains; cultures
Prior art date: 1984-08-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA000488801A

Other languages

English (en)

French (fr)

Inventor

Istvan Ott

Janos Dohy

Sandor Szentmihalyi

Tibor Lang

Janos Seregi

Imre Moravcsik

Gyorgy B. Kiss

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ATK TAKARMANYOZASI KUTATOINTEZET

Teva Hungary Pharmaceutical Marketing PLC

Richter Gedeon Vegyeszeti Gyar Nyrt

Original Assignee

ATK TAKARMANYOZASI KUTATOINTEZET

Institute for Drugs Research Ltd

Richter Gedeon Vegyeszeti Gyar RT

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-15

Filing date

1985-08-15

Publication date

1990-11-13

1985-08-15 Application filed by ATK TAKARMANYOZASI KUTATOINTEZET, Institute for Drugs Research Ltd, Richter Gedeon Vegyeszeti Gyar RT filed Critical ATK TAKARMANYOZASI KUTATOINTEZET

1990-11-13 Application granted granted Critical

1990-11-13 Publication of CA1276084C publication Critical patent/CA1276084C/en

2007-11-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 48
238000000034 method Methods 0.000 title claims abstract description 32
241000282849 Ruminantia Species 0.000 title claims abstract description 25
210000004767 rumen Anatomy 0.000 claims abstract description 107
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 51
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims abstract description 34
241001465754 Metazoa Species 0.000 claims abstract description 32
230000008569 process Effects 0.000 claims abstract description 28
238000002360 preparation method Methods 0.000 claims abstract description 20
238000009629 microbiological culture Methods 0.000 claims abstract description 17
235000019260 propionic acid Nutrition 0.000 claims abstract description 17
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims abstract description 17
239000004480 active ingredient Substances 0.000 claims abstract description 8
230000002085 persistent effect Effects 0.000 claims abstract description 8
239000000126 substance Substances 0.000 claims abstract description 7
239000000969 carrier Substances 0.000 claims abstract description 6
239000003085 diluting agent Substances 0.000 claims abstract description 5
230000000050 nutritive effect Effects 0.000 claims abstract description 5
239000003755 preservative agent Substances 0.000 claims abstract description 4
241000894006 Bacteria Species 0.000 claims description 35
244000005700 microbiome Species 0.000 claims description 33
239000001913 cellulose Substances 0.000 claims description 18
229920002678 cellulose Polymers 0.000 claims description 18
235000013379 molasses Nutrition 0.000 claims description 12
230000003115 biocidal effect Effects 0.000 claims description 11
230000002068 genetic effect Effects 0.000 claims description 11
239000000725 suspension Substances 0.000 claims description 6
239000003550 marker Substances 0.000 claims description 5
235000016709 nutrition Nutrition 0.000 claims description 5
230000035764 nutrition Effects 0.000 claims description 5
229920002472 Starch Polymers 0.000 claims description 4
238000000338 in vitro Methods 0.000 claims description 4
230000004060 metabolic process Effects 0.000 claims description 4
239000008107 starch Substances 0.000 claims description 4
235000019698 starch Nutrition 0.000 claims description 4
238000001727 in vivo Methods 0.000 claims description 2
238000012360 testing method Methods 0.000 claims description 2
150000002016 disaccharides Chemical class 0.000 claims 1
238000009472 formulation Methods 0.000 claims 1
150000002772 monosaccharides Chemical class 0.000 claims 1
229940095574 propionic acid Drugs 0.000 abstract description 14
210000004027 cell Anatomy 0.000 description 33
241001494479 Pecora Species 0.000 description 29
229960001192 bekanamycin Drugs 0.000 description 20
229930182824 kanamycin B Natural products 0.000 description 20
SKKLOUVUUNMCJE-FQSMHNGLSA-N kanamycin B Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SKKLOUVUUNMCJE-FQSMHNGLSA-N 0.000 description 20
235000012054 meals Nutrition 0.000 description 20
239000000243 solution Substances 0.000 description 19
235000013339 cereals Nutrition 0.000 description 16
235000011054 acetic acid Nutrition 0.000 description 13
229960000583 acetic acid Drugs 0.000 description 13
230000001580 bacterial effect Effects 0.000 description 13
238000004519 manufacturing process Methods 0.000 description 13
235000014113 dietary fatty acids Nutrition 0.000 description 12
229930195729 fatty acid Natural products 0.000 description 12
239000000194 fatty acid Substances 0.000 description 12
150000004665 fatty acids Chemical class 0.000 description 12
230000012010 growth Effects 0.000 description 12
239000007787 solid Substances 0.000 description 11
239000013612 plasmid Substances 0.000 description 9
108090000623 proteins and genes Proteins 0.000 description 9
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 8
229910052799 carbon Inorganic materials 0.000 description 8
229930027917 kanamycin Natural products 0.000 description 8
229960000318 kanamycin Drugs 0.000 description 8
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 8
229930182823 kanamycin A Natural products 0.000 description 8
239000007788 liquid Substances 0.000 description 8
241000283690 Bos taurus Species 0.000 description 7
150000003839 salts Chemical class 0.000 description 7
108020004414 DNA Proteins 0.000 description 6
206010016717 Fistula Diseases 0.000 description 6
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
239000002253 acid Substances 0.000 description 6
239000003242 anti bacterial agent Substances 0.000 description 6
239000000872 buffer Substances 0.000 description 6
230000003890 fistula Effects 0.000 description 6
239000008103 glucose Substances 0.000 description 6
230000000813 microbial effect Effects 0.000 description 6
230000037396 body weight Effects 0.000 description 5
238000005119 centrifugation Methods 0.000 description 5
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 5
238000011161 development Methods 0.000 description 5
239000012266 salt solution Substances 0.000 description 5
230000001954 sterilising effect Effects 0.000 description 5
238000004659 sterilization and disinfection Methods 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
229920001817 Agar Polymers 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical class CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 4
241000357437 Mola Species 0.000 description 4
239000000654 additive Substances 0.000 description 4
239000008272 agar Substances 0.000 description 4
229940088710 antibiotic agent Drugs 0.000 description 4
235000013365 dairy product Nutrition 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
238000000855 fermentation Methods 0.000 description 4
235000013336 milk Nutrition 0.000 description 4
239000008267 milk Substances 0.000 description 4
210000004080 milk Anatomy 0.000 description 4
230000002269 spontaneous effect Effects 0.000 description 4
229910001868 water Inorganic materials 0.000 description 4
241000588724 Escherichia coli Species 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
-1 HCl monohydrate Chemical class 0.000 description 3
PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
240000008042 Zea mays Species 0.000 description 3
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
235000002017 Zea mays subsp mays Nutrition 0.000 description 3
229940041514 candida albicans extract Drugs 0.000 description 3
229910002092 carbon dioxide Inorganic materials 0.000 description 3
230000008859 change Effects 0.000 description 3
229960005091 chloramphenicol Drugs 0.000 description 3
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 3
235000005822 corn Nutrition 0.000 description 3
230000029087 digestion Effects 0.000 description 3
239000012153 distilled water Substances 0.000 description 3
230000004151 fermentation Effects 0.000 description 3
238000001914 filtration Methods 0.000 description 3
230000002401 inhibitory effect Effects 0.000 description 3
238000002372 labelling Methods 0.000 description 3
235000013372 meat Nutrition 0.000 description 3
238000002156 mixing Methods 0.000 description 3
230000002688 persistence Effects 0.000 description 3
235000018102 proteins Nutrition 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
238000000926 separation method Methods 0.000 description 3
239000011734 sodium Substances 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 3
235000019345 sodium thiosulphate Nutrition 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
230000009466 transformation Effects 0.000 description 3
239000012138 yeast extract Substances 0.000 description 3
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
241000283707 Capra Species 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 2
229930191564 Monensin Natural products 0.000 description 2
GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 2
241000589180 Rhizobium Species 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
235000015278 beef Nutrition 0.000 description 2
210000000349 chromosome Anatomy 0.000 description 2
238000012258 culturing Methods 0.000 description 2
235000021051 daily weight gain Nutrition 0.000 description 2
230000034994 death Effects 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
230000037213 diet Effects 0.000 description 2
239000003651 drinking water Substances 0.000 description 2
235000020188 drinking water Nutrition 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
239000012530 fluid Substances 0.000 description 2
KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 2
238000002955 isolation Methods 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
239000002609 medium Substances 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
229960005358 monensin Drugs 0.000 description 2
GAOZTHIDHYLHMS-KEOBGNEYSA-N monensin A Chemical compound C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O2 GAOZTHIDHYLHMS-KEOBGNEYSA-N 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
229960005419 nitrogen Drugs 0.000 description 2
239000002245 particle Substances 0.000 description 2
238000009304 pastoral farming Methods 0.000 description 2
230000035479 physiological effects, processes and functions Effects 0.000 description 2
230000035935 pregnancy Effects 0.000 description 2
230000006798 recombination Effects 0.000 description 2
230000010076 replication Effects 0.000 description 2
230000001932 seasonal effect Effects 0.000 description 2
229910000029 sodium carbonate Inorganic materials 0.000 description 2
239000011573 trace mineral Substances 0.000 description 2
235000013619 trace mineral Nutrition 0.000 description 2
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
229940005605 valeric acid Drugs 0.000 description 2
235000019786 weight gain Nutrition 0.000 description 2
230000004584 weight gain Effects 0.000 description 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
239000004184 Avoparcin Substances 0.000 description 1
241000606125 Bacteroides Species 0.000 description 1
OWNRRUFOJXFKCU-UHFFFAOYSA-N Bromadiolone Chemical compound C=1C=C(C=2C=CC(Br)=CC=2)C=CC=1C(O)CC(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=CC=C1 OWNRRUFOJXFKCU-UHFFFAOYSA-N 0.000 description 1
244000025254 Cannabis sativa Species 0.000 description 1
241000283705 Capra hircus Species 0.000 description 1
241000282994 Cervidae Species 0.000 description 1
102000053602 DNA Human genes 0.000 description 1
241000283014 Dama Species 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
230000005526 G1 to G0 transition Effects 0.000 description 1
108010015899 Glycopeptides Proteins 0.000 description 1
102000002068 Glycopeptides Human genes 0.000 description 1
241000257303 Hymenoptera Species 0.000 description 1
229930182504 Lasalocid Natural products 0.000 description 1
101100536883 Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) thi5 gene Proteins 0.000 description 1
240000004658 Medicago sativa Species 0.000 description 1
235000010624 Medicago sativa Nutrition 0.000 description 1
229920000562 Poly(ethylene adipate) Polymers 0.000 description 1
108020005091 Replication Origin Proteins 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
239000004189 Salinomycin Substances 0.000 description 1
KQXDHUJYNAXLNZ-XQSDOZFQSA-N Salinomycin Chemical compound O1[C@@H]([C@@H](CC)C(O)=O)CC[C@H](C)[C@@H]1[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(C=C[C@@H](O)[C@@]3(O[C@@](C)(CC3)[C@@H]3O[C@@H](C)[C@@](O)(CC)CC3)O2)O1 KQXDHUJYNAXLNZ-XQSDOZFQSA-N 0.000 description 1
101100240664 Schizosaccharomyces pombe (strain 972 / ATCC 24843) nmt1 gene Proteins 0.000 description 1
241000605036 Selenomonas Species 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
235000019742 Vitamins premix Nutrition 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
108010020588 actaplanin Proteins 0.000 description 1
BDNDRNLSLGGULA-UHFFFAOYSA-N actaplanin Chemical compound C=1C2=CC=C(O)C=1C1=C(OC3C(C(O)C(O)C(CO)O3)O)C=C(O)C=C1C(C(=O)OC)NC(=O)C1NC(=O)C2NC(=O)C2NC(=O)C(C=3C=C(C(=C(O)C=3)C)OC=3C(O)=CC=C(C=3)C(N)C(=O)N3)NC(=O)C3CC(C=C3)=CC=C3OC(C=3OC4C(C(O)C(O)C(CO)O4)O)=CC2=CC=3OC(C(=C2)Cl)=CC=C2C1OC1CC(N)C(O)C(C)O1 BDNDRNLSLGGULA-UHFFFAOYSA-N 0.000 description 1
229950002379 actaplanin Drugs 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
108010053278 avoparcin Proteins 0.000 description 1
235000019377 avoparcin Nutrition 0.000 description 1
JWFVWARSGMYXRN-HTQQBIQNSA-N avoparcin Chemical compound O([C@H]1[C@H](C(N[C@H](C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(N[C@H](C4=CC(O)=CC(O)=C4C=4C(O)=CC=C3C=4)C(O)=O)=O)CC3=C(O[C@@H]4O[C@@H](C)[C@H](O)[C@H](N)C4)C=C(C(=C3)Cl)OC=3C=C2C=C(C=3O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2O[C@@H](C)[C@H](O)[C@H](N)C2)OC2=CC=C1C=C2)C=1C=CC(O)=CC=1)=O)NC(=O)[C@@H](NC)C=1C=CC(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)=CC=1)[C@@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@H]1O JWFVWARSGMYXRN-HTQQBIQNSA-N 0.000 description 1
229950001335 avoparcin Drugs 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229910021538 borax Inorganic materials 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
239000003224 coccidiostatic agent Substances 0.000 description 1
239000002131 composite material Substances 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
235000013325 dietary fiber Nutrition 0.000 description 1
235000019621 digestibility Nutrition 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
238000007865 diluting Methods 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
AJFXNBUVIBKWBT-UHFFFAOYSA-N disodium;boric acid;hydrogen borate Chemical compound [Na+].[Na+].OB(O)O.OB(O)O.OB(O)O.OB([O-])[O-] AJFXNBUVIBKWBT-UHFFFAOYSA-N 0.000 description 1
230000035622 drinking Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
DANUORFCFTYTSZ-UHFFFAOYSA-N epinigericin Natural products O1C2(C(CC(C)(O2)C2OC(C)(CC2)C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)C)C(C)C(OC)CC1CC1CCC(C)C(C(C)C(O)=O)O1 DANUORFCFTYTSZ-UHFFFAOYSA-N 0.000 description 1
FZWBABZIGXEXES-UHFFFAOYSA-N ethane-1,2-diol;hexanedioic acid Chemical compound OCCO.OC(=O)CCCCC(O)=O FZWBABZIGXEXES-UHFFFAOYSA-N 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
235000021050 feed intake Nutrition 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000003102 growth factor Substances 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
239000004463 hay Substances 0.000 description 1
244000309465 heifer Species 0.000 description 1
244000038280 herbivores Species 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
230000006651 lactation Effects 0.000 description 1
BBMULGJBVDDDNI-OWKLGTHSSA-N lasalocid Chemical compound C([C@@H]1[C@@]2(CC)O[C@@H]([C@H](C2)C)[C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCC=2C(=C(O)C(C)=CC=2)C(O)=O)C[C@](O)(CC)[C@H](C)O1 BBMULGJBVDDDNI-OWKLGTHSSA-N 0.000 description 1
229960000320 lasalocid Drugs 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
230000033001 locomotion Effects 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
229910000357 manganese(II) sulfate Inorganic materials 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000007269 microbial metabolism Effects 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
239000013642 negative control Substances 0.000 description 1
DANUORFCFTYTSZ-BIBFWWMMSA-N nigericin Chemical compound C([C@@H]1C[C@H]([C@H]([C@]2([C@@H](C[C@](C)(O2)C2O[C@@](C)(CC2)C2[C@H](CC(O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C)O1)C)OC)[C@H]1CC[C@H](C)C([C@@H](C)C(O)=O)O1 DANUORFCFTYTSZ-BIBFWWMMSA-N 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000012071 phase Substances 0.000 description 1
HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical group [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
125000005506 phthalide group Chemical class 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
239000013641 positive control Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
229960001548 salinomycin Drugs 0.000 description 1
235000019378 salinomycin Nutrition 0.000 description 1
238000005070 sampling Methods 0.000 description 1
239000013049 sediment Substances 0.000 description 1
239000006152 selective media Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
XOIQMTLWECTKJL-BEMBKCOJSA-M sodium;(2s,3r,4s)-4-[(2s,7s,8r,9s)-2-[(2r,5s)-5-ethyl-5-[(2r,3s,5r)-5-[(2s,3s,5r,6r)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]oxolan-2-yl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoate Chemical compound [Na+].C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)CC21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O2 XOIQMTLWECTKJL-BEMBKCOJSA-M 0.000 description 1
235000021055 solid food Nutrition 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
150000004685 tetrahydrates Chemical class 0.000 description 1
238000000844 transformation Methods 0.000 description 1
230000032258 transport Effects 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Microbiology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Food Science & Technology (AREA)
Animal Husbandry (AREA)
Mycology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Birds (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Physiology (AREA)
Fodder In General (AREA)
Feed For Specific Animals (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CA000488801A 1984-08-15 1985-08-15 Composition and method for improving the efficiency of ruminant feed utilization Expired - Lifetime CA1276084C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU3084/84		1984-08-15
HU843084A HU193294B (en)	1984-08-15	1984-08-15	Preparation influencing the digestion of ruminants advantageously

Publications (1)

Publication Number	Publication Date
CA1276084C true CA1276084C (en)	1990-11-13

Family

ID=10962468

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000488801A Expired - Lifetime CA1276084C (en)	1984-08-15	1985-08-15	Composition and method for improving the efficiency of ruminant feed utilization

Country Status (24)

Country	Link
JP (1)	JPS6192539A (no)
AT (1)	AT392287B (no)
AU (1)	AU596076B2 (no)
BE (1)	BE903079A (no)
CA (1)	CA1276084C (no)
CH (1)	CH676189A5 (no)
CS (1)	CS593085A3 (no)
DE (1)	DE3529383A1 (no)
DK (1)	DK370585A (no)
ES (1)	ES8706386A1 (no)
FI (1)	FI853125L (no)
FR (1)	FR2569085B1 (no)
GB (1)	GB2163650B (no)
GR (1)	GR851991B (no)
HU (1)	HU193294B (no)
IL (1)	IL76104A0 (no)
IT (1)	IT1188183B (no)
MX (1)	MX7713E (no)
NL (1)	NL8502260A (no)
NO (1)	NO164152C (no)
NZ (1)	NZ213117A (no)
SE (1)	SE8503815L (no)
SU (1)	SU1625317A3 (no)
ZA (1)	ZA856200B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO974299D0 (no) *	1997-09-18	1997-09-18	Forskningsparken I Aas As	Metode for stabil merking av mikroorganismer
ES2261059B1 (es) *	2005-01-05	2007-11-01	Alimentacion Siglo Xxii, S.L.	Procedimiento de seleccion de microorganismos celuloliticos a partir de flora ruminal y reproduccion por fermentacion industrial de la flora seleccionada.
EP2082739A1 (en)	2008-01-25	2009-07-29	PURAC Biochem BV	Lactylates for the prevention and treatment of infections caused by gram-positive bacteria in animals

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5310129B2 (no) *	1972-05-29	1978-04-11
SE393517B (sv) *	1973-06-25	1977-05-16	Grace W R & Co	Sett att oka mjolkproduktionen hos kor
GB1443392A (en) *	1974-02-20	1976-07-21	Grace W R & Co	Ruminant feed additive
FR2261757A1 (en) *	1974-02-27	1975-09-19	Grace W R Ltd	Feed additive for ruminants with digestive upsets - prepd. by incubation of rumen microorganisms in starch-contg. concentrate feed medium
HU173822B (hu) *	1975-06-02	1979-08-28	Chinoin Gyogyszer Es Vegyeszet	Sposob poluchenija pitatel'nykh sred dlja razmozhenija kormovykh drozhej i nitchatykh gribov i/ili belkov iz rastitel'nykh skhodov
AT365046B (de) *	1978-07-13	1981-12-10	Sp Kt Bjuro Dezintegrator	Verfahren zur herstellung eines futtermittels fuer nutztiere und gefluegel
US4764510A (en) *	1986-04-11	1988-08-16	Eli Lilly And Company	Antibiotic A42125 and process for its production

1984
- 1984-08-15 HU HU843084A patent/HU193294B/hu not_active IP Right Cessation
1985
- 1985-07-15 CS CS855930A patent/CS593085A3/cs unknown
- 1985-08-14 AU AU46196/85A patent/AU596076B2/en not_active Ceased
- 1985-08-14 ES ES546144A patent/ES8706386A1/es not_active Expired
- 1985-08-14 AT AT2369/85A patent/AT392287B/de not_active IP Right Cessation
- 1985-08-14 FR FR858512387A patent/FR2569085B1/fr not_active Expired - Lifetime
- 1985-08-14 IT IT21933/85A patent/IT1188183B/it active
- 1985-08-14 GR GR851991A patent/GR851991B/el unknown
- 1985-08-14 CH CH3493/85A patent/CH676189A5/de not_active IP Right Cessation
- 1985-08-14 GB GB08520398A patent/GB2163650B/en not_active Expired
- 1985-08-15 FI FI853125A patent/FI853125L/fi not_active Application Discontinuation
- 1985-08-15 MX MX851048U patent/MX7713E/es unknown
- 1985-08-15 SU SU853946999A patent/SU1625317A3/ru active
- 1985-08-15 NO NO85853212A patent/NO164152C/no unknown
- 1985-08-15 NZ NZ213117A patent/NZ213117A/xx unknown
- 1985-08-15 CA CA000488801A patent/CA1276084C/en not_active Expired - Lifetime
- 1985-08-15 NL NL8502260A patent/NL8502260A/nl not_active Application Discontinuation
- 1985-08-15 JP JP60179999A patent/JPS6192539A/ja active Pending
- 1985-08-15 DK DK370585A patent/DK370585A/da not_active Application Discontinuation
- 1985-08-15 ZA ZA856200A patent/ZA856200B/xx unknown
- 1985-08-15 IL IL76104A patent/IL76104A0/xx not_active IP Right Cessation
- 1985-08-15 SE SE8503815A patent/SE8503815L/xx unknown
- 1985-08-16 DE DE19853529383 patent/DE3529383A1/de not_active Withdrawn
- 1985-08-16 BE BE1/011317A patent/BE903079A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPS6192539A (ja)	1986-05-10
DE3529383A1 (de)	1986-05-07
NO164152C (no)	1990-09-05
NL8502260A (nl)	1986-03-03
FI853125A0 (fi)	1985-08-15
SU1625317A3 (ru)	1991-01-30
MX7713E (es)	1990-10-05
ATA236985A (de)	1990-08-15
FI853125L (fi)	1986-02-16
DK370585A (da)	1986-02-16
GB2163650B (en)	1989-02-01
SE8503815L (sv)	1986-02-16
IT8521933A0 (it)	1985-08-14
FR2569085B1 (fr)	1990-05-04
IL76104A0 (en)	1985-12-31
NZ213117A (en)	1989-01-27
FR2569085A1 (fr)	1986-02-21
GB2163650A (en)	1986-03-05
NO853212L (no)	1986-02-17
AU4619685A (en)	1986-02-20
AU596076B2 (en)	1990-04-26
HU193294B (en)	1987-09-28
BE903079A (fr)	1986-02-17
IT1188183B (it)	1988-01-07
NO164152B (no)	1990-05-28
ES8706386A1 (es)	1987-07-01
DK370585D0 (da)	1985-08-15
AT392287B (de)	1991-02-25
ZA856200B (en)	1986-04-30
CS593085A3 (en)	1992-01-15
ES546144A0 (es)	1987-07-01
CH676189A5 (no)	1990-12-28
SE8503815D0 (sv)	1985-08-15
GB8520398D0 (en)	1985-09-18
GR851991B (no)	1985-12-17

Publication	Publication Date	Title
CN106282072B (zh)	2019-12-20	一种复合乳酸菌微生态制剂及其制备方法与应用
CN101671638B (zh)	2011-11-30	一种双歧杆菌新菌株及其发酵制备方法与应用
EP0287699A2 (en)	1988-10-26	Feeds containing bacillus subtilis C-3102
CN107047934A (zh)	2017-08-18	利用枯草芽孢杆菌菌株以增强动物健康的方法
CN116083262B (zh)	2025-01-28	有水产病原菌拮抗特性的植物乳杆菌菌株及其制剂的制备及应用
WO1994011492A1 (en)	1994-05-26	Method of favorably modifying poultry intestinal microflora
US5139777A (en)	1992-08-18	Composition and method for improving the efficiency of ruminant feed utilization
CN114908013B (zh)	2023-01-31	一株产ddp-iv抑制剂的厦门希瓦氏菌及其应用
EP0271364B1 (en)	1992-09-09	Preparation suitable for treating enteric disorders
KR100541379B1 (ko)	2006-01-10	사료 첨가물 및 그 제조방법
CN110628669B (zh)	2021-07-13	枯草芽孢杆菌ly-5、菌剂及其应用和应用其的产品
CA1276084C (en)	1990-11-13	Composition and method for improving the efficiency of ruminant feed utilization
CN115851556B (zh)	2023-04-28	一种非解乳糖链球菌及其应用
CN116286514A (zh)	2023-06-23	多功能菌剂及其所含的罗伊氏乳杆菌及其应用
CN110257299B (zh)	2022-06-10	一种阴沟肠杆菌在促进反刍动物生长的应用
Fonty et al.	1993	Manipulation of the gut microflora: experimental approach in animals
JP3180886B2 (ja)	2001-06-25	動物成長促進剤
CN111349581A (zh)	2020-06-30	一种嗜酸乳酸菌的选育及其应用
CN116042491A (zh)	2023-05-02	功能微生态制剂及其所含唾液联合乳杆菌与应用
CS227683B2 (en)	1984-05-14	Production method of antibioticum a 4696 factor g
CN116286515A (zh)	2023-06-23	一株健康哺乳母猪肠道来源的鼠李糖乳杆菌及其应用
CN116891818A (zh)	2023-10-17	一株运动芽孢杆菌及其应用
CN119351267A (zh)	2025-01-24	一种地衣芽孢杆菌rdy21、含有该菌的菌剂及其应用
CN117530360A (zh)	2024-02-09	盐枝芽孢杆菌lmvs的用途及一种饲料
CN119404964A (zh)	2025-02-11	一种断奶仔兔复合微生态全价料配方及制备方法

Legal Events

Date	Code	Title	Description
1993-05-15	MKLA	Lapsed