CA1244017A - Method for preparing 6-chloro-n-methyl-2,3,4,5- tetrahydro-1h-3-benzazepine - Google Patents

Method for preparing 6-chloro-n-methyl-2,3,4,5- tetrahydro-1h-3-benzazepine

Info

Publication number: CA1244017A
Authority: CA; Canada
Prior art keywords: methyl; benzazepine; tetrahydro; chloro; trichlorobenzene
Prior art date: 1984-09-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000488976A

Other languages

English (en)

French (fr)

Inventor

Stanley J. Borowski

Thomas A. Post

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GlaxoSmithKline Inc

Original Assignee

Smith Kline and French Canada Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-09-05

Filing date

1985-08-19

Publication date

1988-11-01

1985-08-19 Application filed by Smith Kline and French Canada Ltd filed Critical Smith Kline and French Canada Ltd

1988-11-01 Application granted granted Critical

1988-11-01 Publication of CA1244017A publication Critical patent/CA1244017A/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

CA000488976A 1984-09-05 1985-08-19 Method for preparing 6-chloro-n-methyl-2,3,4,5- tetrahydro-1h-3-benzazepine Expired CA1244017A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US647,552		1984-09-05
US06/647,552 US4541954A (en)	1984-09-05	1984-09-05	Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (1)

Publication Number	Publication Date
CA1244017A true CA1244017A (en)	1988-11-01

Family

ID=24597406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000488976A Expired CA1244017A (en)	1984-09-05	1985-08-19	Method for preparing 6-chloro-n-methyl-2,3,4,5- tetrahydro-1h-3-benzazepine

Country Status (19)

Country	Link
US (1)	US4541954A (xx)
EP (1)	EP0174118A3 (xx)
JP (1)	JPS6168469A (xx)
KR (1)	KR860002470A (xx)
AU (1)	AU581918B2 (xx)
CA (1)	CA1244017A (xx)
DK (1)	DK379985A (xx)
EG (1)	EG17149A (xx)
ES (1)	ES8609266A1 (xx)
FI (1)	FI853255L (xx)
GR (1)	GR852041B (xx)
HU (1)	HU194181B (xx)
IL (1)	IL76100A0 (xx)
NO (1)	NO853255L (xx)
NZ (1)	NZ213141A (xx)
PH (1)	PH20796A (xx)
PT (1)	PT81018B (xx)
ZA (1)	ZA856268B (xx)
ZW (1)	ZW13385A1 (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993000811A1 (en) *	1991-07-01	1993-01-21	The General Hospital Corporation	Invertebrate phenylethanolamine transporter and the use thereof
CA2100678A1 (en) *	1991-12-06	1993-06-07	Hiroshi Kagawa	Film type battery and layer-built film type battery
US6953787B2 (en)	2002-04-12	2005-10-11	Arena Pharmaceuticals, Inc.	5HT2C receptor modulators
AU2004267016B2 (en)	2003-06-17	2011-11-24	Arena Pharmaceuticals, Inc.	Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
EA016558B1 (ru)	2003-06-17	2012-05-30	Арена Фармасьютикалз, Инк.	Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
KR101281919B1 (ko)	2004-12-21	2013-07-03	아레나 파마슈티칼스, 인크.	(ｒ)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 히드로클로라이드의 결정질 형태
KR101426850B1 (ko)	2004-12-23	2014-08-05	아레나 파마슈티칼스, 인크.	5ｈｔ２ｃ 수용체 조정물질 조성물 및 그의 사용 방법
JP5199997B2 (ja)	2006-04-03	2013-05-15	アリーナファーマシューティカルズ，インコーポレイテッド	８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
ES2522587T3 (es) *	2006-12-05	2014-11-17	Arena Pharmaceuticals, Inc.	Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
WO2009111004A1 (en) *	2008-03-04	2009-09-11	Arena Pharmaceuticals, Inc.	Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
WO2010148207A2 (en)	2009-06-18	2010-12-23	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-ht2c receptor agonists
KR20130112848A (ko)	2010-06-02	2013-10-14	아레나 파마슈티칼스, 인크.	5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
WO2012030957A2 (en)	2010-09-01	2012-03-08	Arena Pharmaceuticals, Inc.	Non-hygroscopic salts of 5-ht2c agonists
KR20140091458A (ko)	2010-09-01	2014-07-21	아레나 파마슈티칼스, 인크.	신장 손상을 갖는 개체에 대한 로카세린의 투여
JP6272695B2 (ja)	2010-09-01	2018-01-31	エーザイ・アール・アンド・ディー・マネジメント株式会社	体重管理のために有用な５−ｈｔ２ｃアゴニストの改変放出剤形
WO2012030938A1 (en)	2010-09-01	2012-03-08	Arena Pharmaceuticals, Inc.	Salts of lorcaserin with optically active acids
CA2886875A1 (en)	2012-10-09	2014-04-17	Arena Pharmaceuticals, Inc.	Method of weight management

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1118688A (en) *	1967-02-17	1968-07-03	Scherico Ltd	Novel benzazepines and process for making same
CH481110A (de) *	1967-02-17	1969-11-15	Geigy Ag J R	Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
US4251660A (en) *	1978-08-10	1981-02-17	Smithkline Corporation	Method for preparing tetrahydroisoquinolines
US4200754A (en) *	1979-02-02	1980-04-29	Smithkline Corporation	Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
IE53962B1 (en) *	1981-11-27	1989-04-26	Smithkline Beckman Corp	3-benzazepines as alpha-2 antagonists
EP0161350A1 (en) *	1981-11-27	1985-11-21	Smithkline Beckman Corporation	Process for preparing benzazepines
ZA827887B (en) *	1981-11-27	1983-11-30	Smithkline Beckman Corp	Pharmaceutical compositions and method of producing alpha2 antagonism

1984
- 1984-09-05 US US06/647,552 patent/US4541954A/en not_active Expired - Fee Related
1985
- 1985-08-14 EP EP85305780A patent/EP0174118A3/en not_active Ceased
- 1985-08-15 IL IL76100A patent/IL76100A0/xx unknown
- 1985-08-19 PH PH32660A patent/PH20796A/en unknown
- 1985-08-19 NZ NZ213141A patent/NZ213141A/xx unknown
- 1985-08-19 NO NO853255A patent/NO853255L/no unknown
- 1985-08-19 CA CA000488976A patent/CA1244017A/en not_active Expired
- 1985-08-19 ZA ZA856268A patent/ZA856268B/xx unknown
- 1985-08-20 JP JP60183788A patent/JPS6168469A/ja active Pending
- 1985-08-20 ZW ZW133/85A patent/ZW13385A1/xx unknown
- 1985-08-20 ES ES546285A patent/ES8609266A1/es not_active Expired
- 1985-08-21 AU AU46481/85A patent/AU581918B2/en not_active Ceased
- 1985-08-21 HU HU853190A patent/HU194181B/hu unknown
- 1985-08-21 DK DK379985A patent/DK379985A/da not_active Application Discontinuation
- 1985-08-22 GR GR852041A patent/GR852041B/el unknown
- 1985-08-22 KR KR1019850006061A patent/KR860002470A/ko not_active Application Discontinuation
- 1985-08-23 FI FI853255A patent/FI853255L/fi not_active Application Discontinuation
- 1985-08-23 PT PT81018A patent/PT81018B/pt unknown
- 1985-09-04 EG EG545/85A patent/EG17149A/xx active

Also Published As

Publication number	Publication date
EP0174118A3 (en)	1986-12-30
JPS6168469A (ja)	1986-04-08
AU4648185A (en)	1986-03-13
FI853255L (fi)	1986-03-06
AU581918B2 (en)	1989-03-09
EG17149A (en)	1989-06-30
DK379985D0 (da)	1985-08-21
GR852041B (xx)	1985-12-19
KR860002470A (ko)	1986-04-26
HU194181B (en)	1988-01-28
PT81018A (en)	1985-09-01
ES546285A0 (es)	1986-09-01
DK379985A (da)	1986-03-06
ES8609266A1 (es)	1986-09-01
PH20796A (en)	1987-04-14
NZ213141A (en)	1988-07-28
HUT38617A (en)	1986-06-30
US4541954A (en)	1985-09-17
ZW13385A1 (en)	1985-11-20
EP0174118A2 (en)	1986-03-12
ZA856268B (en)	1986-07-30
IL76100A0 (en)	1985-12-31
FI853255A0 (fi)	1985-08-23
NO853255L (no)	1986-03-06
PT81018B (en)	1987-06-24

Publication	Publication Date	Title
CA1244017A (en)	1988-11-01	Method for preparing 6-chloro-n-methyl-2,3,4,5- tetrahydro-1h-3-benzazepine
EP2471780B1 (en)	2014-11-26	Crystalline Ivabradine Oxalate Salts and Polymorphs Thereof
EP1430008A2 (en)	2004-06-23	Process for preparing pentacene derivatives
US3639407A (en)	1972-02-01	Novel 1 2 3 4 5 6-hexahydro-6-phenyl-2 6-methano-3-benzazocines
EP0161350A1 (en)	1985-11-21	Process for preparing benzazepines
NZ234845A (en)	1992-03-26	Dibenzothiazine derivatives and pharmaceutical compositions
US6500954B1 (en)	2002-12-31	Synthesis of 5- or 8-bromoisoquinoline derivatives
DE3688788T2 (de)	1994-03-03	Benzazepinderivate.
US4555570A (en)	1985-11-26	Substituted 4-alkyl-2-(1H) quinazolinone-1-alkanoic acid derivatives
EP0233049A1 (en)	1987-08-19	2,3,4,8,9,9a-Hexahydro-4-aryl-1H-indeno[1,7-cd]azepines
GB2207427A (en)	1989-02-01	Benzazepine derivatives
US5571918A (en)	1996-11-05	Method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine
KR100392060B1 (ko)	2003-11-28	5-ht2수용체에대한친화성을가진치환된테트라사이클릭아제핀유도체
EP0300074A1 (en)	1989-01-25	Processes and intermediates useful in the preparation of Cis 1,3,4,6,7 llb-Hexa-hydro-7-aryl-2H-pyrazino[2,1-a]isoquinolines
JPH051071A (ja)	1993-01-08	抗アテローム性動脈硬化症フロクロモン
GB1596170A (en)	1981-08-19	1,2,3,4,4a,10b-hexahydro-benz(f)isouqinolines
US3583997A (en)	1971-06-08	Benzothiopyrano(2,3-c)pyridines
EP0033632B1 (en)	1983-03-30	7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines, process for their preparation and pharmaceutical compositions containing them
EP0009284A1 (en)	1980-04-02	Novel tetracyclic compounds, processes for their preparation and pharmaceutical compositions
AU753563B2 (en)	2002-10-24	Improved method for preparing pharmaceutically valuable norbenzomorphane derivatives
WO2006006184A2 (en)	2006-01-19	A process for the manufacturing of loratadine and its intermediates
KR910002879B1 (ko)	1991-05-09	1,5-벤조티아제핀 유도체의 제조방법
US3329677A (en)	1967-07-04	N-benzhydryloxyphthalimides and pryidinealdehyde o-benzhydryloximes
US5574160A (en)	1996-11-12	Syntheis of benzoquinolinones
HU193563B (en)	1987-10-28	Process for producing n-/cyclopropyl-methyl/-6,14-endoethano-7-/1-hydroxy-1,2,2-trimethyl-propyl/-dihydronormorphin-6-methylester

Legal Events

Date	Code	Title	Description
2005-11-01	MKEX	Expiry