CA1118446A - Racemic forms and optically active forms of 2-(4-biphenylyl)-n-(diethylamino alkyl) propionamide and salts thereof as well as processes for their production and use as spasmoltyic agents - Google Patents

Racemic forms and optically active forms of 2-(4-biphenylyl)-n-(diethylamino alkyl) propionamide and salts thereof as well as processes for their production and use as spasmoltyic agents

Info

Publication number: CA1118446A
Authority: CA; Canada
Prior art keywords: biphenyl; propionamide; ethyl; diethyl; bromide
Prior art date: 1977-11-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

CA000317175A

Other languages

English (en)

French (fr)

Inventor

Vittorio Pestellini

Mario Ghelardoni

Claudio Bianchini

Piero Del Soldato

Giovanna Volterra

Alberto Meli

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

A Menarini SAS

Original Assignee

A Menarini SAS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-11-30

Filing date

1978-11-30

Publication date

1982-02-16

1978-11-30 Application filed by A Menarini SAS filed Critical A Menarini SAS

1982-02-16 Application granted granted Critical

1982-02-16 Publication of CA1118446A publication Critical patent/CA1118446A/en

Status Expired legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CA000317175A 1977-11-30 1978-11-30 Racemic forms and optically active forms of 2-(4-biphenylyl)-n-(diethylamino alkyl) propionamide and salts thereof as well as processes for their production and use as spasmoltyic agents Expired CA1118446A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT964377A IT1090782B (it)	1977-11-30	1977-11-30	2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi
IT9643A/77		1977-11-30

Publications (1)

Publication Number	Publication Date
CA1118446A true CA1118446A (en)	1982-02-16

Family

ID=11132874

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000317175A Expired CA1118446A (en)	1977-11-30	1978-11-30	Racemic forms and optically active forms of 2-(4-biphenylyl)-n-(diethylamino alkyl) propionamide and salts thereof as well as processes for their production and use as spasmoltyic agents

Country Status (9)

Country	Link
JP (1)	JPS5490157A (ja)
BE (1)	BE872403A (ja)
CA (1)	CA1118446A (ja)
CH (1)	CH637370A5 (ja)
DE (1)	DE2851416A1 (ja)
ES (1)	ES475533A1 (ja)
FR (1)	FR2410641A1 (ja)
IT (1)	IT1090782B (ja)
NL (1)	NL7811698A (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20012025A1 (it) *	2001-09-28	2003-03-28	Dompe Spa	Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
US20090221703A1 (en)	2006-07-09	2009-09-03	Chongxi Yu	High penetration composition and uses thereof
US20090238763A1 (en)	2006-07-09	2009-09-24	Chongxi Yu	High penetration compositions and uses thereof
PL2049482T3 (pl) *	2006-08-08	2016-04-29	Techfields Biochem Co Ltd	Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów arylo- i heteroarylooctowych o bardzo dużej szybkości przenikania przez skórę
JP5424880B2 (ja) *	2006-08-15	2014-02-26	テックフィールズバイオケムカンパニーリミテッド	非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ
AU2013206218B2 (en) *	2006-08-15	2016-06-30	Techfields Biochem Co. Ltd	Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
RU2509076C2 (ru)	2007-06-04	2014-03-10	Текфилдз Инк	Пролекарства нестероидных противовоспалительных средств (nsaia) c очень высокой скоростью проникновения через кожу и мембраны и новые медицинские применения указанных пролекарств
RU2765463C2 (ru)	2008-12-04	2022-01-31	Чунси ЮЙ	Композиции интенсивного проникновения и их применение
JP5940036B2 (ja) *	2013-10-08	2016-06-29	テックフィールズバイオケムカンパニーリミテッド	非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ
JP6290947B2 (ja) *	2016-02-05	2018-03-07	テックフィールズバイオケムカンパニーリミテッド	非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1584547A (ja) *	1968-06-05	1969-12-26
FR1593024A (ja) *	1968-09-18	1970-05-25
FR2119846A1 (en) *	1970-12-28	1972-08-11	Choay Sa	N,n-diethylaminoethylamide of para isobutyl phenylacetic - acid - antiinflammatory and analgesic
US4145435A (en) *	1976-11-12	1979-03-20	The Upjohn Company	2-aminocycloaliphatic amide compounds

1977
- 1977-11-30 IT IT964377A patent/IT1090782B/it active
1978
- 1978-11-28 CH CH1216178A patent/CH637370A5/it not_active IP Right Cessation
- 1978-11-28 DE DE19782851416 patent/DE2851416A1/de active Granted
- 1978-11-29 NL NL7811698A patent/NL7811698A/xx not_active Application Discontinuation
- 1978-11-29 ES ES475533A patent/ES475533A1/es not_active Expired
- 1978-11-30 BE BE192036A patent/BE872403A/xx not_active IP Right Cessation
- 1978-11-30 JP JP14730778A patent/JPS5490157A/ja active Granted
- 1978-11-30 FR FR7833889A patent/FR2410641A1/fr active Granted
- 1978-11-30 CA CA000317175A patent/CA1118446A/en not_active Expired

Also Published As

Publication number	Publication date
FR2410641A1 (fr)	1979-06-29
BE872403A (fr)	1979-03-16
NL7811698A (nl)	1979-06-01
IT1090782B (it)	1985-06-26
DE2851416C2 (ja)	1989-02-23
JPS5490157A (en)	1979-07-17
CH637370A5 (en)	1983-07-29
DE2851416A1 (de)	1979-05-31
FR2410641B1 (ja)	1983-04-15
ES475533A1 (es)	1980-01-16
JPS631286B2 (ja)	1988-01-12

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Legal Events

Date	Code	Title	Description
1999-02-16	MKEX	Expiry