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BRPI0923500A2 - uso e composição farmacêutica compreendendo agonista ou modulador do receptor s1p, e kit. - Google Patents

uso e composição farmacêutica compreendendo agonista ou modulador do receptor s1p, e kit.

Info

Publication number
BRPI0923500A2
BRPI0923500A2 BRPI0923500-0A BRPI0923500A BRPI0923500A2 BR PI0923500 A2 BRPI0923500 A2 BR PI0923500A2 BR PI0923500 A BRPI0923500 A BR PI0923500A BR PI0923500 A2 BRPI0923500 A2 BR PI0923500A2
Authority
BR
Brazil
Prior art keywords
modulator
kit
composition
receptor agonist
pharmaceutical use
Prior art date
Application number
BRPI0923500-0A
Other languages
English (en)
Inventor
Schmouder Robert
Dumortier Thomas
David Olivier
Looby Michael
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41667217&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0923500(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0923500A2 publication Critical patent/BRPI0923500A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/10Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0923500-0A 2008-12-22 2009-12-21 uso e composição farmacêutica compreendendo agonista ou modulador do receptor s1p, e kit. BRPI0923500A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US13967208P 2008-12-22 2008-12-22
US61/139,672 2008-12-22
US21853009P 2009-06-19 2009-06-19
US61/218,530 2009-06-19
US24671509P 2009-09-29 2009-09-29
US61/246,715 2009-09-29
PCT/US2009/068888 WO2010075239A1 (en) 2008-12-22 2009-12-21 Dosage regimen for a s1p receptor agonist

Publications (1)

Publication Number Publication Date
BRPI0923500A2 true BRPI0923500A2 (pt) 2018-05-29

Family

ID=41667217

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923500-0A BRPI0923500A2 (pt) 2008-12-22 2009-12-21 uso e composição farmacêutica compreendendo agonista ou modulador do receptor s1p, e kit.

Country Status (43)

Country Link
US (12) US20100160259A1 (pt)
EP (7) EP3453387B1 (pt)
JP (7) JP2012513401A (pt)
KR (1) KR101347919B1 (pt)
CN (1) CN102264359A (pt)
AR (1) AR074826A1 (pt)
AU (1) AU2009330176C9 (pt)
BR (1) BRPI0923500A2 (pt)
CA (1) CA2747802C (pt)
CL (2) CL2011001529A1 (pt)
CO (1) CO6390117A2 (pt)
CR (1) CR20110274A (pt)
CU (1) CU20110136A7 (pt)
CY (4) CY1116990T1 (pt)
DK (4) DK3453387T3 (pt)
EA (1) EA201100978A1 (pt)
EC (1) ECSP11011222A (pt)
ES (4) ES2552823T3 (pt)
FI (2) FI4098256T3 (pt)
FR (2) FR20C1060I1 (pt)
HN (1) HN2011001759A (pt)
HR (4) HRP20250568T1 (pt)
HU (6) HUE048717T4 (pt)
IL (3) IL213170A0 (pt)
LT (5) LT3409274T (pt)
LU (1) LUC00183I2 (pt)
MA (1) MA32981B1 (pt)
ME (2) ME03802B (pt)
MX (3) MX385959B (pt)
NO (1) NO2020038I1 (pt)
NZ (1) NZ593065A (pt)
PE (1) PE20120337A1 (pt)
PL (4) PL4098256T3 (pt)
PT (4) PT3453387T (pt)
RS (3) RS66784B9 (pt)
SG (1) SG171404A1 (pt)
SI (4) SI3453387T1 (pt)
SM (2) SMT202000441T1 (pt)
TN (1) TN2011000272A1 (pt)
TW (1) TW201028143A (pt)
UY (1) UY32352A (pt)
WO (1) WO2010075239A1 (pt)
ZA (2) ZA201103863B (pt)

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DK2278960T4 (da) 2008-03-17 2020-01-27 Actelion Pharmaceuticals Ltd Dosisregimen til en selektiv sip1 receptoragonist
ES2552823T3 (es) 2008-12-22 2015-12-02 Novartis Ag Régimen de dosificación para fingolimod para el tratamiento de la esclerosis múltiple
BR112012006957A2 (pt) 2009-09-29 2016-06-14 Novartis Ag regime de dosagem de um modulador de receptor de s1p
US20110124605A1 (en) * 2009-11-20 2011-05-26 Shreeram Aradhye Use of an S1P Receptor Agonist
SG10201500639TA (en) 2010-01-27 2015-03-30 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
EA201201515A1 (ru) * 2010-05-06 2013-08-30 Новартис Аг Схема приема производных диарилсульфидов
EP2455080A1 (en) * 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of multiple sclerosis
FR2968556B1 (fr) 2010-12-13 2013-12-27 Centre Nat Rech Scient Inhibiteurs des infections a vih et leurs utilisations
MA34897B1 (fr) 2011-01-07 2014-02-01 Novartis Ag Formulations d'immunosupresseurs
DK2675893T3 (en) 2011-02-18 2019-04-15 Scripps Research Inst Directed differentiation of oligodendrocyte precursor cells into a myelinating cell fate
JO3177B1 (ar) 2011-04-01 2018-03-08 Novartis Ag تركيبات تتالف من 2-أمينو-2- [ 2- ( 4- أكتيل فينيل ) إثيل ] بروبان - 3, 1- ديول
US9592268B2 (en) 2011-05-23 2017-03-14 Cornell University Endothelium protective materials and methods of use
TW201320994A (zh) * 2011-10-11 2013-06-01 Novartis Ag 投藥療程
SMT202000298T1 (it) 2012-08-17 2020-07-08 Actelion Pharmaceuticals Ltd Processo per la produzione di (2z,5z)-5-(3-cloro-4((r)-2,3-diidrossipropossi) benziliden)-2-(propilimmino)-3-(o-tolil)tiazolidin-4-one e intermedio usato in detto processo
US20160129084A1 (en) * 2013-03-06 2016-05-12 Acorda Therapeutics, Inc. Therapeutic Dosing of a Neuregulin or a Fragment Thereof for Treatment or Prophylaxis of Heart Failure
EP3054933A4 (en) 2013-10-11 2017-03-15 Teikoku Pharma USA, Inc. Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same
WO2015053879A1 (en) 2013-10-11 2015-04-16 Teikoku Pharma Usa, Inc. Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same
RU2020107732A (ru) * 2014-04-10 2020-03-30 Новартис Аг Схема дозирования модулятора s1p с немедленным высвобождением
PL3256125T3 (pl) 2014-12-11 2022-05-09 Actelion Pharmaceuticals Ltd Schemat dawkowania ponesimodu, selektywnego agonisty receptora s1p1
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
PL3242666T3 (pl) * 2015-01-06 2025-02-17 Arena Pharmaceuticals, Inc. Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1
WO2016135644A1 (en) 2015-02-26 2016-09-01 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
JP6838744B2 (ja) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ, インコーポレイテッド S1P1レセプター関連障害における使用のための(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸(化合物1)の結晶性L−アルギニン塩
AU2018220521A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
CA3053416A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
KR102859841B1 (ko) 2018-06-06 2025-09-12 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 병태의 치료 방법
WO2021084068A1 (en) 2019-10-31 2021-05-06 Idorsia Pharmaceuticals Ltd Combination of a cxcr7 antagonist with an s1p1 receptor modulator
WO2021158838A1 (en) 2020-02-07 2021-08-12 Argentum Pharmaceuticals Llc Dosage regimen of an s1p receptor modulator
WO2021158848A1 (en) * 2020-02-07 2021-08-12 Argentum Pharmaceuticals Llc Dosage regimen of an s1p receptor agonist
CA3169569A1 (en) * 2020-02-28 2021-09-02 Damian Grobelny S1p receptor modulators
CN113332435B (zh) * 2021-06-18 2022-10-18 广州中医药大学(广州中医药研究院) 鞘氨醇-1-磷酸4受体激动剂及其与真武汤联合在制备治疗慢性肾小球肾炎药物中的应用

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KR0155015B1 (ko) 1992-10-21 1998-12-01 고우야 마사시 2-아미노-1,3-프로판디올 화합물 및 면역 억제제
CA2421893A1 (en) 2000-08-31 2002-03-07 Merck And Co., Inc. Phosphate derivatives as immunoregulatory agents
KR20120125398A (ko) 2002-05-16 2012-11-14 노파르티스 아게 암에서 edg 수용체 결합제의 용도
JP4861177B2 (ja) * 2003-09-12 2012-01-25 ニューロノバ エービー 神経系の障害の処置
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
ES2495690T3 (es) * 2004-11-29 2014-09-17 Novartis Ag Régimen de dosificación de un agonista del receptor S1P
EP1688141A1 (en) * 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
WO2006085316A2 (en) * 2005-02-10 2006-08-17 G.I. View Ltd. Advancement techniques for gastrointestinal tool with guiding element
EP2465492B1 (en) * 2007-10-12 2015-07-01 Novartis AG Compositions comprising sphingosine I phosphate (sip) receptor modulators
DK2278960T4 (da) * 2008-03-17 2020-01-27 Actelion Pharmaceuticals Ltd Dosisregimen til en selektiv sip1 receptoragonist
JP2011525189A (ja) * 2008-06-20 2011-09-15 ノバルティス アーゲー 多発性硬化症を治療するための小児科の組成物
AR074825A1 (es) 2008-12-22 2011-02-16 Novartis Ag Regimen de dosificacion de un agonista de los receptores de s1p, metodo de tratamiento y kit
ES2552823T3 (es) 2008-12-22 2015-12-02 Novartis Ag Régimen de dosificación para fingolimod para el tratamiento de la esclerosis múltiple

Also Published As

Publication number Publication date
HUE026869T2 (en) 2016-08-29
JP2012513401A (ja) 2012-06-14
SMT202000054T1 (it) 2020-03-13
JP2017141238A (ja) 2017-08-17
CL2013001558A1 (es) 2013-10-25
LT3453387T (lt) 2020-08-25
TN2011000272A1 (en) 2012-12-17
FR20C1060I1 (fr) 2020-12-25
AR074826A1 (es) 2011-02-16
US20250262171A1 (en) 2025-08-21
DK3409274T3 (da) 2019-12-16
DK2379067T3 (en) 2015-12-07
AU2009330176B2 (en) 2014-03-06
ZA201205942B (en) 2013-03-27
FIC20253002I1 (fi) 2025-05-23
AU2009330176A1 (en) 2011-07-07
CY1123255T1 (el) 2021-10-29
EP4098256B1 (en) 2025-02-26
JP2024129030A (ja) 2024-09-26
ME03802B (me) 2021-04-20
HUE052048T2 (hu) 2021-04-28
HRP20250568T1 (hr) 2025-07-04
SI3409274T1 (sl) 2020-03-31
PT3453387T (pt) 2020-08-11
LTPA2020005I1 (lt) 2020-12-10
AU2009330176C9 (en) 2017-01-05
HUE048717T2 (hu) 2020-08-28
IL213170A0 (en) 2011-07-31
HUE048717T4 (hu) 2022-02-28
HN2011001759A (es) 2013-11-26
EP3120844A1 (en) 2017-01-25
ECSP11011222A (es) 2011-08-31
RS66784B1 (sr) 2025-06-30
KR20110096175A (ko) 2011-08-29
ES3017254T3 (en) 2025-05-12
EP2379067A1 (en) 2011-10-26
MX385959B (es) 2025-03-18
US20110257133A1 (en) 2011-10-20
US20190091180A1 (en) 2019-03-28
MA32981B1 (fr) 2012-01-02
CY2020036I1 (el) 2021-03-12
DK3453387T3 (da) 2020-08-10
DK4098256T3 (da) 2025-04-22
HRP20192175T1 (hr) 2020-03-20
EP3409274A1 (en) 2018-12-05
DK4098256T5 (da) 2025-07-21
RS60666B1 (sr) 2020-09-30
SG171404A1 (en) 2011-07-28
US20180289638A1 (en) 2018-10-11
WO2010075239A1 (en) 2010-07-01
PL3453387T3 (pl) 2020-11-02
EA201100978A1 (ru) 2012-01-30
US20160263061A1 (en) 2016-09-15
US20220142949A1 (en) 2022-05-12
SI3453387T1 (sl) 2020-10-30
HUE071189T2 (hu) 2025-08-28
US20100160259A1 (en) 2010-06-24
EP3453387B1 (en) 2020-06-03
LTPA2025520I1 (pt) 2025-06-25
PL3409274T3 (pl) 2020-06-01
US20170189353A1 (en) 2017-07-06
US20140148415A1 (en) 2014-05-29
HRP20201167T1 (hr) 2020-12-11
UY32352A (es) 2010-07-30
PL2379067T3 (pl) 2016-02-29
LT3409274T (lt) 2020-02-10
EP4098256B9 (en) 2025-06-18
PT4098256T (pt) 2025-04-10
EP3409274B1 (en) 2019-11-20
NZ593065A (en) 2012-11-30
EP2907511A1 (en) 2015-08-19
SI4098256T1 (sl) 2025-06-30
EP3453387A1 (en) 2019-03-13
HUS2500026I1 (hu) 2025-07-28
JP2016135752A (ja) 2016-07-28
EP4098256A1 (en) 2022-12-07
IL274756A (en) 2020-07-30
JP2014144970A (ja) 2014-08-14
US20140066657A1 (en) 2014-03-06
AU2009330176C1 (en) 2016-12-08
MX2021010759A (es) 2022-07-19
CN102264359A (zh) 2011-11-30
HUS2000046I1 (hu) 2020-12-28
EP2379067B1 (en) 2015-09-02
US20160081949A1 (en) 2016-03-24
CA2747802A1 (en) 2010-07-01
SI2379067T1 (sl) 2016-01-29
LT4098256T (lt) 2025-06-10
CA2747802C (en) 2021-02-09
CY1122812T1 (el) 2021-05-05
JP7329965B2 (ja) 2023-08-21
CO6390117A2 (es) 2012-02-29
CL2011001529A1 (es) 2012-02-24
ME03594B (me) 2020-07-20
SMT202000441T1 (it) 2020-09-10
PT2379067E (pt) 2015-12-23
MX2011006623A (es) 2011-07-12
RS66784B9 (sr) 2025-08-29
HRP20151190T1 (hr) 2016-01-01
IL278914A (en) 2021-01-31
TW201028143A (en) 2010-08-01
ES2810823T3 (es) 2021-03-09
LUC00183I2 (pt) 2024-07-01
KR101347919B1 (ko) 2014-01-07
ZA201103863B (en) 2012-10-31
FR25C1012I1 (fr) 2025-06-13
FI4098256T3 (fi) 2025-03-31
EP3677260A1 (en) 2020-07-08
PE20120337A1 (es) 2012-04-24
NO2020038I1 (no) 2020-11-18
JP2022103194A (ja) 2022-07-07
CR20110274A (es) 2011-07-19
PT3409274T (pt) 2019-12-17
US20200330407A1 (en) 2020-10-22
JP2019167360A (ja) 2019-10-03
ES2552823T3 (es) 2015-12-02
CY2020036I2 (el) 2021-06-25
CU20110136A7 (es) 2012-01-31
PL4098256T3 (pl) 2025-06-09
RS59857B1 (sr) 2020-02-28
CY1116990T1 (el) 2017-04-05
ES2760607T3 (es) 2020-05-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]