BRPI0923176A8 - sal de hemifumarato de ácido 1-[4-[1-(4-ciclo-hexil-3 trifluorometilbenzilóxi-imino)-etil]-2etil-benzil]-azetidina-3-carboxílio. - Google Patents

sal de hemifumarato de ácido 1-[4-[1-(4-ciclo-hexil-3 trifluorometilbenzilóxi-imino)-etil]-2etil-benzil]-azetidina-3-carboxílio.

Info

Publication number: BRPI0923176A8
Authority: BR; Brazil
Prior art keywords: ethyl; trifluoromethylbenzyloxy; azetidine; imino; cyclohexyl
Prior art date: 2008-12-18

Application number

BRPI0923176A

Other languages

English (en)

Inventor

Vogel Caspar

Riegert Christian

Ciszewski Lech

De La Cruz Marilyn

Mutz Michael

H Karpinki Piotr

Schneeberger Ricardo

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-18

Filing date

2009-12-16

Publication date

2017-09-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42236293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0923176(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-12-16 Application filed by Novartis Ag filed Critical Novartis Ag

2016-02-16 Publication of BRPI0923176A2 publication Critical patent/BRPI0923176A2/pt

2017-09-12 Publication of BRPI0923176A8 publication Critical patent/BRPI0923176A8/pt

2020-12-01 Publication of BRPI0923176B1 publication Critical patent/BRPI0923176B1/pt

2021-05-25 Publication of BRPI0923176B8 publication Critical patent/BRPI0923176B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0923176A 2008-12-18 2009-12-16 forma cristalina do sal de hemifumarato de ácido 1-(4-{1-[(e)- 4-ciclo-hexil-3-trifluormetil-benzilóxi-imino]-etil}-2- etil-benzil)-azetidina-3-carboxílico e composição farmaceutica BRPI0923176B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20305308P	2008-12-18	2008-12-18
US61/203,053		2008-12-18
PCT/US2009/068143 WO2010080409A1 (en)	2008-12-18	2009-12-16	Hemifumarate salt of 1- [4- [1- ( 4 -cyclohexyl-3 -trifluoromethyl-benzyloxyimino ) -ethyl] -2 -ethyl-benzyl] -a zetidine-3-carboxylic acid

Publications (4)

Publication Number	Publication Date
BRPI0923176A2 BRPI0923176A2 (pt)	2016-02-16
BRPI0923176A8 true BRPI0923176A8 (pt)	2017-09-12
BRPI0923176B1 BRPI0923176B1 (pt)	2020-12-01
BRPI0923176B8 BRPI0923176B8 (pt)	2021-05-25

Family

ID=42236293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0923176A BRPI0923176B8 (pt)	2008-12-18	2009-12-16	forma cristalina do sal de hemifumarato de ácido 1-(4-{1-[(e)- 4-ciclo-hexil-3-trifluormetil-benzilóxi-imino]-etil}-2- etil-benzil)-azetidina-3-carboxílico e composição farmaceutica

Country Status (36)

Country	Link
US (7)	US20120115840A1 (pt)
EP (2)	EP2676953B1 (pt)
JP (1)	JP5627597B2 (pt)
KR (5)	KR101885052B1 (pt)
CN (2)	CN104803902A (pt)
AR (3)	AR074694A1 (pt)
AU (1)	AU2009335924B2 (pt)
BR (1)	BRPI0923176B8 (pt)
CA (2)	CA2951479A1 (pt)
CL (1)	CL2011001490A1 (pt)
CO (1)	CO6390104A2 (pt)
CY (2)	CY1114662T1 (pt)
DK (2)	DK2379497T3 (pt)
EC (1)	ECSP11011210A (pt)
ES (2)	ES2436197T3 (pt)
HK (1)	HK1159631A1 (pt)
HR (2)	HRP20131106T1 (pt)
HU (1)	HUE034819T2 (pt)
IL (3)	IL294514A (pt)
JO (1)	JO2894B1 (pt)
LT (1)	LT2676953T (pt)
MA (1)	MA32961B1 (pt)
MX (1)	MX2011006609A (pt)
MY (1)	MY152669A (pt)
NZ (1)	NZ593061A (pt)
PE (2)	PE20142374A1 (pt)
PL (2)	PL2676953T3 (pt)
PT (2)	PT2676953T (pt)
RS (2)	RS56110B1 (pt)
RU (1)	RU2518114C3 (pt)
SG (1)	SG171785A1 (pt)
SI (2)	SI2676953T1 (pt)
TW (2)	TWI591055B (pt)
UY (1)	UY32330A (pt)
WO (1)	WO2010080409A1 (pt)
ZA (1)	ZA201103709B (pt)

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US11958805B2 (en) *	2017-03-09	2024-04-16	Novartis Ag	Solid forms comprising an oxime ether compound, compositions and methods of use thereof
US11629124B2 (en)	2017-03-09	2023-04-18	Novartis Ag	Solid forms comprising an oxime ether compound, compositions and methods of use thereof
US11434200B2 (en)	2017-03-09	2022-09-06	Novartis Ag	Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
JP7271517B2 (ja) *	2017-09-27	2023-05-11	ノバルティスアーゲー	シポニモドを含む非経口製剤
CN111405897A (zh)	2017-09-27	2020-07-10	雷迪博士实验室有限公司	辛波莫德、其盐及其固态形式的制备方法
AU2018341154A1 (en)	2017-09-29	2020-03-12	Novartis Ag	Dosing regimen of siponimod
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JP7604387B2 (ja)	2019-03-28	2024-12-23	ファースト・バイオセラピューティクス・インコーポレイテッド	ベンゾチアゾール化合物の薬学的塩、多形体及びその製造方法
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WO2021240547A2 (en) *	2020-05-29	2021-12-02	Cipla Limited	Methods for the preparation of sphingosine 1-phosphate receptor modulators and solid forms thereof
CN116456977A (zh) *	2020-09-25	2023-07-18	斯索恩有限公司	西尼莫德盐和共晶
US20240010616A1 (en) *	2020-09-25	2024-01-11	Synthon B.V.	Siponimod salts and cocrystals
CN112402610A (zh) *	2020-11-20	2021-02-26	睿阜隆(杭州)生物医药有限公司	1-磷酸鞘氨醇受体调节剂在制备治疗糖尿病的药物中的新用途
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2009
- 2009-12-16 JP JP2011542351A patent/JP5627597B2/ja active Active
- 2009-12-16 ES ES09793413T patent/ES2436197T3/es active Active
- 2009-12-16 KR KR1020187000381A patent/KR101885052B1/ko active Active
- 2009-12-16 HU HUE13177190A patent/HUE034819T2/en unknown
- 2009-12-16 CN CN201510102280.1A patent/CN104803902A/zh active Pending
- 2009-12-16 PL PL13177190T patent/PL2676953T3/pl unknown
- 2009-12-16 MY MYPI20112413 patent/MY152669A/en unknown
- 2009-12-16 CA CA2951479A patent/CA2951479A1/en not_active Abandoned
- 2009-12-16 DK DK09793413.7T patent/DK2379497T3/da active
- 2009-12-16 MX MX2011006609A patent/MX2011006609A/es active IP Right Grant
- 2009-12-16 PT PT131771909T patent/PT2676953T/pt unknown
- 2009-12-16 UY UY0001032330A patent/UY32330A/es not_active Application Discontinuation
- 2009-12-16 BR BRPI0923176A patent/BRPI0923176B8/pt active IP Right Grant
- 2009-12-16 CA CA2747437A patent/CA2747437C/en active Active
- 2009-12-16 AU AU2009335924A patent/AU2009335924B2/en active Active
- 2009-12-16 KR KR1020167013818A patent/KR20160064245A/ko not_active Ceased
- 2009-12-16 KR KR1020167030350A patent/KR20160129915A/ko not_active Ceased
- 2009-12-16 EP EP13177190.9A patent/EP2676953B1/en active Active
- 2009-12-16 SI SI200931675A patent/SI2676953T1/sl unknown
- 2009-12-16 WO PCT/US2009/068143 patent/WO2010080409A1/en active Application Filing
- 2009-12-16 US US13/140,478 patent/US20120115840A1/en not_active Abandoned
- 2009-12-16 MA MA34008A patent/MA32961B1/fr unknown
- 2009-12-16 RU RU2011129222A patent/RU2518114C3/ru active Protection Beyond IP Right Term
- 2009-12-16 EP EP09793413.7A patent/EP2379497B1/en active Active
- 2009-12-16 IL IL294514A patent/IL294514A/en unknown
- 2009-12-16 AR ARP090104917A patent/AR074694A1/es not_active Application Discontinuation
- 2009-12-16 SG SG2011036886A patent/SG171785A1/en unknown
- 2009-12-16 DK DK13177190.9T patent/DK2676953T3/en active
- 2009-12-16 NZ NZ593061A patent/NZ593061A/xx unknown
- 2009-12-16 IL IL253845A patent/IL253845B/en unknown
- 2009-12-16 RS RS20170599A patent/RS56110B1/sr unknown
- 2009-12-16 ES ES13177190.9T patent/ES2631203T3/es active Active
- 2009-12-16 CN CN2009801512748A patent/CN102256943A/zh active Pending
- 2009-12-16 RS RS20130510A patent/RS53041B/en unknown
- 2009-12-16 KR KR1020117016548A patent/KR20110096584A/ko not_active Application Discontinuation
- 2009-12-16 SI SI200930750T patent/SI2379497T1/sl unknown
- 2009-12-16 LT LTEP13177190.9T patent/LT2676953T/lt unknown
- 2009-12-16 PE PE2014001111A patent/PE20142374A1/es not_active Application Discontinuation
- 2009-12-16 KR KR1020177014691A patent/KR20170062554A/ko not_active Ceased
- 2009-12-16 PT PT97934137T patent/PT2379497E/pt unknown
- 2009-12-16 PL PL09793413T patent/PL2379497T3/pl unknown
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- 2009-12-17 TW TW103142662A patent/TWI591055B/zh active
- 2009-12-17 JO JO2009488A patent/JO2894B1/en active
- 2009-12-17 TW TW098143443A patent/TWI500603B/zh active
2011
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- 2011-05-23 IL IL213071A patent/IL213071A0/en unknown
- 2011-06-17 CL CL2011001490A patent/CL2011001490A1/es unknown
- 2011-06-23 CO CO11079284A patent/CO6390104A2/es not_active Application Discontinuation
- 2011-07-15 EC EC2011011210A patent/ECSP11011210A/es unknown
2012
- 2012-01-09 HK HK12100216.4A patent/HK1159631A1/xx unknown
2013
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- 2013-11-20 HR HRP20131106AT patent/HRP20131106T1/hr unknown
- 2013-11-20 CY CY20131101026T patent/CY1114662T1/el unknown
2015
- 2015-03-03 US US14/636,248 patent/US20150175536A1/en not_active Abandoned
2017
- 2017-06-14 HR HRP20170916TT patent/HRP20170916T1/hr unknown
- 2017-06-22 CY CY20171100669T patent/CY1119037T1/el unknown
- 2017-10-31 US US15/799,235 patent/US20180118678A1/en not_active Abandoned
2018
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2020
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2021
- 2021-03-22 AR ARP210100712A patent/AR121635A2/es unknown
2022
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2024
- 2024-02-06 US US18/434,514 patent/US20240239743A1/en active Pending

Also Published As

Publication number	Publication date
US20210323915A1 (en)	2021-10-21
IL213071A0 (en)	2011-07-31
EP2676953A1 (en)	2013-12-25
ES2631203T3 (es)	2017-08-29
TWI500603B (zh)	2015-09-21
KR101885052B1 (ko)	2018-08-02
CN104803902A (zh)	2015-07-29
HRP20170916T1 (hr)	2017-09-22
HUE034819T2 (en)	2018-02-28
AR121635A2 (es)	2022-06-22
WO2010080409A1 (en)	2010-07-15
KR20180006492A (ko)	2018-01-17
US20180118678A1 (en)	2018-05-03
MA32961B1 (fr)	2012-01-02
MY152669A (en)	2014-10-31
US20150175536A1 (en)	2015-06-25
RU2518114C2 (ru)	2014-06-10
MX2011006609A (es)	2011-06-30
HRP20131106T1 (hr)	2013-12-20
PT2676953T (pt)	2017-06-29
TW201509909A (zh)	2015-03-16
DK2676953T3 (en)	2017-07-03
PT2379497E (pt)	2013-11-29
BRPI0923176B1 (pt)	2020-12-01
PE20120336A1 (es)	2012-04-30
CA2747437C (en)	2018-08-21
US20220402870A1 (en)	2022-12-22
JP2012512881A (ja)	2012-06-07
KR20160129915A (ko)	2016-11-09
IL253845B (en)	2022-08-01
SI2379497T1 (sl)	2013-12-31
US20230357142A9 (en)	2023-11-09
LT2676953T (lt)	2017-06-26
US20140005162A1 (en)	2014-01-02
DK2379497T3 (da)	2013-11-25
ECSP11011210A (es)	2011-08-31
RS56110B1 (sr)	2017-10-31
CL2011001490A1 (es)	2012-01-13
SG171785A1 (en)	2011-07-28
AR112227A2 (es)	2019-10-02
CA2747437A1 (en)	2010-07-15
PE20142374A1 (es)	2015-01-30
KR20160064245A (ko)	2016-06-07
RS53041B (en)	2014-04-30
CY1114662T1 (el)	2016-10-05
AR074694A1 (es)	2011-02-02
JO2894B1 (en)	2015-09-15
UY32330A (es)	2010-07-30
US20240239743A1 (en)	2024-07-18
CN102256943A (zh)	2011-11-23
IL294514A (en)	2022-09-01
CO6390104A2 (es)	2012-02-29
SI2676953T1 (sl)	2017-07-31
AU2009335924B2 (en)	2012-11-08
NZ593061A (en)	2013-08-30
AU2009335924A1 (en)	2011-06-30
EP2676953B1 (en)	2017-03-22
KR20110096584A (ko)	2011-08-30
TWI591055B (zh)	2017-07-11
CY1119037T1 (el)	2018-01-10
ES2436197T3 (es)	2013-12-27
PL2676953T3 (pl)	2017-09-29
KR20170062554A (ko)	2017-06-07
BRPI0923176B8 (pt)	2021-05-25
HK1159631A1 (pt)	2012-08-03
BRPI0923176A2 (pt)	2016-02-16
IL253845A0 (en)	2017-09-28
CA2951479A1 (en)	2010-07-15
EP2379497A1 (en)	2011-10-26
JP5627597B2 (ja)	2014-11-19
EP2379497B1 (en)	2013-08-21
US20120115840A1 (en)	2012-05-10
RU2011129222A (ru)	2013-01-27
PL2379497T3 (pl)	2014-01-31
TW201035048A (en)	2010-10-01
ZA201103709B (en)	2012-01-25
RU2518114C3 (ru)	2021-11-24

Publication	Publication Date	Title
BRPI0923176A8 (pt)	2017-09-12	sal de hemifumarato de ácido 1-[4-[1-(4-ciclo-hexil-3 trifluorometilbenzilóxi-imino)-etil]-2etil-benzil]-azetidina-3-carboxílio.
GB201108086D0 (en)	2011-06-29	Financial data comparsion tool
BRPI0722082A2 (pt)	2014-04-01	Ligantes para imagiologia da inervação cardíaca
DK2342663T3 (da)	2015-06-08	Distribueret datalagring
EP2304619A4 (en)	2011-08-10	RECOMMENDATION OF CORRELATED INFORMATION
EP2334170A4 (en)	2012-05-30	IMPROVED KÖDERBLEI FOR FISHING
GB201010785D0 (en)	2010-08-11	Data storage
BRPI0908346A2 (pt)	2019-09-24	beteria
FR2933381B1 (fr)	2016-03-18	Distributeur a tete amovible.
GB0811503D0 (en)	2008-07-30	Document access monitoring
HK1157041A1 (zh)	2012-06-22	鈔票存放器
ZA201003031B (en)	2011-10-26	4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid-465
IT1391060B1 (it)	2011-11-18	Metodo e macchina per la verifica di contenitori.
IL210380A0 (en)	2011-03-31	Event-based assistance data delivery
ITMI20061804A1 (it)	2008-03-23	Passerella di accesso per imbarcazioni in titanio
FR2939829B1 (fr)	2011-07-01	Store type venitien.
FR2932363B1 (fr)	2010-09-10	Abreuvoir pour le betail
GB0809846D0 (en)	2008-07-09	Fishing rig storage unit
ITBS20080160A1 (it)	2010-02-28	Coprizoccolo per cavalli
CN301015239S (zh)	2009-09-16	牙刷保存盒(医生)
GB0813174D0 (en)	2008-08-27	Asset monitoring system
ITRM20080071A1 (it)	2009-08-08	Scatola per bobine cinematografiche.
GB0909808D0 (en)	2009-07-22	Data storage
ITMC20080004U1 (it)	2009-08-08	Cavalletto per prosciutto.
ES1062094Y (es)	2006-08-01	Carrete desmontable.

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2020-03-10	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-03-17	B06U	Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
2020-08-04	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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