BRPI0922981A8 - método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae - Google Patents
método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae Download PDFInfo
- Publication number
- BRPI0922981A8 BRPI0922981A8 BRPI0922981A BRPI0922981A8 BR PI0922981 A8 BRPI0922981 A8 BR PI0922981A8 BR PI0922981 A BRPI0922981 A BR PI0922981A BR PI0922981 A8 BRPI0922981 A8 BR PI0922981A8
- Authority
- BR
- Brazil
- Prior art keywords
- streptococcus pneumoniae
- fermentation culture
- molecular weight
- weight control
- addition
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 229920001282 polysaccharide Polymers 0.000 title abstract 5
- 239000005017 polysaccharide Substances 0.000 title abstract 5
- 241000193998 Streptococcus pneumoniae Species 0.000 title abstract 4
- 229940031000 streptococcus pneumoniae Drugs 0.000 title abstract 4
- 238000004260 weight control Methods 0.000 title abstract 2
- 238000000855 fermentation Methods 0.000 abstract 7
- 230000004151 fermentation Effects 0.000 abstract 7
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
"método para o controle do peso molecular de polissacarídeo para o sorotipo 19a de streptococcus pneumoniae". a presente invenção refere-se a métodos melhorados para a produção de uma solução contendo polissacarídeos capsulares 19a de streptococcus pneumoniae isolado de alto peso molecular. em certos métodos, uma cultura de fermentação de células bacterianas de streptococcus pneumoniae que produzem polissacarídeos capsulares para o sorotipo 19a é fermentada durante menos do que 6 horas antes das células bacterianas serem submetidas à lise e os polissacarídeos capsulares são colhidos. em outros métodos, co2 é fornecido à cultura de fermentação. o fornecimento de co2 à cultura de fermentação inclui a adição de íons de bicarbonato na cultura de fermentação, a adição de íons de carbonato na cultura de fermentação, a adição de misturas de íons de bicarbonato e carbonato na cultura de fermentação, e sobreposição da cultura de fermentação com co2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13856308P | 2008-12-18 | 2008-12-18 | |
| PCT/US2009/068429 WO2010080486A2 (en) | 2008-12-18 | 2009-12-17 | Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0922981A2 BRPI0922981A2 (pt) | 2015-08-25 |
| BRPI0922981A8 true BRPI0922981A8 (pt) | 2019-11-26 |
Family
ID=42266457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0922981-7 BRPI0922981A8 (pt) | 2008-12-18 | 2009-12-17 | método para o controle do peso molecular polissacarídeo para o sorotipo 19a de streptococcus pneumoniae |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8795689B2 (pt) |
| EP (1) | EP2379734B1 (pt) |
| JP (1) | JP5843612B2 (pt) |
| KR (2) | KR20110091546A (pt) |
| CN (1) | CN102257155B (pt) |
| AU (1) | AU2009335826B2 (pt) |
| BR (1) | BRPI0922981A8 (pt) |
| CA (1) | CA2743710C (pt) |
| DK (1) | DK2379734T3 (pt) |
| ES (1) | ES2666698T3 (pt) |
| HK (1) | HK1163750A1 (pt) |
| HU (1) | HUE037465T2 (pt) |
| IL (1) | IL213169A (pt) |
| MX (1) | MX2011006432A (pt) |
| PL (1) | PL2379734T3 (pt) |
| PT (1) | PT2379734T (pt) |
| RU (1) | RU2511404C2 (pt) |
| SI (1) | SI2379734T1 (pt) |
| WO (1) | WO2010080486A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2385981T1 (sl) * | 2008-12-18 | 2019-11-29 | Wyeth Llc | Postopek za nadzorovanje molekulske mase polisaharida streptococcus pneumoniae z uporabo ogljika |
| DK2424562T3 (en) | 2009-04-30 | 2015-12-07 | Coley Pharm Group Inc | Pneumococcal vaccine and uses thereof |
| US9249439B2 (en) | 2011-12-15 | 2016-02-02 | Serum Institute Of India Ltd. | Process of cultivating bacteria for yield improvement of capsular polyoses |
| BR112015005081B1 (pt) | 2012-09-07 | 2021-10-26 | Sk Bioscience Co., Ltd. | Método para produzir um polissacarídeo capsular tendo um sorotipo de pneumococo |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| MX2019007910A (es) | 2016-12-30 | 2019-12-05 | Sutrovax Inc | Conjugados de polipeptido-antigeno con aminoacidos no naturales. |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| US11090374B2 (en) | 2017-02-24 | 2021-08-17 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of Streptococcus pneumoniae polysaccharide-protein conjugates |
| KR102634811B1 (ko) | 2017-06-10 | 2024-02-06 | 인벤트프라이즈 인크. | 면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신 |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| CN111065387B (zh) | 2017-09-07 | 2023-08-25 | 默沙东有限责任公司 | 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途 |
| CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| EP3720483A2 (en) | 2017-12-06 | 2020-10-14 | Merck Sharp&Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| KR20190121713A (ko) * | 2018-04-18 | 2019-10-28 | 에스케이바이오사이언스(주) | 스트렙토코커스 뉴모니애 협막 다당류 및 그의 면역원성 접합체 |
| CN112074293A (zh) | 2018-04-30 | 2020-12-11 | 默沙东公司 | 生产肺炎链球菌荚膜多糖载体蛋白缀合物的方法 |
| JP7489324B2 (ja) | 2018-04-30 | 2024-05-23 | メルク・シャープ・アンド・ドーム・エルエルシー | リオスフィアから肺炎連鎖球菌莢膜多糖類キャリアタンパク質コンジュゲートを生産する方法 |
| JP7397000B2 (ja) | 2018-04-30 | 2023-12-12 | メルク・シャープ・アンド・ドーム・エルエルシー | 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法 |
| US20220296695A1 (en) | 2018-12-19 | 2022-09-22 | Merck Sharp & Dohme Corp. | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| US12053515B2 (en) | 2020-08-10 | 2024-08-06 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24F |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1115210A (en) | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4221906A (en) | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
| US4242501A (en) | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US4686102A (en) | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| US5314822A (en) * | 1992-10-15 | 1994-05-24 | Merck & Co., Inc. | Method of clonal growth of Streptococcus pneumoniae |
| US5714354A (en) | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| DK1268844T3 (da) * | 2000-03-16 | 2009-11-16 | Philadelphia Children Hospital | Modulering af fremstilling af pneumococcus kapselformigt polysaccharid |
| US6743610B2 (en) | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| ITTS20010013A1 (it) | 2001-06-04 | 2002-12-04 | Ct Ricerche Poly Tec H A R L S | Nuovi derivati di ialuronano. |
| SI1664319T1 (sl) | 2003-09-11 | 2010-06-30 | An Vws De Staat Der Nederlande | Postopek za pripravo kapsularnega polisaharida zauporabo v konjugatnih vakcinah |
| KR102220506B1 (ko) | 2005-04-08 | 2021-03-02 | 와이어쓰 엘엘씨 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| DK3466982T3 (da) * | 2005-04-08 | 2020-08-03 | Wyeth Llc | Separation af forurenende kontaminanter fra streptococcus pneumoniae-polysaccharid ved ph-manipulation |
| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| RU2460539C2 (ru) | 2006-10-10 | 2012-09-10 | Вайет | СПОСОБ ОЧИСТКИ ПОЛИСАХАРИДОВ Streptococcus pneumoniae 3 ТИПА (ВАРИАНТЫ) |
| US7860500B2 (en) * | 2006-10-27 | 2010-12-28 | Motorola, Inc. | Method and apparatus for determining appropriate channels for communication |
| CL2008000831A1 (es) * | 2007-03-23 | 2008-07-04 | Wyeth Corp | Procesos para extraer exceso de proteina soluble e impurezas a partir de lisados celulares de serotipos de streptococcus pneumoniae utilizados en la produccion de polisacaridos neumococales. |
| SI2385981T1 (sl) | 2008-12-18 | 2019-11-29 | Wyeth Llc | Postopek za nadzorovanje molekulske mase polisaharida streptococcus pneumoniae z uporabo ogljika |
-
2009
- 2009-12-17 ES ES09795862.3T patent/ES2666698T3/es active Active
- 2009-12-17 DK DK09795862.3T patent/DK2379734T3/en active
- 2009-12-17 CA CA2743710A patent/CA2743710C/en active Active
- 2009-12-17 AU AU2009335826A patent/AU2009335826B2/en active Active
- 2009-12-17 WO PCT/US2009/068429 patent/WO2010080486A2/en active Application Filing
- 2009-12-17 EP EP09795862.3A patent/EP2379734B1/en active Active
- 2009-12-17 KR KR1020117013836A patent/KR20110091546A/ko not_active Ceased
- 2009-12-17 RU RU2011128564/10A patent/RU2511404C2/ru active
- 2009-12-17 PT PT97958623T patent/PT2379734T/pt unknown
- 2009-12-17 SI SI200931830T patent/SI2379734T1/en unknown
- 2009-12-17 PL PL09795862T patent/PL2379734T3/pl unknown
- 2009-12-17 US US12/640,769 patent/US8795689B2/en active Active
- 2009-12-17 MX MX2011006432A patent/MX2011006432A/es active IP Right Grant
- 2009-12-17 JP JP2011542425A patent/JP5843612B2/ja active Active
- 2009-12-17 CN CN200980150879.5A patent/CN102257155B/zh active Active
- 2009-12-17 HU HUE09795862A patent/HUE037465T2/hu unknown
- 2009-12-17 BR BRPI0922981-7 patent/BRPI0922981A8/pt not_active Application Discontinuation
- 2009-12-17 KR KR1020137031507A patent/KR101593770B1/ko active Active
-
2011
- 2011-05-26 IL IL213169A patent/IL213169A/en active IP Right Grant
-
2012
- 2012-04-24 HK HK12104021.1A patent/HK1163750A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK2379734T3 (en) | 2018-04-23 |
| WO2010080486A2 (en) | 2010-07-15 |
| KR20110091546A (ko) | 2011-08-11 |
| WO2010080486A3 (en) | 2010-11-04 |
| KR101593770B1 (ko) | 2016-02-15 |
| US8795689B2 (en) | 2014-08-05 |
| KR20130136011A (ko) | 2013-12-11 |
| US20100158953A1 (en) | 2010-06-24 |
| CA2743710C (en) | 2017-01-24 |
| SI2379734T1 (en) | 2018-05-31 |
| IL213169A (en) | 2015-02-26 |
| JP2012512660A (ja) | 2012-06-07 |
| RU2011128564A (ru) | 2013-01-27 |
| PT2379734T (pt) | 2018-04-27 |
| EP2379734A2 (en) | 2011-10-26 |
| MX2011006432A (es) | 2011-09-29 |
| CA2743710A1 (en) | 2010-07-15 |
| EP2379734B1 (en) | 2018-03-21 |
| HK1163750A1 (zh) | 2012-09-14 |
| JP5843612B2 (ja) | 2016-01-13 |
| RU2511404C2 (ru) | 2014-04-10 |
| IL213169A0 (en) | 2011-07-31 |
| HUE037465T2 (hu) | 2018-09-28 |
| AU2009335826A1 (en) | 2010-07-15 |
| CN102257155A (zh) | 2011-11-23 |
| BRPI0922981A2 (pt) | 2015-08-25 |
| PL2379734T3 (pl) | 2018-08-31 |
| CN102257155B (zh) | 2016-03-02 |
| AU2009335826B2 (en) | 2013-10-31 |
| ES2666698T3 (es) | 2018-05-07 |
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Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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Owner name: WYETH LLC (US) |