BRPI0909333A2 - derivado de espiroindolinona - Google Patents
derivado de espiroindolinonaInfo
- Publication number
- BRPI0909333A2 BRPI0909333A2 BRPI0909333A BRPI0909333A BRPI0909333A2 BR PI0909333 A2 BRPI0909333 A2 BR PI0909333A2 BR PI0909333 A BRPI0909333 A BR PI0909333A BR PI0909333 A BRPI0909333 A BR PI0909333A BR PI0909333 A2 BRPI0909333 A2 BR PI0909333A2
- Authority
- BR
- Brazil
- Prior art keywords
- spiroindolinone
- derivative
- spiroindolinone derivative
- compounds
- general formulas
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3779908P | 2008-03-19 | 2008-03-19 | |
| PCT/EP2009/052737 WO2009115425A1 (en) | 2008-03-19 | 2009-03-09 | Spiroindolinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0909333A2 true BRPI0909333A2 (pt) | 2019-09-24 |
Family
ID=40595697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0909333A BRPI0909333A2 (pt) | 2008-03-19 | 2009-03-09 | derivado de espiroindolinona |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7723372B2 (pt) |
| EP (1) | EP2265583B1 (pt) |
| JP (1) | JP2011515353A (pt) |
| KR (1) | KR20100121521A (pt) |
| CN (1) | CN101977898A (pt) |
| AT (1) | ATE528290T1 (pt) |
| AU (1) | AU2009226866A1 (pt) |
| BR (1) | BRPI0909333A2 (pt) |
| CA (1) | CA2716979A1 (pt) |
| ES (1) | ES2373857T3 (pt) |
| IL (1) | IL208025A0 (pt) |
| MX (1) | MX2010009927A (pt) |
| WO (1) | WO2009115425A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2499145B1 (en) | 2009-11-12 | 2016-01-27 | The Regents Of The University Of Michigan | Spiro-oxindole mdm2 antagonists |
| JP2014500870A (ja) | 2010-11-12 | 2014-01-16 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン | スピロ−オキシインドールｍｄｍ２アンタゴニスト |
| CN103635473B (zh) | 2011-03-10 | 2016-08-17 | 第一三共株式会社 | 二螺吡咯烷衍生物 |
| CN102180828A (zh) * | 2011-03-31 | 2011-09-14 | 四川大学 | 手性吲哚啉酮螺五环骨架化合物及不对称合成 |
| MX346375B (es) | 2011-05-11 | 2017-03-16 | Univ Michigan Regents | Antagonistas de espiro-oxindol de mdm2. |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| CN103172555B (zh) * | 2012-12-07 | 2014-07-09 | 山东绿叶制药有限公司 | 升麻中分离的吲哚生物碱化合物、制备方法及其用途 |
| EP3458101B1 (en) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac antibody conjugates and methods of use |
| EP3511334A1 (en) * | 2018-01-16 | 2019-07-17 | Adamed sp. z o.o. | 1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5114937A (en) * | 1989-11-28 | 1992-05-19 | Warner-Lambert Company | Renin inhibiting nonpeptides |
| FR2740136B1 (fr) | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
| GB9819860D0 (en) * | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
| JP5248866B2 (ja) * | 2005-02-22 | 2013-07-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | Ｍｄｍ２の小分子阻害剤およびその使用 |
| US7495007B2 (en) * | 2006-03-13 | 2009-02-24 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US20070213341A1 (en) * | 2006-03-13 | 2007-09-13 | Li Chen | Spiroindolinone derivatives |
| US7638548B2 (en) * | 2006-11-09 | 2009-12-29 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US20080188506A1 (en) | 2007-02-07 | 2008-08-07 | Qingjie Ding | Spiroindolinone derivatives |
| US7553833B2 (en) | 2007-05-17 | 2009-06-30 | Hoffmann-La Roche Inc. | 3,3-spiroindolinone derivatives |
| US7834179B2 (en) | 2007-05-23 | 2010-11-16 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
-
2009
- 2009-02-18 US US12/372,926 patent/US7723372B2/en not_active Expired - Fee Related
- 2009-03-09 ES ES09722134T patent/ES2373857T3/es active Active
- 2009-03-09 JP JP2011500149A patent/JP2011515353A/ja active Pending
- 2009-03-09 WO PCT/EP2009/052737 patent/WO2009115425A1/en active Application Filing
- 2009-03-09 CA CA2716979A patent/CA2716979A1/en not_active Abandoned
- 2009-03-09 BR BRPI0909333A patent/BRPI0909333A2/pt not_active IP Right Cessation
- 2009-03-09 AT AT09722134T patent/ATE528290T1/de not_active IP Right Cessation
- 2009-03-09 MX MX2010009927A patent/MX2010009927A/es active IP Right Grant
- 2009-03-09 AU AU2009226866A patent/AU2009226866A1/en not_active Abandoned
- 2009-03-09 CN CN2009801094982A patent/CN101977898A/zh active Pending
- 2009-03-09 EP EP09722134A patent/EP2265583B1/en not_active Not-in-force
- 2009-03-09 KR KR1020107021030A patent/KR20100121521A/ko not_active Ceased
-
2010
- 2010-09-06 IL IL208025A patent/IL208025A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2716979A1 (en) | 2009-09-24 |
| US20090239889A1 (en) | 2009-09-24 |
| JP2011515353A (ja) | 2011-05-19 |
| US7723372B2 (en) | 2010-05-25 |
| MX2010009927A (es) | 2010-09-30 |
| ATE528290T1 (de) | 2011-10-15 |
| KR20100121521A (ko) | 2010-11-17 |
| WO2009115425A1 (en) | 2009-09-24 |
| ES2373857T3 (es) | 2012-02-09 |
| AU2009226866A1 (en) | 2009-09-24 |
| IL208025A0 (en) | 2010-12-30 |
| EP2265583B1 (en) | 2011-10-12 |
| CN101977898A (zh) | 2011-02-16 |
| EP2265583A1 (en) | 2010-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |