BRPI0906436A2 - Derivados de ftalazinona - Google Patents
Derivados de ftalazinonaInfo
- Publication number
- BRPI0906436A2 BRPI0906436A2 BRPI0906436-2A BRPI0906436A BRPI0906436A2 BR PI0906436 A2 BRPI0906436 A2 BR PI0906436A2 BR PI0906436 A BRPI0906436 A BR PI0906436A BR PI0906436 A2 BRPI0906436 A2 BR PI0906436A2
- Authority
- BR
- Brazil
- Prior art keywords
- phthalazinone derivatives
- phthalazinone
- derivatives
- Prior art date
Links
- IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical class C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2290008P | 2008-01-23 | 2008-01-23 | |
| US14241309P | 2009-01-05 | 2009-01-05 | |
| PCT/GB2009/000181 WO2009093032A1 (en) | 2008-01-23 | 2009-01-23 | Phthalazinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0906436A2 true BRPI0906436A2 (pt) | 2015-07-14 |
Family
ID=40510546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0906436-2A BRPI0906436A2 (pt) | 2008-01-23 | 2009-01-23 | Derivados de ftalazinona |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8129380B2 (pt) |
| EP (1) | EP2231638A1 (pt) |
| JP (1) | JP2011510056A (pt) |
| KR (1) | KR20100116187A (pt) |
| CN (1) | CN101925595A (pt) |
| AR (1) | AR070221A1 (pt) |
| AU (1) | AU2009207498A1 (pt) |
| BR (1) | BRPI0906436A2 (pt) |
| CA (1) | CA2708175A1 (pt) |
| CL (1) | CL2009000133A1 (pt) |
| CO (1) | CO6290715A2 (pt) |
| DO (1) | DOP2010000219A (pt) |
| EA (1) | EA201070523A1 (pt) |
| EC (1) | ECSP10010349A (pt) |
| IL (1) | IL206026A0 (pt) |
| MX (1) | MX2010006364A (pt) |
| NI (1) | NI201000120A (pt) |
| NZ (1) | NZ585982A (pt) |
| PE (1) | PE20091335A1 (pt) |
| SV (1) | SV2010003625A (pt) |
| TW (1) | TW200936577A (pt) |
| UY (1) | UY31603A1 (pt) |
| WO (1) | WO2009093032A1 (pt) |
| ZA (1) | ZA201003752B (pt) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006240730A1 (en) * | 2005-04-21 | 2006-11-02 | Nippon Shinyaku Co., Ltd. | Phthalazinone derivative and pharmaceutical comprising the same |
| GB0521373D0 (en) * | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| ES2383969T3 (es) * | 2006-01-16 | 2012-06-27 | Ube Industries, Ltd. | Compuesto de pirrolopiridazinona como inhibidor de PDE4 |
| US20080280910A1 (en) * | 2007-03-22 | 2008-11-13 | Keith Allan Menear | Phthalazinone derivatives |
| TW200900396A (en) * | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
| AR079774A1 (es) | 2009-07-15 | 2012-02-22 | Astrazeneca Ab | Compuesto de ftalazinona como forma cristalina c , composicion farmaceutica y usos del mismo |
| WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
| WO2011058766A1 (en) * | 2009-11-16 | 2011-05-19 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as ttx-s blockers |
| JP2013532683A (ja) | 2010-07-27 | 2013-08-19 | カディラ ヘルスケア リミティド | ポリ（ａｄｐリボース）ポリメラーゼ−１阻害剤としての、置換４−（４−フルオロ−３−（ピペラジン−１−カルボニル）ベンジル）フタラジン−１（２ｈ）−オン誘導体 |
| CN102372706A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| CN102485721B (zh) * | 2010-12-03 | 2015-12-09 | 曹亚 | 取代的2,3-二氮杂萘酮化合物及其用途 |
| CA2875025C (en) | 2011-05-31 | 2021-08-03 | Newgen Therapeutics, Inc. | Tricyclic inhibitors of poly(adp-ribose)polymerase |
| AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| CN103130723B (zh) * | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
| CN102702108A (zh) * | 2012-06-27 | 2012-10-03 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
| CN102863393A (zh) * | 2012-09-26 | 2013-01-09 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
| US9624197B2 (en) * | 2012-11-27 | 2017-04-18 | Merck Sharp & Dohme Corp. | 2-pyridylamino-4-nitrile-piperidinyl orexin receptor antagonists |
| CN104918917A (zh) * | 2012-12-31 | 2015-09-16 | 卡迪拉保健有限公司 | 作为聚(adp-核糖)聚合酶-1的选择性抑制剂的取代的酞嗪-1(2h)-酮衍生物 |
| WO2014137883A1 (en) * | 2013-03-08 | 2014-09-12 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-ether orexin receptor antagonists |
| EP3027598B1 (en) * | 2013-07-31 | 2017-04-12 | Merck Patent GmbH | Oxoquinazolinyl-butanamide derivatives |
| KR101670126B1 (ko) | 2013-09-13 | 2016-10-27 | 일동제약(주) | 신규 프탈라지논 유도체 및 그 제조방법 |
| CN109415345B (zh) * | 2016-06-29 | 2022-01-11 | 豪夫迈·罗氏有限公司 | 基于哒嗪酮的广谱抗流感抑制剂 |
| SMT202000243T1 (it) | 2017-03-20 | 2020-07-08 | Forma Therapeutics Inc | Composizioni di pirrolopirrolo come attivatori di piruvato chinasi (pkr) |
| AU2018260094A1 (en) | 2017-04-28 | 2019-11-07 | Akribes Biomedical Gmbh | A PARP inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
| JP2021516229A (ja) | 2018-02-28 | 2021-07-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 低親和性ポリ（ａｄ−リボース）ポリメラーゼ１依存性細胞毒性剤 |
| CN110577953B (zh) * | 2018-06-11 | 2024-02-20 | 深圳华大生命科学研究院 | 基因突变体及其应用 |
| CN108727338B (zh) * | 2018-07-05 | 2020-12-15 | 福建医科大学 | 一种4-哌啶酮类化合物及其制备方法与应用 |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| CN113166060B (zh) | 2018-09-19 | 2024-01-09 | 诺沃挪第克健康护理股份公司 | 用丙酮酸激酶激活化合物治疗镰状细胞病 |
| CN109748923A (zh) * | 2019-01-31 | 2019-05-14 | 中国药科大学 | 含苯并[4,5]咪唑[1,2-a]吡嗪酮类衍生物及其制备方法与用途 |
| KR20220008869A (ko) * | 2019-05-14 | 2022-01-21 | 누베이션 바이오 인크. | 항암 핵 호르몬 수용체-표적화 화합물 |
| TWI837403B (zh) | 2019-07-19 | 2024-04-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
| CA3151612A1 (en) | 2019-09-19 | 2021-03-25 | George P. Luke | Pyruvate kinase r (pkr) activating compositions |
| TW202131930A (zh) | 2019-11-13 | 2021-09-01 | 美商諾維雪碧歐公司 | 抗癌核荷爾蒙受體標靶化合物 |
| BR112022021321A2 (pt) | 2020-04-21 | 2022-12-20 | Idience Co Ltd | Formas cristalinas do composto de ftalazinona. |
| WO2021214502A1 (en) | 2020-04-21 | 2021-10-28 | Idience Co., Ltd. | Process for preparing a phthalazinone derivative and intermediates thereof |
| US12059419B2 (en) | 2020-10-16 | 2024-08-13 | Idience Co., Ltd. | Pharmaceutical composition comprising phthalazinone derivatives |
| CN112624981B (zh) * | 2021-03-09 | 2021-05-25 | 南京桦冠生物技术有限公司 | 一种2-氟-5-[(4-氧代-3h-2,3-二氮杂萘基)甲基]苯甲酸的制备方法 |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| WO2022204184A1 (en) | 2021-03-23 | 2022-09-29 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| AU2022251588A1 (en) | 2021-04-01 | 2023-10-19 | Transthera Sciences (Nanjing) , Inc. | Method for preparing phosphodiesterase inhibitor |
| JP2024516024A (ja) | 2021-05-03 | 2024-04-11 | ニューベイション・バイオ・インコーポレイテッド | 抗がん核内ホルモン受容体標的化化合物 |
| US20240343727A1 (en) * | 2021-08-17 | 2024-10-17 | InventisBio Co., Ltd. | Pyridazinone or pyridinone compounds, preparation methods and uses thereof |
| TW202430518A (zh) * | 2023-01-06 | 2024-08-01 | 大陸商齊魯製藥有限公司 | Parp7抑制劑的製備方法 |
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-
2009
- 2009-01-21 AR ARP090100183A patent/AR070221A1/es not_active Application Discontinuation
- 2009-01-21 UY UY031603A patent/UY31603A1/es not_active Application Discontinuation
- 2009-01-22 US US12/357,957 patent/US8129380B2/en not_active Expired - Fee Related
- 2009-01-23 JP JP2010543563A patent/JP2011510056A/ja active Pending
- 2009-01-23 CN CN2009801027174A patent/CN101925595A/zh active Pending
- 2009-01-23 AU AU2009207498A patent/AU2009207498A1/en not_active Abandoned
- 2009-01-23 WO PCT/GB2009/000181 patent/WO2009093032A1/en active Application Filing
- 2009-01-23 PE PE2009000100A patent/PE20091335A1/es not_active Application Discontinuation
- 2009-01-23 EA EA201070523A patent/EA201070523A1/ru unknown
- 2009-01-23 TW TW098103128A patent/TW200936577A/zh unknown
- 2009-01-23 MX MX2010006364A patent/MX2010006364A/es not_active Application Discontinuation
- 2009-01-23 CA CA2708175A patent/CA2708175A1/en not_active Abandoned
- 2009-01-23 KR KR1020107017727A patent/KR20100116187A/ko not_active Withdrawn
- 2009-01-23 BR BRPI0906436-2A patent/BRPI0906436A2/pt not_active IP Right Cessation
- 2009-01-23 EP EP09703506A patent/EP2231638A1/en not_active Withdrawn
- 2009-01-23 NZ NZ585982A patent/NZ585982A/en not_active IP Right Cessation
- 2009-01-23 CL CL2009000133A patent/CL2009000133A1/es unknown
-
2010
- 2010-05-26 ZA ZA2010/03752A patent/ZA201003752B/en unknown
- 2010-05-27 IL IL206026A patent/IL206026A0/en unknown
- 2010-07-16 CO CO10087223A patent/CO6290715A2/es not_active Application Discontinuation
- 2010-07-16 EC EC2010010349A patent/ECSP10010349A/es unknown
- 2010-07-16 DO DO2010000219A patent/DOP2010000219A/es unknown
- 2010-07-16 NI NI201000120A patent/NI201000120A/es unknown
- 2010-07-19 SV SV2010003625A patent/SV2010003625A/es not_active Application Discontinuation
-
2012
- 2012-01-30 US US13/361,911 patent/US20120129855A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100116187A (ko) | 2010-10-29 |
| WO2009093032A1 (en) | 2009-07-30 |
| MX2010006364A (es) | 2010-07-05 |
| AR070221A1 (es) | 2010-03-25 |
| CL2009000133A1 (es) | 2010-10-15 |
| NI201000120A (es) | 2011-03-23 |
| ECSP10010349A (es) | 2010-08-31 |
| EA201070523A1 (ru) | 2011-02-28 |
| TW200936577A (en) | 2009-09-01 |
| ZA201003752B (en) | 2011-03-30 |
| US8129380B2 (en) | 2012-03-06 |
| CO6290715A2 (es) | 2011-06-20 |
| AU2009207498A1 (en) | 2009-07-30 |
| EP2231638A1 (en) | 2010-09-29 |
| PE20091335A1 (es) | 2009-10-04 |
| NZ585982A (en) | 2011-12-22 |
| US20120129855A1 (en) | 2012-05-24 |
| JP2011510056A (ja) | 2011-03-31 |
| SV2010003625A (es) | 2011-05-20 |
| UY31603A1 (es) | 2009-08-31 |
| IL206026A0 (en) | 2010-11-30 |
| CA2708175A1 (en) | 2009-07-30 |
| DOP2010000219A (es) | 2010-08-15 |
| US20090192156A1 (en) | 2009-07-30 |
| CN101925595A (zh) | 2010-12-22 |
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