BRPI0823128A2 - Composição farmacêutica de liberação controlada dependente do ph para não opioides com resistência contra a influência de etanol. - Google Patents

Composição farmacêutica de liberação controlada dependente do ph para não opioides com resistência contra a influência de etanol.

Info

Publication number: BRPI0823128A2
Authority: BR; Brazil
Prior art keywords: opioids; ethanol; influence; pharmaceutical composition; controlled release
Prior art date: 2008-09-24

Application number

BRPI0823128-1A

Other languages

English (en)

Inventor

Hans Bär

Thomas Fürst

Gerhard Renner

Michael Gottschalk

Original Assignee

Evonik Roehm Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-24

Filing date

2008-09-24

Publication date

2015-06-16

2008-09-24 Application filed by Evonik Roehm Gmbh filed Critical Evonik Roehm Gmbh

2015-06-16 Publication of BRPI0823128A2 publication Critical patent/BRPI0823128A2/pt

2019-05-07 Publication of BRPI0823128B1 publication Critical patent/BRPI0823128B1/pt

2022-07-05 Publication of BRPI0823128B8 publication Critical patent/BRPI0823128B8/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0823128A 2008-09-24 2008-09-24 composição farmacêutica de liberação controlada dependente do ph para não opioides com resistência contra a influência de etanol, e processo para sua preparação BRPI0823128B8 (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP2008/062767 WO2010034344A1 (en)	2008-09-24	2008-09-24	Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol

Publications (3)

Publication Number	Publication Date
BRPI0823128A2 true BRPI0823128A2 (pt)	2015-06-16
BRPI0823128B1 BRPI0823128B1 (pt)	2019-05-07
BRPI0823128B8 BRPI0823128B8 (pt)	2022-07-05

Family

ID=40756228

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0823128A BRPI0823128B8 (pt)	2008-09-24	2008-09-24	composição farmacêutica de liberação controlada dependente do ph para não opioides com resistência contra a influência de etanol, e processo para sua preparação

Country Status (13)

Country	Link
US (1)	US10933024B2 (pt)
EP (1)	EP2326313B1 (pt)
JP (1)	JP5453434B2 (pt)
KR (1)	KR101535701B1 (pt)
CN (1)	CN102164589A (pt)
BR (1)	BRPI0823128B8 (pt)
CA (1)	CA2738197C (pt)
ES (1)	ES2537622T3 (pt)
IL (1)	IL211305A (pt)
MX (1)	MX2011003050A (pt)
PL (1)	PL2326313T3 (pt)
SI (1)	SI2326313T1 (pt)
WO (1)	WO2010034344A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI2408436T1 (sl)	2009-03-18	2017-06-30	Evonik Roehm Gmbh	Farmacevtski sestavek z nadzorovanim sproščanjem z odpornostjo na vpliv etanola, ki uporablja oplaščenje, ki vsebuje nevtralne vinil polimere in ekscipiente
AU2011252040C1 (en)	2010-05-10	2015-04-02	Euro-Celtique S.A.	Manufacturing of active-free granules and tablets comprising the same
WO2011141490A1 (en)	2010-05-10	2011-11-17	Euro-Celtique S.A.	Combination of active loaded granules with additional actives
SG184523A1 (en)	2010-05-10	2012-11-29	Euro Celtique Sa	Pharmaceutical compositions comprising hydromorphone and naloxone
RU2606588C2 (ru)	2011-06-17	2017-01-10	Эвоник Рем ГмбХ	Композиция покрытия, подходящая для фармацевтических или нутрицевтических дозированных форм
KR101799625B1 (ko)	2011-06-17	2017-11-20	에보니크 룀 게엠베하	제약 또는 기능식품 투여 형태에 적합한 코팅 조성물
JP6099638B2 (ja) *	2011-06-17	2017-03-22	エボニックレームゲゼルシャフトミットベシュレンクテルハフツングＥｖｏｎｉｋＲｏｅｈｍＧｍｂＨ	エタノールの影響に耐性のある胃液抵抗性の医薬又は栄養補助組成物
WO2015023675A2 (en)	2013-08-12	2015-02-19	Pharmaceutical Manufacturing Research Services, Inc.	Extruded immediate release abuse deterrent pill
SG11201602884WA (en)	2013-11-13	2016-05-30	Euro Celtique Sa	Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
US9492444B2 (en)	2013-12-17	2016-11-15	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
US10172797B2 (en)	2013-12-17	2019-01-08	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
AU2015290098B2 (en)	2014-07-17	2018-11-01	Pharmaceutical Manufacturing Research Services, Inc.	Immediate release abuse deterrent liquid fill dosage form
WO2016046817A1 (en) *	2014-09-24	2016-03-31	Vital Beverages Global Inc.	Compositions and methods for selective gi tract delivery
JP2017531026A (ja)	2014-10-20	2017-10-19	ファーマシューティカルマニュファクチュアリングリサーチサービシズ，インコーポレーテッド	徐放性乱用抑止性液体充填剤形
BR112017014953A2 (pt) *	2015-01-12	2018-03-13	Nano Pharmaceutical Laboratories Llc	microglóbulos de liberação controlada em camadas e métodos para produção dos mesmos
US20170042806A1 (en)	2015-04-29	2017-02-16	Dexcel Pharma Technologies Ltd.	Orally disintegrating compositions
US10076494B2 (en)	2016-06-16	2018-09-18	Dexcel Pharma Technologies Ltd.	Stable orally disintegrating pharmaceutical compositions
US20200289423A1 (en)	2017-09-14	2020-09-17	Evonik Operations Gmbh	Polymer and dosage form with sustained release properties and resistance against the influence of ethanol
KR20200130369A (ko)	2018-03-09	2020-11-18	에보니크 오퍼레이션즈 게엠베하	에탄올의 영향에 대한 내성을 갖는 중합체 혼합물
CN114983973B (zh) *	2022-05-31	2023-05-05	石家庄四药有限公司	一种乌拉地尔缓释胶囊及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4996047A (en) *	1988-11-02	1991-02-26	Richardson-Vicks, Inc.	Sustained release drug-resin complexes
FR2655266B1 (fr) *	1989-12-05	1992-04-03	Smith Kline French Lab	Compositions pharmaceutiques a base de cimetidine.
US7374779B2 (en)	1999-02-26	2008-05-20	Lipocine, Inc.	Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US20030118641A1 (en)	2000-07-27	2003-06-26	Roxane Laboratories, Inc.	Abuse-resistant sustained-release opioid formulation
EP1212061B1 (en)	1999-08-27	2004-10-27	Southern Research Institute	Injectable buprenorphine microparticle compositions and their use in reducing consumption of heroin and alcohol
DE10250543A1 (de) *	2002-10-29	2004-05-19	Röhm GmbH & Co. KG	Mehrschichtige Arzneiform
DE102005024614A1 (de) *	2005-05-25	2006-11-30	Röhm Gmbh	Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug
RU2433817C2 (ru) *	2006-01-21	2011-11-20	Эбботт Гмбх Унд Ко.Кг	Лекарственная форма и способ для доставки вызывающих зависимость лекарственных веществ
DK2719378T3 (en) *	2006-06-19	2016-10-17	Alpharma Pharmaceuticals Llc	pharmaceutical compositions
DE102006051020A1 (de)	2006-10-26	2008-04-30	Evonik Röhm Gmbh	Verwendung von (Meth)acrylat-Copolymeren in Retard-Arzneiformen zur Verringerung des Einflusses von Ethanol auf die Wirkstofffreisetzung
EP2187875B1 (en)	2007-09-21	2012-09-05	Evonik Röhm GmbH	Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol
PL2187876T3 (pl)	2007-09-21	2013-01-31	Evonik Roehm Gmbh	Farmaceutyczna kompozycja opioidowa o zależnym od pH kontrolowanym uwalnianiu z odpornością przed wpływem etanolu

2008
- 2008-09-24 CN CN2008801312249A patent/CN102164589A/zh active Pending
- 2008-09-24 EP EP08804672.7A patent/EP2326313B1/en active Active
- 2008-09-24 JP JP2011528192A patent/JP5453434B2/ja not_active Expired - Fee Related
- 2008-09-24 ES ES08804672.7T patent/ES2537622T3/es active Active
- 2008-09-24 KR KR1020117006639A patent/KR101535701B1/ko not_active Expired - Fee Related
- 2008-09-24 BR BRPI0823128A patent/BRPI0823128B8/pt not_active IP Right Cessation
- 2008-09-24 WO PCT/EP2008/062767 patent/WO2010034344A1/en active Application Filing
- 2008-09-24 CA CA2738197A patent/CA2738197C/en not_active Expired - Fee Related
- 2008-09-24 US US13/120,112 patent/US10933024B2/en not_active Expired - Fee Related
- 2008-09-24 PL PL08804672T patent/PL2326313T3/pl unknown
- 2008-09-24 SI SI200831431T patent/SI2326313T1/sl unknown
- 2008-09-24 MX MX2011003050A patent/MX2011003050A/es active IP Right Grant
2011
- 2011-02-20 IL IL211305A patent/IL211305A/en active IP Right Grant

Also Published As

Publication number	Publication date
KR101535701B1 (ko)	2015-07-09
BRPI0823128B1 (pt)	2019-05-07
US20110229562A1 (en)	2011-09-22
CA2738197C (en)	2016-01-05
EP2326313B1 (en)	2015-03-04
SI2326313T1 (sl)	2015-06-30
HK1211491A1 (en)	2016-05-27
IL211305A0 (en)	2011-04-28
ES2537622T3 (es)	2015-06-10
US10933024B2 (en)	2021-03-02
CA2738197A1 (en)	2010-04-01
MX2011003050A (es)	2011-04-11
CN102164589A (zh)	2011-08-24
PL2326313T3 (pl)	2015-08-31
EP2326313A1 (en)	2011-06-01
WO2010034344A1 (en)	2010-04-01
IL211305A (en)	2015-01-29
KR20110058836A (ko)	2011-06-01
JP5453434B2 (ja)	2014-03-26
BRPI0823128B8 (pt)	2022-07-05
JP2012503609A (ja)	2012-02-09

Publication	Publication Date	Title
BRPI0823128A2 (pt)	2015-06-16	Composição farmacêutica de liberação controlada dependente do ph para não opioides com resistência contra a influência de etanol.
BRPI0823096A2 (pt)	2015-06-16	Composição de opioide farmacêutica de liberação controlada, dependente do ph, com resistência contra a influência do etanol
PL2187875T3 (pl)	2013-01-31	Kompozycja farmaceutyczna o zależnym od pH kontrolowanym uwalnianiu dla nieopioidów z odpornością przed wpływem etanolu
SI2187876T1 (sl)	2012-12-31	Od pH odvisen opioidni farmacevtski sestavek z nadzorovanim sproĹˇÄŤanjem z odpornostjo na vpliv etanola
BRPI0814687A2 (pt)	2015-01-20	MÉTODO IN VITRO PARA INIBIR UM MEMBRO DA FAMÍLIA GTPase DE Rho, COMPOSTO, E, COMPOSIÇÃO FARMACÊUTICA.
BRPI0815709A2 (pt)	2017-06-13	composro, composição farmacêutica, e, uso de um composto.
BRPI1007018A2 (pt)	2016-03-29	composto, composição farmacêutica, e , uso de um composto.
BRPI0819218A2 (pt)	2015-05-05	Métodos, estojos e composições para administração de compostos farmacêuticos
BRPI1008906A2 (pt)	2016-03-15	composto, composição farmacêutica, e, uso de um composto.
DK2345410T3 (da)	2021-02-01	Farmaceutisk sammensætning til modificeret frigivelse
BRPI0907562A2 (pt)	2017-05-23	composto, composição farmacêutica, e, uso de um composto
BRPI1014700A2 (pt)	2016-04-12	composição de revestimento e método para a fabricação e uso da mesma.
BRPI0916689A2 (pt)	2015-11-17	composição farmacêutica estabilizada, preparação sólida, e, métodos para estabilizar uma composição farmacêutica, e para estabilizar uma preparação sólida.
BRPI0917579A2 (pt)	2016-10-11	composto, composição farmacêutica, métodos, e, uso de um composto
BRPI0818459A2 (pt)	2015-04-14	Composição farmacêutica adequada para uso oftálmico.
BRPI0813600A2 (pt)	2015-09-22	formatação de pulso para egprs-2
DK2108260T3 (da)	2013-07-08	Sammensætning med biocid aktivitet til vandige præparater
BRPI0822026A2 (pt)	2014-10-07	Prepação farmacêutica ou nutracêutica revestida com liberação acentuada de substância ativa no cólon.
BRPI0809661A2 (pt)	2014-10-14	Composição farmacêutica estabilizada contendo pregabalina
BRPI1009757A2 (pt)	2016-03-15	composto, composição farmacêutica, e , uso de um composto.
BRPI0822206A2 (pt)	2015-06-23	Formulação líquida para deferiprona com um sabor agradável.
BRPI0906937A2 (pt)	2016-04-19	composto, composição farmacêutica, e, uso de um composto
BRPI0922341A2 (pt)	2016-01-12	composição farmacêutica revestida em fusão com liberação rápida.
BRPI0915473A2 (pt)	2015-11-10	composto, composição farmacêutica, e, uso de um composto
BRPI0814261A2 (pt)	2014-10-21	Micor-organismos termofílicos para produção de etanol

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-07-03	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-12-04	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2019-03-06	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-05-07	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 07/05/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 07/05/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/09/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2022-05-24	B25D	Requested change of name of applicant approved	Owner name: ROEHM GMBH (DE)
2022-06-07	B25G	Requested change of headquarter approved	Owner name: ROEHM GMBH (DE)
2022-06-21	B25A	Requested transfer of rights approved	Owner name: EVONIK DEGUSSA GMBH (DE)
2022-07-05	B25D	Requested change of name of applicant approved	Owner name: EVONIK OPERATIONS GMBH (DE)
2023-07-18	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 15A ANUIDADE.
2023-10-31	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2741 DE 18-07-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.