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BRPI0812909A2 - Derivados de guanina policíclica e métodos de uso dos mesmos. - Google Patents

Derivados de guanina policíclica e métodos de uso dos mesmos.

Info

Publication number
BRPI0812909A2
BRPI0812909A2 BRPI0812909-6A2A BRPI0812909A BRPI0812909A2 BR PI0812909 A2 BRPI0812909 A2 BR PI0812909A2 BR PI0812909 A BRPI0812909 A BR PI0812909A BR PI0812909 A2 BRPI0812909 A2 BR PI0812909A2
Authority
BR
Brazil
Prior art keywords
policyclic
methods
guanine derivatives
guanine
derivatives
Prior art date
Application number
BRPI0812909-6A2A
Other languages
English (en)
Inventor
Deen Tulshian
Willaim B Geiss
Gregory S Martin
Duc Van Le
James C Haber
Julius J Matasi
Michael F Czarniecki
Stephanie Nicole Cooke
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BRPI0812909A2 publication Critical patent/BRPI0812909A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0812909-6A2A 2007-06-21 2008-06-18 Derivados de guanina policíclica e métodos de uso dos mesmos. BRPI0812909A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94545207P 2007-06-21 2007-06-21
PCT/US2008/007592 WO2009002423A2 (en) 2007-06-21 2008-06-18 Polycyclic guanine derivatives and use thereof

Publications (1)

Publication Number Publication Date
BRPI0812909A2 true BRPI0812909A2 (pt) 2014-12-09

Family

ID=40186205

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812909-6A2A BRPI0812909A2 (pt) 2007-06-21 2008-06-18 Derivados de guanina policíclica e métodos de uso dos mesmos.

Country Status (17)

Country Link
US (1) US8349858B2 (pt)
EP (1) EP2170896A2 (pt)
JP (1) JP2010530427A (pt)
KR (1) KR20100023040A (pt)
AR (1) AR067060A1 (pt)
AU (1) AU2008269177A1 (pt)
BR (1) BRPI0812909A2 (pt)
CA (1) CA2691194A1 (pt)
CL (1) CL2008001835A1 (pt)
CO (1) CO6251257A2 (pt)
EC (1) ECSP099822A (pt)
IL (1) IL202754A0 (pt)
MX (1) MX2010000098A (pt)
PE (1) PE20090418A1 (pt)
RU (1) RU2010101611A (pt)
TW (1) TW200911817A (pt)
WO (1) WO2009002423A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2523561A4 (en) * 2009-12-22 2013-06-05 Merck Sharp & Dohme 7,8-DIHYDRO-1H-IMIDAZO [2,1-B] PURINE-4 (5H) -ONE DERIVATIVES AND METHOD OF USE
US8691832B2 (en) * 2010-12-06 2014-04-08 Merck Sharp & Dohme Corp. Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
JP6263469B2 (ja) 2011-07-15 2018-01-17 ノバルティス アーゲー アザ二環式ジ−アリールエーテルの塩およびその製造方法またはその前駆体の製造方法
EP2797933B1 (en) * 2011-12-30 2017-08-16 Dow AgroSciences LLC Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same
HUE052275T2 (hu) * 2013-01-28 2021-04-28 Incozen Therapeutics Pvt Ltd Eljárások autoimmun, légzõszervi és gyulladásos rendellenességek kezelésére roflumilaszt N-oxid inhalálásával
WO2014152589A1 (en) 2013-03-14 2014-09-25 Janssen Pharmaceutica Nv P2x7 modulators
JP6467404B2 (ja) * 2013-03-14 2019-02-13 ヤンセン ファーマシューティカ エヌ．ベー． Ｐ２ｘ７モジュレーター
TWI599567B (zh) 2013-03-14 2017-09-21 健生藥品公司 Ｐ２ｘ７調節劑
JO3509B1 (ar) 2013-03-14 2020-07-05 Janssen Pharmaceutica Nv معدلات p2x7
EP3191488B1 (en) 2014-09-12 2019-08-14 Janssen Pharmaceutica NV P2x7 modulating n-acyl-triazolopyrazines
JP6592510B2 (ja) 2014-09-12 2019-10-16 ヤンセン ファーマシューティカ エヌ．ベー． Ｐ２ｘ７調節因子
DK3287443T3 (da) 2015-04-24 2022-02-07 Shionogi & Co 6-leddet heterocyklisk derivat og farmaceutisk sammensætning, som omfatter dette
CA3039458A1 (en) * 2016-10-17 2018-04-26 Shionogi & Co., Ltd. Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same
TW202035409A (zh) 2018-09-28 2020-10-01 比利時商健生藥品公司 單醯基甘油脂肪酶調節劑
JOP20210058A1 (ar) 2018-09-28 2021-03-24 Janssen Pharmaceutica Nv مُعدلات ليباز أُحادِيُّ الجلِيسِريد
AU2020358948A1 (en) 2019-09-30 2022-05-26 Janssen Pharmaceutica Nv Radiolabelled MGL PET ligands
CN115335378B (zh) 2020-03-26 2025-03-04 詹森药业有限公司 单酰基甘油脂肪酶调节剂

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0119372A1 (en) 1983-03-21 1984-09-26 Svecia Silkscreen Maskiner AB Conveying device using a number of rollers
ZA914727B (en) * 1990-06-21 1992-03-25 Schering Corp Polycyclic guanine derivatives
CA2156918A1 (en) * 1993-02-26 1994-09-01 Deen Tulshian 2-benzyl-polycyclic guanine derivatives and process for preparing them
JPH10501122A (ja) 1994-05-27 1998-02-03 グラクソ、グループ、リミテッド Ｐ▲下２ｘ▼レセプター（プリノセプターファミリー）
US5856129A (en) 1996-10-30 1999-01-05 Incyte Pharmaceuticals, Inc. DNA encoding a human purinoceptor
WO1999055901A2 (en) 1998-04-30 1999-11-04 Abbott Laboratories Screening assay for identifying human purinoreceptor ligands
JP2004530100A (ja) 2000-10-13 2004-09-30 ブリストル−マイヤーズ　スクイブ　カンパニー タリウム（ｉ）感受性アッセイを用いるイオンチャネル調節剤の検出方法
US20020182646A1 (en) 2001-04-30 2002-12-05 Ke Huazhu Methods and products for identifying modulators of P2X7 receptor activity, and their use in the treatment of skeletal disorders
MXPA04001891A (es) * 2001-08-28 2004-06-15 Schering Corp Inhibidores policiclicos de guanina fosfodiesterasa v.
US20050238650A1 (en) 2002-04-17 2005-10-27 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
JP2005509038A (ja) * 2001-11-09 2005-04-07 シェーリング　コーポレイション 多環式グアニン誘導体ホスホジエステラーゼｖ阻害剤
US7560243B2 (en) 2003-04-21 2009-07-14 Wisconsin Alumni Research Foundation White blood cell functional assay
GB0323147D0 (en) 2003-10-03 2003-11-05 Medical Res Council Improvements in or relating to concentration of intracellular agents
EP2305258A3 (en) 2005-05-31 2011-07-06 Duska Scientific Co Inhibition of neuronal damage
WO2007115192A2 (en) 2006-03-31 2007-10-11 Abbott Laboratories P2x7 antagonists to treat affective disorders

Also Published As

Publication number Publication date
ECSP099822A (es) 2010-01-29
US20110065738A1 (en) 2011-03-17
RU2010101611A (ru) 2011-07-27
WO2009002423A3 (en) 2009-04-23
KR20100023040A (ko) 2010-03-03
TW200911817A (en) 2009-03-16
MX2010000098A (es) 2010-04-21
EP2170896A2 (en) 2010-04-07
AU2008269177A1 (en) 2008-12-31
JP2010530427A (ja) 2010-09-09
CL2008001835A1 (es) 2008-12-26
CO6251257A2 (es) 2011-02-21
IL202754A0 (en) 2010-06-30
PE20090418A1 (es) 2009-04-18
US8349858B2 (en) 2013-01-08
CA2691194A1 (en) 2008-12-31
WO2009002423A2 (en) 2008-12-31
AR067060A1 (es) 2009-09-30

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]