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BRPI0711481A8 - derivados radiomarcados de dihidrotetrabenzeno e seu uso como agente de imagens - Google Patents

derivados radiomarcados de dihidrotetrabenzeno e seu uso como agente de imagens

Info

Publication number
BRPI0711481A8
BRPI0711481A8 BRPI0711481A BRPI0711481A BRPI0711481A8 BR PI0711481 A8 BRPI0711481 A8 BR PI0711481A8 BR PI0711481 A BRPI0711481 A BR PI0711481A BR PI0711481 A BRPI0711481 A BR PI0711481A BR PI0711481 A8 BRPI0711481 A8 BR PI0711481A8
Authority
BR
Brazil
Prior art keywords
derivatives
dihydrotetrabenzene
radiolabeled
imaging agents
imaging
Prior art date
Application number
BRPI0711481A
Other languages
English (en)
Inventor
M Skovronsky Daniel
F Kung Hank
Kung Mei-Ping
Kilbourn Michael
Original Assignee
Univ Michigan Regents
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan Regents, Univ Pennsylvania filed Critical Univ Michigan Regents
Publication of BRPI0711481A2 publication Critical patent/BRPI0711481A2/pt
Publication of BRPI0711481A8 publication Critical patent/BRPI0711481A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

derivados radiomarcados de diidro-tetrabenazina e seu uso como agente de imagens. este invento se refere a um método de imagem de transportadores vesiculares de monoamina e a compostos marcados e composições farmacêuticas deles, e métodos de tornar os compostos marcados úteis para obter imagem de transportadores vesiculares de monoamina. este invento também se refere a compostos e métodos de monitorar a progressão de uma doença relacionada com os transportadores vesiculares de monoamina.
BRPI0711481A 2006-05-02 2007-05-01 derivados radiomarcados de dihidrotetrabenzeno e seu uso como agente de imagens BRPI0711481A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79651806P 2006-05-02 2006-05-02
US60/796,518 2006-05-02
US90811607P 2007-03-26 2007-03-26
US60/908,116 2007-03-26
PCT/US2007/010478 WO2007130365A2 (en) 2006-05-02 2007-05-01 Radiolabeled dihydrotetrabenazine derivatives and their use as imaging agents

Publications (2)

Publication Number Publication Date
BRPI0711481A2 BRPI0711481A2 (pt) 2011-11-16
BRPI0711481A8 true BRPI0711481A8 (pt) 2017-11-28

Family

ID=38668238

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0711481A BRPI0711481A8 (pt) 2006-05-02 2007-05-01 derivados radiomarcados de dihidrotetrabenzeno e seu uso como agente de imagens

Country Status (19)

Country Link
US (1) US8562949B2 (pt)
EP (2) EP2604290A3 (pt)
JP (1) JP5392622B2 (pt)
KR (1) KR101429302B1 (pt)
CN (1) CN101484190B (pt)
AU (1) AU2007248764B2 (pt)
BR (1) BRPI0711481A8 (pt)
CA (1) CA2650904C (pt)
DK (1) DK2012833T3 (pt)
ES (1) ES2525932T3 (pt)
IL (1) IL195044A (pt)
MX (1) MX2008014064A (pt)
NO (1) NO341065B1 (pt)
PL (1) PL2012833T3 (pt)
PT (1) PT2012833E (pt)
SI (1) SI2012833T1 (pt)
TW (1) TWI432214B (pt)
WO (1) WO2007130365A2 (pt)
ZA (1) ZA200810200B (pt)

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US7897768B2 (en) 2007-06-08 2011-03-01 General Electric Company Method for making tetrabenazine compounds
US7897770B2 (en) 2007-10-25 2011-03-01 General Electric Company Fluorinated dihydrotetrabenazine ether imaging agents and probes
WO2009055520A2 (en) * 2007-10-25 2009-04-30 General Electric Company Fluorinated dihydrotetrabenazine ether imaging agents and probes
US7897769B2 (en) 2007-10-25 2011-03-01 General Electric Company Intermediates for fluorinated dihydrotetrabenazine ether imaging agents and probes
EP2211911A4 (en) * 2007-10-31 2012-11-14 Alseres Pharmaceuticals Inc METHOD FOR DIAGNOSIS AND MONITORING OF THE TREATMENT OF LEWY BODILY DAMAGE BY EVALUATING THE DOPAMIN TRANSPORTER MIRROR
US7902364B2 (en) 2007-11-29 2011-03-08 General Electric Company Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US7910738B2 (en) 2007-11-29 2011-03-22 General Electric Company Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes
US8053578B2 (en) * 2007-11-29 2011-11-08 General Electric Company Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes
US8013161B1 (en) 2007-12-07 2011-09-06 General Electric Company Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes
US7919622B2 (en) 2007-12-07 2011-04-05 Kande Kankanamalage Dayarathna Amarasinghe Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
ES2896678T3 (es) 2008-09-18 2022-02-25 Auspex Pharmaceuticals Inc Derivados deuterados de benzoquinolina como inhibidores del transportador de monoamina vesicular 2
JP5273571B2 (ja) * 2009-03-19 2013-08-28 国立大学法人京都大学 膵島イメージング用分子プローブ前駆体及びその使用
CN102120742B (zh) * 2010-01-08 2013-03-13 中国药科大学 一种丁苯那嗪的制备方法
EP2394668A1 (en) * 2010-06-01 2011-12-14 Julius-Maximilians-Universität Würzburg PET radiopharmaceuticals for differential diagnosis between bilateral and unilateral conditions of primary hyperaldosteronism
AU2011261551B2 (en) 2010-06-01 2016-10-20 Auspex Pharmaceutical, Inc. Benzoquinolone inhibitors of VMAT2
CN101985446B (zh) * 2010-06-10 2012-05-30 江苏省原子医学研究所 一种(±)-9-O-去甲基-α-二氢丁苯那嗪合成方法
WO2012121746A2 (en) * 2011-03-09 2012-09-13 The General Hospital Corporation Imaging beta cell mass
CN102260255B (zh) * 2011-07-07 2013-07-10 江苏省原子医学研究所 一种9,10-二甲氧基-1,3,4,6,7,11b-六氢-3-异丁基-2H-苯并[a]喹嗪-2-酮的简便合成方法
IN2015DN01662A (pt) 2012-09-18 2015-07-03 Auspex Pharmaceuticals Inc
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
CN102936246A (zh) * 2012-11-08 2013-02-20 江苏暨明医药科技有限公司 丁苯那嗪的合成方法
US20160068526A1 (en) 2013-01-31 2016-03-10 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
WO2015048370A1 (en) * 2013-09-27 2015-04-02 Auspex Pharmaceuticals, Inc. Benzoquinolone inhibitors of vmat2
MX2016006622A (es) * 2013-11-22 2016-12-09 Auspex Pharmaceuticals Inc Metodos para tratar actividad muscular anormal.
WO2015077521A1 (en) * 2013-11-22 2015-05-28 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
JP6542222B2 (ja) 2013-12-03 2019-07-10 オースペックス ファーマシューティカルズ インコーポレイテッド ベンゾキノリン化合物の製造方法
WO2015112707A1 (en) 2014-01-27 2015-07-30 Auspex Pharmaceuticals, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
CA2938244A1 (en) 2014-02-07 2015-08-13 Auspex Pharamaceuticals, Inc. Novel pharmaceutical formulations
CN114796209A (zh) 2015-03-06 2022-07-29 奥斯拜客斯制药有限公司 氘代丁苯那嗪或包含氘代丁苯那嗪的组合物
AR106313A1 (es) 2015-10-09 2018-01-03 Teva Pharmaceuticals Int Gmbh Combinación de levodopa deuterada con carbidopa y opicapona para el tratamiento de enfermedad de parkinson
TW201906818A (zh) 2017-05-31 2019-02-16 美商５１１製藥公司 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用
CN108912118A (zh) * 2018-07-12 2018-11-30 新乡学院 一种四氢异喹啉并三嗪骨架化合物及其制备方法
JP2022547390A (ja) * 2019-08-12 2022-11-14 シャンドン ルイ ファーマシューティカル カンパニー リミテッド Ｖｍａｔ２阻害剤、及びその調製方法、及びその使用
CN111320620A (zh) * 2020-03-17 2020-06-23 四川大学华西医院 一种异喹啉并哒嗪酮类化合物及其合成方法和应用
TW202304901A (zh) 2021-03-22 2023-02-01 美商紐羅克里生物科學有限公司 Vmat2抑制劑及其使用方法
CN114288419B (zh) * 2021-12-30 2023-08-18 中山大学附属第八医院（深圳福田） 一种利福平纳米递药系统的制备及其在防治帕金森病方面的应用
CN115536705B (zh) * 2022-09-23 2024-09-06 江苏省原子医学研究所 靶向ii型囊泡单胺转运体分子探针及其制备方法和应用

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Also Published As

Publication number Publication date
MX2008014064A (es) 2009-06-12
AU2007248764B2 (en) 2013-08-01
CA2650904C (en) 2015-07-07
CA2650904A1 (en) 2007-11-15
EP2604290A3 (en) 2013-07-10
EP2012833A4 (en) 2011-06-29
IL195044A (en) 2013-08-29
ES2525932T3 (es) 2015-01-02
JP5392622B2 (ja) 2014-01-22
US20080050312A1 (en) 2008-02-28
KR101429302B1 (ko) 2014-08-11
KR20090007781A (ko) 2009-01-20
IL195044A0 (en) 2011-08-01
PL2012833T3 (pl) 2015-05-29
TWI432214B (zh) 2014-04-01
US8562949B2 (en) 2013-10-22
EP2604290A2 (en) 2013-06-19
JP2009535403A (ja) 2009-10-01
DK2012833T3 (en) 2015-01-19
CN101484190B (zh) 2011-07-20
ZA200810200B (en) 2012-02-29
TW200810783A (en) 2008-03-01
EP2012833B1 (en) 2014-10-29
AU2007248764A1 (en) 2007-11-15
CN101484190A (zh) 2009-07-15
EP2012833A2 (en) 2009-01-14
NO341065B1 (no) 2017-08-14
NO20085004L (no) 2009-02-02
PT2012833E (pt) 2014-12-23
WO2007130365A2 (en) 2007-11-15
WO2007130365A3 (en) 2008-11-27
BRPI0711481A2 (pt) 2011-11-16
SI2012833T1 (sl) 2015-03-31

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements