[go: up one dir, main page]

BRPI0609392B8 - substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso - Google Patents

substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso

Info

Publication number
BRPI0609392B8
BRPI0609392B8 BRPI0609392A BRPI0609392A BRPI0609392B8 BR PI0609392 B8 BRPI0609392 B8 BR PI0609392B8 BR PI0609392 A BRPI0609392 A BR PI0609392A BR PI0609392 A BRPI0609392 A BR PI0609392A BR PI0609392 B8 BRPI0609392 B8 BR PI0609392B8
Authority
BR
Brazil
Prior art keywords
multilayer structure
substitute
osteochondral
cartilaginous
relates
Prior art date
Application number
BRPI0609392A
Other languages
English (en)
Inventor
Tampieri Anna
De Luca Claudio
Pressato Daniele
Landi Elena
Di Fede Sergio
Original Assignee
Fin Ceram Faenza Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fin Ceram Faenza Spa filed Critical Fin Ceram Faenza Spa
Publication of BRPI0609392A2 publication Critical patent/BRPI0609392A2/pt
Publication of BRPI0609392B1 publication Critical patent/BRPI0609392B1/pt
Publication of BRPI0609392B8 publication Critical patent/BRPI0609392B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/102Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24Collagen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/26Mixtures of macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/30Inorganic materials
    • A61L27/32Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Road Paving Structures (AREA)
  • Furnace Housings, Linings, Walls, And Ceilings (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Feedback Control In General (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Laminated Bodies (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Packages (AREA)

Abstract

substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso. trata-se de uma estrutura de camadas múltiplas (1) que inclui uma primeira camada superior (2), que consiste em uma matriz orgânica incluindo colágeno e pelo menos uma camada inferior (3, 4, ..., 10), que consiste em uma matriz composta incluindo hidroxiapatita e colágeno. além disso, a presente invenção se refere a um substituto cartilaginoso incluindo a referida estrutura de múltiplas camadas (1) assim como um substituto osteocondral incluindo a referida estrutura de camadas múltiplas (1). finalmente, a presente invenção se refere ao uso da referida estrutura de múltiplas camadas (1) para o preparo do referido substituto cartilaginoso e do referido substituto osteocondral para o tratamento de defeitos cartilaginosos e de defeitos osteocondrais ou para a neoformação de um tecido cartilaginoso e/ou de um tecido ósseo subcondral.
BRPI0609392A 2005-03-04 2006-03-02 substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso BRPI0609392B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000343A ITMI20050343A1 (it) 2005-03-04 2005-03-04 Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego
ITMI2005A000343 2005-03-04
PCT/IB2006/000452 WO2006092718A2 (en) 2005-03-04 2006-03-02 Cartilaginiform and osteochondral sustitute comprising a multilayer structure and use thereof

Publications (3)

Publication Number Publication Date
BRPI0609392A2 BRPI0609392A2 (pt) 2010-03-30
BRPI0609392B1 BRPI0609392B1 (pt) 2018-05-29
BRPI0609392B8 true BRPI0609392B8 (pt) 2021-06-22

Family

ID=36917317

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609392A BRPI0609392B8 (pt) 2005-03-04 2006-03-02 substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso

Country Status (13)

Country Link
US (1) US9155818B2 (pt)
EP (1) EP1858562B1 (pt)
JP (1) JP5289772B2 (pt)
CN (1) CN101163512B (pt)
AT (1) ATE447986T1 (pt)
BR (1) BRPI0609392B8 (pt)
CA (1) CA2600893C (pt)
DE (1) DE602006010341D1 (pt)
DK (1) DK1858562T3 (pt)
ES (1) ES2336359T3 (pt)
IT (1) ITMI20050343A1 (pt)
WO (1) WO2006092718A2 (pt)
ZA (1) ZA200707511B (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43714E1 (en) 1999-12-15 2012-10-02 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
GB2424223C (en) * 2005-03-07 2011-02-02 Massachusetts Inst Technology Biomaterial.
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
EP1964583A1 (en) 2007-02-09 2008-09-03 Royal College of Surgeons in Ireland Process for producing a collagen/hydroxyapatite composite scaffold
EP2389204B1 (en) 2009-01-23 2019-07-03 Royal College of Surgeons in Ireland Layered scaffold suitable for osteochondral repair
CA2754501A1 (en) * 2009-03-05 2010-09-10 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
JP5545563B2 (ja) * 2009-09-08 2014-07-09 利江 土屋 軟骨用移植材
IT1396934B1 (it) 2009-11-25 2012-12-20 Fin Ceramica Faenza Spa Materiali bio-mimetici compositi, relativo processo di preparazione e loro uso per la realizzazione di strutture mono-, bi- o multi-strato per la rigenerazione di tessuto osseo, cartilagineo o osteocartilagineo
US11786636B2 (en) * 2010-06-15 2023-10-17 Versitech Limited Methods for complex tissue engineering
WO2011163669A2 (en) * 2010-06-25 2011-12-29 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
WO2012017045A1 (de) * 2010-08-04 2012-02-09 Technische Universität Dresden Wachstumsinhibierter hydroxylapatit, verfahren zu dessen herstellung und verwendung
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
ITMI20102070A1 (it) 2010-11-08 2012-05-09 Consiglio Nazionale Ricerche Impianti per sostituzioni ossee "load bearing" ad architettura gerarchicamente organizzata derivante dalla trasformazione di strutture vegetali
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
KR101375828B1 (ko) * 2011-03-31 2014-03-17 인제대학교 산학협력단 골-연골 재생용 복합 지지체, 이의 제조 방법 및 이를 유효성분으로 함유하는 골-연골 질환 치료용 조성물
EP2786770B1 (en) * 2011-08-30 2017-04-19 Kyoto University Porous scaffold material, and method for producing same
JP6018477B2 (ja) * 2011-11-11 2016-11-02 Hoya株式会社 人工骨−軟骨複合体及びその製造方法
EP2788171B1 (de) 2011-12-08 2021-02-17 Stuckensen, Kai Herstellung anisotrop strukturierter werkstoffe
US10576694B2 (en) 2011-12-08 2020-03-03 Julius-Maximilians-Universitaet Wuerzburg Production of materials having an anisotropic structure
CN102580156B (zh) * 2012-03-29 2014-10-08 陕西博鸿生物科技有限公司 一种组织工程软骨支架材料及其制备方法和装置
CN103920190B (zh) * 2013-01-14 2017-09-29 陕西博鸿生物科技集团有限公司 一种关节软骨移植物及其制备方法
ITMI20130636A1 (it) 2013-04-18 2014-10-19 Novagenit S R L Metodo per la preparazione di biomateriali biocompatibili e biodegradabili a base di collagene e granuli di idrossiapatite/¿-tricalcio fosfato per uso in chirurgia ortopedica e biomateriali così ottenuti
EP2826495A1 (en) 2013-07-19 2015-01-21 Geistlich Pharma AG Biomimetic collagen-hydroxyapatite composite material
KR20150053606A (ko) * 2013-11-08 2015-05-18 세원셀론텍(주) 콜라겐과 히알루론산의 천연가교를 통한 고무성질의 물성이 강화된 생체재료물질 및 그 제조방법
CN104324418B (zh) * 2014-10-27 2016-04-06 东华大学 一种组织工程纳米纤维骨软骨修复支架及其制备方法
CN104307047B (zh) * 2014-10-29 2017-02-01 中国科学院长春应用化学研究所 一种双梯度仿生修复支架及其制备方法
CN106139255A (zh) * 2015-04-17 2016-11-23 天津市赛宁生物工程技术有限公司 一种胶原蛋白结合磷酸钙的医用海绵支架的新型材料和制备方法
CN106806940A (zh) * 2015-12-02 2017-06-09 中国科学院大连化学物理研究所 一种掺杂纳米羟基磷灰石的多孔仿生骨支架的制备方法
EP3175869A1 (en) * 2015-12-04 2017-06-07 Geistlich Pharma AG Resorbable crosslinked formstable membrane
WO2018047785A1 (ja) * 2016-09-07 2018-03-15 ナガセケムテックス株式会社 コラーゲン様ポリペプチド
IT201600094601A1 (it) 2016-09-21 2018-03-21 Fin Ceram Faenza S P A “apparecchiatura e kit per la realizzazione di fori a profondità controllata e di diverso diametro su superfici condrali ed osteocondrali”
EP3409303A1 (en) * 2017-06-02 2018-12-05 Geistlich Pharma AG Use of a resorbable crosslinked form stable composition for preparing a membrane
CN107669371B (zh) * 2017-08-02 2018-08-03 中南大学湘雅医院 三相组织工程支架
CN107789668B (zh) * 2017-11-03 2020-10-27 华中科技大学同济医学院附属协和医院 具有多层结构的仿生胶原蛋白骨修复材料及其制备方法
CN108355174A (zh) * 2018-05-06 2018-08-03 西北工业大学 一种多功能分层关节软骨支架的制备方法
WO2020120805A2 (en) 2018-12-14 2020-06-18 Institut Químic De Sarrià Cets Fundació Privada Heterogeneous scaffolds and methods of functionalising surfaces
CN109628387A (zh) * 2018-12-28 2019-04-16 广州赛莱拉干细胞科技股份有限公司 组合物、含有该组合物的分化诱导培养液及诱导方法
CN110368529B (zh) * 2019-08-19 2021-08-31 江苏地韵医疗科技有限公司 软骨或软骨下骨全层修复支架及其制备方法
US11633879B2 (en) 2020-01-21 2023-04-25 United States Government As Represented By The Department Of Veterans Affairs Anatomic tissue-engineered osteochondral implant and method for fabrication thereof
CN111330080B (zh) * 2020-03-31 2021-12-07 江苏白衣缘生物工程有限公司 一种引导口腔骨再生的生物膜及其制备方法
CN111375088B (zh) * 2020-04-29 2022-06-14 陕西巨子生物技术有限公司 双层骨软骨组织修复支架及其制备方法
CA3194691A1 (en) * 2020-11-05 2022-05-12 Ran Kapri Multi-layered collagen structure
CN113559329A (zh) * 2021-09-03 2021-10-29 北京大学口腔医学院 一种仿牙周有序双层结构支架材料及其制备方法和应用
CN114732957B (zh) * 2022-03-16 2022-12-23 武汉理工大学 一种具有预应力的矿化肌腱复合材料及其制备方法与应用
SK1172022A3 (sk) 2022-12-05 2024-06-19 Ústav materiálového výskumu Slovenskej akadémie vied, verejná výskumná inštitúcia Kompozitný biocementový systém

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3082503B2 (ja) * 1993-02-26 2000-08-28 株式会社神戸製鋼所 人工骨製造用前駆体および人工骨の製法
US6117979A (en) * 1997-08-18 2000-09-12 Medtronic, Inc. Process for making a bioprosthetic device and implants produced therefrom
GB9727048D0 (en) * 1997-12-22 1998-02-18 Abonetics Ltd Process for the preparation of magnesium and carbonate substituted hydroxyapatite
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
CN1169494C (zh) * 2001-05-23 2004-10-06 中国科学院化学研究所 组织工程用复合结构细胞支架及其制法和用途
US6626950B2 (en) * 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
GB0121985D0 (en) * 2001-09-11 2001-10-31 Isis Innovation Tissue engineering scaffolds
US7163965B2 (en) * 2002-05-01 2007-01-16 Japan Science And Technology Agency Process for producing porous composite materials
JP4416152B2 (ja) * 2003-03-28 2010-02-17 独立行政法人物質・材料研究機構 生体組織補填材とその製造方法
EP1642599B1 (en) * 2003-05-26 2010-12-01 HOYA Corporation Porous composite containing calcium phosphate and process for producing the same
US20050074877A1 (en) * 2003-07-28 2005-04-07 Mao Jeremy Jian Biological engineering of articular structures containing both cartilage and bone
US7217294B2 (en) * 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof

Also Published As

Publication number Publication date
DE602006010341D1 (de) 2009-12-24
US9155818B2 (en) 2015-10-13
EP1858562A2 (en) 2007-11-28
WO2006092718A3 (en) 2007-01-25
EP1858562B1 (en) 2009-11-11
ZA200707511B (en) 2008-11-26
WO2006092718A2 (en) 2006-09-08
BRPI0609392B1 (pt) 2018-05-29
JP2008531171A (ja) 2008-08-14
ATE447986T1 (de) 2009-11-15
CN101163512B (zh) 2010-11-17
ES2336359T3 (es) 2010-04-12
ITMI20050343A1 (it) 2006-09-05
CN101163512A (zh) 2008-04-16
US20090232875A1 (en) 2009-09-17
CA2600893C (en) 2014-04-29
DK1858562T3 (da) 2010-03-22
JP5289772B2 (ja) 2013-09-11
BRPI0609392A2 (pt) 2010-03-30
CA2600893A1 (en) 2006-09-08

Similar Documents

Publication Publication Date Title
BRPI0609392B8 (pt) substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso
Wu et al. Bone and cartilage changes following experimental varus or valgus tibial angulation
ATE454910T1 (de) Zusammengesetzte strukturen mit hyaluronsäure und derivaten davon als neue knochensubstitute und transplantate
EP2664341A3 (en) Native (telopeptide) placental collagen compositions
BRPI0912411A2 (pt) uso de uma muteína de interleucina humana-2 (muteína de hil-2) ou de um fragmento da mesma, composição farmacêutica para o tratamento e/ou profilaxia de uma doença autoimune, uso de muteína de interleucina humana-2 (muteína de hil-2) ou de uma seção da mesma, agete para formação de células t regulatórias (treg) em um organismo, método para tratamento e/ou profilaxia de uma doença autoimune em um organismo, método para formação de células t regulatórias (treg) em um organismo, método para formação de células t regulatórias (treg) in vitro.
MX2010000060A (es) Malla implantable para trauma musculoesqueletal, reconstruccion ortopedica y reparacion de tejido blando.
Sundar et al. Tendon bone healing can be enhanced by demineralized bone matrix: a functional and histological study
JP2012519556A5 (pt)
AR057458A1 (es) Polieteresteres reabsorbibles y su utilizacion para la preparacion de implantes medicinales
NZ602861A (en) Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
WO2007025290A3 (en) Implants and methods for repair, replacement and treatment of joint disease
BRPI0517616A (pt) composição implantável, métodos para aumentar tecido mole em um indivìduo, e para preparar uma composição de colágeno implantável, e kit
WO2008078166A3 (en) In situ system for intra-articular chondral and osseous tissue repair
NZ630312A (en) An implant
RU2013127019A (ru) Имплантаты для замены "несущей нагрузки" кости, имеющие иерархически организованную архитектуру, полученные посредством превращения растительных структур
GB2443938B (en) Preparation of tissue for meniscal implantation
WO2007054939A3 (en) Method for non-autologous cartilage regeneration
WO2007100459A3 (en) Surgical slings
Chung et al. Cartilage extra-cellular matrix biomembrane for the enhancement of microfractured defects
CL2008002984A1 (es) Composicion farmaceutica que comprende micofenolato sodico y su uso para el tratamiento y/o prevencion en enfermedades autoinmunes tales como el rechazo de aloinjertos o xenoinjertos de organos, celulas o tejidos y como antiinflamatorio.
AR082451A1 (es) Materiales biomimeticos compuestos, proceso de preparacion de los mismos y uso de los mismos para producir estructuras mono, bi o multi-capa para la regeneracion del tejido oseo, osteocartilaginoso o cartilaginoso
BR0310011A (pt) Composição para reparar tecido, métodos para fabricar a mesma, para preparar tecido e para reparar um defeito tecidual em um paciente, composição injetável para reparar tecido, método para fabricar a mesma, e, dispositivo para reparar tecido
DE602006016860D1 (de) Mit mehreren schleifen konstruiertes herzmuskelgewebe
DE602004029271D1 (de) Zusammengesetzte biomaterialien für knochenimplantate
BRPI0607882A2 (pt) método e composição para tratamento de diabetes

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/05/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/03/2006, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO