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BRPI0514422A - biotransformação enantioseletiva para o preparo de intermediários do inibidor de proteìna tirosina quinase - Google Patents

biotransformação enantioseletiva para o preparo de intermediários do inibidor de proteìna tirosina quinase

Info

Publication number
BRPI0514422A
BRPI0514422A BRPI0514422-1A BRPI0514422A BRPI0514422A BR PI0514422 A BRPI0514422 A BR PI0514422A BR PI0514422 A BRPI0514422 A BR PI0514422A BR PI0514422 A BRPI0514422 A BR PI0514422A
Authority
BR
Brazil
Prior art keywords
preparation
dichloro
enantioselective
biotransformation
tyrosine kinase
Prior art date
Application number
BRPI0514422-1A
Other languages
English (en)
Inventor
Pei-Pei Kung
Carlos Alberto Martinez
Junhua Tao
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0514422A publication Critical patent/BRPI0514422A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

BIOTRANSFORMAçãO ENANTIOSELETIVA PARA O PREPARO DE INTERMEDIáRIOS DO INIBIDOR DE PROTEìNA TIROSINA QUINASE A invenção está relacionada com métodos biocatalíticos para o preparo de esterecisómeros enantiomericamente puros de 1-(2,6-dicloro--3-fluorfenil)etanol. São divulgados métodos de preparo do (S)-enantiómero desejado, cujos métodos são baseados em una combinação de resolução enzimática, esterificação química e hidrólise química com inversão de ésteres de l-(2,6-dicloro-3-fluorfenil)etila ou bio-redução estereoseletiva de 2,6-dicloro-3-flúor-acetofenona com um biocatalisador tal como uma enzima ou um microorganismo. O (S)-enantiómero quiral pode ser usado na síntese de certos compostos de 2-aminopiridina ligados a éteres enantiomericamente enriquecidos que inibem potencialmente a auto-fosiforilação do receptor do fator de crescimento de hepatócito humano.
BRPI0514422-1A 2004-08-26 2005-08-15 biotransformação enantioseletiva para o preparo de intermediários do inibidor de proteìna tirosina quinase BRPI0514422A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60511804P 2004-08-26 2004-08-26
PCT/IB2005/002839 WO2006021885A1 (en) 2004-08-26 2005-08-15 Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates

Publications (1)

Publication Number Publication Date
BRPI0514422A true BRPI0514422A (pt) 2008-06-10

Family

ID=35395953

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514422-1A BRPI0514422A (pt) 2004-08-26 2005-08-15 biotransformação enantioseletiva para o preparo de intermediários do inibidor de proteìna tirosina quinase

Country Status (16)

Country Link
US (1) US7465842B2 (pt)
EP (1) EP1791965A1 (pt)
JP (1) JP2008510791A (pt)
KR (2) KR20070038571A (pt)
CN (1) CN101027404A (pt)
AR (1) AR050847A1 (pt)
AU (1) AU2005276136A1 (pt)
BR (1) BRPI0514422A (pt)
CA (1) CA2578298A1 (pt)
IL (1) IL181287A0 (pt)
MX (1) MX2007002247A (pt)
NO (1) NO20071298L (pt)
RU (1) RU2007106863A (pt)
TW (1) TW200621991A (pt)
WO (1) WO2006021885A1 (pt)
ZA (1) ZA200700922B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME01788B (me) * 2004-08-26 2011-02-28 Pfizer Enantiomerno čista aminoheteroaril jedinjenja kao inhibitori protein kinaza
CN101426921B (zh) 2006-04-21 2013-08-14 巴斯夫欧洲公司 用醇脱氢酶使光学活性仲醇外消旋化的方法
CN101611006A (zh) * 2006-12-13 2009-12-23 辉瑞产品公司 3-(4-(2,4-二氟苄氧基)-3-溴-6-甲基-2-氧代吡啶-1(2h)-基)-n,4-二甲基苯甲酰胺的制备方法
CN101855342B (zh) 2007-09-13 2013-07-10 科德克希思公司 用于还原苯乙酮的酮还原酶多肽
CN102925498A (zh) * 2012-11-17 2013-02-13 苏州卡耐博生物技术有限公司 一种（r）1-（2，6-二氯-3-氟-苯基）乙醇的制备方法
JP6291179B2 (ja) * 2013-07-26 2018-03-14 関東化學株式会社 光学活性２級アルコールの製造方法
CN104313064A (zh) * 2014-10-01 2015-01-28 青岛科技大学 一种细胞法生产手性溴苯基丙酸甲酯的方法
CN104328153A (zh) * 2014-10-13 2015-02-04 青岛科技大学 一种细胞法生产手性烯醇的方法
US10544434B2 (en) * 2015-06-29 2020-01-28 Noramco, Inc. Process for the preparation of lisdexamfetamine and related derivatives
DK3393655T3 (da) * 2015-12-22 2021-03-15 Zogenix International Ltd Fenfluramin-sammensætninger og fremgangsmåder til fremstilling af samme
CN105906656B (zh) * 2016-05-17 2018-01-23 凯莱英医药集团（天津）股份有限公司 一种克唑替尼中间体的合成方法
CN109486896A (zh) * 2018-12-04 2019-03-19 南京工业大学 一种催化拆分制备异甘草酸的方法
CN110184245B (zh) * 2019-05-23 2023-09-05 安徽趣酶生物科技有限公司 酮还原酶突变体及其在制备克唑替尼手性醇中间体及其类似物中的应用
CN112301008A (zh) * 2019-07-24 2021-02-02 中国医学科学院药物研究所 一种醛还原酶的氨基酸序列及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942872A1 (de) 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur enantioselektiven darstellung von ((omega)-1)-hydroxyalkylxanthinen
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
WO1992014835A1 (en) * 1991-02-19 1992-09-03 Daicel Chemical Industries, Ltd. Process for producing optically active 3-chloro-1-phenyl-1-propanol and derivative thereof
CA2103932A1 (en) 1992-11-05 1994-05-06 Ramesh N. Patel Stereoselective reduction of ketones
DE69914458T2 (de) 1998-02-17 2004-10-28 G.D. Searle & Co., Chicago Verfahren zur enzymatischen auflösung von laktamen
US5928933A (en) 1998-06-26 1999-07-27 E. I. Du Pont De Nemours & Company Process for the enzymatic resolution of N-(alkoxycarbonyl)-4-ketoproline alkyl esters or N-(alkoxycarbonyl)-4-hydroxyproline alkyl esters using Candida antarctica lipase B
AU2571300A (en) 1999-02-16 2000-09-04 Kaneka Corporation Substituted acetylpyridine derivatives and process for the preparation of intermediates for optically active beta3 agonist by the use of the same
US6451587B1 (en) 1999-09-29 2002-09-17 Pfizer Inc. Microbial asymmetric reduction of 2-chloro-1-[-6-(2,5-dimethyl-pyrrol-1-yl)-pyridin-3-yl]-ethanone
CN1498273A (zh) * 2001-03-22 2004-05-19 ����˹�ж�-����˹˹������˾ 取代乙酰苯的立体选择还原
AU2003235980A1 (en) 2002-04-30 2003-11-17 Kaneka Corporation Novel carbonyl reductase, gene thereof and use of the same
EP1603570B9 (en) 2003-02-26 2013-10-23 Sugen, Inc. Aminoheteroaryl compounds as protein kinase inhibitors

Also Published As

Publication number Publication date
TW200621991A (en) 2006-07-01
MX2007002247A (es) 2007-04-20
AR050847A1 (es) 2006-11-29
CA2578298A1 (en) 2006-03-02
AU2005276136A1 (en) 2006-03-02
US7465842B2 (en) 2008-12-16
KR20080072105A (ko) 2008-08-05
NO20071298L (no) 2007-05-29
WO2006021885A1 (en) 2006-03-02
ZA200700922B (en) 2008-08-27
RU2007106863A (ru) 2008-08-27
JP2008510791A (ja) 2008-04-10
KR20070038571A (ko) 2007-04-10
EP1791965A1 (en) 2007-06-06
US20060046287A1 (en) 2006-03-02
CN101027404A (zh) 2007-08-29
IL181287A0 (en) 2007-07-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.