[go: up one dir, main page]

BRPI0416132A - sistema e método para liberação de vacina transdérmica - Google Patents

sistema e método para liberação de vacina transdérmica

Info

Publication number
BRPI0416132A
BRPI0416132A BRPI0416132-7A BRPI0416132A BRPI0416132A BR PI0416132 A BRPI0416132 A BR PI0416132A BR PI0416132 A BRPI0416132 A BR PI0416132A BR PI0416132 A BRPI0416132 A BR PI0416132A
Authority
BR
Brazil
Prior art keywords
microprojections
vaccine
transdermal
iontophoresis
electrode
Prior art date
Application number
BRPI0416132-7A
Other languages
English (en)
Inventor
Janardhanan Subramony
Joseph B Phipps
Michel J N Cormier
Georg Widera
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0416132A publication Critical patent/BRPI0416132A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/20Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00765Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

"SISTEMA E MéTODO PARA LIBERAçãO, DE VACINA TRANSDéRMICA". Um sistema e método para liberar transdermicamente uma vacina para um paciente, incluindo um dispositivo de liberação de iontoforese que tem um eletrodo doador, um contra-eletrodo, e circuito elétrico para suprir energia de iontoforese para os eletrodos, e um membro de microprojeção não eletroativo que possui uma pluralidade de microprojeções que penetram o estrato córneo estendendo-se a partir dele. A vacina pode estar contida em uma formulação de hidrogel em um reservatório de agente disposto próximo ao eletrodo doador, em um revestimento biocompatível que é disposto sobre as microprojeções ou em ambos.
BRPI0416132-7A 2003-10-31 2004-10-21 sistema e método para liberação de vacina transdérmica BRPI0416132A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51618403P 2003-10-31 2003-10-31
PCT/US2004/034924 WO2005044366A2 (en) 2003-10-31 2004-10-21 System and method for transdermal vaccine delivery

Publications (1)

Publication Number Publication Date
BRPI0416132A true BRPI0416132A (pt) 2007-01-02

Family

ID=34572873

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416132-7A BRPI0416132A (pt) 2003-10-31 2004-10-21 sistema e método para liberação de vacina transdérmica

Country Status (11)

Country Link
US (1) US20050123565A1 (pt)
EP (1) EP1680178A4 (pt)
JP (1) JP2007509704A (pt)
KR (1) KR20060127394A (pt)
CN (1) CN1897920A (pt)
AR (1) AR046922A1 (pt)
AU (1) AU2004287411A1 (pt)
BR (1) BRPI0416132A (pt)
CA (1) CA2543639A1 (pt)
TW (1) TW200528153A (pt)
WO (1) WO2005044366A2 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007503268A (ja) * 2003-08-25 2007-02-22 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾化合物の送達
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
EP1768742A4 (en) * 2004-07-06 2007-10-17 Transpharma Medical Ltd ADMINISTRATION SYSTEM FOR TRANSDERMAL IMMUNIZATION
US8048017B2 (en) 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
EP1885405A1 (en) * 2005-06-02 2008-02-13 Alza Corporation, Inc. Method for terminal sterilization of transdermal delivery devices
WO2006130869A1 (en) * 2005-06-02 2006-12-07 Alza Corporation Method for terminal sterilization of transdermal delivery devices
JP2008543359A (ja) * 2005-06-10 2008-12-04 トランスファーマ メディカル,リミティド 経皮投薬用のパッチ
US20070009542A1 (en) * 2005-07-05 2007-01-11 Galit Levin Method and device for transdermal immunization
WO2007033015A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
JP2009509659A (ja) * 2005-09-30 2009-03-12 Tti・エルビュー株式会社 生体界面への活性物質の送達のイオントフォレーシス装置及び方法
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
EP1965856A2 (en) * 2005-12-30 2008-09-10 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US20080287857A1 (en) * 2006-02-11 2008-11-20 Rune Kjeken Device and method for single-needle in vivo electroporation
KR101385865B1 (ko) 2006-02-11 2014-04-17 제네트로닉스, 인코포레이티드 싱글-니들 생체내 일렉트로포레이션용 장치
JP5049268B2 (ja) * 2006-04-07 2012-10-17 久光製薬株式会社 マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
JP5298011B2 (ja) * 2007-05-15 2013-09-25 久光製薬株式会社 マイクロニードルのコーティング方法
WO2009039366A1 (en) * 2007-09-20 2009-03-26 Transport Pharmaceuticals, Inc. Method of enhancing iontophoretic delivery of a peptide
WO2009047365A1 (en) * 2007-10-12 2009-04-16 Capsulution Nanoscience Ag Drug delivery system
CA2704164A1 (en) * 2007-10-29 2009-05-07 Transpharma Medical Ltd. Vertical patch drying
WO2010001671A1 (ja) 2008-06-30 2010-01-07 久光製薬株式会社 マイクロニードルデバイスおよびマイクロニードルデバイスによるインフルエンザワクチンの奏功性を上昇させる方法
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
EP2408521B1 (en) 2009-03-17 2014-06-25 Cardio Thrive, Inc External defibrillator
US8747362B2 (en) 2009-06-10 2014-06-10 Hisamitsu Pharmaceutical Co., Inc Microneedle device
ES2826882T3 (es) 2009-07-23 2021-05-19 Hisamitsu Pharmaceutical Co Matriz de microagujas
US8512679B2 (en) 2011-03-04 2013-08-20 Elwha Llc Glassy compositions
CN103796683A (zh) 2011-04-21 2014-05-14 塔夫茨大学信托人 用于活性试剂稳定化的方法和组合物
EP3473296B1 (en) * 2011-06-28 2020-08-05 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device
WO2013012875A2 (en) 2011-07-18 2013-01-24 Mount Sinai School Of Medicine Bacterial rnas as vaccine adjuvants
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
FR3024368A1 (fr) * 2014-07-29 2016-02-05 Oreal Dispositif d'iontophorese a embout multi-electrodes
KR102552848B1 (ko) * 2016-08-29 2023-07-06 더 리전츠 오브 더 유니버시티 오브 캘리포니아 피부 치료를 위한 이온성 약제에 기초한 국소 제형
KR20240023684A (ko) 2016-09-13 2024-02-22 알레간 인코포레이티드 안정화된 비단백질 클로스트리듐 독소 조성물
WO2018053524A1 (en) 2016-09-19 2018-03-22 Vaxess Technologies, Inc. Vaccine formulations with increased stability
US11540380B2 (en) * 2017-09-29 2022-12-27 Korea Institute Of Materials Science Flexible active species generator and use thereof
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
CN110404161A (zh) * 2019-09-10 2019-11-05 中山大学 一种基于微针式离子泳器件的透皮精确给药装置及其制备方法
US11904126B2 (en) * 2020-08-28 2024-02-20 City University Of Hong Kong Cryo formulation-based microneedle device for transdermal delivery of bioactive therapeutic agents and performing vaccination using a cryo-microneedle patch
CN117700523A (zh) * 2023-12-14 2024-03-15 西南大学 一种能够募集树突状细胞的重组蛋白及其在免疫治疗方面的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ240357A (en) * 1990-10-29 1993-04-28 Alza Corp Dry state iontophoresis electrodes containing non-hydrated agent and method of hydrating same
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
WO1996015826A1 (en) * 1994-11-17 1996-05-30 Alza Corporation Composition and method for enhancing electrotransport agent delivery
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
EP1345646A2 (en) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
JP2004528900A (ja) * 2001-04-20 2004-09-24 アルザ・コーポレーシヨン 有益な作用物質を含有するコーティングを有する微小突起アレイ
CN1253220C (zh) * 2001-06-29 2006-04-26 贝克顿迪肯森公司 通过微管在真皮内输入疫苗和基因治疗剂

Also Published As

Publication number Publication date
WO2005044366A2 (en) 2005-05-19
US20050123565A1 (en) 2005-06-09
CA2543639A1 (en) 2005-05-19
AU2004287411A1 (en) 2005-05-19
CN1897920A (zh) 2007-01-17
TW200528153A (en) 2005-09-01
WO2005044366A3 (en) 2006-03-16
KR20060127394A (ko) 2006-12-12
EP1680178A4 (en) 2008-01-02
AR046922A1 (es) 2006-01-04
EP1680178A2 (en) 2006-07-19
JP2007509704A (ja) 2007-04-19

Similar Documents

Publication Publication Date Title
BRPI0416132A (pt) sistema e método para liberação de vacina transdérmica
BRPI0415466A (pt) método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
Priya et al. Transdermal iontophoresis
Gupta et al. Kinetics of skin resealing after insertion of microneedles in human subjects
ES2452517T3 (es) Composiciones y métodos para el tratamiento del trastorno de déficit de atención y del trastorno de déficit de atención e hiperactividad con metilfenidato
BR0313474A (pt) dispositivo de distribuição transdérmica de vacina tendo microprotuberáncias revestidas
EP1448263B1 (en) Device for controlled delivery of active substance into the skin
BRPI0509493A (pt) aparelho e método para a liberação transdérmica de vacina da influenza
BRPI0417757A (pt) método e sistema de liberação de agente transdérmico assistida por freqüência
US20060264804A1 (en) Device and kit for delivery of encapsulated substances and methods of use thereof
BRPI0517501A (pt) dispositivo médico apropriado para uso na administração de um componente ativo na ou através da pele
BR0114909A (pt) Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas
US20060264805A1 (en) Permeabilization of biological membranes
BR0209046A (pt) Disposição de microprojeção que possui um agente benéfico contendo revestimento
WO2011044175A3 (en) Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes
AR046696A1 (es) Aplicador auto-accionante para grupo de microproyecciones
BRPI0916150B1 (pt) Arranjo de microagulhas ocas
BRPI0415986A (pt) método e aparelho para reduzir a incidência do uso de tabaco
AR048827A1 (es) Aparato y metodo para la administracion transdermica de agentes basados en fentanil
CN108704218A (zh) 一种皮肤无痛给药贴片
ITTO960488A1 (it) Dispositivo e procedimento per la somministrazione transdermica median te elettrotrasporto di fentanil e sufentanil.
AR054225A1 (es) Aparato y metodo para suministro transdermico de agentes basados en epoyetina
Kalluri et al. Evaluation of microneedles in human subjects
CN109481422B (zh) 一种氧化石墨烯电热膜透皮贴剂
JP7326516B2 (ja) 外用薬

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.