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BRPI0412915A - uso de 2,4-bis(alquilamino)pirimidinas ou -quinazolinas substituìdas como antimicrobianos - Google Patents

uso de 2,4-bis(alquilamino)pirimidinas ou -quinazolinas substituìdas como antimicrobianos

Info

Publication number
BRPI0412915A
BRPI0412915A BRPI0412915A BRPI0412915A BR PI0412915 A BRPI0412915 A BR PI0412915A BR PI0412915 A BRPI0412915 A BR PI0412915A BR PI0412915 A BRPI0412915 A BR PI0412915A
Authority
BR
Brazil
Prior art keywords
c6alkyl
pyrimidines
alkylamino
bis
c10aryl
Prior art date
Application number
Other languages
English (en)
Inventor
Sophie Marquais-Bienewald
Werner H Lzl
Andrea Preuss
Andreas Mehlin
Original Assignee
Ciba Sc Holding Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Sc Holding Ag filed Critical Ciba Sc Holding Ag
Publication of BRPI0412915A publication Critical patent/BRPI0412915A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/28—Heterocyclic compounds containing nitrogen in the ring
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
    • D06M13/35—Heterocyclic compounds
    • D06M13/355—Heterocyclic compounds having six-membered heterocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
    • Y10T442/2525—Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Agronomy & Crop Science (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Textile Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Detergent Compositions (AREA)
  • Paints Or Removers (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

"USO DE 2,4-BIS(ALQUILAMINO)PIRIMIDINAS OU -QUINAZOLINAS SUBSTITUìDAS COMO ANTIMICROBIANOS". O uso de 2,4-bis(alquilamino)pirimidinas de fórmula R~ 1~ é C~ 1~-C~ 12~alquila ou C~ 6~-C~ 10~arila; R~ 2~ é hidrogênio ou C~ 1~-C~ 12~alquila; ou R~ 1~ e R~ 2~ juntos formam um radical de fórmula, em que R<39> e R<39><39> são cada um independentemente do outro hidrogênio, C~ 1~-C~ 6~alquila ou C~ 1~-C~ 6~alcóxi; R~ 3~ e R~ 5~ são cada um independentemente do outro hidrogênio ou C~ 1~-C~ 8~alquila; R~ 4~ é C~ 1~-C~ 20~,alquila, fenila não-substituída, C~ 6~-C~ 10~arila, C~ 6~-C~ 10~aril-C~ 1~-C~ 6~alquila, hidróxi-C~ 1~-C~ 6~alquila, di-C~ 1~-C~ 6~alquilamino-C~ 1~-C~ 6~alquila, mono-C~ 1~-C~ 6~alquilamino-C~ 1-C~ 6~alquila, -(CH~ 2~)~ 2~-(O-(CH~ 2~)~ 2~)~ 1-4~-OH ou -(CH~ 2~)~ 2~-(O-(CH~ 2~)~ 2~)~ 1-4~-NH~ 2~; R~ 6~ é C~ 1~-C~ 20~alquila, C~ 6~-C~ 10~arila, C~ 6~-C~ 10~aril-C~ 1~-C~ 8~alquila, hidróxi-C~ 1~-C~ 6~alquila, di-C~ 1~-C~ 6~alquilamino-C~ 1~-C~ 6~alquila, mono-C~ 1~-C~ 6~alquilamino-C~ 1~-C~ 6~alquila, -(CH~ 2~)~ 2~-(O-(CH~ 2~)~ 2~)~ 1-4~-OH ou -(CH~ 2~)~ 2~-(O-(CH~ 2~)~ 2~)~ 1-4~-NH~ 2~; ou R~ 3~e R~ 4~ e/ou R~ 5~ e R~ 6~ juntos formam um anel de pirrolidina, piperidina, hexametilenoimina ou morfolina; no tratamento antimicrobiano de superfícies.
BRPI0412915 2003-07-25 2004-07-16 uso de 2,4-bis(alquilamino)pirimidinas ou -quinazolinas substituìdas como antimicrobianos BRPI0412915A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03102296 2003-07-25
PCT/EP2004/051516 WO2005011758A2 (en) 2003-07-25 2004-07-16 Use of substituted 2,4-bis (alkylamino) pyrimidines or -quinazolines as antimicrobials

Publications (1)

Publication Number Publication Date
BRPI0412915A true BRPI0412915A (pt) 2006-09-26

Family

ID=34112473

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412915 BRPI0412915A (pt) 2003-07-25 2004-07-16 uso de 2,4-bis(alquilamino)pirimidinas ou -quinazolinas substituìdas como antimicrobianos

Country Status (12)

Country Link
US (1) US7722893B2 (pt)
EP (1) EP1648524B1 (pt)
JP (1) JP2007500683A (pt)
KR (1) KR20060052806A (pt)
CN (1) CN100441228C (pt)
AT (1) ATE420667T1 (pt)
BR (1) BRPI0412915A (pt)
DE (1) DE602004019094D1 (pt)
ES (1) ES2320772T3 (pt)
MX (1) MXPA06000771A (pt)
TW (1) TWI329640B (pt)
WO (1) WO2005011758A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004261484A1 (en) * 2003-07-30 2005-02-10 Cyclacel Limited 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
HN2005000795A (es) 2004-10-15 2010-08-19 Aventis Pharma Inc Pirimidinas como antagonistas del receptor de prostaglandina d2
US20090124645A1 (en) 2005-10-14 2009-05-14 Neurosearch A/S Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels
WO2007065913A1 (en) * 2005-12-07 2007-06-14 Neurosearch A/S Novel quinazoline-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
US7797509B2 (en) * 2007-01-11 2010-09-14 Netlogic Microsystems, Inc. Systems and methods for utilizing an extended translation look-aside buffer having a hybrid memory structure
KR101789042B1 (ko) * 2010-10-28 2017-10-23 스탈 인터내셔날 비.브이. 비-금속 태닝 방법
KR101682417B1 (ko) * 2011-02-25 2016-12-06 주식회사유한양행 다이아미노피리미딘 유도체 및 그의 제조방법
US9850227B2 (en) * 2011-02-25 2017-12-26 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
US9783903B2 (en) * 2013-12-06 2017-10-10 Rohm And Haas Electronic Materials Llc Additives for electroplating baths
CN104997782B (zh) * 2015-06-16 2018-02-23 北京师范大学 DBeQ在抑制白色念珠菌菌丝生长中的应用
CN106087103B (zh) * 2016-07-28 2018-06-08 杭州纱农纺织有限公司 一种抗菌抗紫外的纤维及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2674598A (en) 1952-01-17 1954-04-06 Monsanto Chemicals 2-amino-4-methyl-6-alkylamino-pyrimidines and salts thereof
GB935381A (en) 1958-12-15 1963-08-28 Wellcome Found 2, 4-diaminoquinazolines and their preparation
DE2403165A1 (de) 1974-01-23 1975-07-31 Wacker Chemie Gmbh Pesticide
GB1523274A (en) * 1974-08-05 1978-08-31 Ici Ltd Herbicidal compositions containing substituted pyrimidine
DE3717480A1 (de) * 1987-05-23 1988-12-01 Shell Agrar Gmbh & Co Kg Neue herbizid und mikrobizid wirksame 2,6-diaminopyrimidine
HUT64323A (en) * 1992-06-09 1993-12-28 Richter Gedeon Vegyeszet Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof

Also Published As

Publication number Publication date
WO2005011758A3 (en) 2005-04-28
ES2320772T3 (es) 2009-05-28
CN100441228C (zh) 2008-12-10
EP1648524A2 (en) 2006-04-26
US7722893B2 (en) 2010-05-25
KR20060052806A (ko) 2006-05-19
MXPA06000771A (es) 2006-04-18
TW200510340A (en) 2005-03-16
ATE420667T1 (de) 2009-01-15
DE602004019094D1 (de) 2009-03-05
TWI329640B (en) 2010-09-01
JP2007500683A (ja) 2007-01-18
WO2005011758A2 (en) 2005-02-10
US20060188453A1 (en) 2006-08-24
CN1829538A (zh) 2006-09-06
EP1648524B1 (en) 2009-01-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 8A ANUIDADE.