BRPI0410343A - formas truncadas de dbf4 humana, complexos com seus pares de interação e métodos para identificação de seus inibidores - Google Patents
formas truncadas de dbf4 humana, complexos com seus pares de interação e métodos para identificação de seus inibidoresInfo
- Publication number
- BRPI0410343A BRPI0410343A BRPI0410343-2A BRPI0410343A BRPI0410343A BR PI0410343 A BRPI0410343 A BR PI0410343A BR PI0410343 A BRPI0410343 A BR PI0410343A BR PI0410343 A BRPI0410343 A BR PI0410343A
- Authority
- BR
- Brazil
- Prior art keywords
- human
- complex
- dbf4
- truncated forms
- inhibitors
- Prior art date
Links
- 101150093523 dbf4 gene Proteins 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000003993 interaction Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 101000884714 Homo sapiens Beta-defensin 4A Proteins 0.000 abstract 1
- 101150065030 cdc7 gene Proteins 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000833 heterodimer Substances 0.000 abstract 1
- 102000049262 human DEFB4A Human genes 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000006916 protein interaction Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"FORMAS TRUNCADAS DE Dbf4 HUMANA, COMPLEXOS COM SEUS PARES DE INTERAçãO E MéTODOS PARA IDENTIFICAçãO DE SEUS INIBIDORES". A presente invenção refere-se em geral ao esboço, expressão e purificação de formas truncadas da proteína dfb4 humana, opcionalmente em complexo com pares de interação com dbf4, tal como edc7 humana, e ao seu uso no encontro, identificação e caracterização de inibidores dos componentes do complexo, ou quando associadas ou quando presentes como proteínas não-complexadas in situ ou in vitro. Mais especificamente, a presente invenção refere-se à utilização de formas truncadas específicas de dbf4 humana para a produção de um heterodímero ativo, não-agregado, monodisperso, de dbf4 humana complexada para cdc7 humana, ou outros agentes de interação de proteína.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46795603P | 2003-05-05 | 2003-05-05 | |
| PCT/EP2004/050568 WO2004099243A2 (en) | 2003-05-05 | 2004-04-20 | Truncated forms of human dbf4, complexes with their interacting partners and methods for identification of inhibitors thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0410343A true BRPI0410343A (pt) | 2006-05-30 |
Family
ID=33435149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0410343-2A BRPI0410343A (pt) | 2003-05-05 | 2004-04-20 | formas truncadas de dbf4 humana, complexos com seus pares de interação e métodos para identificação de seus inibidores |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1622934A2 (pt) |
| BR (1) | BRPI0410343A (pt) |
| CA (1) | CA2524528A1 (pt) |
| WO (1) | WO2004099243A2 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10335471B2 (en) | 2015-08-28 | 2019-07-02 | Immatics Biotechnologies Gmbh | Method for treating cancer with activated T cells |
| GB201515321D0 (en) | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| TWI803835B (zh) | 2015-08-28 | 2023-06-01 | 德商英麥提克生物技術股份有限公司 | 用於多種癌症之免疫治療的新穎胜肽、胜肽的組合物及支架 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003076623A1 (fr) * | 2002-03-12 | 2003-09-18 | Japan Science And Technology Agency | Complexe de cdc7-ask kinase, son substrat, anticorps specifique pour ce substrat et procede de criblage d'un compose capable d'inhiber cdc7-ask kinase |
-
2004
- 2004-04-20 BR BRPI0410343-2A patent/BRPI0410343A/pt not_active Application Discontinuation
- 2004-04-20 CA CA002524528A patent/CA2524528A1/en not_active Abandoned
- 2004-04-20 WO PCT/EP2004/050568 patent/WO2004099243A2/en not_active Application Discontinuation
- 2004-04-20 EP EP04728359A patent/EP1622934A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004099243A8 (en) | 2005-03-03 |
| CA2524528A1 (en) | 2004-11-18 |
| WO2004099243A2 (en) | 2004-11-18 |
| EP1622934A2 (en) | 2006-02-08 |
| WO2004099243A3 (en) | 2005-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE304017T1 (de) | Oxazolylpyrazol-derivate als kinase-inhibitoren | |
| DE60313597D1 (de) | Topische pharmazeutische zusammensetzungen mit proanthocyanidinen, glycyrrhetinic säure und telmesteine zur behandlung von dermatitis | |
| ECSP088350A (es) | Pirazolopirimidinas como inhibidores de protein quinasas | |
| BRPI0410418A (pt) | fenil quinolinas e seu uso como moduladores do receptor de estrogênio | |
| BR0007527A (pt) | Fenilfenantridinas com atividade inibitória depde-iv | |
| WO2004089396A3 (en) | Anti-fungal peptidomimetics | |
| BR0207775A (pt) | Lipossomos anfotéricos métodos para carregamento dos mesmos com ingredientes ativos e sua utilização | |
| ATE448232T1 (de) | Substituierte heterozyklen | |
| BRPI0408782A (pt) | inibidores cìclicos da proteìna tirosina cinase | |
| ATE420883T1 (de) | Pyrrolopyrimidine verwendbar als protein kinase inhibitoren | |
| BRPI0414000B8 (pt) | composição farmacêutica sólida oral de liberação prolongada contendo tacrolimus na forma de uma dispersão sólida, forma de dosagem, e, uso da composição farmacêutica | |
| SV2002000245A (es) | Oxazolidinonas substituidas y su uso ref. lea 34122-sv | |
| TW200640487A (en) | Combination of XOLAIR with immunosuppressive agent | |
| BRPI0407583A (pt) | solução oftálmica lìmpida e estável | |
| EP1639141A4 (en) | METHOD FOR THE TREATMENT OF LENTIVIRUS INFECTIONS | |
| DE60126970D1 (de) | Kristallstruktur von bace und verwendungen dafür | |
| ATE350377T1 (de) | Substituierte 3-pyrrolidin-indol-derivate | |
| CY1108540T1 (el) | Ταυτοποιηση θεραπευτικων ενωσεων | |
| ATE496892T1 (de) | Tetrahydroisochinolinverbindungen zur behandlung von zns-erkrankungen | |
| TR200200359T2 (tr) | Cgrp Antagonist'lerinin ve cgrp-release (Gevşeme)-Engelleyici Menopoza Bağlı Deri Kızarıklıklarında Kullanılması | |
| DK1228097T3 (da) | Antimikrobiel aktivitet af den förste kationiske humane lactoferrin-klynge | |
| BRPI0410343A (pt) | formas truncadas de dbf4 humana, complexos com seus pares de interação e métodos para identificação de seus inibidores | |
| DE50213507D1 (de) | Verfahren und mittel zur beeinflussung von interzellulärer kommunikation und interzellulärem organellentransport | |
| ATE361068T1 (de) | Wirkstoff zur entfernung einer unerwünschten proteinpopulation aus dem plasma | |
| Rubio et al. | Epigenetic control of somatostatin and cortistatin expression by β amyloid peptide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |