BRPI0410343A - truncated forms of human dbf4, complex with their interaction pairs, and methods for identifying their inhibitors - Google Patents
truncated forms of human dbf4, complex with their interaction pairs, and methods for identifying their inhibitorsInfo
- Publication number
- BRPI0410343A BRPI0410343A BRPI0410343-2A BRPI0410343A BRPI0410343A BR PI0410343 A BRPI0410343 A BR PI0410343A BR PI0410343 A BRPI0410343 A BR PI0410343A BR PI0410343 A BRPI0410343 A BR PI0410343A
- Authority
- BR
- Brazil
- Prior art keywords
- human
- complex
- dbf4
- truncated forms
- inhibitors
- Prior art date
Links
- 101150093523 dbf4 gene Proteins 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000003993 interaction Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 101000884714 Homo sapiens Beta-defensin 4A Proteins 0.000 abstract 1
- 101150065030 cdc7 gene Proteins 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000833 heterodimer Substances 0.000 abstract 1
- 102000049262 human DEFB4A Human genes 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000006916 protein interaction Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"FORMAS TRUNCADAS DE Dbf4 HUMANA, COMPLEXOS COM SEUS PARES DE INTERAçãO E MéTODOS PARA IDENTIFICAçãO DE SEUS INIBIDORES". A presente invenção refere-se em geral ao esboço, expressão e purificação de formas truncadas da proteína dfb4 humana, opcionalmente em complexo com pares de interação com dbf4, tal como edc7 humana, e ao seu uso no encontro, identificação e caracterização de inibidores dos componentes do complexo, ou quando associadas ou quando presentes como proteínas não-complexadas in situ ou in vitro. Mais especificamente, a presente invenção refere-se à utilização de formas truncadas específicas de dbf4 humana para a produção de um heterodímero ativo, não-agregado, monodisperso, de dbf4 humana complexada para cdc7 humana, ou outros agentes de interação de proteína."Truncated forms of Dbf4 HUMAN, COMPLEX WITH ITS INTERACTION COUPLES AND METHODS FOR IDENTIFYING YOUR INHIBITORS". The present invention relates generally to the sketching, expression and purification of truncated forms of human dfb4 protein, optionally in complex with dbf4 interaction pairs such as human edc7, and its use in the discovery, identification and characterization of human dfb4 inhibitors. components of the complex, or when associated or when present as non-complexed proteins in situ or in vitro. More specifically, the present invention relates to the use of specific truncated forms of human dbf4 for the production of an active, non-aggregated, monodispersed, human cdc7 complexed human dbf4 heterodimer, or other protein interaction agents.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46795603P | 2003-05-05 | 2003-05-05 | |
| PCT/EP2004/050568 WO2004099243A2 (en) | 2003-05-05 | 2004-04-20 | Truncated forms of human dbf4, complexes with their interacting partners and methods for identification of inhibitors thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0410343A true BRPI0410343A (en) | 2006-05-30 |
Family
ID=33435149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0410343-2A BRPI0410343A (en) | 2003-05-05 | 2004-04-20 | truncated forms of human dbf4, complex with their interaction pairs, and methods for identifying their inhibitors |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1622934A2 (en) |
| BR (1) | BRPI0410343A (en) |
| CA (1) | CA2524528A1 (en) |
| WO (1) | WO2004099243A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10335471B2 (en) | 2015-08-28 | 2019-07-02 | Immatics Biotechnologies Gmbh | Method for treating cancer with activated T cells |
| GB201515321D0 (en) | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| TWI803835B (en) | 2015-08-28 | 2023-06-01 | 德商英麥提克生物技術股份有限公司 | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003076623A1 (en) * | 2002-03-12 | 2003-09-18 | Japan Science And Technology Agency | Cdc7-ASK KINASE COMPLEX, SUBSTRATE OF THE KINASE COMPLEX, ANTIBODY SPECIFIC TO THE SUBSTRATE, AND METHOD OF SCREENING COMPOUND CAPABLE OF INHIBITING Cdc7-ASK KINASE USING THE SAME |
-
2004
- 2004-04-20 BR BRPI0410343-2A patent/BRPI0410343A/en not_active Application Discontinuation
- 2004-04-20 CA CA002524528A patent/CA2524528A1/en not_active Abandoned
- 2004-04-20 WO PCT/EP2004/050568 patent/WO2004099243A2/en not_active Application Discontinuation
- 2004-04-20 EP EP04728359A patent/EP1622934A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004099243A8 (en) | 2005-03-03 |
| CA2524528A1 (en) | 2004-11-18 |
| WO2004099243A2 (en) | 2004-11-18 |
| EP1622934A2 (en) | 2006-02-08 |
| WO2004099243A3 (en) | 2005-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |