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BRPI0212298B8 - composição farmacêutica compreendendo gabapentina ou um análogo da mesma e (alfa)-aminoamida e seu uso analgésico - Google Patents

composição farmacêutica compreendendo gabapentina ou um análogo da mesma e (alfa)-aminoamida e seu uso analgésico

Info

Publication number
BRPI0212298B8
BRPI0212298B8 BRPI0212298A BR0212298A BRPI0212298B8 BR PI0212298 B8 BRPI0212298 B8 BR PI0212298B8 BR PI0212298 A BRPI0212298 A BR PI0212298A BR 0212298 A BR0212298 A BR 0212298A BR PI0212298 B8 BRPI0212298 B8 BR PI0212298B8
Authority
BR
Brazil
Prior art keywords
aminoamide
gabapentin
analogue
pharmaceutical composition
alpha
Prior art date
Application number
BRPI0212298A
Other languages
English (en)
Other versions
BR0212298A (pt
BRPI0212298B1 (pt
Inventor
Benatti Luca
Veneroni Orietta
Salvati Patricia
Maj Roberto
Fariello Ruggero
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of BR0212298A publication Critical patent/BR0212298A/pt
Publication of BRPI0212298B1 publication Critical patent/BRPI0212298B1/pt
Publication of BRPI0212298B8 publication Critical patent/BRPI0212298B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"composição farmacêutica compreendendo gabapentina ou um análogo da mesma e <244>-aminoamida e seu uso analgésico". a invenção revela uma composição farmacêutica que compreende gabapentina ou um análogo da mesma (pregabalina ou tiagabina) e uma <244>-aminoamida e seu uso como analgésico. um efeito sinergético das respectivas atividades analgésicas foi observado sem aumento concomitante dos efeitos colaterais.
BRPI0212298A 2001-09-03 2002-08-09 composição farmacêutica compreendendo gabapentina ou um análogo da mesma e (alfa)-aminoamida e seu uso analgésico BRPI0212298B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01121069 2001-09-03
PCT/EP2002/008910 WO2003020273A2 (en) 2001-09-03 2002-08-09 Pharmaceutical composition comprising gabapentin or an analogue thereof and an $g(a)-aminoamide and its analgesic use

Publications (3)

Publication Number Publication Date
BR0212298A BR0212298A (pt) 2004-09-14
BRPI0212298B1 BRPI0212298B1 (pt) 2015-11-03
BRPI0212298B8 true BRPI0212298B8 (pt) 2021-05-25

Family

ID=8178510

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0212298A BRPI0212298B8 (pt) 2001-09-03 2002-08-09 composição farmacêutica compreendendo gabapentina ou um análogo da mesma e (alfa)-aminoamida e seu uso analgésico

Country Status (20)

Country Link
US (2) US8084447B2 (pt)
EP (1) EP1423168B1 (pt)
JP (1) JP4350508B2 (pt)
KR (1) KR100890875B1 (pt)
CN (1) CN1274306C (pt)
AT (1) ATE317280T1 (pt)
AU (1) AU2002333374B2 (pt)
BR (1) BRPI0212298B8 (pt)
CA (1) CA2459470C (pt)
DE (1) DE60209152T2 (pt)
DK (1) DK1423168T3 (pt)
ES (1) ES2253579T3 (pt)
IL (2) IL160523A0 (pt)
MX (1) MXPA04002009A (pt)
NO (1) NO331298B1 (pt)
NZ (1) NZ531586A (pt)
PT (1) PT1423168E (pt)
RU (1) RU2295337C2 (pt)
SI (1) SI1423168T1 (pt)
WO (1) WO2003020273A2 (pt)

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DK1963280T3 (en) 2005-12-22 2015-12-14 Newron Pharm Spa 2-phenylethylamine derivatives by calcium and / or sodium channel
JP5240476B2 (ja) * 2006-06-19 2013-07-17 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー ２−［４−（３−及び２−フルオロベンジルオキシ）ベンジルアミノ］プロパンアミドの製造方法
CN101687773B (zh) 2007-06-15 2014-07-30 纽朗制药有限公司 取代的2-[2-(苯基)乙氨基]烷酰胺衍生物及其作为钠和/或钙通道调节剂的应用
EP2229351B1 (en) 2007-12-11 2017-11-08 Newron Pharmaceuticals S.p.A. Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree
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CN112955145A (zh) * 2018-09-04 2021-06-11 密涅瓦神经科学有限公司 使用苯氧丙胺化合物治疗疼痛的方法

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Also Published As

Publication number Publication date
IL160523A (en) 2009-02-11
NO331298B1 (no) 2011-11-21
CA2459470C (en) 2010-10-12
US8084447B2 (en) 2011-12-27
CN1556720A (zh) 2004-12-22
RU2295337C2 (ru) 2007-03-20
NZ531586A (en) 2005-09-30
EP1423168B1 (en) 2006-02-08
JP2005504782A (ja) 2005-02-17
IL160523A0 (en) 2004-07-25
MXPA04002009A (es) 2004-07-08
WO2003020273A3 (en) 2003-09-04
US20120142777A1 (en) 2012-06-07
CA2459470A1 (en) 2003-03-13
DE60209152T2 (de) 2006-08-03
CN1274306C (zh) 2006-09-13
ATE317280T1 (de) 2006-02-15
PT1423168E (pt) 2006-05-31
DE60209152D1 (de) 2006-04-20
BR0212298A (pt) 2004-09-14
AU2002333374A2 (en) 2003-03-18
KR20040034686A (ko) 2004-04-28
SI1423168T1 (sl) 2006-06-30
US8710040B2 (en) 2014-04-29
BRPI0212298B1 (pt) 2015-11-03
AU2002333374B2 (en) 2007-03-22
KR100890875B1 (ko) 2009-03-31
JP4350508B2 (ja) 2009-10-21
US20040248978A1 (en) 2004-12-09
EP1423168A2 (en) 2004-06-02
DK1423168T3 (da) 2006-05-15
HK1070305A1 (en) 2005-06-17
WO2003020273A2 (en) 2003-03-13
NO20040907L (no) 2004-05-14
ES2253579T3 (es) 2006-06-01
RU2004110041A (ru) 2005-03-10

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