BR9904847A - Loção em emulsão de vitamina d3 ativa - Google Patents
Loção em emulsão de vitamina d3 ativaInfo
- Publication number
- BR9904847A BR9904847A BR9904847-7A BR9904847A BR9904847A BR 9904847 A BR9904847 A BR 9904847A BR 9904847 A BR9904847 A BR 9904847A BR 9904847 A BR9904847 A BR 9904847A
- Authority
- BR
- Brazil
- Prior art keywords
- active vitamin
- active
- vitamin
- emulsion
- lotion
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 3
- 239000006210 lotion Substances 0.000 title abstract 3
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 title 1
- 229940021056 vitamin d3 Drugs 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229930003316 Vitamin D Natural products 0.000 abstract 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 2
- 239000002736 nonionic surfactant Substances 0.000 abstract 2
- 229920001282 polysaccharide Polymers 0.000 abstract 2
- 239000005017 polysaccharide Substances 0.000 abstract 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 2
- 235000019166 vitamin D Nutrition 0.000 abstract 2
- 239000011710 vitamin D Substances 0.000 abstract 2
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 2
- 229940046008 vitamin d Drugs 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 abstract 1
- 235000019271 petrolatum Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 229940032094 squalane Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
- 239000003871 white petrolatum Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
''LOçãO EM EMULSãO DE VITAMINA D~ 3~ ATIVA'' A presente invenção provê uma composição farmacêutica para administração local na forma de uma emulsão que contém vitamina D~ 3~ ativa e é apropriada para aplicação a áreas com cabelo, enquanto também tendo atividade farmacológica satisfatória, estabilidade de droga primária e estabilidade física. Esta loção contém (a) uma quantidade terapeuticamente efetiva de vitamina D~ 3~ ativa, (b) um componente de fase aquosa contendo um componente de óleo sólido compreendendo petrolato branco e um álcool superior, e um componente de óleo liquido compreendendo esqualano, (c) um componente de fase aquosa contendo polissacarídeo iónico, e (d) tensoativo não iónico, em que (1) o teor de referido polissacarídeo iónico é 0,3 a 1,0 partes em peso de preparação completa, (2) o teor de referido álcool superior é 0,2 a 1,0 partes em peso de preparação completa, e (3) o HLB de referido tensoativo não iónico é 10 ou mais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5201998 | 1998-03-04 | ||
PCT/JP1999/001025 WO1999044617A1 (fr) | 1998-03-04 | 1999-03-03 | Lotions de vitamines d3 activees sous forme d'emulsion |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9904847A true BR9904847A (pt) | 2000-09-05 |
BR9904847B1 BR9904847B1 (pt) | 2010-07-13 |
Family
ID=12903112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9904847-7A BR9904847B1 (pt) | 1998-03-04 | 1999-03-03 | loção em emulsão de vitamina d3 ativa. |
Country Status (24)
Country | Link |
---|---|
US (1) | US6187763B1 (pt) |
EP (1) | EP0979654B1 (pt) |
JP (1) | JP4046363B2 (pt) |
KR (1) | KR100491202B1 (pt) |
CN (1) | CN1152689C (pt) |
AT (1) | ATE302608T1 (pt) |
AU (1) | AU744712B2 (pt) |
BR (1) | BR9904847B1 (pt) |
CA (1) | CA2288694C (pt) |
CZ (1) | CZ298971B6 (pt) |
DE (1) | DE69926843T2 (pt) |
DK (1) | DK0979654T3 (pt) |
ES (1) | ES2245511T3 (pt) |
HK (1) | HK1029933A1 (pt) |
HU (1) | HU226610B1 (pt) |
IL (1) | IL132750A (pt) |
MY (1) | MY122390A (pt) |
NO (1) | NO328086B1 (pt) |
NZ (1) | NZ500769A (pt) |
PL (1) | PL192825B1 (pt) |
RU (1) | RU2207843C2 (pt) |
SK (1) | SK285439B6 (pt) |
TW (1) | TWI240635B (pt) |
WO (1) | WO1999044617A1 (pt) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8263580B2 (en) * | 1998-09-11 | 2012-09-11 | Stiefel Research Australia Pty Ltd | Vitamin formulation |
CN1173703C (zh) * | 1999-04-23 | 2004-11-03 | 里奥药物制品有限公司 | 药物组合物 |
DE19955684A1 (de) * | 1999-11-19 | 2001-05-23 | Hilti Ag | Ankerstange für Verankerungen mit organischen und/oder anorganischen Mörtelmassen |
US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
US6881427B2 (en) * | 2002-01-31 | 2005-04-19 | Alticor Inc. | Topical anti-inflammatory composition containing linseed and licorice extracts |
US20030185915A1 (en) * | 2002-03-28 | 2003-10-02 | Jaime Carlo | Synergetic composition for the treatment of psoriasis and other skin disorders and method therefor |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
NZ540166A (en) | 2002-10-25 | 2007-06-29 | Foamix Ltd | Cosmetic and pharmaceutical foam |
US8119150B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US20060018937A1 (en) * | 2002-10-25 | 2006-01-26 | Foamix Ltd. | Steroid kit and foamable composition and uses thereof |
US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
WO2007054818A2 (en) | 2005-05-09 | 2007-05-18 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
CA2611147C (en) * | 2005-06-01 | 2013-04-09 | Stiefel Research Australia Pty Ltd. | Topical emulsion formulation |
JP5103188B2 (ja) * | 2005-11-07 | 2012-12-19 | 株式会社カネカ | 酸化に対して安定な還元型補酵素q10含有組成物、及び還元型補酵素q10を安定化する方法 |
FR2893847B1 (fr) * | 2005-11-30 | 2010-10-29 | Galderma Sa | Composition sous forme de spray comprenant un derive de vitamine d et une phase huileuse |
WO2007086582A1 (ja) | 2006-01-30 | 2007-08-02 | Maruho Co., Ltd. | 22-オキサ-1α,25-ジヒドロキシビタミンD3を含有する水中油型乳剤性ローション剤およびそれを用いた皮膚疾患の治療方法 |
EP2494959B1 (en) * | 2006-07-05 | 2014-11-19 | Foamix Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
US8518376B2 (en) | 2007-12-07 | 2013-08-27 | Foamix Ltd. | Oil-based foamable carriers and formulations |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
AU2009205314A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
CA2760186C (en) | 2009-04-28 | 2019-10-29 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
WO2011013008A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
US8470304B2 (en) | 2009-08-04 | 2013-06-25 | Avidas Pharmaceuticals Llc | Therapeutic vitamin D sun-protecting formulations and methods for their use |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
AU2010302350B2 (en) | 2009-10-02 | 2015-06-18 | Journey Medical Corporation | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
JP2014508796A (ja) * | 2011-03-24 | 2014-04-10 | レオ ファーマ アクティーゼルスカブ | 脂質ナノ粒子とコルチコステロイドまたはビタミンd誘導体とを含む組成物 |
WO2013003803A1 (en) * | 2011-06-29 | 2013-01-03 | Avidas Pharmaceuticals Llc | Topical formulations including lipid microcapsule delivery vehicles and their uses |
NZ596015A (en) * | 2011-10-26 | 2014-04-30 | Anzamed Internat Ltd | Method and composition for the treatment of pain and/or inflammation |
CA2978573A1 (en) | 2016-09-08 | 2018-03-08 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
CN114159567B (zh) * | 2020-09-10 | 2023-03-31 | 南京海融医药科技股份有限公司 | 一种治疗皮肤病的混悬凝胶剂 |
WO2024237182A1 (ja) * | 2023-05-12 | 2024-11-21 | アピ株式会社 | 外用組成物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60174707A (ja) * | 1984-02-21 | 1985-09-09 | Kanebo Ltd | 頭髪用化粧料 |
CA1272953A (en) * | 1984-10-08 | 1990-08-21 | Yuji Makino | Pharmaceutical composition for external use containing active-type vitamin d.sub.3 |
JPS61212515A (ja) * | 1985-03-16 | 1986-09-20 | Taisho Pharmaceut Co Ltd | 痔疾用軟膏 |
JPH04230317A (ja) | 1990-12-27 | 1992-08-19 | Lion Corp | 乳液状組成物 |
JP3480956B2 (ja) * | 1992-10-16 | 2003-12-22 | 株式会社コーセー | 皮膚外用剤 |
GB9226860D0 (en) * | 1992-12-23 | 1993-02-17 | Leo Pharm Prod Ltd | Novel treatment |
SG52313A1 (en) * | 1993-09-01 | 1998-09-28 | Teijin Ltd | 1A, 24-(OH)2-V.D3 emulsion composition |
JP3839502B2 (ja) * | 1994-03-03 | 2006-11-01 | 帝人株式会社 | 湿疹・皮膚炎群治療剤 |
JPH08295628A (ja) * | 1995-04-27 | 1996-11-12 | Teijin Ltd | 脱毛症外用治療剤 |
JPH09249555A (ja) | 1996-03-12 | 1997-09-22 | Kowa Co | 乳剤性ローション |
-
1999
- 1999-03-03 KR KR10-1999-7010194A patent/KR100491202B1/ko not_active IP Right Cessation
- 1999-03-03 BR BRPI9904847-7A patent/BR9904847B1/pt not_active IP Right Cessation
- 1999-03-03 CZ CZ0390099A patent/CZ298971B6/cs not_active IP Right Cessation
- 1999-03-03 PL PL336621A patent/PL192825B1/pl unknown
- 1999-03-03 WO PCT/JP1999/001025 patent/WO1999044617A1/ja active IP Right Grant
- 1999-03-03 CA CA002288694A patent/CA2288694C/en not_active Expired - Fee Related
- 1999-03-03 DE DE69926843T patent/DE69926843T2/de not_active Expired - Lifetime
- 1999-03-03 DK DK99937875T patent/DK0979654T3/da active
- 1999-03-03 NZ NZ500769A patent/NZ500769A/en not_active IP Right Cessation
- 1999-03-03 JP JP54453799A patent/JP4046363B2/ja not_active Expired - Lifetime
- 1999-03-03 RU RU99126121/14A patent/RU2207843C2/ru not_active IP Right Cessation
- 1999-03-03 US US09/423,230 patent/US6187763B1/en not_active Expired - Lifetime
- 1999-03-03 EP EP99937875A patent/EP0979654B1/en not_active Expired - Lifetime
- 1999-03-03 ES ES99937875T patent/ES2245511T3/es not_active Expired - Lifetime
- 1999-03-03 SK SK1514-99A patent/SK285439B6/sk not_active IP Right Cessation
- 1999-03-03 CN CNB998006351A patent/CN1152689C/zh not_active Expired - Fee Related
- 1999-03-03 HU HU0002547A patent/HU226610B1/hu not_active IP Right Cessation
- 1999-03-03 AU AU32743/99A patent/AU744712B2/en not_active Ceased
- 1999-03-03 IL IL13275099A patent/IL132750A/en not_active IP Right Cessation
- 1999-03-03 AT AT99937875T patent/ATE302608T1/de active
- 1999-03-04 MY MYPI99000793A patent/MY122390A/en unknown
- 1999-03-04 TW TW088103327A patent/TWI240635B/zh not_active IP Right Cessation
- 1999-11-03 NO NO19995367A patent/NO328086B1/no not_active IP Right Cessation
-
2001
- 2001-02-06 HK HK01100836A patent/HK1029933A1/xx not_active IP Right Cessation
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