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BR9814877A - Formulações de dosagem oral de elevada carga medicamentosa de liberação imediata e modificada e processos para sua fabricação - Google Patents

Formulações de dosagem oral de elevada carga medicamentosa de liberação imediata e modificada e processos para sua fabricação

Info

Publication number
BR9814877A
BR9814877A BR9814877-0A BR9814877A BR9814877A BR 9814877 A BR9814877 A BR 9814877A BR 9814877 A BR9814877 A BR 9814877A BR 9814877 A BR9814877 A BR 9814877A
Authority
BR
Brazil
Prior art keywords
immediate
processes
modified release
dosage
manufacture
Prior art date
Application number
BR9814877-0A
Other languages
English (en)
Inventor
Gopadi M Venkatesh
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9814877A publication Critical patent/BR9814877A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"FORMULAçõES DE DOSAGEM ORAL DE ELEVADA CARGA MEDICAMENTOSA DE LIBERAçãO IMEDIATA E MODIFICADA E PROCESSOS PARA SUA FRABRICAçãO" Esta invenção se refere a granulação de elevada carga medicamentosa de ácido (E) -<244>- [2-n-butil-1- [(4-carboxifenil) metil]-1H-imidazol-5-il] metileno-2-tiofeno propiónico na forma anidra, um processo para sua produção, composições contendo o composto e métodos para a utilização do composto para bloquear os receptores da angiotensina II e para tratar a hipertensão, a deficiência cardíaca congestiva e a deficiência renal.
BR9814877-0A 1997-11-17 1998-11-17 Formulações de dosagem oral de elevada carga medicamentosa de liberação imediata e modificada e processos para sua fabricação BR9814877A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6591897P 1997-11-17 1997-11-17
PCT/US1998/024502 WO1999025321A1 (en) 1997-11-17 1998-11-17 High drug load immediate and modified release oral dosage formulations and processes for their manufacture

Publications (1)

Publication Number Publication Date
BR9814877A true BR9814877A (pt) 2000-10-03

Family

ID=22066009

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814877-0A BR9814877A (pt) 1997-11-17 1998-11-17 Formulações de dosagem oral de elevada carga medicamentosa de liberação imediata e modificada e processos para sua fabricação

Country Status (14)

Country Link
EP (1) EP1033974B1 (pt)
JP (1) JP4880118B2 (pt)
KR (1) KR100597922B1 (pt)
CN (1) CN1285739A (pt)
AU (1) AU750611B2 (pt)
BR (1) BR9814877A (pt)
CA (1) CA2310028C (pt)
HU (1) HUP0004407A3 (pt)
IL (1) IL136142A0 (pt)
NO (1) NO329206B1 (pt)
NZ (1) NZ504565A (pt)
PL (1) PL340587A1 (pt)
TR (1) TR200001412T2 (pt)
WO (1) WO1999025321A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000004862A2 (en) * 1998-07-20 2000-02-03 Smithkline Beecham Corporation Bioenhanced formulations comprising eprosartan in oral solid dosage form
MXPA02004413A (es) 1999-11-02 2002-09-02 Depomed Inc Induccion farmacologica del modo de alimentacion, para la administracion aumentada de drogas al estomago.
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
GB0228878D0 (en) * 2002-06-21 2003-01-15 Unilever Plc Hair conditioning composition
KR20120058618A (ko) 2003-01-31 2012-06-07 다이이찌 산쿄 가부시키가이샤 동맥 경화 및 고혈압증의 예방 및 치료를 위한 의약
CA2651813A1 (en) * 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
PL3067043T3 (pl) * 2007-11-06 2023-05-08 Novartis Ag Kompozycje farmaceutyczne oparte na superstrukturach antagonisty/blokera receptora angiotensyny (arb) i inhibitora obojętnej endopeptydazy (nep)
AR072477A1 (es) * 2008-07-11 2010-09-01 Solvay Pharm Bv Formulacion farmaceutica de eprosartan. uso.
JP5476782B2 (ja) * 2009-04-21 2014-04-23 大正製薬株式会社 アルギニン含有錠剤の製造方法
JP5446716B2 (ja) * 2009-10-21 2014-03-19 大正製薬株式会社 アルギニン及びカルニチン含有錠剤の製造方法
TR201007508A1 (tr) * 2010-09-14 2012-04-24 Sanovel İlaç San. Ve Ti̇c. A.Ş. Oral yolla dağılan bileşimler
CN104546779A (zh) * 2013-10-14 2015-04-29 深圳海王药业有限公司 高药物荷载的枸橼酸西地那非片剂及其制备方法
WO2019072877A1 (en) * 2017-10-10 2019-04-18 Capsugel Belgium Nv GETTING MULTIPARTICULAR COMPOSITIONS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
WO1992010189A1 (en) * 1990-12-14 1992-06-25 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
EP0712314A1 (en) * 1993-08-02 1996-05-22 Prizm Pharmaceuticals, Inc. Monogenous preparations of cytotoxic conjugates
CZ293345B6 (cs) * 1996-03-29 2004-04-14 Smithkline Beecham Corporation Dihydrát monomethansulfonatu kyseliny (E)-alfa-[2-n-butyl-1-[(4-karboxyfenyl)methyl]-1H-imidazol-5-yl]methylen-2-thiofenpropionové

Also Published As

Publication number Publication date
AU750611B2 (en) 2002-07-25
HUP0004407A3 (en) 2002-03-28
JP2001522872A (ja) 2001-11-20
JP4880118B2 (ja) 2012-02-22
TR200001412T2 (tr) 2000-09-21
NO329206B1 (no) 2010-09-13
PL340587A1 (en) 2001-02-12
HUP0004407A1 (hu) 2002-02-28
AU1588799A (en) 1999-06-07
CN1285739A (zh) 2001-02-28
KR100597922B1 (ko) 2006-07-10
CA2310028C (en) 2008-06-10
IL136142A0 (en) 2001-05-20
CA2310028A1 (en) 1999-05-27
NO20002526D0 (no) 2000-05-16
EP1033974A1 (en) 2000-09-13
EP1033974A4 (en) 2007-05-02
NO20002526L (no) 2000-05-16
KR20010032129A (ko) 2001-04-16
NZ504565A (en) 2002-11-26
WO1999025321A1 (en) 1999-05-27
EP1033974B1 (en) 2014-01-22

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO DISPOSTO NOS ARTIGOS 8O, 11 E 13 DAB LEI 9.279/96

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.