[go: up one dir, main page]

BR9810500A - System and apparatus for the transfer of nucleic acid in vivo into the cells of multicellular eukaryotic organisms - Google Patents

System and apparatus for the transfer of nucleic acid in vivo into the cells of multicellular eukaryotic organisms

Info

Publication number
BR9810500A
BR9810500A BR9810500-0A BR9810500A BR9810500A BR 9810500 A BR9810500 A BR 9810500A BR 9810500 A BR9810500 A BR 9810500A BR 9810500 A BR9810500 A BR 9810500A
Authority
BR
Brazil
Prior art keywords
cells
nucleic acid
vivo
transfer
devices
Prior art date
Application number
BR9810500-0A
Other languages
Portuguese (pt)
Inventor
Michel Bureau
Lluis Mir
Daniel Scherman
Bertrand Schwartz
Original Assignee
Rhone Poulenc Rorer Sa
Roussy Inst Gustave
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9708233A external-priority patent/FR2765242B1/en
Priority claimed from FR9708232A external-priority patent/FR2765241B1/en
Application filed by Rhone Poulenc Rorer Sa, Roussy Inst Gustave, Centre Nat Rech Scient filed Critical Rhone Poulenc Rorer Sa
Publication of BR9810500A publication Critical patent/BR9810500A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Electrotherapy Devices (AREA)

Abstract

"SISTEMA E APARELHO PARA A TRANSFERêNCIA DE áCIDO NUCLéICO IN VIVO PARA O INTERIOR DE CéLULAS DE ORGANISMOS EUCARIóTICOS PLURICELULARES". Esta invenção refere-se a sistemas e aparelhos que proporcionam um aumento notável da transferência, in vivo, para o interior de células, particularmente células de músculos e células de tumor, de vetores de ácidos nucléicos utilizando-se campos elétricos fracos, de modo a incrementar a eficiência desse tipo de transferências. Os aparelhos da invenção são projetados para proporcionar um gradiente de voltagem ótimo para incrementar a migração de vetores de ácido nucléico para o interior de células, sem danificar as células ou o tecido. Esses aparelhos caracterizam-se por disposições únicas de eletrodos, e por limites de potência únicos definidos por ajustes de voltagem máxima."SYSTEM AND APPARATUS FOR THE TRANSFER OF NUCLEIC ACID IN VIVO TO THE INTERIOR OF CELLS OF PLURICELLULAR EUCHARIOTIC ORGANISMS". This invention relates to systems and devices that provide a notable increase in the transfer, in vivo, into cells, particularly muscle cells and tumor cells, of nucleic acid vectors using weak electric fields in order to increase the efficiency of such transfers. The devices of the invention are designed to provide an optimal voltage gradient to increase the migration of nucleic acid vectors into cells, without damaging cells or tissue. These devices are characterized by unique electrode arrangements, and unique power limits defined by maximum voltage adjustments.

BR9810500-0A 1997-06-30 1998-06-30 System and apparatus for the transfer of nucleic acid in vivo into the cells of multicellular eukaryotic organisms BR9810500A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR9708233A FR2765242B1 (en) 1997-06-30 1997-06-30 IMPROVEMENT OF THE TRANSFER OF NUCLEIC ACID IN THE STRIKE MUSCLE AND COMBINATION ALLOWING THE IMPLEMENTATION OF THE PROCESS
FR9708232A FR2765241B1 (en) 1997-06-30 1997-06-30 IMPROVEMENT OF NUCLEIC ACID TRANSFER IN CELLS OF PLURICELLULAR EUKARYOTIC ORGANISMS AND COMBINATION FOR CARRYING OUT THE METHOD
US6748797P 1997-12-01 1997-12-01
US6748897P 1997-12-01 1997-12-01
US8385898P 1998-05-01 1998-05-01
PCT/EP1998/003976 WO1999001175A1 (en) 1997-06-30 1998-06-30 Device for optimized electrotransfer of nucleic acid vectors to tissues in vivo

Publications (1)

Publication Number Publication Date
BR9810500A true BR9810500A (en) 2000-09-05

Family

ID=27515625

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810500-0A BR9810500A (en) 1997-06-30 1998-06-30 System and apparatus for the transfer of nucleic acid in vivo into the cells of multicellular eukaryotic organisms

Country Status (11)

Country Link
EP (1) EP0993318A1 (en)
JP (1) JP2002515816A (en)
KR (1) KR20010014298A (en)
CN (1) CN1261812A (en)
AU (1) AU8730798A (en)
BR (1) BR9810500A (en)
CA (1) CA2295029A1 (en)
IL (1) IL133709A0 (en)
NO (1) NO996540L (en)
PL (1) PL337617A1 (en)
WO (1) WO1999001175A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753379B1 (en) 1996-09-13 1998-10-30 Rhone Poulenc Rorer Sa METHOD OF TREATING AMYOTROPHIC SIDE SCLEROSIS
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
AU2868200A (en) * 1999-02-08 2000-08-25 Chiron Corporation Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo
ES2368419T3 (en) 2000-03-13 2011-11-17 Cornell Research Foundation, Inc. BLOCK OF MIGRATION OF LEUCOCITS AND INFLAMMATION BY INTERFERENCE WITH CD99 / HEC2.
JP2003531149A (en) 2000-04-13 2003-10-21 ザ・ロツクフエラー・ユニバーシテイ Enhancement of antibody-derived immune response
US6928318B2 (en) 2000-05-22 2005-08-09 Merck & Co., Inc. System and method for assessing the performance of a pharmaceutical agent delivery system
US7118756B2 (en) 2000-12-28 2006-10-10 Wyeth Recombinant protective protein from Streptococcus pneumoniae
WO2002070665A2 (en) 2001-03-02 2002-09-12 The Rockefeller University Recombinant hybrid allergen constructs with reduced allergenicity that retain immunogenicity of the natural allergen
US20020198567A1 (en) * 2001-06-07 2002-12-26 Yona Keisari Electro-endocytotic therapy as a treatment modality of cancer
MX339524B (en) 2001-10-11 2016-05-30 Wyeth Corp NEW IMMUNOGENIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCICAL DISEASE.
JP2005518904A (en) 2002-03-07 2005-06-30 マーク アンド カンパニー インコーポレイテッド Clinical syringe with electrical stimulation aspect
NZ554740A (en) 2002-05-24 2009-01-31 Schering Corp Neutralizing human anti-IGFR antibody
US7785608B2 (en) 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
EP1759714A1 (en) * 2005-09-02 2007-03-07 Bioalliance Pharma Electrotransfer of nucleic acid into tissue cells
CN112402798B (en) * 2005-10-03 2021-11-16 诺沃库勒有限责任公司 Optimizing electric field characteristics to increase the effect of an electric field on proliferating cells
JP4961137B2 (en) * 2005-12-14 2012-06-27 久光製薬株式会社 Device for iontophoresis
ES2658239T3 (en) 2006-10-19 2018-03-08 Csl Limited Interleukin-13 alpha 1 receptor high affinity antibody antagonists
DK2068922T3 (en) 2006-10-19 2012-10-08 Csl Ltd Anti-IL-13Ralfa1 antibodies and their applications
AR064642A1 (en) 2006-12-22 2009-04-15 Wyeth Corp POLINUCLEOTIDE VECTOR THAT INCLUDES IT RECOMBINATING CELL THAT UNDERSTANDS THE VECTOR POLYPEPTIDE, ANTIBODY, COMPOSITION THAT UNDERSTANDS THE POLINUCLEOTIDE, VECTOR, RECOMBINATING CELL POLYPEPTIDE OR ANTIBODY, USE OF THE COMPOSITION AND A COMPOSITION AND A METHOD
US8246176B2 (en) 2007-03-06 2012-08-21 Sanyo Electric Co., Ltd. Projection display device having an operation section for displacing a lens
US8093043B2 (en) 2008-06-04 2012-01-10 New York University β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
US20120088842A1 (en) * 2008-07-18 2012-04-12 Maxcyte, Inc. Methods for optimizing electroporation
PE20120116A1 (en) 2008-11-05 2012-02-18 Wyeth Llc MULTICOMPONENT IMMUNOGENIC COMPOSITION FOR THE PREVENTION OF BETA HEMOLITIC STREPTOCOCCAL DISEASE (BHS)
MX350142B (en) 2010-08-23 2017-08-28 Wyeth Llc * STABLE FORMULATIONS OF NEISSERIA MENINGITIDIS rLP2086 ANTIGENS.
SG187912A1 (en) 2010-09-10 2013-04-30 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
KR101763625B1 (en) 2012-03-09 2017-08-01 화이자 인코포레이티드 Neisseria meningitidis compositions and methods thereof
SA115360586B1 (en) 2012-03-09 2017-04-12 فايزر انك Neisseria meningitidis compositions and methods thereof
WO2014107739A1 (en) 2013-01-07 2014-07-10 Eleven Biotherapeutics, Inc. Antibodies against pcsk9
WO2014136064A2 (en) 2013-03-08 2014-09-12 Pfizer Inc. Immunogenic fusion polypeptides
CA2923129C (en) 2013-09-08 2020-06-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN107249626A (en) 2015-02-19 2017-10-13 辉瑞大药厂 Neisseria meningitidis compositions and methods thereof
PE20191107A1 (en) 2017-01-31 2019-08-26 Pfizer COMPOSITIONS OF NEISSERIA MENINGITIDIS AND RESPECTIVE METHODS
CN110527625A (en) * 2018-05-24 2019-12-03 苏州壹达生物科技有限公司 A kind of streaming electrotransfection device of combination high pressure and low-voltage
CA3155669A1 (en) 2019-09-27 2021-04-01 Pfizer Inc. Neisseria meningitidis compositions and methods thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317380D0 (en) * 1993-08-20 1993-10-06 Therexsys Ltd Transfection process
US5641680A (en) * 1994-11-14 1997-06-24 Zhao; Xi Gene transfer apparatus and method for using the same
WO1997007826A1 (en) * 1995-08-29 1997-03-06 Cbr Laboratories, Inc. In vivo electroporation of cells

Also Published As

Publication number Publication date
KR20010014298A (en) 2001-02-26
JP2002515816A (en) 2002-05-28
NO996540D0 (en) 1999-12-29
WO1999001175A1 (en) 1999-01-14
AU8730798A (en) 1999-01-25
CN1261812A (en) 2000-08-02
PL337617A1 (en) 2000-08-28
IL133709A0 (en) 2001-04-30
CA2295029A1 (en) 1999-01-14
NO996540L (en) 2000-02-03
EP0993318A1 (en) 2000-04-19

Similar Documents

Publication Publication Date Title
BR9810500A (en) System and apparatus for the transfer of nucleic acid in vivo into the cells of multicellular eukaryotic organisms
NO996541L (en) Improved method of transferring nucleic acid to cells in multicellular, eukaryotic organism combined with this
BR9912587A (en) System and device process for enhancing cellular absorption of a substance, processes for enhancing gene transfection of a gene transferred to a target region of a patient's body and to promote angiogenesis in ischemic limbs, and, kit
EP0892644A4 (en) IN VIVO GENE TRANSFER METHOD FOR WOUND HEALING
PL337583A1 (en) Improved method of transferring nucleic acid to a striated muscle and connection enabling accomplishment of this method
ATE307878T1 (en) ELECTROSPRAY ASSEMBLY FOR INTRODUCTION OF MATERIAL INTO CELLS
BR0209989A (en) Chromosome-based platforms
BR0115701A (en) Power supply
MX152447A (en) IMPROVEMENTS IN THE ELECTRICAL ENERGY CONTROL SYSTEM TO SUPPLY LOADS AS FLUORESCENT, INCANDESCENT OR SIMILAR LIGHTING
BR9801936C1 (en) Transmission duct apparatus and installation method
DE59712359D1 (en) Arrangement for the supply of electrical energy
DE59912054D1 (en) Device for the supply of electrical energy
AU2001281911A1 (en) Method for introducing nucleic acids and other biologically active molecules into the nucleus of higher eukaryotic cells by means of an electrical current
ITPC970039A0 (en) FLEXIBLE SYSTEM FOR THE DISTRIBUTION OF ENERGY AND ELECTRICAL SIGNALS
DE69839411D1 (en) System for electric power transmission, with DC voltage regulation
SE8602907D0 (en) DEVICE FOR TREATMENT OF WORK PIECE WITH AN EVACUABLE ROOM
BR9907269A (en) Nucleic acid transfer agent, composition, use of a transfer agent, and nucleic acid transfer processes in cells, preparation of a composition and treatment of diseases.
IT1268536B1 (en) PERFECTED DEVICE FOR THE ENERGY MANAGEMENT OF ELECTRICAL LOADS
DE69824346D1 (en) Process for controlling the power of electric arc furnaces
BR9914624A (en) Process of controlling the addition of zinc to a power reactor
DE69830978D1 (en) Improvements in terms of conductor installations for electrical energy
IT1309204B1 (en) TERMINALS FOR THE CONNECTION OF CABLES, ELECTRIC AND NON-ELECTRIC POWER CONDUCTORS.
AU1029099A (en) Transfection system for the transfer of nucleic acids into cells
DE69835733D1 (en) Electric power distribution system
BR0005110A (en) Electric conduction system

Legal Events

Date Code Title Description
TC Change of name
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007.