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BR9809481A - Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um paciente - Google Patents

Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um paciente

Info

Publication number
BR9809481A
BR9809481A BR9809481-5A BR9809481A BR9809481A BR 9809481 A BR9809481 A BR 9809481A BR 9809481 A BR9809481 A BR 9809481A BR 9809481 A BR9809481 A BR 9809481A
Authority
BR
Brazil
Prior art keywords
preparation
compound
treat
risk
processes
Prior art date
Application number
BR9809481-5A
Other languages
English (en)
Inventor
David Cheshire
Andrew Cooke
Martin Cooper
David Donald
Mark Furber
Matthew Perry
Philip Thorne
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Publication of BR9809481A publication Critical patent/BR9809481A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Liquid Crystal (AREA)

Abstract

"COMPOSTO, PROCESSO PARA SUA PREPARAçãO, USO DO MESMO, COMPOSIçãO FARMACêUTICA, E, PROCESSOS PARA SUA PREPARAçãO, PARA EFETUAR A IMUNOSSUPRESSãO E PARA TRATAR OU REDUZIR O RISCO DE UMA DOENçA OBSTRUTIVA REVERSìVEL DAS VIAS AéREAS EM UM PACIENTE". Composto de fórmula (I) em que R, R^ 1^, R^ 2^ e R^ 3^ têm os significados dados na descrição. O composto (I) é útil no tratamento (profilático) de doenças autoimunes, inflamatórias, proliferativas e hiperproliferativas e de doenças mediadas imunologicamente, incluindo a rejeição de órgãos ou tecidos transplantados e a síndrome da imunodeficiência adquirida (AIDS).
BR9809481-5A 1997-05-28 1998-05-18 Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um paciente BR9809481A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds
PCT/SE1998/000935 WO1998054190A1 (en) 1997-05-28 1998-05-18 Novel compounds

Publications (1)

Publication Number Publication Date
BR9809481A true BR9809481A (pt) 2000-06-20

Family

ID=20407123

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809481-5A BR9809481A (pt) 1997-05-28 1998-05-18 Composto, processo para sua preparação, uso do mesmo, composição farmacêutica, e, processos para sua preparação, para efetuar a imunossupressão e para tratar ou reduzir o risco de uma doença obstrutiva reversìvel das vias aéreas em um paciente

Country Status (28)

Country Link
US (2) US6180635B1 (pt)
EP (1) EP0991653B1 (pt)
JP (1) JP2002500666A (pt)
KR (1) KR100561988B1 (pt)
CN (1) CN1122037C (pt)
AT (1) ATE226205T1 (pt)
AU (1) AU723708B2 (pt)
BR (1) BR9809481A (pt)
CA (1) CA2289509C (pt)
CZ (1) CZ297536B6 (pt)
DE (1) DE69808765T2 (pt)
DK (1) DK0991653T3 (pt)
EE (1) EE04018B1 (pt)
ES (1) ES2184270T3 (pt)
HU (1) HU226627B1 (pt)
ID (1) ID28432A (pt)
IL (2) IL132763A0 (pt)
IS (1) IS1983B (pt)
NO (1) NO323752B1 (pt)
NZ (1) NZ500853A (pt)
PL (1) PL199567B1 (pt)
PT (1) PT991653E (pt)
RU (1) RU2225410C2 (pt)
SE (1) SE9702001D0 (pt)
SK (1) SK283589B6 (pt)
TR (1) TR199902904T2 (pt)
UA (1) UA61111C2 (pt)
WO (1) WO1998054190A1 (pt)

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SE9801399D0 (sv) 1998-04-21 1998-04-21 Astra Pharma Prod Method and apparatus for filling containers
GB9819384D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds II
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
DE60104677T2 (de) * 2000-05-04 2005-07-28 Astrazeneca Ab THIENO[2,3-d]PYRIMIDINDIONE UND IHRE VERWENDUNG ALS PHARMAZEUTISCHE MITTEL
GB2361917A (en) * 2000-05-04 2001-11-07 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones
GB2363377B (en) * 2000-06-14 2004-06-09 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones and therapeutic uses thereof
WO2002064598A1 (en) * 2001-02-14 2002-08-22 Warner-Lambert Company Llc Thieno'2,3-d pyrimidindione derivatives as matrix metalloproteinase inhibitors
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
EP2305648A1 (en) * 2001-12-21 2011-04-06 Novo Nordisk A/S Amide derivatives useful as glucokinase activators
JP4881559B2 (ja) * 2002-06-27 2012-02-22 ノボ・ノルデイスク・エー／エス 治療薬としてのアリールカルボニル誘導体
US6890923B2 (en) * 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
EP1587811A1 (en) * 2003-01-17 2005-10-26 AstraZeneca AB Thienopyridazinones and their use in modulation of autoimmune disease
SE0300117D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel Compounds
SE0300119D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
RU2386622C9 (ru) * 2004-01-06 2021-04-21 Ново Нордиск А/С Гетероароматические производные мочевины и их применение в качестве активаторов глюкокиназы
JP2009500377A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス ジシクロアルキルウレア型グルコキナーゼ活性化剤
JP2009500378A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス グルコキナーゼ活性化剤としてのジシクロアルキルカルバモイル尿素
EP1904467B1 (en) * 2005-07-14 2013-05-01 Novo Nordisk A/S Urea glucokinase activators
JP2009528389A (ja) * 2006-03-02 2009-08-06 シーブイ・セラピューティクス・インコーポレイテッド Ａ２ａアデノシン受容体拮抗剤
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
CA2670788A1 (en) * 2006-12-01 2008-06-12 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
US8138185B2 (en) * 2007-01-09 2012-03-20 Novo Nordisk A/S Urea glucokinase activators
WO2008084044A1 (en) 2007-01-11 2008-07-17 Novo Nordisk A/S Urea glucokinase activators
EP2008656A1 (en) * 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions for the treatment of hyperphenylalaninemia
SI2411395T1 (sl) * 2009-03-23 2013-07-31 Glenmark Pharmaceuticals S.A. Furopirimidindionski derivati kot TRPA1 modulatorji
EA033598B1 (ru) * 2011-11-11 2019-11-07 Gilead Apollo Llc Ингибиторы асс и их применения
JP6268093B2 (ja) * 2012-09-14 2018-01-24 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
AU2014334040A1 (en) 2013-10-07 2016-04-28 Bayer Pharma Aktiengesellschaft Cyclic thienouracil-carboxamides and use thereof
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
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CN108290902B (zh) 2015-11-25 2021-08-31 吉利德阿波罗公司 酯类acc抑制剂及其用途
BR112018010113B1 (pt) 2015-11-25 2022-06-14 Gilead Apollo, Llc Composto de pirazol útil como inibidor da acetil-coa carboxilase (acc)
EA201890910A1 (ru) 2015-11-25 2018-11-30 Джилид Аполло, Ллс ФУНГИЦИДНЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 2,4-ДИОКСО-1,4-ДИГИДРОТИЕНО[2,3-d]ПИРИМИДИНА
EA201890926A1 (ru) 2015-11-25 2018-12-28 Джилид Аполло, Ллс ТРИАЗОЛОВЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
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Also Published As

Publication number Publication date
SK283589B6 (sk) 2003-10-07
CZ297536B6 (cs) 2007-01-03
CN1264382A (zh) 2000-08-23
DK0991653T3 (da) 2003-01-06
IS1983B (is) 2005-01-14
NO323752B1 (no) 2007-07-02
US6180635B1 (en) 2001-01-30
IS5264A (is) 1999-11-23
EE9900539A (et) 2000-06-15
NO995810L (no) 2000-01-27
HU226627B1 (en) 2009-05-28
ID28432A (id) 2001-05-24
CN1122037C (zh) 2003-09-24
IL132763A (en) 2007-03-08
EE04018B1 (et) 2003-04-15
RU2225410C2 (ru) 2004-03-10
KR100561988B1 (ko) 2006-03-17
AU723708B2 (en) 2000-09-07
PL199567B1 (pl) 2008-10-31
HUP0003355A2 (hu) 2001-02-28
NO995810D0 (no) 1999-11-26
UA61111C2 (uk) 2003-11-17
IL132763A0 (en) 2001-03-19
PL337126A1 (en) 2000-07-31
SK151399A3 (en) 2000-05-16
KR20010013107A (ko) 2001-02-26
US6342502B1 (en) 2002-01-29
PT991653E (pt) 2003-02-28
JP2002500666A (ja) 2002-01-08
EP0991653A1 (en) 2000-04-12
CA2289509A1 (en) 1998-12-03
DE69808765T2 (de) 2003-07-24
CZ420199A3 (cs) 2000-07-12
DE69808765D1 (de) 2002-11-21
CA2289509C (en) 2007-10-02
SE9702001D0 (sv) 1997-05-28
ATE226205T1 (de) 2002-11-15
NZ500853A (en) 2001-05-25
HUP0003355A3 (en) 2003-03-28
EP0991653B1 (en) 2002-10-16
ES2184270T3 (es) 2003-04-01
AU7680898A (en) 1998-12-30
WO1998054190A1 (en) 1998-12-03
TR199902904T2 (xx) 2000-06-21

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