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BR9807568A - Processo para a produção de ácido 4-amino-1-hidroxibutilideno-1 - Google Patents

Processo para a produção de ácido 4-amino-1-hidroxibutilideno-1

Info

Publication number
BR9807568A
BR9807568A BR9807568A BR9807568A BR9807568A BR 9807568 A BR9807568 A BR 9807568A BR 9807568 A BR9807568 A BR 9807568A BR 9807568 A BR9807568 A BR 9807568A BR 9807568 A BR9807568 A BR 9807568A
Authority
BR
Brazil
Prior art keywords
acid
hydroxybutylidene
amino
production
salts
Prior art date
Application number
BR9807568A
Other languages
English (en)
Inventor
Rudolf Kubela
Yong Tao
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Publication of BR9807568A publication Critical patent/BR9807568A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

HIDROXIBUTILIDENO-1,1-BISFOSFÈNICO". <D> é provido um processo para a produção de ácido 4-amino-1-hidroxibutilideno-1,1-bisfosfónico ou os sais deste que compreende: a) ragir ácido 4-aminibutícico com ácido fosforoso e tricloreto de fósforo na presença de um poli (alquileno glicol); e b) recuperar dito ácido 4-amino-1-hidroxibutildeno-1,1-bisfosfónico.
BR9807568A 1997-02-11 1998-02-06 Processo para a produção de ácido 4-amino-1-hidroxibutilideno-1 BR9807568A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002197267A CA2197267C (en) 1997-02-11 1997-02-11 Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PCT/CA1998/000091 WO1998034940A1 (en) 1997-02-11 1998-02-06 Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid

Publications (1)

Publication Number Publication Date
BR9807568A true BR9807568A (pt) 2000-03-21

Family

ID=4159900

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807568A BR9807568A (pt) 1997-02-11 1998-02-06 Processo para a produção de ácido 4-amino-1-hidroxibutilideno-1

Country Status (12)

Country Link
US (1) US5908959A (pt)
EP (1) EP0971938B1 (pt)
AT (1) ATE220404T1 (pt)
AU (1) AU728164B2 (pt)
BR (1) BR9807568A (pt)
CA (1) CA2197267C (pt)
DE (1) DE69806470T2 (pt)
DK (1) DK0971938T3 (pt)
ES (1) ES2180141T3 (pt)
PL (1) PL335053A1 (pt)
PT (1) PT971938E (pt)
WO (1) WO1998034940A1 (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE271057T1 (de) * 1999-02-17 2004-07-15 Teva Pharma Verfahren zur herstellung von alendron-säure
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011065A1 (es) * 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales
TR200101250A2 (tr) 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
CA2470495A1 (en) * 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
US7038083B2 (en) * 2002-05-17 2006-05-02 Teva Pharmaceutical Industries, Ltd. Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
HUP0300227A2 (hu) 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20040213917A1 (en) * 2003-04-23 2004-10-28 Courtney Douglas L. Spray booth and filter system
PL1656386T3 (pl) 2003-08-21 2010-05-31 Sun Pharmaceuticals Ind Ltd Proces wytwarzania związków kwasu difosfonowego
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
WO2006134603A1 (en) * 2005-06-13 2006-12-21 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
EP1803727B1 (en) 2005-12-27 2009-03-11 IPCA Laboratories Limited Improved process for manufacture of 4-amino-hydroxybutylidene-1,1-bisphosphonic acid and its salts
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
US20090137808A1 (en) * 2006-03-21 2009-05-28 Albemarle Corporation Process for manufacturing bisphosphonic acids
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
JP2009536639A (ja) 2006-05-11 2009-10-15 アイエヌディー−スイフト ラボラトリーズ リミテッド 純リセドロン酸または塩を調製するための方法
CA2656053A1 (en) * 2006-07-03 2008-01-10 Generics [Uk] Limited Novel process for the preparation of bisphosphonic acids
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
WO2008157050A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
WO2010003704A2 (en) 2008-07-11 2010-01-14 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
WO2010060619A1 (en) * 2008-11-26 2010-06-03 Synthon B.V. Process for making zoledronic acid
EP2192126B1 (en) 2008-11-26 2013-03-27 Synthon B.V. Process for making zoledronic acid
EA201270328A1 (ru) 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
PL2483283T3 (pl) 2009-10-02 2015-06-30 Monsanto Technology Llc Sposób wytwarzania kwasów aminohydroksydifosfonowych

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163733A (en) * 1977-10-25 1979-08-07 Buckman Laboratories, Inc. Synergistic compositions for corrosion and scale control
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Also Published As

Publication number Publication date
US5908959A (en) 1999-06-01
ATE220404T1 (de) 2002-07-15
DK0971938T3 (da) 2002-10-14
AU728164B2 (en) 2001-01-04
CA2197267C (en) 2000-02-08
EP0971938B1 (en) 2002-07-10
MX9801171A (es) 1998-12-31
CA2197267A1 (en) 1998-08-11
AU5977298A (en) 1998-08-26
ES2180141T3 (es) 2003-02-01
DE69806470T2 (de) 2003-02-20
WO1998034940A1 (en) 1998-08-13
PL335053A1 (en) 2000-03-27
EP0971938A1 (en) 2000-01-19
PT971938E (pt) 2002-11-29
DE69806470D1 (de) 2002-08-14

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]