AR058168A1 - Sintesis del alendronato de sodio trihidratado - Google Patents
Sintesis del alendronato de sodio trihidratadoInfo
- Publication number
- AR058168A1 AR058168A1 ARP060104748A AR058168A1 AR 058168 A1 AR058168 A1 AR 058168A1 AR P060104748 A ARP060104748 A AR P060104748A AR 058168 A1 AR058168 A1 AR 058168A1
- Authority
- AR
- Argentina
- Prior art keywords
- synthesis
- sodium alendronate
- trihydrated
- trihydrated sodium
- water
- Prior art date
Links
- DCSBSVSZJRSITC-UHFFFAOYSA-M alendronate sodium trihydrate Chemical compound O.O.O.[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O DCSBSVSZJRSITC-UHFFFAOYSA-M 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
- 229960004343 alendronic acid Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Un procedimiento para preparar un compuesto de formula (1) que comprende las etapas: a) hacer reaccionar ácido alendronico con una base fuerte en agua; b) ajustar el pH entre 4,3 y 4,4; c) concentrar la solucion; d) cristalizar la sal en agua.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73417905P | 2005-11-07 | 2005-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058168A1 true AR058168A1 (es) | 2008-01-23 |
Family
ID=37944596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104748 AR058168A1 (es) | 2005-11-07 | 2006-10-30 | Sintesis del alendronato de sodio trihidratado |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR058168A1 (es) |
| TW (1) | TW200736268A (es) |
| WO (1) | WO2007056417A2 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510517A (en) * | 1993-08-25 | 1996-04-23 | Merck & Co., Inc. | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| PL346347A1 (en) * | 1998-08-27 | 2002-02-11 | Teva Pharma | Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
-
2006
- 2006-10-30 AR ARP060104748 patent/AR058168A1/es not_active Application Discontinuation
- 2006-11-03 WO PCT/US2006/043422 patent/WO2007056417A2/en active Application Filing
- 2006-11-03 TW TW095140904A patent/TW200736268A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200736268A (en) | 2007-10-01 |
| WO2007056417A3 (en) | 2007-07-05 |
| WO2007056417A2 (en) | 2007-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |