BR9704117B1 - derivados de insulina com maior ligação com zinco. - Google Patents

derivados de insulina com maior ligação com zinco.

Info

Publication number: BR9704117B1
Authority: BR; Brazil
Prior art keywords: insulin derivatives; zinc binding; greater zinc; binding; insulin
Prior art date: 1996-07-26

Application number

BRPI9704117-3A

Other languages

English (en)

Other versions

BR9704117A (pt

Inventor

Johann Dr Ertl

Paul Dr Habermann

Karl Dr Geisen

Gerhard Dr Seipke

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-26

Filing date

1997-07-28

Publication date

2009-08-11

1997-07-28 Application filed filed Critical

1998-12-29 Publication of BR9704117A publication Critical patent/BR9704117A/pt

2009-08-11 Publication of BR9704117B1 publication Critical patent/BR9704117B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI9704117-3A 1996-07-26 1997-07-28 derivados de insulina com maior ligação com zinco. BR9704117B1 (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19630242		1996-07-26

Publications (2)

Publication Number	Publication Date
BR9704117A BR9704117A (pt)	1998-12-29
BR9704117B1 true BR9704117B1 (pt)	2009-08-11

Family

ID=7800962

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9704117-3A BR9704117B1 (pt)	1996-07-26	1997-07-28	derivados de insulina com maior ligação com zinco.

Country Status (25)

Country	Link
US (1)	US6221837B1 (pt)
EP (1)	EP0821006B1 (pt)
JP (1)	JP4046388B2 (pt)
KR (1)	KR100547922B1 (pt)
CN (2)	CN1158305C (pt)
AR (1)	AR008269A1 (pt)
AT (1)	ATE264871T1 (pt)
AU (1)	AU725201B2 (pt)
BR (1)	BR9704117B1 (pt)
CA (1)	CA2207078C (pt)
CZ (1)	CZ292274B6 (pt)
DE (1)	DE59711533D1 (pt)
DK (1)	DK0821006T3 (pt)
ES (1)	ES2218622T3 (pt)
HK (1)	HK1048125A1 (pt)
HU (1)	HU224591B1 (pt)
IL (2)	IL121382A0 (pt)
NO (1)	NO317666B1 (pt)
NZ (1)	NZ328421A (pt)
PL (1)	PL188617B1 (pt)
PT (1)	PT821006E (pt)
RU (1)	RU2176646C2 (pt)
TR (1)	TR199700685A3 (pt)
TW (1)	TW474944B (pt)
ZA (1)	ZA976645B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19825447A1 (de) *	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
DE19838097A1 (de)	1998-08-24	2000-03-02	Hoechst Marion Roussel De Gmbh	Verfahren zur chromatographischen Reinigung von Insulinen
DE19947456A1 (de) *	1999-10-02	2001-04-05	Aventis Pharma Gmbh	C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga
CA2452044A1 (en) *	2001-08-28	2003-03-13	Eli Lilly And Company	Pre-mixes of glp-1 and basal insulin
CA2463803A1 (en) *	2001-10-19	2003-05-01	Eli Lilly And Company	Biphasic mixtures of glp-1 and insulin
KR100769183B1 (ko) *	2001-12-28	2007-10-23	엘지.필립스 엘시디 주식회사	면발광 램프
US20060217290A1 (en) *	2003-04-29	2006-09-28	Kohn Wayne D	Insulin analogs having protracted time action
EP2264065B1 (en) *	2003-08-05	2017-03-08	Novo Nordisk A/S	Novel insulin derivatives
KR101309770B1 (ko)	2004-07-19	2013-09-30	바이오콘 리미티드	인슐린―올리고머 접합체，제형 및 이들의 용도
US7833513B2 (en)	2004-12-03	2010-11-16	Rhode Island Hospital	Treatment of Alzheimer's Disease
US20090074882A1 (en)	2005-12-28	2009-03-19	Novo Nordisk A/S	Insulin compositions and method of making a composition
WO2008015099A2 (en)	2006-07-31	2008-02-07	Novo Nordisk A/S	Pegylated, extended insulins
KR101699370B1 (ko) *	2006-09-22	2017-02-14	노보 노르디스크 에이/에스	프로테아제 내성 인슐린 유사체
EP2502618A3 (en) *	2007-04-30	2012-10-03	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
EP2164459A1 (en) *	2007-06-01	2010-03-24	Novo Nordisk A/S	Stable non-aqueous pharmaceutical compositions
ES2744384T3 (es) *	2007-06-13	2020-02-24	Novo Nordisk As	Formulación farmacéutica que comprende un derivado de insulina
KR101234540B1 (ko) *	2007-10-16	2013-02-19	바이오콘 리미티드	경구 투여가능한 고형 약제학적 조성물 및 그 제조방법
US9260502B2 (en) *	2008-03-14	2016-02-16	Novo Nordisk A/S	Protease-stabilized insulin analogues
US8691759B2 (en)	2008-03-18	2014-04-08	Novo Nordisk A/S	Protease stabilized, acylated insulin analogues
JP4959005B2 (ja) *	2008-10-30	2012-06-20	ノボ・ノルデイスク・エー／エス	毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
KR20150002777A (ko)	2012-04-11	2015-01-07	노보 노르디스크 에이/에스	인슐린 제제
EP2991672A1 (en)	2013-04-30	2016-03-09	Novo Nordisk A/S	Novel administration regime
ES2676065T3 (es)	2013-10-07	2018-07-16	Novo Nordisk A/S	Nuevo derivado de un análogo de la insulina
FR3013049B1 (fr)	2013-11-14	2015-11-13	You-Ping Chan	Analogue de l'insuline glargine
PE20210857A1 (es)	2016-12-16	2021-05-18	Novo Nordisk As	Composiciones farmaceuticas que contienen insulina
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI78616C (fi) *	1982-02-05	1989-09-11	Novo Industri As	Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
DE3326472A1 (de)	1983-07-22	1985-02-14	Hoechst Ag, 6230 Frankfurt	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) *	1983-07-29	1985-02-07	Hoechst Ag, 6230 Frankfurt	Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3440988A1 (de)	1984-11-09	1986-07-10	Hoechst Ag, 6230 Frankfurt	Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
US4569794A (en)	1984-12-05	1986-02-11	Eli Lilly And Company	Process for purifying proteins and compounds useful in such process
US5008241A (en) *	1985-03-12	1991-04-16	Novo Nordisk A/S	Novel insulin peptides
DE3526995A1 (de)	1985-07-27	1987-02-05	Hoechst Ag	Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung
DE3541856A1 (de)	1985-11-27	1987-06-04	Hoechst Ag	Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3636903A1 (de)	1985-12-21	1987-07-02	Hoechst Ag	Fusionsproteine mit eukaryotischem ballastanteil
CA1340522C (en)	1987-03-10	1999-05-04	Heinz Dobeli	Fusion proteins containing neighbouring histidines for improved purification
DE3805150A1 (de)	1987-04-11	1988-10-20	Hoechst Ag	Gentechnologisches verfahren zur herstellung von polypeptiden
DE4012818A1 (de)	1990-04-21	1991-10-24	Hoechst Ag	Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3726655A1 (de)	1987-08-11	1989-02-23	Hoechst Ag	Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
DE3739347A1 (de)	1987-11-20	1989-06-01	Hoechst Ag	Verfahren zur selektiven spaltung von fusionsproteinen
DE58906966D1 (de)	1988-06-23	1994-03-24	Hoechst Ag	Mini-Proinsulin, seine Herstellung und Verwendung.
DE3827533A1 (de) *	1988-08-13	1990-02-15	Hoechst Ag	Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de)	1988-11-08	1990-05-10	Hoechst Ag	Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
NZ232375A (en) *	1989-02-09	1992-04-28	Lilly Co Eli	Insulin analogues modified at b29
DE3921447A1 (de) *	1989-06-30	1991-01-17	Hoechst Ag	Verfahren zur herstellung von n-alkyl-halogenanilinen
US5227293A (en)	1989-08-29	1993-07-13	The General Hospital Corporation	Fusion proteins, their preparation and use
GR1005153B (el)	1989-08-29	2006-03-13	The General Hospital Corporation	Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους.
US5358857A (en)	1989-08-29	1994-10-25	The General Hospital Corp.	Method of preparing fusion proteins
NZ245170A (en) *	1991-11-26	1994-07-26	Lilly Co Eli	Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions
ES2097426T3 (es)	1992-12-02	1997-04-01	Hoechst Ag	Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos.
DE4405179A1 (de)	1994-02-18	1995-08-24	Hoechst Ag	Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
WO1996004925A1 (en) *	1994-08-12	1996-02-22	Immunomedics, Inc.	Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells

1997
- 1997-07-17 EP EP97112197A patent/EP0821006B1/de not_active Expired - Lifetime
- 1997-07-17 DK DK97112197T patent/DK0821006T3/da active
- 1997-07-17 DE DE59711533T patent/DE59711533D1/de not_active Expired - Lifetime
- 1997-07-17 ES ES97112197T patent/ES2218622T3/es not_active Expired - Lifetime
- 1997-07-17 PT PT97112197T patent/PT821006E/pt unknown
- 1997-07-17 AT AT97112197T patent/ATE264871T1/de active
- 1997-07-24 TW TW086110516A patent/TW474944B/zh not_active IP Right Cessation
- 1997-07-24 CZ CZ19972370A patent/CZ292274B6/cs not_active IP Right Cessation
- 1997-07-24 AR ARP970103352A patent/AR008269A1/es active IP Right Grant
- 1997-07-24 IL IL12138297A patent/IL121382A0/xx unknown
- 1997-07-24 RU RU97112742/04A patent/RU2176646C2/ru not_active IP Right Cessation
- 1997-07-24 AU AU30171/97A patent/AU725201B2/en not_active Ceased
- 1997-07-24 TR TR97/00685A patent/TR199700685A3/tr unknown
- 1997-07-24 IL IL12138197A patent/IL121381A/en not_active IP Right Cessation
- 1997-07-24 NZ NZ328421A patent/NZ328421A/xx not_active IP Right Cessation
- 1997-07-25 KR KR1019970034958A patent/KR100547922B1/ko not_active IP Right Cessation
- 1997-07-25 CA CA002207078A patent/CA2207078C/en not_active Expired - Fee Related
- 1997-07-25 ZA ZA9706645A patent/ZA976645B/xx unknown
- 1997-07-25 HU HU9701299A patent/HU224591B1/hu not_active IP Right Cessation
- 1997-07-25 NO NO19973438A patent/NO317666B1/no not_active IP Right Cessation
- 1997-07-25 PL PL97321343A patent/PL188617B1/pl not_active IP Right Cessation
- 1997-07-25 JP JP20000297A patent/JP4046388B2/ja not_active Expired - Fee Related
- 1997-07-25 US US08/900,574 patent/US6221837B1/en not_active Expired - Lifetime
- 1997-07-25 CN CNB971046751A patent/CN1158305C/zh not_active Expired - Fee Related
- 1997-07-28 BR BRPI9704117-3A patent/BR9704117B1/pt not_active IP Right Cessation
2001
- 2001-12-17 CN CN01143664A patent/CN1362417A/zh active Pending
2003
- 2003-01-07 HK HK03100149.7A patent/HK1048125A1/zh unknown

Also Published As

Publication number	Publication date
US6221837B1 (en)	2001-04-24
TR199700685A2 (xx)	1998-02-21
AU725201B2 (en)	2000-10-05
AR008269A1 (es)	1999-12-29
CA2207078C (en)	2008-01-29
IL121382A0 (en)	1998-01-04
CZ237097A3 (cs)	1998-02-18
DE59711533D1 (de)	2004-05-27
NZ328421A (en)	1998-12-23
JP4046388B2 (ja)	2008-02-13
HUP9701299A3 (en)	2001-04-28
IL121381A0 (en)	1998-01-04
PL188617B1 (pl)	2005-03-31
EP0821006B1 (de)	2004-04-21
TW474944B (en)	2002-02-01
HU224591B1 (hu)	2005-11-28
HU9701299D0 (en)	1997-09-29
CN1172811A (zh)	1998-02-11
PL321343A1 (en)	1998-02-02
HUP9701299A1 (hu)	1998-11-30
CA2207078A1 (en)	1998-01-26
ATE264871T1 (de)	2004-05-15
AU3017197A (en)	1998-02-05
KR100547922B1 (ko)	2006-06-22
KR980009281A (ko)	1998-04-30
PT821006E (pt)	2004-09-30
JPH1072496A (ja)	1998-03-17
CN1158305C (zh)	2004-07-21
TR199700685A3 (tr)	1998-02-21
ZA976645B (en)	1998-01-26
IL121381A (en)	2004-09-27
DK0821006T3 (da)	2004-08-16
NO317666B1 (no)	2004-11-29
CZ292274B6 (cs)	2003-08-13
HK1048125A1 (zh)	2003-03-21
MX9705667A (es)	1998-07-31
EP0821006A2 (de)	1998-01-28
EP0821006A3 (de)	2001-11-28
NO973438D0 (no)	1997-07-25
NO973438L (no)	1998-01-27
CN1362417A (zh)	2002-08-07
ES2218622T3 (es)	2004-11-16
RU2176646C2 (ru)	2001-12-10
BR9704117A (pt)	1998-12-29

Publication	Publication Date	Title
BR9704117B1 (pt)	2009-08-11	derivados de insulina com maior ligação com zinco.
DE69730043D1 (de)	2004-09-02	Implantierbare eletrodenleitung
BR9703133A (pt)	1998-09-08	Distribuidor de pastilha com dia de início variável
TR199501528A1 (tr)	1996-11-21	Pirol türevleri.
BR9707770A (pt)	1999-07-27	Tifluzamida com eficácia aperfeiçoada
DE69810478D1 (de)	2003-02-06	Anhänger mit verschiebbarem drehgestell
ES1038214Y (es)	1998-12-01	Cajetin de tabaco perfeccionado.
ES1030941Y (es)	1996-08-01	Anzuelo perfeccionado con señuelo.
ES1034095Y (es)	1997-05-01	Celosia antivandalica.
ES1036010Y (es)	1997-12-16	Cosechadora de tuberculos perfeccionada.
BR7701535U (pt)	1999-01-19	Past proposta com grampo não aparente
ES1024954Y (es)	1994-06-16	Encuadernacion perfeccionada.
ES1037256Y (es)	1998-06-16	Telefono perfeccionado.
ES1037958Y (es)	1998-11-01	Allcancia perfeccionada.
ES1025985Y (es)	1994-08-16	Parche ornamental perfeccionado.
ES1038412Y (es)	1999-01-01	Bisagra perfeccionada.
ES1037570Y (es)	2000-02-16	Bisagra perfeccionada.
ES1031066Y (es)	1996-05-01	Archivador de disketes perfeccionado.
ES1035541Y (es)	1997-10-16	Armadura de gafas perfeccionada.
ES1038052Y (es)	1998-11-01	Papelera perfeccionada.
ES1035506Y (es)	1997-11-16	Nivel perfeccionado.
ES1033464Y (es)	1997-02-01	Nivel perfeccionado.
ES1036311Y (es)	1998-01-01	Seca-vajillas perfeccionado.
ES1032904Y (es)	1996-12-16	Balaustrada perfeccionada.
ES1033836Y (es)	1997-09-01	Somier perfeccionado.

Legal Events

Date	Code	Title	Description
2002-06-11	FB34	Technical and formal requirements: requirement - article 34 of industrial property law
2006-08-29	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2007-01-23	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2007-09-18	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2009-05-05	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2009-11-03	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/11/2009, OBSERVADAS AS CONDICOES LEGAIS.
2015-05-26	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 18A ANUIDADE.
2015-11-24	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2316 DE 26-05-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.