[go: up one dir, main page]

BR9407092A - Processo para a expressao em alto nível da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa em E coli processo para a purificaçao da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa processo para redobrar a proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa substancialmente puras vacina contendo a - Google Patents

Processo para a expressao em alto nível da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa em E coli processo para a purificaçao da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa processo para redobrar a proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa substancialmente puras vacina contendo a

Info

Publication number
BR9407092A
BR9407092A BR9407092A BR9407092A BR9407092A BR 9407092 A BR9407092 A BR 9407092A BR 9407092 A BR9407092 A BR 9407092A BR 9407092 A BR9407092 A BR 9407092A BR 9407092 A BR9407092 A BR 9407092A
Authority
BR
Brazil
Prior art keywords
meningococcal
group
protein
fusion protein
porin
Prior art date
Application number
BR9407092A
Other languages
English (en)
Inventor
Milan S Blake
Joseph Y Tai
Huilin L Qi
Shu-Mei Liang
Lucjan J J Hronowski
Jeffrey K Pullen
Original Assignee
Univ Rockefeller
North American Vaccine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller, North American Vaccine Inc filed Critical Univ Rockefeller
Publication of BR9407092A publication Critical patent/BR9407092A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/848Escherichia
    • Y10S435/849Escherichia coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
BR9407092A 1993-07-23 1994-07-22 Processo para a expressao em alto nível da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa em E coli processo para a purificaçao da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa processo para redobrar a proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa substancialmente puras vacina contendo a BR9407092A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/096,182 US5439808A (en) 1993-07-23 1993-07-23 Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
PCT/US1994/008327 WO1995003413A1 (en) 1993-07-23 1994-07-22 High level expression, purification and refolding of the neisseria meningitidis outer membrane group b porin proteins

Publications (1)

Publication Number Publication Date
BR9407092A true BR9407092A (pt) 1996-09-03

Family

ID=22256136

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9407092A BR9407092A (pt) 1993-07-23 1994-07-22 Processo para a expressao em alto nível da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa em E coli processo para a purificaçao da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa processo para redobrar a proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa substancialmente puras vacina contendo a

Country Status (12)

Country Link
US (3) US5439808A (pt)
EP (1) EP0713530A4 (pt)
JP (1) JPH09500538A (pt)
AU (1) AU690570B2 (pt)
BR (1) BR9407092A (pt)
CA (1) CA2167677A1 (pt)
FI (1) FI960309L (pt)
NO (1) NO960256L (pt)
NZ (1) NZ269996A (pt)
PL (1) PL182573B1 (pt)
RU (1) RU2181378C2 (pt)
WO (1) WO1995003413A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US5830479A (en) * 1994-02-09 1998-11-03 Willmar Poultry Company, Inc. Active immunization using a siderophore receptor protein
WO1995021627A1 (en) * 1994-02-09 1995-08-17 Willmar Poultry Company, Inc. Active immunization using a siderophore receptor protein
WO1996030043A1 (en) * 1995-03-24 1996-10-03 Ophidian Pharmaceuticals Treatment for verotoxin-producing escherichia coli
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
EP0877816A1 (en) * 1996-02-01 1998-11-18 North American Vaccine, Inc. Expression of group b neisseria meningitidis outer membrane (mb3) protein from yeast and vaccines
GB9614700D0 (en) * 1996-07-12 1996-09-04 Medical Res Council Over-expression of proteins in E.Coli
US6030810A (en) 1997-02-26 2000-02-29 Delgado; Stephen Gregory Cloned tetrodotoxin-sensitive sodium channel α-subunit and a splice variant thereof
US6451317B1 (en) 1997-07-17 2002-09-17 Baxter International Inc. Immunogenic conjugates comprising a Group B meningococcal porin and an H influenzae polysaccharide
SE9704175D0 (sv) * 1997-11-14 1997-11-14 Alfa Laval Agri Ab An animal stall
US7638130B2 (en) * 1997-12-24 2009-12-29 The United States Of America As Represented By The Secretary Of The Navy Truncated recombinant major outer membrane protein antigen (R56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
US6482415B1 (en) * 1997-12-24 2002-11-19 The United States Of America As Represented By The Secretary Of The Navy Expression and refolding of truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi and its use in antibody based detection assays and vaccines
US7335477B2 (en) * 1997-12-24 2008-02-26 The United States Of America As Represented By The Secretary Of The Navy Truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines
WO1999036544A2 (en) * 1998-01-14 1999-07-22 Chiron S.P.A. Neisseria meningitidis antigens
AU763349B2 (en) * 1998-02-05 2003-07-17 Henry M. Jackson Foundation For The Advancement Of Military Medicine Simplified method for removing free protein during preparation of protein-polysaccharide conjugates and vaccines using restricted-access media
CN101293920B (zh) 1998-05-01 2012-07-18 诺华疫苗和诊断公司 脑膜炎奈瑟球菌抗原和组合物
HUP0103100A3 (en) * 1998-08-19 2005-11-28 Baxter Healthcare Sa Immunogenic betha-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide
US20110045011A1 (en) * 1998-12-22 2011-02-24 Wei-Mei Ching TRUNCATED RECOMBINANT MAJOR OUTER MEMBRANE PROTEIN ANTIGEN (R56) OF ORIENTIA TSUTSUGAMUSHI STRAINS KARP, KATO and GILLIAM AND ITS USE IN ANTIBODY BASED DETECTION ASSAYS AND VACCINES
US7081244B2 (en) * 1999-02-22 2006-07-25 Health Protection Agency Neisserial vaccine compositions and methods
DK1154791T3 (da) 1999-02-22 2008-06-16 Health Prot Agency Neisseria-vaccinesammensætninger og fremgangsmåder
JP2003518363A (ja) 1999-04-30 2003-06-10 カイロン エセ.ピー.アー. 保存されたナイセリア抗原
EP2270174A1 (en) * 1999-05-19 2011-01-05 Novartis Vaccines and Diagnostics S.r.l. Combination neisserial compositions
JP4840956B2 (ja) 1999-11-29 2011-12-21 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル 85kDaのナイセリア抗原
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
ES2588917T3 (es) 2000-01-17 2016-11-07 Glaxosmithkline Biologicals Sa Vacuna de VME suplementada contra meningococo
CN100339482C (zh) 2000-02-28 2007-09-26 启龙股份公司 奈瑟球菌蛋白质的杂交表达
ATE322288T1 (de) 2001-01-03 2006-04-15 Epitopix Llc Zusammensetzungen zur immunisierung sowie deren verwendung
WO2002083069A2 (en) * 2001-04-13 2002-10-24 United States Of America As Represented By The Secretary Of The Navy Recombinant proteins of orientia tsutsugamushi
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
MX339524B (es) * 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
AU2003257003A1 (en) * 2002-07-30 2004-02-16 Baxter Healthcare S.A. Chimeric multivalent polysaccharide conjugate vaccines
MY149591A (en) * 2002-08-02 2013-09-13 Glaxosmithkline Biolog Sa Vaccines comprising l2 and/or l3 los from neisseria
US20040197845A1 (en) * 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
SI2351579T1 (sl) 2002-10-11 2017-05-31 Glaxosmithkline Biologicals Sa Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam
JP4918356B2 (ja) 2003-06-23 2012-04-18 バクスター・インターナショナル・インコーポレイテッド Y群髄膜炎菌ワクチン及びそれらの髄膜炎菌組合せワクチン
NZ582566A (en) * 2003-09-19 2010-11-26 Epitopix Llc Metal regulated polypeptides and methods of use from campylobacter spp.
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
NZ555937A (en) 2005-01-27 2009-05-31 Childrens Hosp & Res Ct Oak GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
CA2753814C (en) 2009-02-27 2018-07-31 Novartis Ag Novel selection vectors and methods of selecting eukaryotic host cells
AU2011300418B2 (en) 2010-09-10 2016-05-12 Glaxosmithkline Biologicals Sa Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
CN104602704B (zh) 2012-06-14 2019-08-06 诺华股份有限公司 针对血清组x脑膜炎球菌的疫苗
JP6576924B2 (ja) 2013-07-31 2019-09-18 ノバルティス アーゲー 新規の選択ベクターおよび真核宿主細胞を選択する方法
EP3041502A2 (en) 2013-09-08 2016-07-13 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10166280B2 (en) 2016-06-08 2019-01-01 Epitopix, Llc Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4134214A (en) * 1977-08-05 1979-01-16 Merck & Co., Inc. Freeze-drying process for the preparation of meningococcus vaccine without degradation of potency
US4271147A (en) * 1980-01-10 1981-06-02 Behringwerke Aktiengesellschaft Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same
DE3070388D1 (en) * 1980-10-02 1985-05-02 Schering Corp Injectable rabies vaccine composition and method for preparing same
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4451446A (en) * 1982-03-04 1984-05-29 Smithkline-Rit Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4727136A (en) * 1985-10-01 1988-02-23 Canadian Patents And Development Ltd. Modified meningococcal group B polysaccharide for conjugate vaccine
US5192540A (en) * 1988-04-19 1993-03-09 American Cyanamid Company Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine
DE68915046T2 (de) * 1988-04-19 1994-12-08 American Cyanamid Co Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
DE68918189T2 (de) * 1988-06-29 1995-01-12 Univ Rockefeller Neisseria-Vakzine.
WO1990006696A2 (en) * 1988-12-19 1990-06-28 Praxis Biologics, Inc. Meningococcal class 1 outer-membrane protein vaccine
AU5343390A (en) * 1989-03-31 1990-11-05 Immunomed Corporation Preparation of unassembled pilus subunits and vaccines containing them
IL95578A (en) * 1989-09-15 1998-08-16 Gen Hospital Corp A vaccine made from polysaccharide and protein
DE69019164T2 (de) * 1989-12-14 1995-09-07 National Research Council Of Canada, Ottawa, Ontario Verbessertes meningokokkale polysaccharidkonjugatvakzin.
FI903414A (fi) * 1990-07-06 1992-01-07 Kansanterveyslaitos Produktion av proteiner i grampositiva bakterier.
CU22302A1 (es) * 1990-09-07 1995-01-31 Cigb Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales
DE69133276T2 (de) * 1990-07-16 2003-11-27 University Of North Carolina At Chapel Hill, Chapel Hill Mit der familie der hämolysin-toxine verwandte antigene eisen-ubnterdrückende proteine des n. meningitis
CA2047031A1 (en) * 1990-07-19 1992-01-20 Stephen Marburg Peptide-polysaccharide-protein conjugate vaccines
EP0467714A1 (en) * 1990-07-19 1992-01-22 Merck & Co. Inc. The class II protein of the outer membrane of neisseria meningitidis
EP0546118B1 (en) * 1990-08-23 2003-10-29 University Of North Carolina At Chapel Hill Transferrin binding proteins from neisseria gonorrhoeae and neisseria meningitidis
CA2057536C (en) 1990-12-21 1999-10-26 John J. Dunn Cloning and expression of borrelia lipoproteins
CA2059692C (en) * 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
AU1570792A (en) * 1991-03-15 1992-10-21 Univax Biologics Incorporated Lipid a analog/immunogenic carrier conjugates, the use thereof as vaccines and polyvalent hyperimmune gammaglobulins
EP0519554A1 (en) * 1991-06-19 1992-12-23 Merck & Co. Inc. Conjugates of the class II protein of the outer membrane of neisseria meningitidis and of HIV-1 related peptides
US5425946A (en) * 1992-08-31 1995-06-20 North American Vaccine, Inc. Vaccines against group C Neisseria meningitidis

Also Published As

Publication number Publication date
FI960309A0 (fi) 1996-01-23
FI960309L (fi) 1996-03-22
CA2167677A1 (en) 1995-02-02
JPH09500538A (ja) 1997-01-21
NZ269996A (en) 1997-10-24
EP0713530A1 (en) 1996-05-29
US5879686A (en) 1999-03-09
EP0713530A4 (en) 2002-09-18
US5439808A (en) 1995-08-08
NO960256L (no) 1996-03-20
PL312712A1 (en) 1996-05-13
PL182573B1 (pl) 2002-01-31
WO1995003413A1 (en) 1995-02-02
US6013267A (en) 2000-01-11
AU7371694A (en) 1995-02-20
NO960256D0 (no) 1996-01-22
RU2181378C2 (ru) 2002-04-20
AU690570B2 (en) 1998-04-30

Similar Documents

Publication Publication Date Title
BR9407092A (pt) Processo para a expressao em alto nível da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa em E coli processo para a purificaçao da proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa processo para redobrar a proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa proteína porina meningocócica do grupo B ou sua proteína de fusao na membrana externa substancialmente puras vacina contendo a
BR9204274A (pt) Processo e sistema para a producao de oxigenio em membrana
BR9504113A (pt) Membrana uso da mesma processo para a separaçao de oxigênio e dispositivo para a separaçao de fluidos
FI954636A0 (fi) Annostelujärjestelmä säilöntäaineilta vapaiden steriililiuosten annostelemiseksi
BR9405708A (pt) Sistema de processo de rotulagem
DE69421889D1 (de) Modifizierte Glasfasermembranen für Festphase-Extraktionsreinigung von DNA
DE69421432D1 (de) Optische Kollimatoren-Matrix und Verfahren zur Ausrichtung ihrer Achsen
DE3674314D1 (de) Durchsichtige polarisierende verbundscheiben.
BR9600239A (pt) Dispositivo e um processo para o controle de um sistema de transmissão de momento de rotação
BR9106726A (pt) Processo para registro da unidade portatil,processo para revalidacao na unidade portatil e sistema de comunicacoes
DE69103699D1 (de) Kasten zur Aufnahme von Flaschen.
BR9711457A (pt) Compostos e processo para o tratamento e diagnóstico de infecções micobacterianas.
BR9103131A (pt) Sistema e processo aperfeicoados de controle com membrana/desoxo
NO965319D0 (no) Rutil titandioksyd, og fremgangsmåte for fremstilling derav
PT656014E (pt) Proteina rib, uma proteina da superficie celular que confere imunidade a muitas estirpes de estreptococos do grupo b: processo para purificacao da proteina, estojo de reagentes e composicao farmaceutica
DE69403954D1 (de) Verschlusskappen für kulturflaschen
BR9607312A (pt) e dispositivo para execução do processo Processo de controle de recipiente feito de vidro
BR9104205A (pt) Acidos piridin-2-carboxilicos,com substituicao na posicao 4 ou 5,processo para sua preparacao,medicamentos e processo para sua preparacao
BR8900697A (pt) Proteina de antigeno circunsporozoitico;composicao de vacina;composicao utilizavel para o diagnostico de malaria em seres humanos;processo para a producao da proteina de antigeno circunsporozoitico;sistema de vetor baculovirus-celula de inseto
BR9600370A (pt) Benzenossulfoniluréias e-tiouréias substituídas processo para a sua preparação seus usos e medicamento contendo as mesmas
NO20002483D0 (no) Nye 19-nor-steroider substituert i posisjon 11B, fremgangsmÕte for fremstilling av slike samt mellomprodukter, deres anvendelse som medisiner, og farmasøytiske preparater inneholdende disse
NO930775L (no) Bergingssystem for ubemannede fartöyer
BR9405200A (pt) Processo para a preparação de dióxido de titânio segundo o processo sulfato
BR9600290A (pt) Tiofenossulfoniluréia ou-tioréia substituída processo para sua preparação seus usos e medicamento contendo-as
DE59301797D1 (de) Verschluss für eine Medikamentenflasche

Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
B09B Patent application refused [chapter 9.2 patent gazette]