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BR122020015465B8 - Ácido hialurônico modificado, ácidos hialurônicos reticulados, método para reticulação de ácidos hialurônicos, e, composição de polímero - Google Patents

Ácido hialurônico modificado, ácidos hialurônicos reticulados, método para reticulação de ácidos hialurônicos, e, composição de polímero

Info

Publication number
BR122020015465B8
BR122020015465B8 BR122020015465A BR122020015465A BR122020015465B8 BR 122020015465 B8 BR122020015465 B8 BR 122020015465B8 BR 122020015465 A BR122020015465 A BR 122020015465A BR 122020015465 A BR122020015465 A BR 122020015465A BR 122020015465 B8 BR122020015465 B8 BR 122020015465B8
Authority
BR
Brazil
Prior art keywords
cross
hyaluronic
hyaluronic acids
crossed
cutting
Prior art date
Application number
BR122020015465A
Other languages
English (en)
Other versions
BR122020015465B1 (pt
Inventor
Auzely-Velty Rachel
Figueiredo Tamiris
Jing Jing Laura
Steven Harris Craig
Boiteau Jean-Guy
Gerfaud Thibaut
Tomas Loïc
Original Assignee
Centre Nat Rech Scient
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Galderma Res & Dev filed Critical Centre Nat Rech Scient
Publication of BR122020015465B1 publication Critical patent/BR122020015465B1/pt
Publication of BR122020015465B8 publication Critical patent/BR122020015465B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/55—Boron-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00—Crosslinking

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

Um novo hidrogel feito de glicosaminoglicanos reticulados, particularmente ácido hialurônico reticulado, condroitina ou sulfato de condroitina, tendo ligações reversíveis usando ácido borônico ou derivados de boroxol levando a novos benefícios. Glicosaminoglicanos que são reticulados por meio de um ânion de éster alcoxiboronato formado entre uma porção diol de uma fração funcional diol enxertada a um primeiro glicosaminoglicano e um hemiéster boronato enxertado a um segundo glicosaminoglicano.
BR122020015465A 2016-08-03 2017-08-02 Ácido hialurônico modificado, ácidos hialurônicos reticulados, método para reticulação de ácidos hialurônicos, e, composição de polímero BR122020015465B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662370479P 2016-08-03 2016-08-03
US62/370,479 2016-08-03
EP16206624.5 2016-12-23
EP16206624 2016-12-23
PCT/EP2017/069574 WO2018024793A1 (en) 2016-08-03 2017-08-02 Method of crosslinking glycosaminoglycans

Publications (2)

Publication Number Publication Date
BR122020015465B1 BR122020015465B1 (pt) 2022-09-27
BR122020015465B8 true BR122020015465B8 (pt) 2023-03-28

Family

ID=59409350

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112019002287A BR112019002287A2 (pt) 2016-08-03 2017-08-02 glicosaminoglicanos reticulados, método para reticulação de um primeiro glicosaminoglicano enxertado com uma fração funcional diol tendo uma porção diol e um segundo glicosaminoglicano enxertado com um hemiéster boronato, uso de um hemiéster boronato, e, composição de polímero.
BR122020015465A BR122020015465B8 (pt) 2016-08-03 2017-08-02 Ácido hialurônico modificado, ácidos hialurônicos reticulados, método para reticulação de ácidos hialurônicos, e, composição de polímero

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112019002287A BR112019002287A2 (pt) 2016-08-03 2017-08-02 glicosaminoglicanos reticulados, método para reticulação de um primeiro glicosaminoglicano enxertado com uma fração funcional diol tendo uma porção diol e um segundo glicosaminoglicano enxertado com um hemiéster boronato, uso de um hemiéster boronato, e, composição de polímero.

Country Status (9)

Country Link
US (2) US11214655B2 (pt)
EP (2) EP3736296B1 (pt)
CN (2) CN113735992B (pt)
AU (2) AU2017307329B2 (pt)
BR (2) BR112019002287A2 (pt)
ES (2) ES2901326T3 (pt)
HU (1) HUE050368T2 (pt)
PT (1) PT3494144T (pt)
WO (1) WO2018024793A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2583070B (en) * 2019-03-20 2023-09-13 Schlumberger Technology Bv Viscosification of aqueous solutions
FR3099163A1 (fr) * 2019-07-24 2021-01-29 Centre National De La Recherche Scientifique Compositions polymériques injectables d’acide hyaluronique réticulé par des esters de boronate et fonctionnalisé par des peptides RGD pour l’ingénierie cellulaire et tissulaire
EP3878891A1 (en) * 2020-03-10 2021-09-15 Centre National De La Recherche Scientifique -Cnrs- Dynamic covalent hydrogels, precursors thereof and uses thereof
CN112169713A (zh) * 2020-09-09 2021-01-05 江南大学 一种n-烷基乳糖胺表面活性剂小分子醇凝胶及其制备方法
CN112641951B (zh) * 2020-12-18 2023-03-28 河南工业大学 一种生物活性超分子手性水凝胶及其制备方法与应用
WO2023154303A2 (en) * 2022-02-09 2023-08-17 University Of Notre Dame Du Lac Dynamic-covalent hydrogels with glucose-specific and glucose-responsive diboronate crosslinking

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Publication number Priority date Publication date Assignee Title
US5827937A (en) 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
EP2012803A4 (en) * 2006-04-20 2012-08-01 Univ Utah Res Found POLYMERIC COMPOSITIONS AND METHOD FOR THEIR PREPARATION AND USE
US8747870B2 (en) 2006-04-20 2014-06-10 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
AR088669A1 (es) * 2011-11-21 2014-06-25 Lilly Co Eli Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos
CN102772823A (zh) * 2012-07-25 2012-11-14 华南理工大学 透明质酸/明胶/硫酸软骨素骨修复仿生支架的制备方法
EP2727597A1 (en) * 2012-11-06 2014-05-07 Centre National de la Recherche Scientifique (CNRS) Glucose responsive hydrogel comprising pba-grafted hyaluronic acid (ha)
US20140155305A1 (en) 2012-12-04 2014-06-05 Schlumberger Technology Corporation Thickening of fluids
EP2986120B1 (en) * 2013-04-16 2017-12-13 Sloan-kettering Institute For Cancer Research Methyltransferase inhibitors for treating cancer
JP6355959B2 (ja) * 2014-04-24 2018-07-11 国立大学法人京都工芸繊維大学 機能性架橋構造体及びその製造方法並びに医療材料
US9678082B2 (en) * 2014-10-31 2017-06-13 National Sun Yat-Sen University Method of traceless labeling glycoproteins on surface and application thereof
CN105646732A (zh) * 2014-12-02 2016-06-08 上海其胜生物制剂有限公司 一种具有氧化-还原响应的透明质酸钠衍生物的制备方法

Also Published As

Publication number Publication date
PT3494144T (pt) 2020-09-15
AU2021201557A1 (en) 2021-04-01
ES2817427T3 (es) 2021-04-07
AU2017307329B2 (en) 2021-01-28
WO2018024793A1 (en) 2018-02-08
EP3736296A1 (en) 2020-11-11
CN113735992B (zh) 2023-12-05
CN113735992A (zh) 2021-12-03
EP3494144B1 (en) 2020-06-10
BR122020015465B1 (pt) 2022-09-27
US11807726B2 (en) 2023-11-07
CN110023341A (zh) 2019-07-16
HUE050368T2 (hu) 2020-11-30
BR112019002287A2 (pt) 2019-06-18
US20220081519A1 (en) 2022-03-17
US11214655B2 (en) 2022-01-04
ES2901326T3 (es) 2022-03-22
CN110023341B (zh) 2021-06-25
AU2017307329A1 (en) 2019-03-14
EP3736296B1 (en) 2021-09-15
EP3494144A1 (en) 2019-06-12
AU2021201557B2 (en) 2022-08-04
AU2017307329A8 (en) 2019-03-21
US20190169375A1 (en) 2019-06-06

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