BR112019009529A2 - novos derivados de quinolina - Google Patents
novos derivados de quinolina Download PDFInfo
- Publication number
- BR112019009529A2 BR112019009529A2 BR112019009529A BR112019009529A BR112019009529A2 BR 112019009529 A2 BR112019009529 A2 BR 112019009529A2 BR 112019009529 A BR112019009529 A BR 112019009529A BR 112019009529 A BR112019009529 A BR 112019009529A BR 112019009529 A2 BR112019009529 A2 BR 112019009529A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- quinoline derivatives
- new quinoline
- preparing
- pharmaceutical compositions
- Prior art date
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 2
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000006968 Helminthiasis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
novos derivados de quinolina. a presente invenção aborda novos compostos da fórmula geral (i): (i), em que a, r1, r2, r3, r4, r5, r6 e q são como aqui definidos, métodos para preparar os referidos compostos, compostos intermediários úteis para preparar os referidos compostos, composições farmacêuticas e combinações compreendendo os referidos compostos e o uso dos referidos compostos para fabricar composições farmacêuticas para tratamento, controle e/ou prevenção de doenças, em particular de infecções de helmintos, como um agente único ou em combinação com outros ingredientes ativos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16198550 | 2016-11-11 | ||
| PCT/EP2017/078319 WO2018087036A1 (en) | 2016-11-11 | 2017-11-06 | New anthelmintic quinoline-3-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019009529A2 true BR112019009529A2 (pt) | 2019-07-30 |
Family
ID=57321155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019009529A BR112019009529A2 (pt) | 2016-11-11 | 2017-11-06 | novos derivados de quinolina |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US10889573B2 (pt) |
| EP (1) | EP3538512B1 (pt) |
| JP (1) | JP7165129B2 (pt) |
| KR (1) | KR102595730B1 (pt) |
| CN (1) | CN109890793B (pt) |
| AU (1) | AU2017357503B2 (pt) |
| BR (1) | BR112019009529A2 (pt) |
| CA (1) | CA3043298A1 (pt) |
| CL (1) | CL2019001292A1 (pt) |
| CO (1) | CO2019004776A2 (pt) |
| DK (1) | DK3538512T3 (pt) |
| DO (1) | DOP2019000117A (pt) |
| ES (1) | ES2884073T3 (pt) |
| IL (1) | IL266407B (pt) |
| MX (1) | MX2019005569A (pt) |
| MY (1) | MY196327A (pt) |
| NZ (1) | NZ752550A (pt) |
| PH (1) | PH12019501034A1 (pt) |
| PL (1) | PL3538512T3 (pt) |
| PT (1) | PT3538512T (pt) |
| SG (1) | SG11201903059SA (pt) |
| SI (1) | SI3538512T1 (pt) |
| TW (1) | TWI821165B (pt) |
| UA (1) | UA126119C2 (pt) |
| UY (1) | UY37480A (pt) |
| WO (1) | WO2018087036A1 (pt) |
| ZA (1) | ZA201903708B (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3615527B1 (en) | 2017-06-30 | 2024-03-06 | Elanco Animal Health GmbH | New azaquinoline derivatives |
| SG11202000266VA (en) | 2017-08-04 | 2020-02-27 | Bayer Animal Health Gmbh | Quinoline derivatives for treating infections with helminths |
| EP3692037A1 (en) * | 2017-12-15 | 2020-08-12 | Bayer Animal Health GmbH | Process for preparing antihelmintic 4-amino-quinoline-3-carboxamide derivatives |
| WO2019215182A1 (en) | 2018-05-09 | 2019-11-14 | Bayer Animal Health Gmbh | New quinoline derivatives |
| WO2020014068A1 (en) | 2018-07-09 | 2020-01-16 | Boehringer Ingelheim Animal Health USA Inc. | Anthelminthic heterocyclic compounds |
| EP3643711A1 (en) * | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| BR112021012021A2 (pt) * | 2018-12-18 | 2021-09-21 | Elanco Tiergesundheit Ag | Derivados bicíclicos |
| CN113474044A (zh) * | 2018-12-18 | 2021-10-01 | 瑞士伊兰科动物保健有限公司 | 双环衍生物 |
| WO2020191091A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| AU2020289459A1 (en) * | 2019-06-07 | 2022-01-06 | Elanco Tiergesundheit Ag | Bicyclic derivatives for treating endoparasites |
| TWI865563B (zh) * | 2019-07-30 | 2024-12-11 | 德商拜耳動物保健有限公司 | 新穎異喹啉衍生物 |
| CN114845994B (zh) * | 2019-12-18 | 2025-07-18 | 英特维特国际股份有限公司 | 包含喹啉结构的驱虫化合物 |
| BR112022020315A2 (pt) | 2020-04-09 | 2022-12-13 | Bayer Animal Health Gmbh | Novos compostos anti-helmínticos |
| IL298596A (en) | 2020-05-29 | 2023-01-01 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic heterocyclic compounds |
| WO2022106469A2 (en) | 2020-11-18 | 2022-05-27 | Elanco Tiergesundheit Ag | N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo-thiophene-2-carboxamide derivatives and similar compounds for the treatment of heartworm infections |
| TW202237600A (zh) | 2020-12-04 | 2022-10-01 | 瑞士商禮藍動物保健股份有限公司 | 雙環衍生物 |
| CN116888124A (zh) * | 2020-12-04 | 2023-10-13 | 礼蓝动物保健有限公司 | 二环衍生物 |
| JP2023553428A (ja) | 2020-12-11 | 2023-12-21 | インターベット インターナショナル ベー． フェー． | チエノピリジン構造を含む駆虫剤化合物 |
| US20240043385A1 (en) | 2020-12-11 | 2024-02-08 | Intervet Inc. | Anthelmintic compounds comprising a pyridine structure |
| EP4148052A1 (en) | 2021-09-09 | 2023-03-15 | Bayer Animal Health GmbH | New quinoline derivatives |
| US11999742B2 (en) | 2021-11-01 | 2024-06-04 | Boehringer Ingelheim Vetmedica Gmbh | Substituted pyrrolo[1,2-b]pyridazines as anthelmintics |
| WO2024213752A1 (en) | 2023-04-14 | 2024-10-17 | Elanco Animal Health Gmbh | Long-term prevention and/or treatment of a disease by slo-1 inhibitors |
| WO2025027117A1 (en) | 2023-08-02 | 2025-02-06 | Intervet International B.V. | Carboxamide-4-quinoline compounds with anthelmintic activity |
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2017
- 2017-11-06 CN CN201780069050.7A patent/CN109890793B/zh active Active
- 2017-11-06 MY MYPI2019002590A patent/MY196327A/en unknown
- 2017-11-06 BR BR112019009529A patent/BR112019009529A2/pt active Search and Examination
- 2017-11-06 SG SG11201903059SA patent/SG11201903059SA/en unknown
- 2017-11-06 NZ NZ752550A patent/NZ752550A/en unknown
- 2017-11-06 KR KR1020197013186A patent/KR102595730B1/ko active Active
- 2017-11-06 UA UAA201906455A patent/UA126119C2/uk unknown
- 2017-11-06 US US16/348,797 patent/US10889573B2/en active Active
- 2017-11-06 ES ES17791438T patent/ES2884073T3/es active Active
- 2017-11-06 JP JP2019524276A patent/JP7165129B2/ja active Active
- 2017-11-06 WO PCT/EP2017/078319 patent/WO2018087036A1/en active IP Right Grant
- 2017-11-06 SI SI201730854T patent/SI3538512T1/sl unknown
- 2017-11-06 MX MX2019005569A patent/MX2019005569A/es unknown
- 2017-11-06 DK DK17791438.9T patent/DK3538512T3/da active
- 2017-11-06 PT PT177914389T patent/PT3538512T/pt unknown
- 2017-11-06 AU AU2017357503A patent/AU2017357503B2/en active Active
- 2017-11-06 EP EP17791438.9A patent/EP3538512B1/en active Active
- 2017-11-06 PL PL17791438T patent/PL3538512T3/pl unknown
- 2017-11-06 CA CA3043298A patent/CA3043298A1/en active Pending
- 2017-11-10 TW TW106138957A patent/TWI821165B/zh active
- 2017-11-10 UY UY0001037480A patent/UY37480A/es not_active Application Discontinuation
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2019
- 2019-05-02 IL IL266407A patent/IL266407B/en unknown
- 2019-05-09 PH PH12019501034A patent/PH12019501034A1/en unknown
- 2019-05-10 CO CONC2019/0004776A patent/CO2019004776A2/es unknown
- 2019-05-10 CL CL2019001292A patent/CL2019001292A1/es unknown
- 2019-05-10 DO DO2019000117A patent/DOP2019000117A/es unknown
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