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BR112018070653A2 - ingrediente farmacêutico ativo, e, composição - Google Patents

ingrediente farmacêutico ativo, e, composição

Info

Publication number
BR112018070653A2
BR112018070653A2 BR112018070653A BR112018070653A BR112018070653A2 BR 112018070653 A2 BR112018070653 A2 BR 112018070653A2 BR 112018070653 A BR112018070653 A BR 112018070653A BR 112018070653 A BR112018070653 A BR 112018070653A BR 112018070653 A2 BR112018070653 A2 BR 112018070653A2
Authority
BR
Brazil
Prior art keywords
active pharmaceutical
pharmaceutical ingredient
composition
arimoclomol
glucocerebrosidase
Prior art date
Application number
BR112018070653A
Other languages
English (en)
Inventor
Mørkeberg Hinsby Anders
Kolster Fog-Tonnesen Cathrine
Bornaes Claus
Havnsøe Torp Petersen Nikolaj
Kirkegaard Jensen Thomas
Original Assignee
Orphazyme As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orphazyme As filed Critical Orphazyme As
Publication of BR112018070653A2 publication Critical patent/BR112018070653A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

a presente invenção refere-se a um ingrediente farmacêutico ativo selecionado dentre cloreto de n-[2-hidroxi-3-(1-piperidinil)-propoxi]-piridina-1-oxido-3-carboximidoíla, seus estereoisômeros e os sais de adição de ácido dos mesmos (arimoclomol) para uso em um método para tratar distúrbios associados à glicocerebrosidase.
BR112018070653A 2016-04-29 2017-04-28 ingrediente farmacêutico ativo, e, composição BR112018070653A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201670281 2016-04-29
PCT/EP2017/060205 WO2017186919A1 (en) 2016-04-29 2017-04-28 Arimoclomol for treating glucocerebrosidase associated disorders

Publications (1)

Publication Number Publication Date
BR112018070653A2 true BR112018070653A2 (pt) 2019-02-05

Family

ID=58645076

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018070653A BR112018070653A2 (pt) 2016-04-29 2017-04-28 ingrediente farmacêutico ativo, e, composição

Country Status (22)

Country Link
US (3) US20190111041A1 (pt)
EP (2) EP3782624A1 (pt)
JP (2) JP6818045B2 (pt)
KR (2) KR102254140B1 (pt)
CN (1) CN109069496A (pt)
AU (2) AU2017255959B2 (pt)
BR (1) BR112018070653A2 (pt)
CA (1) CA3021900A1 (pt)
CY (1) CY1123717T1 (pt)
DK (1) DK3448382T3 (pt)
ES (1) ES2831764T3 (pt)
HR (1) HRP20210047T1 (pt)
HU (1) HUE052158T2 (pt)
IL (2) IL262411B (pt)
LT (1) LT3448382T (pt)
PL (1) PL3448382T3 (pt)
PT (1) PT3448382T (pt)
RS (1) RS61291B1 (pt)
RU (2) RU2750154C2 (pt)
SI (1) SI3448382T1 (pt)
SM (1) SMT202100022T1 (pt)
WO (1) WO2017186919A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2646044T3 (pl) * 2010-11-30 2020-03-31 Orphazyme A/S Sposoby zwiększenia aktywności wewnątrzkomórkowej Hsp70
AU2021295437A1 (en) * 2020-06-24 2023-02-02 Zevra Denmark A/S Arimoclomol for treating gaucher disease
US20230416224A1 (en) 2020-11-19 2023-12-28 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

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