[go: up one dir, main page]

BR112018069302A2 - naftiridinas como antagonistas de integrina - Google Patents

naftiridinas como antagonistas de integrina

Info

Publication number
BR112018069302A2
BR112018069302A2 BR112018069302A BR112018069302A BR112018069302A2 BR 112018069302 A2 BR112018069302 A2 BR 112018069302A2 BR 112018069302 A BR112018069302 A BR 112018069302A BR 112018069302 A BR112018069302 A BR 112018069302A BR 112018069302 A2 BR112018069302 A2 BR 112018069302A2
Authority
BR
Brazil
Prior art keywords
formula
naphthyridines
compound
integrin antagonists
pharmaceutically acceptable
Prior art date
Application number
BR112018069302A
Other languages
English (en)
Inventor
Paul Hancock Ashley
Mary Redmond Joanna
Martin Pritchard John
Howard James Campbell-Crawford Matthew
Andrew Anderson Niall
Alexandrou Procopiou Panayiotis
Lemma Seble
Leslie Sollis Steven
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of BR112018069302A2 publication Critical patent/BR112018069302A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a invenção refere-se a compostos de fórmula (i): (i) na qual, r1, r2 e r3 são definidos na descrição e reivindicações, ou sais seus aceitos no meio farmacêutico tendo atividade antagonista a integrina avß6. a invenção também se refere a composições farmacêuticas incluindo composto de fórmula (i) ou um sal seu aceito no meio farmacêutico, e ao uso de um composto de fórmula (i) ou um sal seu aceito no meio farmacêutico em terapia, incluindo-se no tratamento de uma doença ou patologia para as quais um antagonista de integrina avß6 é indicado, e, em particular, o tratamento de fibrose pulmonar idiopática.
BR112018069302A 2016-03-21 2017-03-20 naftiridinas como antagonistas de integrina BR112018069302A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1604681.5A GB201604681D0 (en) 2016-03-21 2016-03-21 Chemical Compounds
PCT/EP2017/056527 WO2017162572A1 (en) 2016-03-21 2017-03-20 Naphthyridines as integrin antagonists

Publications (1)

Publication Number Publication Date
BR112018069302A2 true BR112018069302A2 (pt) 2019-01-22

Family

ID=55968580

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018069302A BR112018069302A2 (pt) 2016-03-21 2017-03-20 naftiridinas como antagonistas de integrina

Country Status (14)

Country Link
US (1) US20210206758A1 (pt)
EP (1) EP3433255A1 (pt)
JP (1) JP2019509305A (pt)
KR (1) KR20180128404A (pt)
CN (1) CN108779114A (pt)
AR (1) AR107927A1 (pt)
AU (1) AU2017237362A1 (pt)
BR (1) BR112018069302A2 (pt)
CA (1) CA3018014A1 (pt)
GB (1) GB201604681D0 (pt)
RU (1) RU2018136888A (pt)
TW (1) TW201808949A (pt)
UY (1) UY37160A (pt)
WO (1) WO2017162572A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201305668D0 (en) 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
GB201417094D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417011D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417018D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201604680D0 (en) 2016-03-21 2016-05-04 Glaxosmithkline Ip Dev Ltd Chemical Compounds
MA52117A (fr) 2017-02-28 2022-04-06 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
RU2769702C2 (ru) 2017-02-28 2022-04-05 Морфик Терапьютик, Инк. Ингибиторы интегрина avb6
KR102787602B1 (ko) 2018-03-07 2025-03-31 플라이언트 테라퓨틱스, 인크. 아미노산 화합물 및 사용 방법
WO2020047207A1 (en) * 2018-08-29 2020-03-05 Morphic Therapeutics, Inc. Inhibitors of (alpha-v)(beta-6) integrin
DK3844162T3 (da) * 2018-08-29 2025-03-03 Morphic Therapeutic Inc Hæmmere af alfa-v-beta6-integrin
EP4086254B1 (en) * 2018-08-29 2024-12-18 Morphic Therapeutic, Inc. Integrin inhibitors
CN113620938A (zh) * 2020-05-07 2021-11-09 北京康派森医药科技有限公司 一种恩格列净异构体杂质的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024797A1 (en) * 1999-10-04 2001-04-12 Merck & Co., Inc. Integrin receptor antagonists
BR0015384A (pt) * 1999-11-08 2002-10-08 Merck & Co Inc Processo para a preparação de um composto, e, composto
US6921767B2 (en) 2000-06-15 2005-07-26 Pharmacia Corporation Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
WO2003100033A2 (en) 2002-03-13 2003-12-04 Biogen Idec Ma Inc. ANTI-αvβ6 ANTIBODIES
US20040224986A1 (en) * 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
EP2668191A4 (en) 2011-01-19 2014-08-20 Albany Molecular Res Inc BENZOFURO- [3,2-C-] PYRIDINES AND RELATED ANALOGS AS SEROTONIN-SUBTYPE-6 (5-HT6) MODULATORS FOR THE TREATMENT OF ADIPOSITAS, METABOLISM SYNDROME, COGNITION AND SCHIZOPHRENIA
US20150178760A1 (en) 2012-07-24 2015-06-25 Empire Technology Development Llc Methods for valuation of recycling credits
GB201305668D0 (en) 2013-03-28 2013-05-15 Glaxosmithkline Ip Dev Ltd Avs6 Integrin Antagonists
GB201417011D0 (en) * 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201417002D0 (en) 2014-09-26 2014-11-12 Glaxosmithkline Ip Dev Ltd Novel compound

Also Published As

Publication number Publication date
RU2018136888A (ru) 2020-04-22
WO2017162572A1 (en) 2017-09-28
EP3433255A1 (en) 2019-01-30
US20210206758A1 (en) 2021-07-08
AR107927A1 (es) 2018-06-28
CA3018014A1 (en) 2017-09-28
CN108779114A (zh) 2018-11-09
AU2017237362A1 (en) 2018-08-09
GB201604681D0 (en) 2016-05-04
TW201808949A (zh) 2018-03-16
KR20180128404A (ko) 2018-12-03
JP2019509305A (ja) 2019-04-04
UY37160A (es) 2017-09-29

Similar Documents

Publication Publication Date Title
BR112018069302A2 (pt) naftiridinas como antagonistas de integrina
PE20170502A1 (es) ACIDO 4-(3-FLUORO-3-(2-(5,6,7,8-TETRAHIDRO-1,8-NAFTIRIDIN-2-IL)ETIL)PIRROLIDIN-1-IL)-3-(3-(2-METOXIETOXI)FENIL)BUTANOICO COMO ANTAGONISTA DE INTEGRINA aVß6
BR112018070602A2 (pt) composto, composição farmacêutica, uso do composto, e, método para tratar uma doença ou distúrbio
BR112015001419A8 (pt) composto, composição farmacêutica, e, uso de um composto ou de um sal farmaceuticamente aceitável do mesmo
BR112017017135A2 (pt) inibidores de tgf-beta
BR112016016844A2 (pt) Compostos heterocíclicos
BR112019007039A2 (pt) pirrolidinas substituídas e seus métodos de uso no tratamento de fibrose cística
BR112015022993A8 (pt) inibidores de jak2 e alk2 e métodos para sua utilização.
BR112015020152A2 (pt) derivados de sais de 2-amino-1-hidroxietil-8-hidroxiquinolin-2(1h)-ona tendo tanto atividade de agonista de receptor adrenérgico beta2 quanto atividade de antagonista de receptor muscarínico m3
SI2989100T1 (en) NAFTIRIDINE DERIVATIVES USED AS ANTAGONISTS INTEGRITY OF ALFA-V-BETA-6
BR112014029161A2 (pt) benzamidas n-substituídas e seu uso no tratamento de dor
BR112015023397A2 (pt) benzoxazois substituídos e métodos de uso dos mesmos
BR112016028288A2 (pt) ?composto, composição farmacêutica, métodos para tratamento de um indivíduo com uma doença ou condição e para inibir a quinase, e, uso de um composto?
BR112014010617A8 (pt) Derivados de 2-(1,2,3-triazol-2-il)benzamida e 3-(1,2,3-triazol-2-il)picolinamida como antagonistas do receptor de orexina
BR112015022488A2 (pt) triazolopiridinas substituídas e métodos de uso das mesmas
BR112018007772A2 (pt) compostos de imidazo[4,5-c]quinolin-2-ona e seu uso no tratamento do câncer
BR112021022536A2 (pt) Derivado de fenilpropenilpiridina substituída e método de preparação do mesmo e uso médico do mesmo
CU20150084A7 (es) Derivados del ácido 4-((1,1) bisfenil -4-il)-3-(3-fosfonopropanamido)butanoico,activo como inhibidores de nep(endopeptidasa neutral)
BR112014031108A2 (pt) compostos de pirazol substituído como antagonistas de lpar
BR112017019653A2 (pt) derivados heteroaril bicíclicos fundidos tendo atividade como inibidores de phd
BR112019005318A2 (pt) compostos de aza-indazol para uso em lesões no tendão e/ou ligamento
BR112015022631A2 (pt) formas cristalinas de inibidores de tirosina cinase e seus sais
MX2019015431A (es) Compuesto cíclico tipo cumarina como inhibidor de mek y su uso.
HRP20210486T1 (hr) Trans-4-{2-[4-(2,3-diklorofenil)-piperazin-1-il]-etil}-n,n-dimetilkarbamoil-cikloheksilamin za liječenje primarnih negativnih simptoma shizofrenije
MX371178B (es) Orvepitant para el tratamiento de la tos crónica.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired
B350 Update of information on the portal [chapter 15.35 patent gazette]