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BR112018010690A8 - vírus vivo tendo um banco de cepas atenuadas do vírus da dengue, e uma vacina da dengue contendo as mesmas como antígenos - Google Patents

vírus vivo tendo um banco de cepas atenuadas do vírus da dengue, e uma vacina da dengue contendo as mesmas como antígenos Download PDF

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Publication number
BR112018010690A8
BR112018010690A8 BR112018010690A BR112018010690A BR112018010690A8 BR 112018010690 A8 BR112018010690 A8 BR 112018010690A8 BR 112018010690 A BR112018010690 A BR 112018010690A BR 112018010690 A BR112018010690 A BR 112018010690A BR 112018010690 A8 BR112018010690 A8 BR 112018010690A8
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BR
Brazil
Prior art keywords
dengue
virus
antigens
bank
vaccine containing
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BR112018010690A
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English (en)
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BR112018010690A2 (pt
Inventor
Fukuda Aki
Komura Fusae
Kameyama Kazuhisa
Sonoda Kengo
Yoshimura Masaya
Abe Motoharu
Uchida Naomi
Maruno Shinichi
Takagi Shota
Yamaori Susumu
Shinmura Yasuhiko
Hayashi Yasuhisa
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The Chemo Sero Therapeutic Res Institute
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Application filed by The Chemo Sero Therapeutic Res Institute filed Critical The Chemo Sero Therapeutic Res Institute
Publication of BR112018010690A2 publication Critical patent/BR112018010690A2/pt
Publication of BR112018010690A8 publication Critical patent/BR112018010690A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/08—Inactivation or attenuation by serial passage of virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24151—Methods of production or purification of viral material
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C12N2770/24164—Methods of inactivation or attenuation by serial passage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
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  • Genetics & Genomics (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
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  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

a presente invenção refere-se a uma vacina altamente segura da dengue a qual se descobriu que induziu uma resposta de anticorpos neutralizantes contra todos os quatro sorotipos do vírus da dengue sem desenvolver mais do que um nível fixo de viremia com uma única administração. a presente invenção se refere a proporcionar uma formulação de vírus da dengue tetravalente que é excelente tanto em eficácia (resposta de anticorpos neutralizantes) quanto em segurança (viremia).
BR112018010690A 2015-11-27 2016-11-25 vírus vivo tendo um banco de cepas atenuadas do vírus da dengue, e uma vacina da dengue contendo as mesmas como antígenos BR112018010690A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015232013 2015-11-27
JP2015-232013 2015-11-27
PCT/JP2016/085077 WO2017090762A1 (ja) 2015-11-27 2016-11-25 デングウイルス弱毒株をバンク化した生ウイルス、及びそれらを抗原とするデングワクチン

Publications (2)

Publication Number Publication Date
BR112018010690A2 BR112018010690A2 (pt) 2018-11-13
BR112018010690A8 true BR112018010690A8 (pt) 2019-02-26

Family

ID=58763255

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018010690A BR112018010690A8 (pt) 2015-11-27 2016-11-25 vírus vivo tendo um banco de cepas atenuadas do vírus da dengue, e uma vacina da dengue contendo as mesmas como antígenos

Country Status (15)

Country Link
US (1) US10655110B2 (pt)
EP (1) EP3382012A4 (pt)
JP (2) JP6910956B2 (pt)
KR (2) KR102297300B1 (pt)
CN (1) CN108699534B (pt)
AU (1) AU2016360487C1 (pt)
BR (1) BR112018010690A8 (pt)
CA (1) CA3005814C (pt)
IL (1) IL259451B (pt)
MX (1) MX393033B (pt)
MY (1) MY194650A (pt)
PH (1) PH12018501107A1 (pt)
SG (2) SG10201913338XA (pt)
TW (1) TWI736563B (pt)
WO (1) WO2017090762A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116143914B (zh) * 2022-12-30 2023-08-22 珠海重链生物科技有限公司 一种针对登革病毒ns1蛋白的抗体及其相关应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000057910A1 (en) 1999-03-26 2000-10-05 Walter Reed Army Institute Of Research Attenuated dengue-4 virus vaccine
EP1263965B1 (en) * 2000-02-16 2011-09-28 The Government of the United States of America, as represented by the Secretary, Department of Health & Human Services Avirulent, immunogenic flavivirus chimeras
EP1159969A1 (fr) * 2000-05-30 2001-12-05 Aventis Pasteur Vaccine composition
PT1159968E (pt) 2000-05-30 2008-11-20 Univ Mahidol Estirpes atenuadas de vírus do dengue e a sua utilização numa composição de vacina
CA2611934C (en) 2005-06-17 2015-11-03 Sanofi Pasteur Dengue serotype 1 attenuated strain
CA2611954C (en) 2005-06-17 2014-01-28 Sanofi Pasteur Dengue serotype 2 attenuated strain
AR061197A1 (es) 2006-06-07 2008-08-13 Sanofi Pasteur Cepas del virus 3 del dengue vivas atenuadas
FR2906724B1 (fr) * 2006-10-04 2009-03-20 Sanofi Pasteur Sa Methode d'immunisation contre les 4 serotypes de la dengue.
WO2012051461A2 (en) * 2010-10-13 2012-04-19 Primordial Soup, Llc Screw captivator
US20150196631A1 (en) * 2012-07-24 2015-07-16 Sanofi Pasteur Vaccine compositions
SG11201502221WA (en) * 2012-09-21 2015-05-28 Agency Science Tech & Res Novel attenuated dengue virus strains for vaccine application
PH12015502120B1 (en) * 2013-03-15 2024-02-16 Takeda Vaccines Inc Compositions and methods for dengue virus chimeric constructs in vaccines

Also Published As

Publication number Publication date
WO2017090762A1 (ja) 2017-06-01
KR102373570B1 (ko) 2022-03-10
JPWO2017090762A1 (ja) 2018-09-20
IL259451B (en) 2022-01-01
NZ742683A (en) 2021-08-27
EP3382012A1 (en) 2018-10-03
JP7232289B2 (ja) 2023-03-02
US10655110B2 (en) 2020-05-19
EP3382012A4 (en) 2019-07-03
CN108699534B (zh) 2022-05-24
MX2018006500A (es) 2019-02-26
AU2016360487C1 (en) 2021-07-22
JP2021168672A (ja) 2021-10-28
TWI736563B (zh) 2021-08-21
MY194650A (en) 2022-12-09
TW201726913A (zh) 2017-08-01
AU2016360487A1 (en) 2018-07-12
AU2016360487A2 (en) 2018-07-26
KR102297300B1 (ko) 2021-09-02
AU2016360487B2 (en) 2021-01-21
US20180340155A1 (en) 2018-11-29
KR20180080331A (ko) 2018-07-11
CN108699534A (zh) 2018-10-23
KR20210083384A (ko) 2021-07-06
SG11201804317YA (en) 2018-06-28
SG10201913338XA (en) 2020-02-27
CA3005814A1 (en) 2017-06-01
CA3005814C (en) 2022-09-27
BR112018010690A2 (pt) 2018-11-13
MX393033B (es) 2025-03-24
PH12018501107A1 (en) 2019-01-21
IL259451A (en) 2018-07-31
JP6910956B2 (ja) 2021-07-28

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B25G Requested change of headquarter approved

Owner name: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE (JP)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

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Owner name: KM BIOLOGICS CO., LTD. (JP)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]