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BR112018008966A2 - compostos inibidores de jak quinase para o tratamento de doença respiratória - Google Patents

compostos inibidores de jak quinase para o tratamento de doença respiratória

Info

Publication number
BR112018008966A2
BR112018008966A2 BR112018008966-4A BR112018008966A BR112018008966A2 BR 112018008966 A2 BR112018008966 A2 BR 112018008966A2 BR 112018008966 A BR112018008966 A BR 112018008966A BR 112018008966 A2 BR112018008966 A2 BR 112018008966A2
Authority
BR
Brazil
Prior art keywords
treatment
jak kinase
compounds
kinase inhibitor
respiratory disease
Prior art date
Application number
BR112018008966-4A
Other languages
English (en)
Other versions
BR112018008966B1 (pt
Inventor
R. Fatheree Paul
R. Jacobsen John
Beausoleil Anne-Marie
E.L. BRANDT Gary
Fleury Melissa
Jiang Lan
Smith Cameron
D.E. Sullivan Steven
Jean Van Orden Lori
Colson Pierre-Jean
Timothy Fass Gene
Rapta Miroslav
Benjamin Noah
Dabros Marta
R. Thalladi Venkat
Original Assignee
Theravance Biopharma R&D Ip, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip, Llc filed Critical Theravance Biopharma R&D Ip, Llc
Publication of BR112018008966A2 publication Critical patent/BR112018008966A2/pt
Publication of BR112018008966B1 publication Critical patent/BR112018008966B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

a invenção fornece compostos de fórmula (i): em que x é (i) e as variáveis são definidas no relatório descritivo, ou um sal farmaceuticamente aceitável destes, que são úteis como inibidores de jak quinase. a invenção também fornece composições farmacêuticas que compreendem esses compostos, métodos de uso desses compostos para tratar doenças respiratórias, e processos e intermediários úteis para a preparação desses compostos.
BR112018008966-4A 2015-11-03 2016-11-02 Compostos inibidores de jak quinase, hidrato cristalino, composição farmacêutica, processos, método de preparação do hidrato cristalino e uso dos referidos compostos e hidrato cristalino no tratamento de doença respiratória BR112018008966B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (2)

Publication Number Publication Date
BR112018008966A2 true BR112018008966A2 (pt) 2018-11-27
BR112018008966B1 BR112018008966B1 (pt) 2023-05-02

Family

ID=57442794

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018008966-4A BR112018008966B1 (pt) 2015-11-03 2016-11-02 Compostos inibidores de jak quinase, hidrato cristalino, composição farmacêutica, processos, método de preparação do hidrato cristalino e uso dos referidos compostos e hidrato cristalino no tratamento de doença respiratória

Country Status (22)

Country Link
US (6) US10100049B2 (pt)
EP (1) EP3371186A1 (pt)
JP (1) JP6800969B2 (pt)
KR (1) KR20180073687A (pt)
CN (1) CN108349972B (pt)
AU (1) AU2016350816B2 (pt)
BR (1) BR112018008966B1 (pt)
CA (1) CA3001542C (pt)
CL (1) CL2018001145A1 (pt)
CO (1) CO2018005640A2 (pt)
EA (1) EA034914B1 (pt)
HK (1) HK1252685A1 (pt)
IL (1) IL258772B (pt)
MX (1) MX374605B (pt)
MY (1) MY195427A (pt)
NZ (1) NZ741737A (pt)
PH (1) PH12018500828B1 (pt)
SA (1) SA518391470B1 (pt)
TW (1) TWI710560B (pt)
UA (1) UA123633C2 (pt)
WO (1) WO2017079205A1 (pt)
ZA (1) ZA201802496B (pt)

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AR111241A1 (es) 2017-03-09 2019-06-19 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
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CN110603255B (zh) 2017-05-01 2023-02-10 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的结晶型式
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CN112739697B (zh) 2018-09-04 2023-10-20 施万生物制药研发Ip有限责任公司 作为jak抑制剂的二甲基氨基氮杂环丁烷酰胺
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CA3212635A1 (en) 2021-03-26 2022-09-29 Theravance Biopharma R&D Ip, Llc Crystalline form of a dihydrochloride salt of a jak inhibitor compound

Also Published As

Publication number Publication date
US20190106420A1 (en) 2019-04-11
CL2018001145A1 (es) 2018-07-06
US10100049B2 (en) 2018-10-16
US11718616B2 (en) 2023-08-08
CN108349972A (zh) 2018-07-31
JP2018531982A (ja) 2018-11-01
US20220306624A1 (en) 2022-09-29
US20170121327A1 (en) 2017-05-04
CN108349972B (zh) 2021-06-08
US20210130351A1 (en) 2021-05-06
US10526330B2 (en) 2020-01-07
NZ741737A (en) 2023-11-24
US10913740B2 (en) 2021-02-09
CO2018005640A2 (es) 2018-05-31
JP6800969B2 (ja) 2020-12-16
US20200087303A1 (en) 2020-03-19
US10183942B2 (en) 2019-01-22
PH12018500828B1 (en) 2023-06-30
US20180319796A1 (en) 2018-11-08
TW201726673A (zh) 2017-08-01
KR20180073687A (ko) 2018-07-02
UA123633C2 (uk) 2021-05-05
MY195427A (en) 2023-01-20
IL258772A (en) 2018-06-28
HK1252685A1 (zh) 2019-05-31
TWI710560B (zh) 2020-11-21
WO2017079205A1 (en) 2017-05-11
IL258772B (en) 2021-01-31
CA3001542C (en) 2021-02-16
SA518391470B1 (ar) 2021-03-31
EA201891091A1 (ru) 2018-12-28
AU2016350816A1 (en) 2018-05-17
CA3001542A1 (en) 2017-05-11
AU2016350816B2 (en) 2020-06-25
MX374605B (es) 2025-03-06
US11299492B2 (en) 2022-04-12
MX2018005446A (es) 2018-08-01
EA034914B1 (ru) 2020-04-06
BR112018008966B1 (pt) 2023-05-02
PH12018500828A1 (en) 2018-10-29
ZA201802496B (en) 2025-01-29
EP3371186A1 (en) 2018-09-12

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2799 DE 27-08-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.