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BR112018000497A2 - processo para preparação de um composto - Google Patents

processo para preparação de um composto

Info

Publication number
BR112018000497A2
BR112018000497A2 BR112018000497A BR112018000497A BR112018000497A2 BR 112018000497 A2 BR112018000497 A2 BR 112018000497A2 BR 112018000497 A BR112018000497 A BR 112018000497A BR 112018000497 A BR112018000497 A BR 112018000497A BR 112018000497 A2 BR112018000497 A2 BR 112018000497A2
Authority
BR
Brazil
Prior art keywords
derivative
compound
cannabidiol compound
dihalo
cannabidiol
Prior art date
Application number
BR112018000497A
Other languages
English (en)
Inventor
Petrovic Denis
Dialer Lukas
Weigl Ulrich
Original Assignee
Noramco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57730761&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112018000497(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Noramco Inc filed Critical Noramco Inc
Publication of BR112018000497A2 publication Critical patent/BR112018000497A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/14Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

a presente revelação se refere à preparação de um composto de canabidiol ou um derivado do mesmo. o composto de canabidiol, ou derivados do mesmo, pode ser preparado por meio de uma reação catalisada por ácido de um di-halo-olivetol adequadamente selecionado e substituído, ou um derivado do mesmo, com um alceno cíclico adequadamente selecionado e substituído para produzir um composto de dihalo-canabidiol ou um derivado do mesmo. o composto de dihalo-canabidiol ou o derivado do mesmo pode ser produzido com alto rendimento, alta estereoespecificidade ou ambos. o mesmo pode ser, então, convertido sob condições redutoras em um composto de canabidiol ou derivados do mesmo.
BR112018000497A 2015-07-10 2016-07-01 processo para preparação de um composto BR112018000497A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562191097P 2015-07-10 2015-07-10
US15/199,528 US10059683B2 (en) 2015-07-10 2016-06-30 Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
PCT/US2016/040635 WO2017011210A1 (en) 2015-07-10 2016-07-01 Process for the production of cannabidiol and delta-9-tetrahydrocannabinol

Publications (1)

Publication Number Publication Date
BR112018000497A2 true BR112018000497A2 (pt) 2018-09-11

Family

ID=57730761

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018000497A BR112018000497A2 (pt) 2015-07-10 2016-07-01 processo para preparação de um composto

Country Status (21)

Country Link
US (4) US20170008869A1 (pt)
EP (2) EP3722276B1 (pt)
JP (2) JP6810842B2 (pt)
CN (1) CN108137526A (pt)
AU (2) AU2016294264B2 (pt)
BR (1) BR112018000497A2 (pt)
CA (1) CA2992043C (pt)
CL (2) CL2018000079A1 (pt)
CO (1) CO2018001290A2 (pt)
CR (1) CR20180094A (pt)
DK (1) DK3319952T3 (pt)
EC (1) ECSP18010065A (pt)
ES (2) ES3010714T3 (pt)
HK (1) HK1255390A1 (pt)
IL (1) IL256750A (pt)
MX (1) MX2018000354A (pt)
MY (1) MY182971A (pt)
NZ (1) NZ738925A (pt)
PH (1) PH12018500093A1 (pt)
PT (1) PT3319952T (pt)
WO (1) WO2017011210A1 (pt)

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GB2531281A (en) 2014-10-14 2016-04-20 Gw Pharma Ltd Use of cannabidiol in the treatment of intractable epilepsy
GB2539472A (en) 2015-06-17 2016-12-21 Gw Res Ltd Use of cannabinoids in the treatment of epilepsy
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US10640482B2 (en) 2017-07-21 2020-05-05 University Of South Florida Synthesis of cannabinoids
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WO2020001770A1 (en) 2018-06-28 2020-01-02 Symrise Ag Synthesis of (+)-cannabinoids and their therapeutic effects
US10736869B2 (en) 2018-07-16 2020-08-11 ECS Health Sciences, Inc. Compositions and methods related to cannabinoids, terpenoids and essential oils
CN108863768A (zh) * 2018-08-03 2018-11-23 上海华堇生物技术有限责任公司 3,5-二甲氧基苯甲酰氯的制备方法
CN113382792A (zh) 2018-08-20 2021-09-10 贝索制药有限责任公司 新型大麻素和大麻素酸及其衍生物
EP3847148A2 (en) * 2018-09-05 2021-07-14 Purisys LLC Cannabidiol compositions having modified cannabinoid profiles
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EP3653596A1 (en) * 2018-11-14 2020-05-20 Indena S.p.A. Continuous flow synthesis of cannabidiol
DE102019104563A1 (de) 2019-02-22 2020-08-27 Chiracon Gmbh Verfahren zur Herstellung von Cannabidiol
CN109970516A (zh) * 2019-03-20 2019-07-05 栾云鹏 一种工业化制备高纯度高收率的大麻酚类物质的合成方法
US10981850B2 (en) 2019-04-15 2021-04-20 Trustees Of Boston University One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives
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IL288196B1 (en) * 2019-05-23 2025-04-01 Kare Chemical Tech Inc Catalytic Cannabinoid Processes and Starting Materials
US20230183157A1 (en) * 2019-05-31 2023-06-15 Purisys Llc Processes for the preparation of halogenated dihydroxybenzene compounds
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WO2020252277A1 (en) * 2019-06-13 2020-12-17 Isomerz, Inc. Making delta 8 thc, delta 10 thc and/or cannabinol from cbd
US20220242810A1 (en) * 2019-06-14 2022-08-04 Purisys Llc Crystalline cannabigerol
GB201910389D0 (en) * 2019-07-19 2019-09-04 Gw Pharma Ltd Novel compounds, methods for their manufacture, and uses thereof
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US11419800B2 (en) 2019-12-06 2022-08-23 JLABS Beauty LLC Topical compositions containing rose oil and cannabidiol and methods of making and using the same
WO2021133989A1 (en) * 2019-12-27 2021-07-01 Baymedica, Inc. Preparation of cannabichromene and related cannabinoids
CN113087743B (zh) * 2020-01-08 2023-04-28 成都百裕制药股份有限公司 四氢大麻酚衍生物及其制备方法和在医药上的应用
CN113087599A (zh) * 2020-01-08 2021-07-09 成都百裕制药股份有限公司 大麻二酚衍生物及其制备方法和在医药上的应用
US20230002425A1 (en) * 2020-01-08 2023-01-05 Chengdu Baiyu Pharmaceutical Co., Ltd. Cannabidiol derivatives, preparation method thereof and use thereof
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US10981849B1 (en) * 2020-02-20 2021-04-20 Sci Pharmtech Inc. Method for preparing cannabinoids
GB202002754D0 (en) 2020-02-27 2020-04-15 Gw Res Ltd Methods of treating tuberous sclerosis complex with cannabidiol and everolimus
AU2021235467A1 (en) 2020-03-12 2021-10-07 Council Of Scientific And Industrial Research Process for the synthesis of cannabidiol and intermediates thereof
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CA3179442A1 (en) 2020-05-22 2021-11-25 Brian Warrington Compositions for treating acne and dermatological conditions
CN112094257B (zh) * 2020-08-19 2023-08-22 公安部禁毒情报技术中心 一种△-9四氢大麻酚的制备方法
CN112811980B (zh) * 2020-12-01 2022-03-25 山东金城金奥医药科技有限公司 一种绿色光氧化连续制备大麻二酚中间体的方法
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Also Published As

Publication number Publication date
EP3722276C0 (en) 2025-01-08
US10059683B2 (en) 2018-08-28
MY182971A (en) 2021-02-05
WO2017011210A1 (en) 2017-01-19
JP2020037596A (ja) 2020-03-12
CA2992043A1 (en) 2017-01-19
CL2019003154A1 (es) 2020-03-06
AU2016294264B2 (en) 2019-06-13
HK1255390A1 (zh) 2019-08-16
ES2784881T3 (es) 2020-10-01
US20170008869A1 (en) 2017-01-12
CN108137526A (zh) 2018-06-08
ES3010714T3 (en) 2025-04-04
JP6810842B2 (ja) 2021-01-13
CR20180094A (es) 2018-06-14
DK3319952T3 (da) 2020-03-23
US20180319763A1 (en) 2018-11-08
CO2018001290A2 (es) 2018-04-19
EP3722276B1 (en) 2025-01-08
PH12018500093A1 (en) 2018-07-09
AU2016294264A1 (en) 2018-02-01
NZ738925A (en) 2019-05-31
EP3319952A1 (en) 2018-05-16
IL256750A (en) 2018-03-29
EP3319952B8 (en) 2020-03-11
ECSP18010065A (es) 2018-05-31
US20210061781A1 (en) 2021-03-04
CL2018000079A1 (es) 2018-08-24
JP2018522944A (ja) 2018-08-16
US20170008868A1 (en) 2017-01-12
MX2018000354A (es) 2018-08-15
EP3319952B1 (en) 2020-02-05
CA2992043C (en) 2020-04-14
PT3319952T (pt) 2020-04-22
EP3722276A1 (en) 2020-10-14
AU2019229416A1 (en) 2019-10-03
US10844035B2 (en) 2020-11-24

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